A modeling analysis of whole-body potassium regulation on a high potassium diet: Proximal tubule and tubuloglomerular feedback effects

In this study, we extend our mathematical model to incorporate recent experimental findings that showed decreased fractional proximal tubule reabsorption under a high K+ diet. We conducted model simulations and sensitivity analyses to investigate how these renal alterations impact whole-body K+ regulation. Model predictions quantify the sensitivity of K+ regulation to various levels of proximal tubule K+ reabsorption adaptation and tubuloglomerular feedback. Our results suggest that the reduced proximal tubule K+ reabsorption under a high K+ diet could achieve K+ balance in isolation, but the resulting tubuloglomerular feedback reduces filtration rate and thus K+ excretion.PMID:38465401 | DOI:10.1152/ajpregu.00283.2023
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Source Type: research