American Journal of Perinatology Reports This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acquired Hemophilia A: A Rare, Acquired Coagulopathy in the Postpartum Setting
AJP Rep 2023; 13: e85-e88 DOI: 10.1055/a-2198-7888Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity. Pregnancy-associated acquired hemophilia A (AHA) caused by autoantibodies against factor VIII can present with recurrent episodes of postpartum bleeding. Case 1 A 50-year-old G2P0112 presented with vaginal bleeding 22 days postcaesarean. She underwent dilation and curettage, hysterectomy, and interventional radiology (IR) embolization before AHA diagnosis. She was hospitalized for 32 days and received 23 units of blood product. She remains without relapse of AHA after 5 years. Case 2 A ...
Source: American Journal of Perinatology Reports - November 28, 2023 Category: Perinatology & Neonatology Authors: Oberlin, Austin Krenitsky, Nicole M. Gandhi, Christy Akpan, Imo Joseph Eisenberger, Andrew Landau, Ruth Yurteri-Kaplan, Ladin Nathan, Lisa Sheen, Jean-Ju LaSala, Anita D'Alton, Mary Tags: Case Report Source Type: research

Transvaginal Ovarian Cyst Drainage in Third Trimester to Facilitate Vaginal Delivery
AJP Rep 2023; 13: e82-e84 DOI: 10.1055/a-2184-0548Adnexal masses in the third trimester of pregnancy may obstruct the pelvic outlet precluding labor induction and vaginal delivery. Expectant versus surgical management of adnexal cysts in pregnancy must carefully weigh maternal–fetal benefits and risks. Simple benign appearing cysts with low likelihood of malignancy may be amenable to percutaneous drainage as a bridge to interval postpartum laparoscopic cystectomy. We demonstrated posterior culdocentesis as a safe, minimally invasive technique to decompress a simple benign appearing left adnexal cyst obstructing the pelvi...
Source: American Journal of Perinatology Reports - November 28, 2023 Category: Perinatology & Neonatology Authors: Meljen, Vivienne T. Avram, Carmen M. Kerner, Nicole P. Rhee, Eleanor H. J. Kuller, Jeffrey A. Wheeler, Sarahn M. Tags: Case Report Source Type: research

A Case of Significant Transaminitis with Liver Biopsy in a Pregnant Patient with COVID-19
We present a morbidly obese 30-year-old woman with COVID-19 at 28 weeks' gestation complicated by significant transaminitis with peak liver enzymes levels of 501/1,313 (aspartate aminotransferase/alanine aminotransferase). Liver biopsy showed reactive changes consistent with medication effect and mild steatosis.Significant transaminitis has been found in both pregnant and nonpregnant patients with COVID-19. Our case demonstrates the multifactorial nature of liver injury in COVID-19 patients including mild underlying liver steatosis combined with possible viral potentiation of medication effect. [...] Thieme Medical Publish...
Source: American Journal of Perinatology Reports - November 28, 2023 Category: Perinatology & Neonatology Authors: Berger, Dana Senderoff Galyean, Anna Nguyen, Kelvin Alshak, Najeeb Blumenthal, Elizabeth Tags: Case Report Source Type: research

Evaluation of Early Screening for Diabetes Mellitus in Pregnancy with Hemoglobin A1c
AJP Rep 2023; 13: e71-e77 DOI: 10.1055/s-0043-1776150Early diabetes screening is recommended for high-risk pregnant women risk via a 1-hour glucose challenge test (1-hour GCT). Hemoglobin A1c (HbA1c) can be obtained with initial obstetric laboratories. We sought to examine the relationship between HbA1c and 1-hour GCT for early diabetes screening in pregnancy.This is a retrospective cohort study of 204 high-risk pregnant women who underwent early HbA1c and 1-hour GCT. Simple logistic regression analysis was performed to predict abnormal 1-hour GCT and diagnosis of diabetes using HbA1c.A total of 158 (77.5%), 44 (21.5%), an...
Source: American Journal of Perinatology Reports - November 7, 2023 Category: Perinatology & Neonatology Authors: Haddad, Andrew S. Fries, Melissa H. Landy, Helain Tripuraneni, Priyanka S. Iqbal, Sara N. Tags: Original Article Source Type: research

Association between Maternal Neuraxial Analgesia and Neonatal Outcomes in Very Preterm Infants
Conclusions Maternal neuraxial analgesia use may be associated with lower odds of adverse outcomes in very preterm infants, even after controlling for existing interventions for prematurity. Prior work has suggested such effects may be due to improved neonatal acid–base status from changes in placental perfusion and maternal pain management, but further work is required to prospectively investigate such associations. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American...
Source: American Journal of Perinatology Reports - November 6, 2023 Category: Perinatology & Neonatology Authors: Liu, Lilly Y. Lange, Elizabeth M. S. Yee, Lynn M. Tags: Original Article Source Type: research

Congenital Sodium Diarrhea: Antenatal Diagnosis May Prevent Unnecessary Surgery in the Neonate
We present a case of CSD that presented with dilated loops of bowel and polyhydramnios at 18 weeks and was thought to be a congenital bowel obstruction. The patient was therefore managed surgically after birth with a diverting ileostomy, however was later found to have elevated stool sodium levels and metabolic derangements consistent with CSD.Our case demonstrates the need for high index of suspicion for congenital diarrheal disorders to prevent unnecessary surgery and a delay in appropriate medical management of this rare condition. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001,...
Source: American Journal of Perinatology Reports - November 6, 2023 Category: Perinatology & Neonatology Authors: Berger, Dana S. Tancioco, Virginia Shrivastava, Vineet K. Tags: Case Report Source Type: research

Double Aneuploidy of Down Syndrome (Trisomy 21) and Jacobs Syndrome (Trisomy XYY) with Complete Tracheal Rings Deformity: Case Report and Literature Review
We present a case of natural conception premature newborn of 30.4 weeks gestational age who had a DS facial phenotype with extensive syndactyly on both hands and feet. Other multisystem congenital anomalies were discovered, including mal-aligned perimembranous ventricular septal defect, bicuspid aortic valve, Dandy–Walker malformation's tetra-ventriculomegaly, and a rare complete tracheal rings deformity (CTRD) with trachea stenosis. Prenatal amniocentesis and postnatal chromosomal karyotyping analysis detected 48, XYY, + 21 nontranslocation trisomy 21, and free-lying Y chromosome without translocation. The existence...
Source: American Journal of Perinatology Reports - November 6, 2023 Category: Perinatology & Neonatology Authors: Adeleke, Omoloro Elmufti, Hussein Zhang, Jie Jagadesan, Bhuvaneshwari Harsono, Mimily Tags: Case Report Source Type: research

Complete Hydatidiform Mole with a Coexisting Viable Male Fetus Detected by Cell-Free DNA
AJP Rep 2023; 13: e49-e52 DOI: 10.1055/s-0043-1774727Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis is challenging due to limited data. Here, we present the case of a patient with noninvasive prenatal test (NIPT) resulting in “likely molar pregnancy” in the second trimester. Subsequent ultrasound confirmed a cystic appearing portion of the placenta. At 22 weeks, the patient delivered a demised fetus and two placentas. Pathology was consistent with CHMCF. This case is the first to show primary detection of a CHMCF with single-nucleotide polymorphism (SNP)-based NIPT prior to ultrasound i...
Source: American Journal of Perinatology Reports - September 30, 2023 Category: Perinatology & Neonatology Authors: Lemieux, Mackenzie Kus, Lauren Stewart, Kali He, Mai Rowe, Jackson Brady, Matthew Bligard, Katherine Lawlor, Megan Kelly, Jeannie Tags: Case Report Source Type: research

Ductus Arteriosus Aneurysm and Pulmonary Artery Thromboses in a Protein S-Deficient Newborn
AJP Rep 2023; 13: e44-e48 DOI: 10.1055/a-2101-7738Ductus arteriosus aneurysm (DAA) asymptomatically occurs in newborn infants and resolves spontaneously. High-risk DAA with compression, rupture, and thrombosis requires early surgical intervention. Newborn infants have the highest risk of thrombosis among pediatric patients, but the genetic predisposition is difficult to determine in infancy. We herein report a neonatal case of massive thromboses in DAA and pulmonary artery. Desaturation occurred in an active full-term infant 2 days after birth. Echocardiography and contrast-enhanced computed tomography indicated thrombotic...
Source: American Journal of Perinatology Reports - July 21, 2023 Category: Perinatology & Neonatology Authors: Shirozu, Hiromitsu Ichiyama, Masako Ishimura, Masataka Ayako, Kuraoka Egami, Naoki Dongchon, Kang Nakano, Toshihide Sagawa, Koichi Ohga, Shouichi Tags: Case Report Source Type: research

Unilateral Lung Agenesis: A Case Series and Review of Literature
We describe their presentation, provide a brief clinical course, and discuss outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 14, 2023 Category: Perinatology & Neonatology Authors: Weber, Jennifer Sati, Sunil Kumar Karody, Vijender Rao Tags: Case Report Source Type: research

Congenital Maxillomandibular Synechia with Multiple Malformations in a Very-Low-Birth-Weight Infant: A Case Report
We report the case of a very-low-birth-weight (VLBW) infant with congenital maxillomandibular synechia and other malformations, including cleft palate, syndactyly, and cryptorchidism. The patient presented with extremely limited mouth opening, and endotracheal intubation seemed impossible; fortunately, the patient did not have respiratory distress syndrome. The patient underwent surgical release of the fibrous bands on days 10 and 17, and good mouth opening was achieved. The patient was able to consume breast milk orally and was discharged home at a corrected gestational age of 1 month without recurrence of difficulty in m...
Source: American Journal of Perinatology Reports - May 19, 2023 Category: Perinatology & Neonatology Authors: Uchi, Ryosuke Koto, Mayu Nakao, Atsushi Hosokawa, Miku Ukawa, Toshiko Tsurisawa, Chisa Hisaeda, Yoshiya Amagata, Shusuke Tags: Case Report Source Type: research

Autoimmune Congenital Complete Heart Block: How Late Can It Occur?
Conclusion Later-onset autoimmune CHB in offspring of SSA/SSB-positive mothers does occur. Our analysis suggests that prenatal surveillance should continue beyond 24 weeks of GA but is limited by inconsistent published surveillance data. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - May 8, 2023 Category: Perinatology & Neonatology Authors: Makadia, Luv Izmirly, Peter Buyon, Jill P. Phoon, Colin K. L. Tags: Review Article Source Type: research

A Neonate with Mucopolysaccharidosis Type VII with Intractable Ascites
We report a case of a patient with severe fetal hydrops and refractory ascites, diagnosed as mucopolysaccharidosis type VII (MPS VII) by whole-exome sequencing, and discharged at 5 months of age after long-term ventilatory management. A male neonate was born by emergency cesarean section due to fetal distress at 301/7 weeks' gestation. Physical examination and X-rays revealed pleural effusion, ascites, and generalized edema, indicating severe fetal hydrops. He underwent tracheal intubation because of respiratory distress that was attributed to massive ascites, pulmonary hypoplasia, and pulmonary hypertension. He received m...
Source: American Journal of Perinatology Reports - March 16, 2023 Category: Perinatology & Neonatology Authors: Fukui, Kana Amari, Shoichiro Yotani, Nobuyuki Kosaki, Rika Hata, Kenichiro Kosuga, Motomichi Sago, Haruhiko Isayama, Tetsuya Ito, Yushi Tags: Case Report Source Type: research

Complete Resolution of Nonimmune Hydrops Fetalis Secondary to Maternal Syphilis Infection
AJP Rep 2023; 13: e21-e24 DOI: 10.1055/a-2028-7727Maternal syphilis infection is a common infectious cause of nonimmune hydrops fetalis. Generally, hydrops fetalis is equated with poor prognoses in affected pregnancies. A 38-year-old G5P2114 presented at 285/7 weeks' gestation with newly diagnosed primary syphilis infection, sonographic findings of hydrops fetalis, and elevated middle cerebral artery Dopplers concerning for fetal anemia. Following treatment with intramuscular penicillin, the symptoms of hydrops fetalis were resolved and our patient delivered a healthy male neonate with no signs of congenital syphilis at th...
Source: American Journal of Perinatology Reports - March 16, 2023 Category: Perinatology & Neonatology Authors: Dinicu, Andreea Penalosa, Patrick Crosland, Brian A. Steller, Jonathan Tags: Case Report Source Type: research

Therapeutic Hypothermia Treatment for an Infant with Hypoxic-Ischemic Encephalopathy and Gastroschisis: A Case Report
We present the case of a female infant with a prenatal diagnosis of gastroschisis who required a prolonged and complex resuscitation after delivery. In addition to her gastroschisis, she presented with a history and physical examination consistent with severe hypoxic-ischemic encephalopathy and was treated with therapeutic hypothermia (TH) without further compromise to her bowel. In addition, careful consideration of neuroprotection, fluid status, bowel viability, and hemodynamics were undertaken in her care. She was discharged home on full enteral feeds, with only mild language and gross motor delays at 6 months of age. T...
Source: American Journal of Perinatology Reports - March 15, 2023 Category: Perinatology & Neonatology Authors: Flores-Fenlon, Nicole Shafer, Grant Awan, Saeed Ahmad, Irfan Tags: Case Report Source Type: research