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Conservative Management of Presumed Fetal Anemia Secondary to Maternal Chemotherapy for Acute Myeloid Leukemia
AJP Rep 2021; 11: e137-e141 DOI: 10.1055/s-0041-1740561Acute myeloid leukemia occurs rarely during pregnancy. When it is diagnosed remote from term, treatment in the form of daunorubicin plus cytarabine induction with consolidative cytarabine is typically undertaken after the first trimester. There is little data to guide fetal monitoring, in particular, whether and how often middle cerebral artery peak systolic velocity (MCA PSV) should be measured to screen for fetal anemia. Cytarabine may be particularly myelosuppressive to the fetus, but information pertaining to the management of this complication is also lacking in p...
Source: American Journal of Perinatology Reports - December 15, 2021 Category: Perinatology & Neonatology Authors: Nowik, Christina M. Gerrie, Alina S. Wong, Jonathan Tags: Case Report Source Type: research

Factors Associated with Meeting Obstetric Care Consensus Guidelines for Nulliparous, Term, Singleton, Vertex Cesarean Births
Conclusion After adjusting for confounding factors, in-house provider coverage, regardless of resident involvement, is associated with increased odds of NTSV cesarean births meeting OCC guidelines. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 15, 2021 Category: Perinatology & Neonatology Authors: Wang, Tiffany Brown, Inga Huang, Jim Kawakita, Tetsuya Moxley, Michael Tags: Original Article Source Type: research

Clinical Implications of Second and Third Trimester Surveillance Ultrasounds of Growth-Restricted Fetuses
Conclusion In the majority of cases, pregnancies diagnosed with FGR during screening ultrasounds resulted in normally grown neonates and term deliveries. These patients may be receiving unnecessary ultrasounds and premature courses of corticosteroids. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 23, 2021 Category: Perinatology & Neonatology Authors: Craig, Amanda M. Kaur, Karampreet Heerboth, Sarah A. Chen, Heidi Lauderdale, Chelsea J. Shannon, Chevis Zuckerwise, Lisa C. Tags: Case Report Source Type: research

Neurally Adjusted Ventilatory Assist in Very Prematurely Born Infants with Evolving/Established Bronchopulmonary Dysplasia
Conclusion The combination of NAVA/NIV-NAVA compared with conventional invasive and NIV modes may be advantageous for preterm infants with evolving/established BPD. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 22, 2021 Category: Perinatology & Neonatology Authors: Shetty, Sandeep Evans, Katie Cornuaud, Peter Kulkarni, Anay Duffy, Donovan Greenough, Anne Tags: Original Manuscripts Source Type: research

Newborn Septic Arthritis —A Rare Presentation of Late-Onset Group B Streptococcal Disease: Case Report and Short Review of the Literature
We present the case of an 11-day-old neonate with septic arthritis as a rare presentation of late-onset disease (LOD) with a favorable short-term outcome. GBS is a leading cause of neonatal infection. Early-onset disease (EOD) is defined as infection from birth to 6 days of age, while LOD occurs from 7 days to approximately 3 months of age. EOD is acquired through vertical transmission and can be reduced through application of intrapartum antibiotic prophylaxis (IAP). LOD can be acquired from the mother or from environmental sources, unlikely to be prevented by IAP. The most common presentation of EOD is bacteremia (83%), ...
Source: American Journal of Perinatology Reports - September 30, 2021 Category: Perinatology & Neonatology Authors: Schuler, Rahel Ehrhardt, Harald Zimmer, Klaus-Peter Berthold, Daniel Trauth, Janina F ölsch, Christian Waitz, Markus Tags: Case Report Source Type: research

Newborn Septic Arthritis —A Rare Presentation of Late-Onset Group B Streptococcal Disease: Case Report and Short Review of the Literature
We present the case of an 11-day-old neonate with septic arthritis as a rare presentation of late-onset disease (LOD) with a favorable short-term outcome. GBS is a leading cause of neonatal infection. Early-onset disease (EOD) is defined as infection from birth to 6 days of age, while LOD occurs from 7 days to approximately 3 months of age. EOD is acquired through vertical transmission and can be reduced through application of intrapartum antibiotic prophylaxis (IAP). LOD can be acquired from the mother or from environmental sources, unlikely to be prevented by IAP. The most common presentation of EOD is bacteremia (83%), ...
Source: American Journal of Perinatology Reports - September 30, 2021 Category: Perinatology & Neonatology Authors: Schuler, Rahel Ehrhardt, Harald Zimmer, Klaus-Peter Berthold, Daniel Trauth, Janina F ölsch, Christian Waitz, Markus Tags: Case Report Source Type: research

Less Invasive Surfactant Administration in Very Prematurely Born Infants
Conclusion LISA on the neonatal unit or the delivery suite was associated with a lower BPD incidence, need for intubation, and duration of invasive ventilation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2021 Category: Perinatology & Neonatology Authors: Shetty, Sandeep Egan, Helen Cornuaud, Peter Kulkarni, Anay Duffy, Donovan Greenough, Anne Tags: Original Article Source Type: research

A Case of an Extremely Low Birth Weight Infant with Morganella morganii Bacteremia and Peritonitis
We describe a case of late onset Morganella morganii sepsis in an extremely low birth weight male neonate born at 23 and 4/7 weeks gestational age to a 30-year-old primigravid mother due to preterm labor. The mother was otherwise healthy with an unremarkable prenatal course. She received steroids and ampicillin prior to delivery. While initial blood cultures were negative, at day of life 4, the neonate developed signs of sepsis with leukocytosis and bandemia, and subsequent blood culture demonstrated growth of M. morganii. The patient then had spontaneous intestinal perforation on day of life 8 with peritoneal cultures gro...
Source: American Journal of Perinatology Reports - August 19, 2021 Category: Perinatology & Neonatology Authors: Pham, Betty Denslow, Anne Mikhael, Michel Lim, Jina Tags: Case Report Source Type: research

Association between Maternal Obesity Class, Adherence to Labor Guidelines, and Perinatal Outcomes
Conclusion There were no differences in adverse perinatal outcomes with increasing BMI. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 15, 2021 Category: Perinatology & Neonatology Authors: Stafford, Irene A. Moustafa, Ahmed S.Z. Spoo, Lauren Berra, Alexandra Burgess, Angela Turrentine, Mark Tags: Original Article Source Type: research

The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
Conclusion A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 30, 2021 Category: Perinatology & Neonatology Authors: Mugarab-Samedi, Veronica Ryan, Michelle D. Awad, Essa Hamdan Al Elsharkawy, Adel Tags: Case Report Source Type: research

Acute Otitis Media in an Extremely Preterm Infant
We present a case of a former 26 weeks old infant who at 29 weeks, 6 days postmenstrual age presented with acute signs and symptoms of systemic sepsis subsequently found to be secondary to AOM with purulent ear drainage. The patient received a septic evaluation, including urine, blood, and cerebrospinal fluid studies. Treatment included intravenous antibiotics with full resolution of symptoms. AOM in extreme preterm infants is multifactorial, with leading causes that include prematurity, the use of oropharyngeal and nasogastric tube placement and endotracheal intubation, eustachian tube dysfunction, and a distinct immune r...
Source: American Journal of Perinatology Reports - June 23, 2021 Category: Perinatology & Neonatology Authors: Janwadkar, Aashika Louis, Shirley Nemerofsky, Sheri L. Tags: Case Report Source Type: research

Neonatal Atypical Hemolytic Uremic Syndrome in the Eculizumab Era
We present a 5-day-old female newborn, born at 36 weeks' twin gestation, by emergency cesarean section due to cord prolapse, with birth weight of 2,035 g and Apgar score of 7/7/7, who develops microangiopathic hemolytic anemia, thrombocytopenia, and progressive acute renal failure. In day 5, after diagnosis of aHUS, a daily infusion of fresh frozen plasma begins, with improvement of thrombocytopenia and very slight improvement in renal function. The etiologic study (congenital infection, Shiga toxin, ADAMTS13 activity, directed metabolic study) was normal. C3c was slightly decreased. On day 16 for maintenance of anemia a...
Source: American Journal of Perinatology Reports - June 23, 2021 Category: Perinatology & Neonatology Authors: Gomes, Sara Madureira Teixeira, Rita Pissarra Rocha, Gustavo Soares, Paulo Guimaraes, Hercilia Santos, Paulo Jardim, Joana Barreira, Jo ão Luís Pinto, Helena Tags: Case Report Source Type: research

Profound Hypotonia and Respiratory Failure due to Suspected Nemaline Myopathy in a Preterm Infant
We present the case of a preterm male infant born at 326/7 weeks' gestation, who was profoundly hypotonic and required intubation at birth. His clinical course progressed from acute to chronic respiratory failure with mechanical ventilation dependence. He developed bilateral chylous pleural effusions during the newborn period. Whole exome sequencing identified an ACTA1 gene mutation leading to the presumed diagnosis of nemaline myopathy. This case highlights the need to include congenital myopathies in the differential for a preterm newborn with hypotonia and respiratory failure. [...] Thieme Medical Publishers, Inc. 333 S...
Source: American Journal of Perinatology Reports - June 23, 2021 Category: Perinatology & Neonatology Authors: Akuamoah-Boateng, Gloria Stetson, Raymond C. Kaemingk, Bethany D. Bieber, David A. Brumbaugh, Jane E. Tags: Case Report Source Type: research

Critical Congenital Heart Disease Detection in the Screening Era: Do Not Neglect the Examination!
We report a full-term male infant with normal perfusion who had passed the CCHD screening at approximately 24 hours after birth with preductal SpO2 of 99% and postductal SpO2 of 97%. Detection of a loud systolic cardiac murmur before discharge led to the diagnosis of pulmonary atresia (PA) with ventricular septal defect (PA-VSD) by echocardiogram. The infant was transferred to a tertiary care center after initiation of prostaglandin E1 (PGE1) therapy. Throughout the initial course, he was breathing comfortably without respiratory distress or desaturations on pulse oximetry. We believe that this is the first documented re...
Source: American Journal of Perinatology Reports - June 16, 2021 Category: Perinatology & Neonatology Authors: Sankaran, Deepika Siefkes, Heather Ing, Frank F. Lakshminrusimha, Satyan Poulain, Francis R. Tags: Case Report Source Type: research

Report of a Confirmed SARS-CoV-2 Positive Newborn after Delivery Despite Negative SARS-CoV-2 Testing on Both Parents
We present a case of a term infant born to an asymptomatic mother at a community hospital who required transfer to a local neonatal intensive care unit (NICU) immediately after birth for respiratory distress. The infant was tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at 24 hours of life by reverse transcription polymerase chain reaction (RT-PCR) testing due to the absence of prenatal maternal COVID-19 testing and was found to be positive for SARS-CoV-2 at that time. A second RT-PCR test was obtained on the infant on day of life (DOL) 4 and was also positive, confirming an accurate diagnosis of...
Source: American Journal of Perinatology Reports - June 16, 2021 Category: Perinatology & Neonatology Authors: Harding, Benjamin R. Vora, Farha Tags: Case Report Source Type: research