Acute Nasal Breathing Lowers Diastolic Blood Pressure and Increases Parasympathetic Contributions to Heart Rate Variability in Young Adults
CONCLUSION: These data suggest that nasal compared with oral breathing acutely 1) lowers mean and diastolic BP, 2) does not affect systolic BP or heart rate, and 3) increases parasympathetic contributions to HRV.PMID:37867476 | DOI:10.1152/ajpregu.00148.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Joseph C Watso Jens N Cuba Savannah L Boutwell Justine Moss Allison K Bowerfind Isabela M Fernandez Jessica M Cassette Allyson M May Katherine F Kirk Source Type: research

Maturation of Lipid Metabolism in the Fetal and Newborn Sheep Heart
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00122.2023. Online ahead of print.ABSTRACTAt birth, the fetus experiences a dramatic change in environment which is accompanied by a shift in myocardial fuel preference from lactate and glucose in fetal life to fatty acid oxidation after birth. We hypothesized that fatty acid metabolic machinery would mature during fetal life in preparation for this extreme metabolic transformation at birth. We quantified the pre- (94-day and 135-day gestation, term ~147 days) and post-natal (5±4 days postnatal) gene expression and protein levels for fatty acid tran...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Rachel R Drake Samantha Louey Kent L Thornburg Source Type: research

The expression of cholesterol synthesis and steroidogenic markers in females of the Chinese brown frog (Rana dybowskii) during pre-spawning and pre-hibernation
In this study, we investigated the expression patterns of the markers that are involved in the de novo steroid synthesis pathway in the oviduct of R. dybowskii during pre-spawning and pre-hibernation. According to histological analysis, the oviduct of R. dybowskii contains epithelial cells, glandular cells, and tubule lumens. During pre-hibernation, oviductal pipe diameter and weight were significantly larger than during pre-spawning. 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), Low-density lipoprotein receptor (LDLR), steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzym...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Yuan Chen Yuning Liu Yankun Wang Yue Zhang Wenqian Xie Haolin Zhang Qiang Weng Meiyu Xu Source Type: research

Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00094.2023. Online ahead of print.ABSTRACTThe sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3 day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lux) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lux) and ordinary light alternatively with bright light after the 1st dark period (24:00 - 4:00 h)...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00044.2023. Online ahead of print.ABSTRACTModerate-to-heavy episodic ("binge") drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro in many species including rats, mice and humans. Despite the critical role played by brain vessels in maintaining neuronal function, there is a shortage of methodologies to simultaneously assess neuron and blood vessel function in deep brain regions. Here, we investigate cerebrovascular responses to ethano...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Kelsey North Steven Mysiewicz Anna N Bukiya Alex M Dopico Source Type: research

Acute Nasal Breathing Lowers Diastolic Blood Pressure and Increases Parasympathetic Contributions to Heart Rate Variability in Young Adults
CONCLUSION: These data suggest that nasal compared with oral breathing acutely 1) lowers mean and diastolic BP, 2) does not affect systolic BP or heart rate, and 3) increases parasympathetic contributions to HRV.PMID:37867476 | DOI:10.1152/ajpregu.00148.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Joseph C Watso Jens N Cuba Savannah L Boutwell Justine Moss Allison K Bowerfind Isabela M Fernandez Jessica M Cassette Allyson M May Katherine F Kirk Source Type: research

Maturation of Lipid Metabolism in the Fetal and Newborn Sheep Heart
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00122.2023. Online ahead of print.ABSTRACTAt birth, the fetus experiences a dramatic change in environment which is accompanied by a shift in myocardial fuel preference from lactate and glucose in fetal life to fatty acid oxidation after birth. We hypothesized that fatty acid metabolic machinery would mature during fetal life in preparation for this extreme metabolic transformation at birth. We quantified the pre- (94-day and 135-day gestation, term ~147 days) and post-natal (5±4 days postnatal) gene expression and protein levels for fatty acid tran...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Rachel R Drake Samantha Louey Kent L Thornburg Source Type: research

The expression of cholesterol synthesis and steroidogenic markers in females of the Chinese brown frog (Rana dybowskii) during pre-spawning and pre-hibernation
In this study, we investigated the expression patterns of the markers that are involved in the de novo steroid synthesis pathway in the oviduct of R. dybowskii during pre-spawning and pre-hibernation. According to histological analysis, the oviduct of R. dybowskii contains epithelial cells, glandular cells, and tubule lumens. During pre-hibernation, oviductal pipe diameter and weight were significantly larger than during pre-spawning. 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), Low-density lipoprotein receptor (LDLR), steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzym...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Yuan Chen Yuning Liu Yankun Wang Yue Zhang Wenqian Xie Haolin Zhang Qiang Weng Meiyu Xu Source Type: research

Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00094.2023. Online ahead of print.ABSTRACTThe sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3 day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lux) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lux) and ordinary light alternatively with bright light after the 1st dark period (24:00 - 4:00 h)...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00044.2023. Online ahead of print.ABSTRACTModerate-to-heavy episodic ("binge") drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro in many species including rats, mice and humans. Despite the critical role played by brain vessels in maintaining neuronal function, there is a shortage of methodologies to simultaneously assess neuron and blood vessel function in deep brain regions. Here, we investigate cerebrovascular responses to ethano...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Kelsey North Steven Mysiewicz Anna N Bukiya Alex M Dopico Source Type: research

Acute Nasal Breathing Lowers Diastolic Blood Pressure and Increases Parasympathetic Contributions to Heart Rate Variability in Young Adults
CONCLUSION: These data suggest that nasal compared with oral breathing acutely 1) lowers mean and diastolic BP, 2) does not affect systolic BP or heart rate, and 3) increases parasympathetic contributions to HRV.PMID:37867476 | DOI:10.1152/ajpregu.00148.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Joseph C Watso Jens N Cuba Savannah L Boutwell Justine Moss Allison K Bowerfind Isabela M Fernandez Jessica M Cassette Allyson M May Katherine F Kirk Source Type: research

Maturation of Lipid Metabolism in the Fetal and Newborn Sheep Heart
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00122.2023. Online ahead of print.ABSTRACTAt birth, the fetus experiences a dramatic change in environment which is accompanied by a shift in myocardial fuel preference from lactate and glucose in fetal life to fatty acid oxidation after birth. We hypothesized that fatty acid metabolic machinery would mature during fetal life in preparation for this extreme metabolic transformation at birth. We quantified the pre- (94-day and 135-day gestation, term ~147 days) and post-natal (5±4 days postnatal) gene expression and protein levels for fatty acid tran...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Rachel R Drake Samantha Louey Kent L Thornburg Source Type: research

The expression of cholesterol synthesis and steroidogenic markers in females of the Chinese brown frog (Rana dybowskii) during pre-spawning and pre-hibernation
In this study, we investigated the expression patterns of the markers that are involved in the de novo steroid synthesis pathway in the oviduct of R. dybowskii during pre-spawning and pre-hibernation. According to histological analysis, the oviduct of R. dybowskii contains epithelial cells, glandular cells, and tubule lumens. During pre-hibernation, oviductal pipe diameter and weight were significantly larger than during pre-spawning. 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR), Low-density lipoprotein receptor (LDLR), steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzym...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Yuan Chen Yuning Liu Yankun Wang Yue Zhang Wenqian Xie Haolin Zhang Qiang Weng Meiyu Xu Source Type: research

Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00094.2023. Online ahead of print.ABSTRACTThe sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3 day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lux) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lux) and ordinary light alternatively with bright light after the 1st dark period (24:00 - 4:00 h)...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research

Dual color miniscope imaging of microvessels and neuronal activity in the hippocampus CA1 region of freely moving mice following alcohol administration
Am J Physiol Regul Integr Comp Physiol. 2023 Oct 23. doi: 10.1152/ajpregu.00044.2023. Online ahead of print.ABSTRACTModerate-to-heavy episodic ("binge") drinking is the most common form of alcohol consumption in the United States. Alcohol at binge drinking concentrations reduces brain artery diameter in vivo and in vitro in many species including rats, mice and humans. Despite the critical role played by brain vessels in maintaining neuronal function, there is a shortage of methodologies to simultaneously assess neuron and blood vessel function in deep brain regions. Here, we investigate cerebrovascular responses to ethano...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - October 23, 2023 Category: Physiology Authors: Kelsey North Steven Mysiewicz Anna N Bukiya Alex M Dopico Source Type: research