Risk Factors for Umbilical Cord Prolapse at the Time of Artificial Rupture of Membranes
AJP Rep 2018; 08: e89-e94 DOI: 10.1055/s-0038-1649486 Objective The aim of the study was to examine the association between cervical exam at the time of artificial rupture of membranes (AROM) and cord prolapse. Study Design We conducted a retrospective cohort study using the data from the Consortium on Safe Labor. We included women with cephalic presentation and singleton pregnancies at ≥ 23 weeks' gestation who underwent AROM during the course of labor. Multivariable logistic regression was used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (95% CI), controlling f...
Source: American Journal of Perinatology Reports - May 10, 2018 Category: Perinatology & Neonatology Authors: Kawakita, Tetsuya Huang, Chun-Chih Landy, Helain J. Tags: Original Article Source Type: research

Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease
We present a preterm neonate who developed fetal hydrops and tricuspid regurgitation in utero. The mother had a history of treated Grave's disease. The infant responded to maternal treatment antenatally and postnatal anti-thyroid treatment, with resolution of both the tricuspid regurgitation and hydrops. To our knowledge, this is the first case report of tricuspid regurgitation associated with fetal and neonatal thyrotoxicosis. Our case also highlights the importance of obtaining a detailed and accurate history in a mother with previous Grave's disease, even if treated. [...] Thieme Medical Publishers 333 Seventh Avenue, N...
Source: American Journal of Perinatology Reports - May 4, 2018 Category: Perinatology & Neonatology Authors: Doucette, Stefani Tierney, Anne Roggensack, Anne Yusuf, Kamran Tags: Case Report Source Type: research

Implementing Obstetric Early Warning Systems
AJP Rep 2018; 08: e79-e84 DOI: 10.1055/s-0038-1641569Severe maternal morbidity and mortality are often preventable and obstetric early warning systems that alert care providers of potential impending critical illness may improve maternal safety. While literature on outcomes and test characteristics of maternal early warning systems is evolving, there is limited guidance on implementation. Given current interest in early warning systems and their potential role in care, the 2017 Society for Maternal-Fetal Medicine (SMFM) Annual Meeting dedicated a session to exploring early warning implementation across a wide range of hosp...
Source: American Journal of Perinatology Reports - April 20, 2018 Category: Perinatology & Neonatology Authors: Friedman, Alexander M. Campbell, Mary L. Kline, Carolyn R. Wiesner, Suzanne D'Alton, Mary E. Shields, Laurence E. Tags: Editorial Source Type: research

Complete Placenta Previa: Ultrasound Biometry and Surgical Outcomes
Conclusion In women with placenta previa, the placental extension ultrasound measurement of ≥40 mm is a predictor of adverse surgical outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 20, 2018 Category: Perinatology & Neonatology Authors: Wortman, Alison C. Schaefer, Stephanie L. McIntire, Donald D. Sheffield, Jeanne S. Twickler, Diane M. Tags: Case Report Source Type: research

Transatlantic Air Travel in the Third Trimester of Pregnancy: Does It Affect the Fetus?
AJP Rep 2018; 08: e71-e73 DOI: 10.1055/s-0038-1641584Most commercial airlines allow pregnant women to fly up to 36 weeks of gestation. Available information suggests that noise, vibration, and cosmic radiation present a small risk for the pregnant air traveler. The goal of the study was to assess the possible effect of transatlantic flights on the condition of the third-trimester fetus. In total, 112 patients were recruited into the study between January 2005 and June 2016. All underwent a transatlantic flight in the third trimester of pregnancy. All underwent nonstress test before and within 12 hours after the transatlant...
Source: American Journal of Perinatology Reports - April 16, 2018 Category: Perinatology & Neonatology Authors: Petrikovsky, B. Terrani, M. Sichinava, L. Tags: Case Report Source Type: research

Slow Elevation in Protein C Activity without a PROC Mutation in a Neonate with Intracranial Hemorrhage
We report a case of hemorrhagic stroke associated with neonatal asphyxia and severe PC deficiency. Plasma PC and protein S activity 7 days after birth was 12% and 43%, respectively. No PROC mutation was found. PC levels did not exceed 20% until 2 months of age, even in the absence of consumption coagulopathy or vitamin K deficiency. Neither thromboembolic nor hemorrhagic events occurred during the infusion of activated PC concentrate (twice weekly, up to 68 days after birth). The PC activity levels gradually increased to the standard value for age by 9 months of age. The present case showed that neonatal PC deficiency with...
Source: American Journal of Perinatology Reports - April 12, 2018 Category: Perinatology & Neonatology Authors: Uehara, Erika Nakao, Hiro Tsumura, Yusuke Nakadate, Hisaya Amari, Shoichiro Fujinaga, Hideshi Tsutsumi, Yoshiyuki Kang, Dongchon Ohga, Shouichi Ishiguro, Akira Tags: Case Report Source Type: research

Preclinical Labor-and-Delivery Shadowing: The Impact on Medical Students' Perceptions of Obstetrics and Gynecology
We described motivation/deterrents for shadowing among students, and experiences/perceptions of those students who shadowed. Results In total, 119/136 (86%) students completed the survey. Of those, 29% participated in shadowing on L&D. Participating students were more likely to be female (79 vs. 21%; p 
Source: American Journal of Perinatology Reports - April 11, 2018 Category: Perinatology & Neonatology Authors: Dotters-Katz, Sarah Panzer, Alexis Givens, Matthew Smid, Marcela Chuang, Alice Tags: Case Report Source Type: research

Pilot Study of Intra-Aortic Balloon Occlusion to Limit Morbidity in Patients with Adherent Placentation Undergoing Cesarean Hysterectomy
Conclusion While we did not detect statistically significant differences, larger studies may be warranted given the potential for extreme morbidity in these cases. This study highlights the potential use of an IAB in the management of these cases. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 11, 2018 Category: Perinatology & Neonatology Authors: Blumenthal, Elizabeth Rao, Rashmi Murphy, Aisling Gornbein, Jeffrey Hong, Richard Moriarty, John M. Kahn, Daniel A. Janzen, Carla Tags: Case Report Source Type: research

Neurocysticercosis in Pregnancy
We present two cases of patients with NCC that became symptomatic during pregnancy or postpartum period. We will review the epidemiology, clinical manifestations, and management of NCC in pregnancy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 9, 2018 Category: Perinatology & Neonatology Authors: Webb, Camille Rosa, Mauricio La Olson, Gayle Cabada, Miguel Tags: Case Report Source Type: research

Mid-Trimester Cervical Consistency Index and Cervical Length to Predict Spontaneous Preterm Birth in a High-Risk Population
The objective of this study was to evaluate the performance of the mid-trimester cervical consistency index (CCI) to predict sPTB in a cohort of high-risk pregnancies and to compare the results with those obtained with the CL. Study Design Prospective cohort study including high-risk singleton pregnancies between 19+0 and 24+6 weeks. The ratio between the anteroposterior diameter of the uterine cervix at maximum compression and at rest was calculated offline to obtain the CCI. Results Eighty-two high sPTB risk women were included. CCI (%) was significantly reduced in women who delivered
Source: American Journal of Perinatology Reports - March 19, 2018 Category: Perinatology & Neonatology Authors: Ba ños, Núria Juli à, Carla Lorente, N úria Ferrero, Silvia Cobo, Teresa Gratacos, Eduard Palacio, Montse Tags: Original Article Source Type: research

A Retrospective Database Analysis of Neonatal Morbidities to Evaluate a Composite Endpoint for Use in Preterm Labor Clinical Trials
AJP Rep 2018; 08: e25-e32 DOI: 10.1055/s-0038-1635097 Objective To propose and assess a composite endpoint (CE) of neonatal benefit based on neonatal mortality and morbidities by gestational age (GA) for use in preterm labor clinical trials. Study Design A descriptive, retrospective analysis of the Medical University of South Carolina Perinatal Information System database was conducted. Neonatal morbidities were assessed for inclusion in the CE based on clinical significance/risk of childhood neurodevelopmental impairment, frequency, and association with GA in a mother–neonate linked cohort, comprisin...
Source: American Journal of Perinatology Reports - March 7, 2018 Category: Perinatology & Neonatology Authors: Pimenta, Jeanne M. Ebeling, Myla Montague, Timothy H. Beach, Kathleen J. Abell, Jill O'Shea, Michael T. Powell, Marcy Hulsey, Thomas C. Tags: Original Article Source Type: research

Transient Neonatal Diabetes Mellitus in a Very Preterm Infant due to ABCC8 Mutation
We report the case of a preterm infant with TNDM due to an ABCC8 mutation identified by next-generation sequencing. The pancreatic adenosine triphosphate (ATP)-sensitive K+ (K-ATP) channel is a key regulator of insulin secretion. Gain-of-function mutations in the genes encoding the Kir6.2 (KCNJ11) and SUR1 (ABCC8) subunits of the channel cause neonatal diabetes. The patient was successfully managed with insulin lispro at a 1:100 dilution, drawn up in an insulin pen injector with a 4-mm needle. The insulin lispro dilution allowed administration of the exact insulin doses, obtaining a good glycemic control and minimizing the...
Source: American Journal of Perinatology Reports - March 7, 2018 Category: Perinatology & Neonatology Authors: Piccini, Barbara Coviello, Caterina Drovandi, Livia Rosangela, Artuso Monzali, Francesca Casalini, Emilio Giglio, Sabrina Toni, Sonia Dani, Carlo Tags: Case Report Source Type: research

Nonoperative Treatment of Appendicitis during Pregnancy in a Remote Area
We report on a pregnant Greenlandic Inuit woman with appendicitis who was treated with intravenous antibiotics. Antibiotic treatment was successful before surgical care became available and the patient was not operated. No complications occurred, and further pregnancy was uneventful. Our case suggests that antibiotic treatment of appendicitis during pregnancy as a bridge-to-surgery may be a sensible treatment option in remote areas, where no surgical care is immediately available. In some cases, antibiotic treatment may turn out to be definitive treatment. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10...
Source: American Journal of Perinatology Reports - February 28, 2018 Category: Perinatology & Neonatology Authors: Carstens, Anne-Kathrine Fensby, Lise Penninga, Luit Tags: Case Report Source Type: research

Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn
We present a rare case of intrauterine HSV-2 infection presenting with a zosteriform eruption mimicking congenital varicella syndrome in a newborn. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 27, 2018 Category: Perinatology & Neonatology Authors: Drumm, Caitlin M. Caufield, Maura C. DeKlotz, Cynthia M. Pasieka, Helena B. Abubakar, Kabir M. Tags: Case Report Source Type: research

Differential Methylation of Syncytin-1 and 2 Distinguishes Fetal Growth Restriction from Physiologic Small for Gestational Age
AJP Rep 2018; 08: e18-e24 DOI: 10.1055/s-0038-1627473 Objective The retroviral genes encoding Syncytin-1 (SYN1) and Syncytin-2 (SYN2) are epigenetically regulated, uniquely expressed in the placenta and critical to placental function. We sought to determine if placental expression and methylation patterns of SYN1 and SYN2 from pregnancies complicated by fetal growth restriction (FGR) differed from physiologic small for gestational age (SGA) and appropriate for gestational age (AGA) controls. Study Design Placental biopsies were obtained from AGA, SGA and FGR neonates delivered at>36 weeks gestation. SGA ...
Source: American Journal of Perinatology Reports - February 21, 2018 Category: Perinatology & Neonatology Authors: Makaroun, Sami P. Himes, Katherine P. Tags: Case Report Source Type: research

Pre-pregnancy Body Mass Index and Third-Trimester Depressive Symptoms in a Healthy Privately Insured Sample
Conclusion Replication in a larger sample is suggested to confirm an independent effect of pregravid overweight on third trimester depression. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 5, 2018 Category: Perinatology & Neonatology Authors: Schuette, Stephanie A. Kominiarek, Michelle A. Wisner, Katherine L. Massey, Suena H. Tags: Original Article Source Type: research

Pregnant Women's Knowledge and Beliefs about the Safety and Outcomes of Delivery at Various Gestational Ages
Conclusion Misconceptions surrounding the definition of a term pregnancy are pervasive and vary by race, obstetric history, and medical comorbidities. Our findings highlight the need for patient education about appropriate gestational length, especially in minority and high-risk populations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - January 19, 2018 Category: Perinatology & Neonatology Authors: Baldwin, Melody A. Swamy, Geeta K. Wheeler, Sarahn M. Tags: Original Article Source Type: research

False Low-Risk Single Nucleotide Polymorphism –Based Noninvasive Prenatal Screening in Pentasomy 49,XXXXY
We report third-trimester sonographic features of a fetus with pentasomy 49,XXXXY and the importance of thorough pre- and posttest counseling for NIPS. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - January 19, 2018 Category: Perinatology & Neonatology Authors: Putra, Manesha Hicks, Melissa A. Abramowicz, Jacques S. Tags: Case Report Source Type: research

Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report
AJP Rep 2018; 08: e1-e3 DOI: 10.1055/s-0037-1615818Congenital anomalies of the spine may occur with malformations of the central nervous, cardiovascular, gastrointestinal, respiratory, and genitourinary systems. This is a case of myelomeningocele with unilateral right renal agenesis in a newborn. The patient suffered complications of cerebrospinal fluid leak and meningitis, but was successfully treated and discharged on day 86. In this case, unilateral right renal agenesis represented a significant surgical risk because failure of the remaining kidney could result in renal failure. Because congenital anomalies of the spine...
Source: American Journal of Perinatology Reports - January 9, 2018 Category: Perinatology & Neonatology Authors: Maeda, Hajime Go, Hayato Sakuma, Jun Imamura, Takashi Sato, Maki Momoi, Nobuo Hosoya, Mitsuaki Tags: Case Report Source Type: research

A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia
Conclusion We speculate that two factors may be associated with the severe pulmonary hypoplasia: decreased thoracic space due to the herniation of visceral organs caused by CDH and thoracic dysplasia due to skeletal deformity and severe scoliosis. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 29, 2017 Category: Perinatology & Neonatology Authors: Ito, Ai Fujinaga, Hideshi Matsui, Sachiko Tago, Kumiko Iwasaki, Yuka Fujino, Shuhei Nagasawa, Junko Amari, Shoichiro Kaneshige, Masao Wada, Yuka Takahashi, Shigehiro Tsukamoto, Keiko Miyazaki, Osamu Yoshioka, Takako Ishiguro, Akira Ito, Yushi Tags: Case Report Source Type: research

Low-Dose Intravenous Paracetamol for Patent Ductus Arteriosus in Indomethacin-Resistant or Contraindicated Preterm Infants: Three Cases Reports
Conclusion The intravenous administration of paracetamol was safe and feasible in premature infants with hsPDA. Future clinical trials with optimized dose and timing of administration are needed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 21, 2017 Category: Perinatology & Neonatology Authors: Matsumura, Shun Oshima, Ayumi Fujinuma, Sumie Tanaka, Kosuke Nagano, Nobuhiko Miyake, Fuyu Masutani, Satoshi Tamura, Masanori Ueda, Keiko Namba, Fumihiko Tags: Case Report Source Type: research

Gorham-Stout Disease Management during Pregnancy
AJP Rep 2017; 07: e226-e229 DOI: 10.1055/s-0037-1615259Gorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. Chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. Extrapulmonary alterations may include chylous ascites, lymphopenia, and destructing bone disease for overgrowth of lymphatic vessels. Here, we report the...
Source: American Journal of Perinatology Reports - December 19, 2017 Category: Perinatology & Neonatology Authors: Bargagli, Elena Piccioli, Caterina Cavigli, Edoardo Scola, Marianna Rosi, Elisabetta Lavorini, Federico Novelli, Luca Ugolini, Dario Notaristefano, Tommaso Filippo, Pieralli Miele, Vittorio Comin, Camilla E. Pistolesi, Massimo Voltolini, Luca Tags: Case Report Source Type: research

Intrahepatic Cholestasis of Pregnancy Refractory to Multiple Medical Therapies and Plasmapheresis
Conclusion TPE often provides longer term relief of itching because of ICP; however, it is not a panacea for these symptoms, and sometimes only delivery of the fetus can relieve maternal symptoms. In addition to the refractoriness to TPE, the case is also unusual for the early onset of ICP symptoms and the comorbidity of hepatitis C. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 14, 2017 Category: Perinatology & Neonatology Authors: Covach, Adam John Rose, William Nicholas Tags: Case Report Source Type: research

Buprenorphine for Medication-Assisted Treatment of Opioid Use Disorder in Pregnancy: Relationship to Neonatal Opioid Withdrawal Syndrome
Conclusion The occurrence of NOWS was not related to buprenorphine dose used for MAT. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 7, 2017 Category: Perinatology & Neonatology Authors: Chavan, Niraj R. Ashford, Kristin B. Wiggins, Amanda T. Lofwall, Michelle R. Critchfield, Agatha S. Tags: Case Report Source Type: research

Treatment of Morbidly Adherent Placentation Utilizing a Standardized Multidisciplinary Approach in the Community Hospital –Private Practice Setting
Conclusion Our data demonstrate the feasibility and utility of a multidisciplinary morbidly adherent placentation program in the private practice/community hospital setting with outcomes similar to those at tertiary teaching hospitals. Implementation of such program may prove beneficial in remote centers, where various factors may prohibit patient travel to a larger center. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 22, 2017 Category: Perinatology & Neonatology Authors: Mansouri, Mahsa DeStefano, Kim Monks, Brian Singh, Jasbir McDonnold, Mollie Morgan, Jamison Hale, Richard Adusumalli, Jasvant Horton, Amanda Haeri, Sina Tags: Case Report Source Type: research

Anti-M Alloimmunization: Management and Outcome at a Single Institution
Conclusion The incidence of severe hemolytic disease of the newborn due to anti-M is extremely low. We found no cases in our review of 195 pregnancies, despite several cases of severe hemolytic disease of the newborn reported in the literature. We have created an algorithm for the management of anti-M antibodies in pregnancy based on our data and extensive literature review. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 22, 2017 Category: Perinatology & Neonatology Authors: Stetson, Bethany Scrape, Scott Markham, Kara Beth Tags: Case Report Source Type: research

The Value of Implementing Multidisciplinary Perinatal Care Conference in the Private Practice Setting
Conclusion Multi-D care is an effective approach to the complicated needs of maternal–fetal medicine patients which may lead to improved patient and family outcomes, high provider satisfaction, and can easily be implemented and utilized within a private practice or community hospital setting. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 13, 2017 Category: Perinatology & Neonatology Authors: Johnston, Robert C. Haeri, Sina Hale, Richard T. Lindsley, William McCormick, Annette Su, Eric Tags: Case Report Source Type: research

IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia
Conclusion Pancytopenia is a rare complication of IVIG treatment in women with pregnancies complicated by NAIT. Serial complete blood counts at the time of treatment would allow for early detection and timely management of the patient. Additionally, limiting the number of infusion Lots may decrease the chance of the described complications. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 29, 2017 Category: Perinatology & Neonatology Authors: Herrmann, Alyssa Samelson-Jones, Benjamin J. Brake, Sami Samelson, Renee Tags: Case Report Source Type: research

Microorganisms Identified in the Maternal Bladder: Discovery of the Maternal Bladder Microbiota
Conclusion There are live bacteria in the bladders of most pregnant women. This challenges the definition of asymptomatic bacteriuria. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 29, 2017 Category: Perinatology & Neonatology Authors: Jacobs, Kristin M. Thomas-White, Krystal J. Hilt, Evann E. Wolfe, Alan J. Waters, Thaddeus P. Tags: Case Report Source Type: research

Fetal Thoracoamniotic Shunting in a Case of Congenital Pulmonary Airway Malformations with Hydrops Fetalis
Conclusion Fetal thoracoamniotic shunting may be life-saving in CPAM complicated by hydrops and that this treatment might be sufficient to cure the child. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2017 Category: Perinatology & Neonatology Authors: Nitta, Hayase Taira, Yusuke Kinjo, Tadatsugu Chinen, Yukiko Masamoto, Hitoshi Sanabe, Naoya Goya, Hideki Yoshida, Tomohide Sugibayashi, Rika Sumie, Masahiro Wada, Seiji Sago, Haruhiko Aoki, Yoichi Tags: Case Report Source Type: research

Neonatal Graves' Disease with Maternal Hypothyroidism
We present a unique case of neonatal Graves' disease in a premature infant with conjugated hyperbilirubinemia born to a mother with hypothyroidism during pregnancy and remote history of Graves' disease. Infant was treated with a combination of methimazole, propranolol, and potassium iodide for 4 weeks. Thyroid function improved after 8 weeks of treatment with full recovery of thyroid function, disappearance of thyroid-stimulating antibodies, and resolution of failure to thrive and conjugated hyperbilirubinemia. This case provides several clinical vignettes as it is a rare, severe, presentation of an uncommon neonatal disea...
Source: American Journal of Perinatology Reports - September 22, 2017 Category: Perinatology & Neonatology Authors: Akangire, Gangaram Cuna, Alain Lachica, Charisse Fischer, Ryan Raman, Sripriya Sampath, Venkatesh Tags: Case Report Source Type: research

Birth Order and Maternal Age for Reported Cases of Severe Prenatal Cortical Hyperostosis (Caffey –Silverman Disease)
AJP Rep 2017; 07: e174-e180 DOI: 10.1055/s-0037-1606364The spectrum of prenatal cortical hyperostosis includes a mild phenotype that typically presents after 35 weeks of gestation, and a severe form that presents earlier. The skeletal and systemic manifestations of the severe phenotype remain unexplained. A review of reported cases indicates that older mothers and firstborn infants are overrepresented. This combination suggests decreased fertility. Fourteen years after the birth of the present case, his mother presented with renal failure from multiple myeloma raising the possibility that a maternal antibody may play a rol...
Source: American Journal of Perinatology Reports - September 11, 2017 Category: Perinatology & Neonatology Authors: Engel, Rolf R. Cifuentes, Raul F. Tags: Original Article Source Type: research

Term Neonate with Atypical Hypoxic-Ischemic Encephalopathy Presentation: A Case Report
We describe a case of atypical hypoxic-ischemic encephalopathy (HIE) in a neonate following a normal pregnancy and delivery who was found to have an umbilical vein thrombosis. The infant arrived to our center with continuous bicycling movement of her lower extremities. She had a continuous electroencephalogram that showed burst suppression and magnetic resonance imaging of the brain showed diffusely abnormal cerebral cortical/subcortical diffusion restriction which may be secondary hypoxic-ischemic injury. Interestingly, a pathology report noted a focal umbilical vein thrombosis appearing to have compressed an umbilical ar...
Source: American Journal of Perinatology Reports - August 28, 2017 Category: Perinatology & Neonatology Authors: Townley, Nick McNellis, Emily Sampath, Venkatesh Tags: Case Report Source Type: research

Congenital Syphilis Masquerading as Leukemia
AJP Rep 2017; 07: e167-e170 DOI: 10.1055/s-0037-1603955As of late, the incidence of congenital syphilis in the United States is increasing. Each new case represents a failure of preventing, diagnosing, and treating syphilis in pregnant women. Pediatricians should confirm that all women have received adequate screening for and management of syphilis during pregnancy. Congenital syphilis is easily treatable but may be a diagnostic challenge with high morbidity and mortality. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstr...
Source: American Journal of Perinatology Reports - August 23, 2017 Category: Perinatology & Neonatology Authors: Lee, Tiffany Bell, Stephanie Scimeme, Jason Maraqa, Nizar Tags: Case Report Source Type: research

Infant Botulism in the Very Young Neonate: A Case Series
AJP Rep 2017; 07: e163-e166 DOI: 10.1055/s-0037-1604407 Background Though botulism is a rare disease overall, all infants younger than 1 year of age are at risk of contracting infant botulism, the most prevalent form reported in the United States. Nonetheless, infant botulism is frequently omitted from the differential diagnosis of the very young neonate exclusively due to age, and the diagnosis is often only considered secondarily after a costly and prolonged work up is undertaken. Delayed diagnosis can lead not only to unnecessary testing but also to prolonged hospital stay and increased morbidity. Case...
Source: American Journal of Perinatology Reports - July 31, 2017 Category: Perinatology & Neonatology Authors: Jackson, Laura Madan-Khetarpal, Suneeta Naik, Monica Michaels, Marian G. Riley, Melissa Tags: Case Report Source Type: research

Survey of Provider Preferences Regarding the Route of Misoprostol for Induction of Labor at Term
Conclusion Although not extensively studied, one-fifth of providers, particularly nurse midwives, prefer buccal administration of misoprostol for IOL. The majority of nurses correctly administered buccal misoprostol. There may be a need for further study and education about buccal administration of misoprostol for IOL. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 25, 2017 Category: Perinatology & Neonatology Authors: Towns, Rachel Quinney, Sara K. Pierson, Rebecca C. Haas, David M. Tags: Case Report Source Type: research

Closed-Incision Negative-Pressure Therapy in Obese Patients Undergoing Cesarean Delivery: A Randomized Controlled Trial
AJP Rep 2017; 07: e151-e157 DOI: 10.1055/s-0037-1603956 Background Postcesarean wound morbidity is a costly complication of cesarean delivery for which preventative strategies remain understudied. Objective We compared surgical site occurrences (SSOs) in cesarean patients receiving closed-incision negative-pressure therapy (ciNPT) or standard-of-care (SOC) dressing. Study Design A single-center randomized controlled trial compared ciNPT (5–7 days) to SOC dressing (1–2 days) in obese women (body mass index [BMI] ≥ 35), undergoing cesarean delivery between 2012 and 2014. P...
Source: American Journal of Perinatology Reports - July 14, 2017 Category: Perinatology & Neonatology Authors: Gunatilake, Ravindu P. Swamy, Geeta K. Brancazio, Leo R. Smrtka, Michael P. Thompson, Jennifer L. Gilner, Jennifer B. Gray, Beverly A. Heine, Robert Phillips Tags: Case Report Source Type: research

Evaluation of Institute of Medicine Guidelines for Gestational Weight Gain in Women with Chronic Hypertension
Conclusion Women with pregnancies complicated by chronic HTN should be counseled regarding the association of LGA with excessive GWG. Additionally, they should be counseled that weight gain below recommendations may be associated with a decreased risk of superimposed preeclampsia; however, this association deserves further investigation. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 12, 2017 Category: Perinatology & Neonatology Authors: Siegel, Anne M. Tita, Alan T. Machemehl, Hannah Biggio, Joseph R. Harper, Lorie M. Tags: Case Report Source Type: research

Addendum: Massive Urinary Protein Excretion Associated with Greater Neonatal Risk in Preeclampsia
AJP Rep 2017; 07: e127-e127 DOI: 10.1055/s-0037-1604063 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 30, 2017 Category: Perinatology & Neonatology Authors: Mateus, Julio Newman, Roger Sibai, Baha M. Li, Qing Barton, John R. Combs, C. Andrew Guzman, Edwin Boggess, Kim A. Gyamfi, Cynthia von Dadelszen, Peter Woelkers, Doug Tags: Addendum Source Type: research

Orbital Subperiosteal Hematoma in the Newborn Causing Unilateral Proptosis: Ultrasound as First-Line Imaging Modality
We describe two cases of neonatal proptosis caused by orbital subperiosteal hematoma highlighting different diagnostic and management approaches, and provide a summary of previously reported cases. Spontaneous resolution occurs in most cases; however, emergent surgical evacuation is warranted in cases of optic nerve compression. This is the first report to provide orbital ultrasound images of uncomplicated neonatal orbital subperiosteal hematoma. Orbital ultrasound followed by magnetic resonance imaging (MRI) is a valid nonradiation approach for assessing neonatal proptosis due to subperiosteal orbital hematoma. [...] Thie...
Source: American Journal of Perinatology Reports - June 30, 2017 Category: Perinatology & Neonatology Authors: Angkasa, Florencia Mohammadi, Leila Taranath, Deepa Taranath, Ajay Brecht, Marcus Tags: Case Report Source Type: research

Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate
We present SSSS in an extremely low-birth-weight (ELBW) infant with recurrent and confirmed bacterial sepsis. We present it to emphasize the importance for clinicians to not only recognize the clinical manifestations of SSSS, but also the need to closely monitor infants, especially very low-birth-weight (VLBW) and ELBW infants with SSSS for recurrence and bacterial sepsis. SSSS in preterm infants is a potentially lethal condition and early recognition and appropriate supportive care could be life-saving. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of conten...
Source: American Journal of Perinatology Reports - June 30, 2017 Category: Perinatology & Neonatology Authors: Davidson, Jennifer Polly, Samantha Hayes, Peter J. Fisher, Kristopher R. Talati, Ajay J. Patel, Tejesh Tags: Case Report Source Type: research

Diabetes during Pregnancy: Influence of Body Mass Index on Composite Morbidity
This study aims to compare composite maternal and neonatal morbidities (MM, NM) among pregnant women with diabetes mellitus whose body mass index (BMI) at delivery was 
Source: American Journal of Perinatology Reports - June 30, 2017 Category: Perinatology & Neonatology Authors: O'Neil Dudley, Amy E. Jenner, Zachary B. Mendez-Figueroa, Hector Ellis, Viviana S. Chauhan, Suneet P. Tags: Case Report Source Type: research

Peculiar Clinical Presentation of Coxsackievirus B4 Infection: Neonatal Restrictive Cardiomyopathy
Conclusion In conclusion, coxsackievirus myocarditis is a cause of restrictive cardiomyopathy, and its diagnosis should involve PCR screening as a more sensitive technique. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 29, 2017 Category: Perinatology & Neonatology Authors: Le Van Quyen, Pauline Desprez, Philippe Livolsi, Angelo Lindner, V éronique Fafi-Kremer, Samira Helms, Pauline Antal, Maria Cristina Tags: Case Report Source Type: research

Outcomes of Admissions for Preterm Labor
This study aims to quantitate the incidence of preterm labor (PTL) admissions and determine the frequency and predictors of preterm delivery (PTD) during these admissions. Study Design Retrospective cohort of singleton pregnancies within Kaiser Permanente Northern California, 2001 to 2011. PTL admissions were defined as inpatient encounters > 24 hours with an International Classification of Diseases, 9th Revision code for PTL. Results Total study population was 365,897 with PTL admission rate 11%. PTD occurred in 85% of pregnancies with PTL admission. Delivery occurred within 48 hours of ad...
Source: American Journal of Perinatology Reports - June 22, 2017 Category: Perinatology & Neonatology Authors: Kuzniewicz, Michael W. Black, Libby Walsh, Eileen M. Li, Sherian X. Greenberg, Mara Tags: Case Report Source Type: research

Etiology and Perinatal Outcome of Nonimmune Hydrops Fetalis in Southern China
Conclusions Hb Bart's disease is the most common cause of NIHF in Southern China. An effective prenatal screening and counseling program for thalassemia in this region may be the most effective way to lower the incidence NIHF. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 12, 2017 Category: Perinatology & Neonatology Authors: He, Sheng Wang, Linlin Pan, Pingshan Wei, Hongwei Meng, Dahua Du, Juan Tian, Xiaoxian Zheng, Chenguang Qiu, Xiaoxia Luo, Guoyang Tags: Case Report Source Type: research

Monochorionic-Triamniotic Triplet Pregnancy Complicated by Twin Reversed Arterial Perfusion Sequence: Case Report and Literature Review
Conclusion Monochorionic-triamniotic triplet pregnancy with TRAP sequence is rare. Although the risk of complications is high, such pregnancies can be managed conservatively in select cases. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 12, 2017 Category: Perinatology & Neonatology Authors: Pan, Pingshan Luo, Guoyang Tang, Lu Rolle, Jeanne D. Qin, Yuqin Zeng, Quan Wei, Jiangting Chen, Yuanfang Wei, Hongwei Tags: Case Report Source Type: research

Application of Selective Bronchial Intubation versus Neurally Adjusted Ventilatory Assist in the Management of Unilateral Pulmonary Interstitial Emphysema: An Illustrative Case and the Literature Review
AJP Rep 2017; 07: e101-e105 DOI: 10.1055/s-0037-1603322In the treatment of left-sided pulmonary interstitial emphysema (PIE) in a 23-week neonate, we used two ventilatory strategies: selective bronchial intubation from day 10 to 15 and neurally adjusted ventilatory assist (NAVA) from day 18 to 26. We compared the effects and adverse effects of these two strategies. On selective bronchial intubation, desaturation was frequent. Fentanyl infusion was required. There was an episode of carbon dioxide retention coupled with hypotension. On NAVA, the neonate was clinically stable without the requirement of sedation. On selective ...
Source: American Journal of Perinatology Reports - May 16, 2017 Category: Perinatology & Neonatology Authors: Lee, Shing-yan Robert Tags: Case Report Source Type: research

Accuracy of Blood Loss Measurement during Cesarean Delivery
Conclusion During cesarean delivery, measuring blood loss using colorimetric image analysis is superior to visual estimation and a gravimetric method. Implementation of colorimetric analysis may enhance the ability of management protocols to improve clinical outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - May 10, 2017 Category: Perinatology & Neonatology Authors: Doctorvaladan, Sahar V. Jelks, Andrea T. Hsieh, Eric W. Thurer, Robert L. Zakowski, Mark I. Lagrew, David C. Tags: Case Report Source Type: research

Under Pressure: Intraluminal Filling Pressures of Postpartum Hemorrhage Tamponade Balloons
Conclusion In the setting of acute hemorrhage, expeditious management is critical. Balloons that have a low intraluminal pressure-volume ratio may fill more rapidly, more easily, and to greater volumes. We found that the BT-Cath, the ebb, and the condom catheter all had low intraluminal pressures throughout filling. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - May 9, 2017 Category: Perinatology & Neonatology Authors: Antony, Kathleen M. Racusin, Diana A. Belfort, Michael A. Dildy, Gary A. Tags: Case Report Source Type: research

A Systematic Review of Intrapartum Fetal Head Compression: What Is the Impact on the Fetal Brain?
Conclusion A review of the literature indicates that fetal intracranial pressure is well protected from extracranial forces. Available data do not support intrapartum fetal extracranial pressure as a cause of fetal brain injury. Precis The fetal brain is relatively unaffected by intrapartum fetal head compression. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 26, 2017 Category: Perinatology & Neonatology Authors: Heyborne, Kent D. Tags: Case Report Source Type: research