American Journal of Physiology. Regulatory, Integrative and Comparative Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00258.2023. Online ahead of print.ABSTRACTObstructive sleep apnea, a common form of sleep-disordered breathing, is characterized by intermittent cessations of breathing that reduce blood oxygen levels and contribute to the development of hypertension. Hypertension is a major complication of obstructive sleep apnea that elevates the risk of end-organ damage. Premenopausal women have a lower prevalence of obstructive sleep apnea and cardiovascular disease than men and postmenopausal women, suggesting that sex hormones play a role in the pathophysiology...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Cephas B Appiah Jennifer J Gardner George E Farmer Rebecca L Cunningham J Thomas Cunningham Source Type: research

Brain atrophy, reduced cerebral perfusion, arterial stiffening and wall thickening with ageing coincide with stimulus-specific changes in fMRI-BOLD responses
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00270.2023. Online ahead of print.ABSTRACTThe aim of this study was to investigate how aging affects blood flow and structure of the brain. It was hypothesized older individuals would have lower grey matter volume (GMV), resting cerebral blood flow (CBF0), and depressed responses to iso-metabolic and neuro-metabolic stimuli. Additionally, increased carotid-femoral pulse wave velocity (PWV), carotid intima-media thickness (IMT), and decreased brachial flow-mediated dilation (FMD) would be associated with lower CBF0, cerebrovascular reactivity (CVR) an...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Nicole S Coverdale Allen A Champagne Matti Douglas Allen Joshua C Tremblay Tarrah S Ethier Juan Fernandez-Ruiz Rory A Marshall Rebecca E K MacPherson Kyra E Pyke Douglas J Cook T Dylan Olver Source Type: research

CD8 < sup > + < /sup > T-cell metabolism is related to cerebrovascular function in middle-aged adults
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00267.2023. Online ahead of print.ABSTRACTCerebrovascular reactivity (CVR) decreases with advancing age, contributing to increased risk of cognitive impairment; however, the mechanisms underlying the age-related decrease in CVR are incompletely understood. Age-related changes to T-cells, such as impaired mitochondrial respiration increase inflammation which likely contribute peripheral and cerebrovascular dysfunction in animals. However, whether T-cell mitochondrial respiration is related to cerebrovascular function in humans is not known. Therefore,...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Theodore Mark DeConne Ibra S Fancher David G Edwards Daniel W Trott Christopher R Martens Source Type: research

Beating the Heart Failure Odds: Long-Term Survival after Myocardial Ischemia in Juvenile Rainbow Trout
Am J Physiol Regul Integr Comp Physiol. 2024 Feb 26. doi: 10.1152/ajpregu.00005.2024. Online ahead of print.ABSTRACTSalmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphologi...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 26, 2024 Category: Physiology Authors: Lucas A Zena Andreas Tommy Ekstr öm Daniel Morgenroth Tristan McArley Michael Axelsson Henrik Sundh Anders Palmquist Ida B Johansen Albin Gr äns Erik Sandblom Source Type: research