American Journal of Physiology. Regulatory, Integrative and Comparative Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression and impaired satellite cell function in mice
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00226.2023. Online ahead of print.ABSTRACTThe effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Kevin O Murray Jason O Brant Ray A Spradlin Trace Thome Orlando Laitano Terence E Ryan Alberto Riva Michael P Kladde Thomas L Clanton Source Type: research

Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00164.2023. Online ahead of print.ABSTRACTDown syndrome (Ds) is associated with congenital heart defects at birth, but cardiac function has not been assessed at older ages. We used the Ts65Dn mouse, a model of Ds, to quantify heart structure and function with echocardiography in 18-month male Ts65Dn and WT mice. Heart weight, nicotinamide adenine dinucleotide (NAD) signaling, and mitochondrial (citrate synthase) activity were investigated, as these pathways may be implicated in the cardiac pathology of Ds. The left ventricle was smaller in Ts65Dn vs W...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Josef Brandauer Candace N Receno Cynthia Anyaoku Lauren E Cooke Hannalyn M Schwarzer Keith C DeRuisseau Caitlin Cunningham Lara R DeRuisseau Source Type: research

Input-size dependence of the baroreflex neural arc transfer characteristics during Gaussian white noise inputs
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00199.2023. Online ahead of print.ABSTRACTAlthough Gaussian white noise (GWN) inputs offer a theoretical framework for identifying higher-order nonlinearity, an actual application to the data of the neural arc of the carotid sinus baroreflex did not succeed in fully predicting the well-known sigmoidal nonlinearity. In the present study, we assumed that the neural arc can be approximated by a cascade of a linear dynamic (LD) component and a nonlinear static (NS) component. We analyzed the data obtained using GWN inputs with a mean of 120 mmHg and stand...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Toru Kawada Tadayoshi Miyamoto Masafumi Fukumitsu Keita Saku Source Type: research

Intermittent Normobaric Hypoxia Alters Substrate Partitioning and Muscle Oxygenation in Obese Individuals: Implications for fat burning
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 4. doi: 10.1152/ajpregu.00153.2023. Online ahead of print.ABSTRACTThis single-blind, crossover study aimed to measure and evaluate the short-term metabolic responses to continuous and intermittent hypoxic patterns in individuals with obesity. Indirect calorimetry was used to quantify changes in resting metabolic rate (RMR), carbohydrate (CHOox, %CHO) and fat oxidation (FATox, %FAT) in nine individuals with obesity pre- and post-: (i) breathing normoxic air [normoxic sham control (NS-control)]; (ii) breathing continuous hypoxia (CH); or (iii) breathing intermittent hypoxia (I...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2023 Category: Physiology Authors: Guillaume Costalat Fr édéric Lemaître Sandra Ramos Gillian M C Renshaw Source Type: research