Methemoglobinemia during the Use of Glyceryl Trinitrate Patches in Neonates: Two Case Reports
In conclusion, routine monitoring of methemoglobin levels should be undertaken when GTN patches are used in very prematurely born infants. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - October 15, 2018 Category: Perinatology & Neonatology Authors: Mintoft, Alison Williams, Emma Harris, Christopher Kennea, Nigel Greenough, Anne Tags: Case Report Source Type: research

Progressive Devascularization: A Novel Surgical Approach for Placenta Previa
Conclusion For patients with placenta previa and low risk for placenta creta, counseling should include the risk for maternal morbidity and criteria for pursuing peripartum hysterectomy. Our devascularization, a stepwise surgical approach, shows promising outcomes in placenta previa cases. Précis We propose a novel surgical approach, using a progressive devascularization surgical technique, for management of women with placenta previa, undergoing cesarean delivery. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  | ...
Source: American Journal of Perinatology Reports - October 15, 2018 Category: Perinatology & Neonatology Authors: Saad, Antonio F. Kirsch, Nathan Saade, George R. Hankins, Gary D. V. Tags: Case Report Source Type: research

Sildenafil Use in the Treatment of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Case Series
Conclusion Sildenafil reduced NTproBNP levels in all infants with BPD-PH but the echocardiographic findings and respiratory scores did not improve consistently. We speculate that this may be due to a delay in diagnosis and initiation of therapy after irreversible pulmonary changes have set in. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - October 15, 2018 Category: Perinatology & Neonatology Authors: Qasim, Amna Dasgupta, Soham Aly, Ashraf M. Jain, Sunil K. Tags: Case Report Source Type: research

Safe Motherhood Initiative: Early Impact of Severe Hypertension in Pregnancy Bundle Implementation
Conclusion There were increasing numbers of patients receiving timely treatment of severe hypertension during early implementation of a Severe Hypertension in Pregnancy bundle in New York State obstetric hospitals. However, bundle implementation requires significant financial and human resources and the long-term impact on maternal morbidity and mortality in our state remains uncertain. Precis There was a tendency toward more timely treatment of severe hypertension following implementation of a Severe Hypertension in Pregnancy bundle in New York obstetric hospitals. [...] Thieme Medical Publishers 333 Seventh Avenu...
Source: American Journal of Perinatology Reports - October 11, 2018 Category: Perinatology & Neonatology Authors: Simpson, Lynn L. Rochelson, Burton Ananth, Cande V. Bernstein, Peter S. D'Alton, Mary Chazotte, Cynthia Lavery, Jessica A. Zielinski, Kristin Tags: Case Report Source Type: research

Visual Estimation of Force Applied During Simulated Deliveries Complicated by Shoulder Dystocia
AJP Rep 2018; 08: e206-e211 DOI: 10.1055/s-0038-1673377 Background Shoulder dystocia occurs when the fetal head delivers, but the shoulder is lodged behind the pubic symphysis. Training for these emergency deliveries is not optimized, and litigation can occur around a shoulder dystocia delivery. Objective Evaluate the ability of an outside observer to visually estimate the amount of traction applied to the fetal head during simulated deliveries complicated by shoulder dystocia. Study Design Simulated deliveries with an objective measurement of traction were randomly organized for estimation of tract...
Source: American Journal of Perinatology Reports - October 9, 2018 Category: Perinatology & Neonatology Authors: Walters, Margaret Eubanks, Allison Weissbrod, Elizabeth Fischer, John Staat, Barton Deering, Shad Tags: Case Report Source Type: research

Fetal Congenital Peripheral Bronchial Atresia Diagnosed by Magnetic Resonance Imaging: Two Case Reports
We report two cases of peripheral bronchial atresia diagnosed by prenatal ultrasonography (US) and magnetic resonance imaging (MRI). Evaluating an enlarged lung mass that is homogeneously hyperechoic on US and hyperintense on T2-weighted MRI can help in determining whether bronchial atresia is present. Proximal type is suggested when a dilated main bronchus is observed as a tubule structure of an involved lung hilum. In our cases, T2-weighted MRI revealed homogeneously hyperintense lung lesion with decreased signal intensity of adjacent lobe, flattening diaphragm, and mediastinal shift. Dilatation of the main bronchus was ...
Source: American Journal of Perinatology Reports - October 9, 2018 Category: Perinatology & Neonatology Authors: Kozaki, Mitsuru Iraha, Yuko Masamoto, Hitoshi Nitta, Hayase Chinen, Yukiko Kinjo, Tadatsugu Mekaru, Keiko Aoki, Yoichi Tags: Case Report Source Type: research

The Use of Fetal Bronchoscopy in the Diagnosis and Management of a Suspected Obstructive Lung Mass
AJP Rep 2018; 08: e195-e200 DOI: 10.1055/s-0038-1673378Etiologies of fetal lung anomalies include congenital pulmonary airway malformation (CPAM), intra- or extralobar pulmonary sequestration, congenital high airway obstruction syndrome (CHAOS), bronchogenic cyst, and bronchial atresia. Fetal tracheobronchoscopy has been reported both as a diagnostic and therapeutic procedure in the setting of severe congenital lung lesions. In this case report, prenatal imaging of a fetus with a large chest mass was suspicious for an obstructive bronchial lesion. The absence of visible normal lung tissue on the right side and mass effect ...
Source: American Journal of Perinatology Reports - September 25, 2018 Category: Perinatology & Neonatology Authors: Chon, Andrew H. Stein, James E. Gerstenfeld, Tammy Wang, Larry Vazquez, Walter D. Chmait, Ramen H. Tags: Case Report Source Type: research

Monitoring of Blood Pressure is not Enough to Avoid Neonatal Postoperative Encephalopathy
Conclusion Perioperative monitoring of blood pressure is not enough in neonatal surgery. Cerebral magnetic resonance imaging should be considered in infants with noncardiac congenital anomalies after neonatal surgery and long-term follow-up is required. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 20, 2018 Category: Perinatology & Neonatology Authors: Lubi án López, Simón Pedro Zuazo Ojeda, Amaya Jimenez G ómez, Gema Benavente Fern ández, Isabel Tags: Case Report Source Type: research

Uterine Monitoring Techniques from Patients' and Users' Perspectives
AJP Rep 2018; 08: e184-e191 DOI: 10.1055/s-0038-1669409 Objective To evaluate preferences from patients and users on 3 uterine monitoring techniques, during labor. Study Design Women in term labor were simultaneously monitored with the intrauterine pressure catheter, the external tocodynamometer, and the electrohysterograph. Postpartum, these women filled out a questionnaire evaluating their preferences and important aspects. Nurses completed a questionnaire evaluating users' preferences. Results Of all 52 participating women, 80.8% preferred the electrohysterograph, 17.3% the intrauterine pressure ...
Source: American Journal of Perinatology Reports - September 14, 2018 Category: Perinatology & Neonatology Authors: Thijssen, Kirsten M. J. Vlemminx, Marion W. C. Westerhuis, Michelle E. M. H. Dieleman, Jeanne P. Van der Hout-Van der Jagt, M. Beatrijs Oei, S. Guid Tags: Case Report Source Type: research

A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability
AJP Rep 2018; 08: e180-e183 DOI: 10.1055/s-0038-1669964Prelabor rupture of the membranes (PROM) near the limit of viability is associated with significant risks for both mother and fetus. Preterm labor, intra-amniotic infection, and placental abruption are the immediate risks to the pregnancy; however, the fetus incurs additional risks related to the sequela of persistent oligohydramnios. Transabdominal intra-amniotic infusions have been studied. Results, suggesting that this intervention may prolong the latency period, and potentially, decrease pulmonary hypoplasia in surviving neonates without evidence of increasing risk...
Source: American Journal of Perinatology Reports - September 14, 2018 Category: Perinatology & Neonatology Authors: Kohari, Katherine Mehlhaff, Krista Merriam, Audrey Abdel-Razeq, Sonya Grechukhina, Olga Leon-Martinez, Daisy Bahtiyar, Mert Ozan Tags: Case Report Source Type: research

Cardiothoracic Area Ratio Predicts Lethal Pulmonary Venous Obstruction in Patients with Single Ventricle and Total Anomalous Pulmonary Venous Connection
Conclusion Reduced CTAR in the antenatal period is a good predictor of l-PVO after birth. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 14, 2018 Category: Perinatology & Neonatology Authors: Emi, Misugi Inamura, Noboru Tags: Original Article Source Type: research

Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience
The objective of this study is to evaluate the efficacy and short-term safety of dexmedetomidine infusion for sedation in term neonates undergoing therapeutic hypothermia for HIE. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 4, 2018 Category: Perinatology & Neonatology Authors: O'Mara, Keliana Weiss, Michael D. Tags: Case Report Source Type: research

Randomized Quality Improvement Trial of Opting-In Versus Opting-Out to Increase Influenza Vaccination Rates during Pregnancy
Conclusion While prenatal influenza vaccination uptake doubled from the 2009–2010 influenza season, opting-out did not perform better than opting-in, a conclusion opposite that we would have reached had this been a nonconcurrent trial. Vaccination rates dropped posttrial; hence, continued research is needed to increase the prenatal influenza immunizations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 28, 2018 Category: Perinatology & Neonatology Authors: Wootton, Susan H. Blackwell, Sean C. Saade, George Berens, Pamela D. Hutchinson, Maria Green, Charles E. Sridhar, Sujatha Elam, Kara M. Tyson, Jon E. Tags: Original Article Source Type: research

Delayed Birth-Related Femur Fracture after Cesarean Section: A Case Report
Conclusion Birth-related fracture should be considered in all neonatal femur fracture cases and in patients with no symptoms at birth. Neonates delivered in the breech presentation by cesarean section should be carefully monitored after birth. The findings of the present case further our understanding of the pathogenic mechanisms underlying delayed diagnosis of birth-related femur fracture. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journa...
Source: American Journal of Perinatology Reports - August 7, 2018 Category: Perinatology & Neonatology Authors: Kanai, Yuji Honda, Yoshinobu Honda, Tsuyoshi Sanpei, Minoru Tags: Case Report Source Type: research

The Contribution of Untreated and Treated Anxiety and Depression to Prenatal, Intrapartum, and Neonatal Outcomes
Conclusion Untreated cases were associated with increased maternal adverse outcomes, whereas treated cases were associated with more adverse neonatal outcomes when compared with unaffected pregnancies. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 10, 2018 Category: Perinatology & Neonatology Authors: Ogunyemi, Dotun Jovanovski, Andrew Liu, James Friedman, Perry Sugiyama, Nathaniel Creps, James Madan, Ichchha Tags: Original Article Source Type: research

Prophylactic Hypogastric Artery Ligation during Placenta Percreta Surgery: A Retrospective Cohort Study
AJP Rep 2018; 08: e142-e145 DOI: 10.1055/s-0038-1666793 Objective To evaluate if prophylactic hypogastric artery ligation (HAL) decreases surgical blood loss and blood products transfused. Study Design This is a retrospective cohort study comparing patients with placenta percreta undergoing prophylactic HAL at the time of cesarean hysterectomy versus those who did not. Data were presented as means ± standard deviations, proportions, or medians with interquartile ranges. Demographic and clinical data were compared in the groups using Student's t-test for normally distributed data or the ...
Source: American Journal of Perinatology Reports - June 28, 2018 Category: Perinatology & Neonatology Authors: Kuhn, Theresa Martimucci, Kristina Al-Khan, Abdulla Bilinski, Robyn Zamudio, Stacy Alvarez-Perez, Jesus Tags: Original Article Source Type: research

An Unusual Neonatal Presentation of Scimitar Syndrome
We present a case of a 37 weeks' gestation male infant with antenatal ultrasound findings of suspected partial anomalous pulmonary venous return (PAPVR) and coarctation of the aorta. The newborn presented with respiratory distress, a chest X-ray and chest computed tomography (CT) angiogram confirmed the diagnosis of scimitar syndrome. The combination of scimitar syndrome with aortic coarctation is extremely rare with only a few cases previously reported. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |&nb...
Source: American Journal of Perinatology Reports - June 20, 2018 Category: Perinatology & Neonatology Authors: Abdul Aziz, Ahmad Thomas, Sumesh Lautner, David Al Awad, Essa Hamadan Tags: Case Report Source Type: research

Immunological Emergency in Neonate: Case Report and Role of Early Screening
We report a case of SCID in term infants born to consanguineous parents who were presented with clinical and laboratory findings of erythroderma, severe infection, failure to thrive, eosinophilia, and elevated immunoglobulin E (IgE) together with immunodeficiency. A timely diagnosis was followed by successful hematopoietic stem cell transplantation (HSCT) therapy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 18, 2018 Category: Perinatology & Neonatology Authors: Samedi, Veronica Mugarab Shafey, Amy Al Awad, Essa Favela, Luis Murguia Tags: Case Report Source Type: research

Sonographic Estimated Fetal Weight among Diabetics at  ≥ 34 Weeks and Composite Neonatal Morbidity
Conclusion Among diabetic women with SEFW > 90th percentile for GA, CNM was significantly higher than in women with estimate at 10 to 90th percentile. Despite the increased risk of CNM, these newborns did not have long-term morbid sequela. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 11, 2018 Category: Perinatology & Neonatology Authors: Al-Hafez, Leen Pirics, Michael L. Chauhan, Suneet P. Tags: Original Article Source Type: research

A Qualitative Analysis of Challenges and Successes in Retinopathy of Prematurity Screening
Conclusion Structure, culture, education, and commitment all contribute to the success of ROP screening in the NICU. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 11, 2018 Category: Perinatology & Neonatology Authors: Bain, Lisa C. Kristensen-Cabrera, Alexandria I. Lee, Henry C. Tags: Case Report Source Type: research

Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births
Conclusion For each CVF cytokine that differed by birth status, values were higher for PTB than term, averaged over trimester. Numerous cytokine profiles varied across trimesters in women delivering term versus preterm in both CVF and serum. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - May 31, 2018 Category: Perinatology & Neonatology Authors: Ashford, Kristin Chavan, Niraj R. Wiggins, Amanda T. Sayre, Molly Malany McCubbin, Andrea Critchfield, Agatha S. O'Brien, John Tags: Original Article Source Type: research

Pharmacokinetics of Hydroxyprogesterone Caproate and its Primary Metabolites during Pregnancy
Conclusion After the first injection, OHPC maximum serum level was approximately half steady-state level. Measurable metabolites of unknown activity were detected. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - May 14, 2018 Category: Perinatology & Neonatology Authors: Boggess, Kim A. Baker, Jeffrey B. Murtha, Amy P. Peaceman, Alan M. Shah, Dinesh M. Siegfried, Sylvia L. Birch, Robert Tags: Case Report Source Type: research

Early Pulmonary Interstitial Emphysema in Preterm Neonates —Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins
AJP Rep 2018; 08: e99-e105 DOI: 10.1055/s-0038-1648253Early pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during non...
Source: American Journal of Perinatology Reports - May 14, 2018 Category: Perinatology & Neonatology Authors: Gronbach, Judith Ehrhardt, Harald Zimmer, Klaus-Peter Waitz, Markus Tags: Case Report Source Type: research

Liver Failure and Conjugated Hyperbilirubinemia in a Preterm Neonate: Role of Early IVIG and Exchange Transfusion
We report a case of liver failure in a premature infant with abnormal iron profile within 48 hours of birth. Lack of accepted guidelines for the initial management of severe jaundice with a high direct component in the first week after birth made treatment challenging. The infant underwent intensive phototherapy along with four exchange transfusions (ET) and two courses of intravenous immunoglobulins (IVIG). The clinical goals were to keep total bilirubin values ≤ 20 mg/dL in this premature neonate and to minimize the risk of bilirubin-induced neurologic dysfunction and decompensated liver failure. Abnorma...
Source: American Journal of Perinatology Reports - May 14, 2018 Category: Perinatology & Neonatology Authors: Nair, Jayasree Kumar, Vasantha H.S. Tags: Case Report Source Type: research

Risk Factors for Umbilical Cord Prolapse at the Time of Artificial Rupture of Membranes
AJP Rep 2018; 08: e89-e94 DOI: 10.1055/s-0038-1649486 Objective The aim of the study was to examine the association between cervical exam at the time of artificial rupture of membranes (AROM) and cord prolapse. Study Design We conducted a retrospective cohort study using the data from the Consortium on Safe Labor. We included women with cephalic presentation and singleton pregnancies at ≥ 23 weeks' gestation who underwent AROM during the course of labor. Multivariable logistic regression was used to calculate the adjusted odds ratio (aOR) with 95% confidence interval (95% CI), controlling f...
Source: American Journal of Perinatology Reports - May 10, 2018 Category: Perinatology & Neonatology Authors: Kawakita, Tetsuya Huang, Chun-Chih Landy, Helain J. Tags: Original Article Source Type: research

Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease
We present a preterm neonate who developed fetal hydrops and tricuspid regurgitation in utero. The mother had a history of treated Grave's disease. The infant responded to maternal treatment antenatally and postnatal anti-thyroid treatment, with resolution of both the tricuspid regurgitation and hydrops. To our knowledge, this is the first case report of tricuspid regurgitation associated with fetal and neonatal thyrotoxicosis. Our case also highlights the importance of obtaining a detailed and accurate history in a mother with previous Grave's disease, even if treated. [...] Thieme Medical Publishers 333 Seventh Avenue, N...
Source: American Journal of Perinatology Reports - May 4, 2018 Category: Perinatology & Neonatology Authors: Doucette, Stefani Tierney, Anne Roggensack, Anne Yusuf, Kamran Tags: Case Report Source Type: research

Implementing Obstetric Early Warning Systems
AJP Rep 2018; 08: e79-e84 DOI: 10.1055/s-0038-1641569Severe maternal morbidity and mortality are often preventable and obstetric early warning systems that alert care providers of potential impending critical illness may improve maternal safety. While literature on outcomes and test characteristics of maternal early warning systems is evolving, there is limited guidance on implementation. Given current interest in early warning systems and their potential role in care, the 2017 Society for Maternal-Fetal Medicine (SMFM) Annual Meeting dedicated a session to exploring early warning implementation across a wide range of hosp...
Source: American Journal of Perinatology Reports - April 20, 2018 Category: Perinatology & Neonatology Authors: Friedman, Alexander M. Campbell, Mary L. Kline, Carolyn R. Wiesner, Suzanne D'Alton, Mary E. Shields, Laurence E. Tags: Editorial Source Type: research

Complete Placenta Previa: Ultrasound Biometry and Surgical Outcomes
Conclusion In women with placenta previa, the placental extension ultrasound measurement of ≥40 mm is a predictor of adverse surgical outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 20, 2018 Category: Perinatology & Neonatology Authors: Wortman, Alison C. Schaefer, Stephanie L. McIntire, Donald D. Sheffield, Jeanne S. Twickler, Diane M. Tags: Case Report Source Type: research

Transatlantic Air Travel in the Third Trimester of Pregnancy: Does It Affect the Fetus?
AJP Rep 2018; 08: e71-e73 DOI: 10.1055/s-0038-1641584Most commercial airlines allow pregnant women to fly up to 36 weeks of gestation. Available information suggests that noise, vibration, and cosmic radiation present a small risk for the pregnant air traveler. The goal of the study was to assess the possible effect of transatlantic flights on the condition of the third-trimester fetus. In total, 112 patients were recruited into the study between January 2005 and June 2016. All underwent a transatlantic flight in the third trimester of pregnancy. All underwent nonstress test before and within 12 hours after the transatlant...
Source: American Journal of Perinatology Reports - April 16, 2018 Category: Perinatology & Neonatology Authors: Petrikovsky, B. Terrani, M. Sichinava, L. Tags: Case Report Source Type: research

Slow Elevation in Protein C Activity without a PROC Mutation in a Neonate with Intracranial Hemorrhage
We report a case of hemorrhagic stroke associated with neonatal asphyxia and severe PC deficiency. Plasma PC and protein S activity 7 days after birth was 12% and 43%, respectively. No PROC mutation was found. PC levels did not exceed 20% until 2 months of age, even in the absence of consumption coagulopathy or vitamin K deficiency. Neither thromboembolic nor hemorrhagic events occurred during the infusion of activated PC concentrate (twice weekly, up to 68 days after birth). The PC activity levels gradually increased to the standard value for age by 9 months of age. The present case showed that neonatal PC deficiency with...
Source: American Journal of Perinatology Reports - April 12, 2018 Category: Perinatology & Neonatology Authors: Uehara, Erika Nakao, Hiro Tsumura, Yusuke Nakadate, Hisaya Amari, Shoichiro Fujinaga, Hideshi Tsutsumi, Yoshiyuki Kang, Dongchon Ohga, Shouichi Ishiguro, Akira Tags: Case Report Source Type: research

Preclinical Labor-and-Delivery Shadowing: The Impact on Medical Students' Perceptions of Obstetrics and Gynecology
We described motivation/deterrents for shadowing among students, and experiences/perceptions of those students who shadowed. Results In total, 119/136 (86%) students completed the survey. Of those, 29% participated in shadowing on L&D. Participating students were more likely to be female (79 vs. 21%; p 
Source: American Journal of Perinatology Reports - April 11, 2018 Category: Perinatology & Neonatology Authors: Dotters-Katz, Sarah Panzer, Alexis Givens, Matthew Smid, Marcela Chuang, Alice Tags: Case Report Source Type: research

Pilot Study of Intra-Aortic Balloon Occlusion to Limit Morbidity in Patients with Adherent Placentation Undergoing Cesarean Hysterectomy
Conclusion While we did not detect statistically significant differences, larger studies may be warranted given the potential for extreme morbidity in these cases. This study highlights the potential use of an IAB in the management of these cases. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 11, 2018 Category: Perinatology & Neonatology Authors: Blumenthal, Elizabeth Rao, Rashmi Murphy, Aisling Gornbein, Jeffrey Hong, Richard Moriarty, John M. Kahn, Daniel A. Janzen, Carla Tags: Case Report Source Type: research

Neurocysticercosis in Pregnancy
We present two cases of patients with NCC that became symptomatic during pregnancy or postpartum period. We will review the epidemiology, clinical manifestations, and management of NCC in pregnancy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 9, 2018 Category: Perinatology & Neonatology Authors: Webb, Camille Rosa, Mauricio La Olson, Gayle Cabada, Miguel Tags: Case Report Source Type: research

Mid-Trimester Cervical Consistency Index and Cervical Length to Predict Spontaneous Preterm Birth in a High-Risk Population
The objective of this study was to evaluate the performance of the mid-trimester cervical consistency index (CCI) to predict sPTB in a cohort of high-risk pregnancies and to compare the results with those obtained with the CL. Study Design Prospective cohort study including high-risk singleton pregnancies between 19+0 and 24+6 weeks. The ratio between the anteroposterior diameter of the uterine cervix at maximum compression and at rest was calculated offline to obtain the CCI. Results Eighty-two high sPTB risk women were included. CCI (%) was significantly reduced in women who delivered
Source: American Journal of Perinatology Reports - March 19, 2018 Category: Perinatology & Neonatology Authors: Ba ños, Núria Juli à, Carla Lorente, N úria Ferrero, Silvia Cobo, Teresa Gratacos, Eduard Palacio, Montse Tags: Original Article Source Type: research

A Retrospective Database Analysis of Neonatal Morbidities to Evaluate a Composite Endpoint for Use in Preterm Labor Clinical Trials
AJP Rep 2018; 08: e25-e32 DOI: 10.1055/s-0038-1635097 Objective To propose and assess a composite endpoint (CE) of neonatal benefit based on neonatal mortality and morbidities by gestational age (GA) for use in preterm labor clinical trials. Study Design A descriptive, retrospective analysis of the Medical University of South Carolina Perinatal Information System database was conducted. Neonatal morbidities were assessed for inclusion in the CE based on clinical significance/risk of childhood neurodevelopmental impairment, frequency, and association with GA in a mother–neonate linked cohort, comprisin...
Source: American Journal of Perinatology Reports - March 7, 2018 Category: Perinatology & Neonatology Authors: Pimenta, Jeanne M. Ebeling, Myla Montague, Timothy H. Beach, Kathleen J. Abell, Jill O'Shea, Michael T. Powell, Marcy Hulsey, Thomas C. Tags: Original Article Source Type: research

Transient Neonatal Diabetes Mellitus in a Very Preterm Infant due to ABCC8 Mutation
We report the case of a preterm infant with TNDM due to an ABCC8 mutation identified by next-generation sequencing. The pancreatic adenosine triphosphate (ATP)-sensitive K+ (K-ATP) channel is a key regulator of insulin secretion. Gain-of-function mutations in the genes encoding the Kir6.2 (KCNJ11) and SUR1 (ABCC8) subunits of the channel cause neonatal diabetes. The patient was successfully managed with insulin lispro at a 1:100 dilution, drawn up in an insulin pen injector with a 4-mm needle. The insulin lispro dilution allowed administration of the exact insulin doses, obtaining a good glycemic control and minimizing the...
Source: American Journal of Perinatology Reports - March 7, 2018 Category: Perinatology & Neonatology Authors: Piccini, Barbara Coviello, Caterina Drovandi, Livia Rosangela, Artuso Monzali, Francesca Casalini, Emilio Giglio, Sabrina Toni, Sonia Dani, Carlo Tags: Case Report Source Type: research

Nonoperative Treatment of Appendicitis during Pregnancy in a Remote Area
We report on a pregnant Greenlandic Inuit woman with appendicitis who was treated with intravenous antibiotics. Antibiotic treatment was successful before surgical care became available and the patient was not operated. No complications occurred, and further pregnancy was uneventful. Our case suggests that antibiotic treatment of appendicitis during pregnancy as a bridge-to-surgery may be a sensible treatment option in remote areas, where no surgical care is immediately available. In some cases, antibiotic treatment may turn out to be definitive treatment. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10...
Source: American Journal of Perinatology Reports - February 28, 2018 Category: Perinatology & Neonatology Authors: Carstens, Anne-Kathrine Fensby, Lise Penninga, Luit Tags: Case Report Source Type: research

Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn
We present a rare case of intrauterine HSV-2 infection presenting with a zosteriform eruption mimicking congenital varicella syndrome in a newborn. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 27, 2018 Category: Perinatology & Neonatology Authors: Drumm, Caitlin M. Caufield, Maura C. DeKlotz, Cynthia M. Pasieka, Helena B. Abubakar, Kabir M. Tags: Case Report Source Type: research

Differential Methylation of Syncytin-1 and 2 Distinguishes Fetal Growth Restriction from Physiologic Small for Gestational Age
AJP Rep 2018; 08: e18-e24 DOI: 10.1055/s-0038-1627473 Objective The retroviral genes encoding Syncytin-1 (SYN1) and Syncytin-2 (SYN2) are epigenetically regulated, uniquely expressed in the placenta and critical to placental function. We sought to determine if placental expression and methylation patterns of SYN1 and SYN2 from pregnancies complicated by fetal growth restriction (FGR) differed from physiologic small for gestational age (SGA) and appropriate for gestational age (AGA) controls. Study Design Placental biopsies were obtained from AGA, SGA and FGR neonates delivered at>36 weeks gestation. SGA ...
Source: American Journal of Perinatology Reports - February 21, 2018 Category: Perinatology & Neonatology Authors: Makaroun, Sami P. Himes, Katherine P. Tags: Case Report Source Type: research

Pre-pregnancy Body Mass Index and Third-Trimester Depressive Symptoms in a Healthy Privately Insured Sample
Conclusion Replication in a larger sample is suggested to confirm an independent effect of pregravid overweight on third trimester depression. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 5, 2018 Category: Perinatology & Neonatology Authors: Schuette, Stephanie A. Kominiarek, Michelle A. Wisner, Katherine L. Massey, Suena H. Tags: Original Article Source Type: research

Pregnant Women's Knowledge and Beliefs about the Safety and Outcomes of Delivery at Various Gestational Ages
Conclusion Misconceptions surrounding the definition of a term pregnancy are pervasive and vary by race, obstetric history, and medical comorbidities. Our findings highlight the need for patient education about appropriate gestational length, especially in minority and high-risk populations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - January 19, 2018 Category: Perinatology & Neonatology Authors: Baldwin, Melody A. Swamy, Geeta K. Wheeler, Sarahn M. Tags: Original Article Source Type: research

False Low-Risk Single Nucleotide Polymorphism –Based Noninvasive Prenatal Screening in Pentasomy 49,XXXXY
We report third-trimester sonographic features of a fetus with pentasomy 49,XXXXY and the importance of thorough pre- and posttest counseling for NIPS. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - January 19, 2018 Category: Perinatology & Neonatology Authors: Putra, Manesha Hicks, Melissa A. Abramowicz, Jacques S. Tags: Case Report Source Type: research

Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report
AJP Rep 2018; 08: e1-e3 DOI: 10.1055/s-0037-1615818Congenital anomalies of the spine may occur with malformations of the central nervous, cardiovascular, gastrointestinal, respiratory, and genitourinary systems. This is a case of myelomeningocele with unilateral right renal agenesis in a newborn. The patient suffered complications of cerebrospinal fluid leak and meningitis, but was successfully treated and discharged on day 86. In this case, unilateral right renal agenesis represented a significant surgical risk because failure of the remaining kidney could result in renal failure. Because congenital anomalies of the spine...
Source: American Journal of Perinatology Reports - January 9, 2018 Category: Perinatology & Neonatology Authors: Maeda, Hajime Go, Hayato Sakuma, Jun Imamura, Takashi Sato, Maki Momoi, Nobuo Hosoya, Mitsuaki Tags: Case Report Source Type: research

A Case of Fatal Pulmonary Hypoplasia with Congenital Diaphragmatic Hernia, Thoracic Myelomeningocele, and Thoracic Dysplasia
Conclusion We speculate that two factors may be associated with the severe pulmonary hypoplasia: decreased thoracic space due to the herniation of visceral organs caused by CDH and thoracic dysplasia due to skeletal deformity and severe scoliosis. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 29, 2017 Category: Perinatology & Neonatology Authors: Ito, Ai Fujinaga, Hideshi Matsui, Sachiko Tago, Kumiko Iwasaki, Yuka Fujino, Shuhei Nagasawa, Junko Amari, Shoichiro Kaneshige, Masao Wada, Yuka Takahashi, Shigehiro Tsukamoto, Keiko Miyazaki, Osamu Yoshioka, Takako Ishiguro, Akira Ito, Yushi Tags: Case Report Source Type: research

Low-Dose Intravenous Paracetamol for Patent Ductus Arteriosus in Indomethacin-Resistant or Contraindicated Preterm Infants: Three Cases Reports
Conclusion The intravenous administration of paracetamol was safe and feasible in premature infants with hsPDA. Future clinical trials with optimized dose and timing of administration are needed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 21, 2017 Category: Perinatology & Neonatology Authors: Matsumura, Shun Oshima, Ayumi Fujinuma, Sumie Tanaka, Kosuke Nagano, Nobuhiko Miyake, Fuyu Masutani, Satoshi Tamura, Masanori Ueda, Keiko Namba, Fumihiko Tags: Case Report Source Type: research

Gorham-Stout Disease Management during Pregnancy
AJP Rep 2017; 07: e226-e229 DOI: 10.1055/s-0037-1615259Gorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. Chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. Extrapulmonary alterations may include chylous ascites, lymphopenia, and destructing bone disease for overgrowth of lymphatic vessels. Here, we report the...
Source: American Journal of Perinatology Reports - December 19, 2017 Category: Perinatology & Neonatology Authors: Bargagli, Elena Piccioli, Caterina Cavigli, Edoardo Scola, Marianna Rosi, Elisabetta Lavorini, Federico Novelli, Luca Ugolini, Dario Notaristefano, Tommaso Filippo, Pieralli Miele, Vittorio Comin, Camilla E. Pistolesi, Massimo Voltolini, Luca Tags: Case Report Source Type: research

Intrahepatic Cholestasis of Pregnancy Refractory to Multiple Medical Therapies and Plasmapheresis
Conclusion TPE often provides longer term relief of itching because of ICP; however, it is not a panacea for these symptoms, and sometimes only delivery of the fetus can relieve maternal symptoms. In addition to the refractoriness to TPE, the case is also unusual for the early onset of ICP symptoms and the comorbidity of hepatitis C. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 14, 2017 Category: Perinatology & Neonatology Authors: Covach, Adam John Rose, William Nicholas Tags: Case Report Source Type: research

Buprenorphine for Medication-Assisted Treatment of Opioid Use Disorder in Pregnancy: Relationship to Neonatal Opioid Withdrawal Syndrome
Conclusion The occurrence of NOWS was not related to buprenorphine dose used for MAT. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 7, 2017 Category: Perinatology & Neonatology Authors: Chavan, Niraj R. Ashford, Kristin B. Wiggins, Amanda T. Lofwall, Michelle R. Critchfield, Agatha S. Tags: Case Report Source Type: research

Treatment of Morbidly Adherent Placentation Utilizing a Standardized Multidisciplinary Approach in the Community Hospital –Private Practice Setting
Conclusion Our data demonstrate the feasibility and utility of a multidisciplinary morbidly adherent placentation program in the private practice/community hospital setting with outcomes similar to those at tertiary teaching hospitals. Implementation of such program may prove beneficial in remote centers, where various factors may prohibit patient travel to a larger center. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 22, 2017 Category: Perinatology & Neonatology Authors: Mansouri, Mahsa DeStefano, Kim Monks, Brian Singh, Jasbir McDonnold, Mollie Morgan, Jamison Hale, Richard Adusumalli, Jasvant Horton, Amanda Haeri, Sina Tags: Case Report Source Type: research

Anti-M Alloimmunization: Management and Outcome at a Single Institution
Conclusion The incidence of severe hemolytic disease of the newborn due to anti-M is extremely low. We found no cases in our review of 195 pregnancies, despite several cases of severe hemolytic disease of the newborn reported in the literature. We have created an algorithm for the management of anti-M antibodies in pregnancy based on our data and extensive literature review. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 22, 2017 Category: Perinatology & Neonatology Authors: Stetson, Bethany Scrape, Scott Markham, Kara Beth Tags: Case Report Source Type: research