GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil
Conclusions: The frequency of GRN mutations was 9.6% and that of MAPT mutations was 7.1%. Among familial cases of FTD, the frequency of GRN mutations was 31.5% and that of MAPT mutations was 10.5%. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients
Conclusion: Our findings suggest that rs2075650 of TOMM40 could be involved in earlier presentation of LOAD in the Colombian population. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease
In this study, we aimed to investigate the effect of age at onset and apoE genotype on white-matter changes in AD using diffusion tensor imaging. About 213 patients with AD and 66 normal individuals underwent diffusion tensor imaging, and apoE genotype was obtained in all AD patients and in 24 normal individuals. When multiple regression analysis was conducted, a younger age at onset was associated with lower fractional anisotropy in both deep-located long-range limbic and association fibers and superficial-located short-range association fibers in the frontal, the temporal, and the parietal lobes, and with a higher mean d...
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Default Mode Network Functional Connectivity in Early and Late Mild Cognitive Impairment: Results From the Alzheimer’s Disease Neuroimaging Initiative
Conclusions: Our results suggest that the breakdown of DMN connectivity may occur in the early stage of MCI. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Cholinergic Changes in Aging and Alzheimer Disease: An [18F]-F-A-85380 Exploratory PET Study.
Authors: Lagarde J, Sarazin M, Chauviré V, Stankoff B, Kas A, Lacomblez L, Peyronneau MA, Bottlaender M Abstract The central cholinergic system undergoes changes during the physiological process of aging and the pathologic process of Alzheimer disease (AD). We aimed to analyze the impairment of cholinergic pathways by positron emission tomography using the [F]-F-A-85380 (FA85) tracer, which has a high affinity for nicotinic acetylcholine receptors (nAChRs). Aging was assessed by comparing young (n=10) and elderly (n=4) healthy subjects, and the pathologic process of AD was assessed by comparing elderly contr...
Source: Alzheimer Disease and Associated Disorders - September 30, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE- ε4.
Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):210-5 Authors: Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R Abstract We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0...
Source: Alzheimer Disease and Associated Disorders - August 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predicting the Rate of Cognitive Decline in Alzheimer Disease: Data From the ICTUS Study.
CONCLUSIONS: A slow progression of cognitive decline is common among AD patients. The influence of age and baseline cognitive impairment should always be carefully considered when designing AD trials and defining study populations. PMID: 27556936 [PubMed - in process] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

MRI Markers Predict Cognitive Decline Assessed by Telephone Interview: The Northern Manhattan Study.
CONCLUSIONS: Telephone cognitive assessments can detect decline due to white matter lesions and smaller brain volumes. PMID: 27467026 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 30, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dementia and Cognitive Impairment Prevalence and Associated Factors in Indigenous Populations: A Systematic Review
In this study, a systematic review of the literature on the subject “cognitive impairment in indigenous elderly population” in the databases MEDLINE via PubMed, Lilacs, and Scopus showed that the prevalence of dementia in indigenous populations between 45 and 94 years old, originally from different countries, varied between 0.5% and 26.8% for age 60 and older, whereas the prevalence of cognitive impairment not dementia varied between 4.4% and 17.7%. Early onset of the disease, older age, low education level, and several poor health conditions were associated with prevalence rates and conversion from normal to a...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Review Article Source Type: research

Posterior Cortical Atrophy: A Case Report of a 6-Year Natural Progression
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Heterozygous Chorein Deficiency in Probable Tau-negative Early-onset Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembé, Brazil
Background: The prevalence of cognitive impairment is insufficiently determined in developing countries. The aim of this study was to ascertain the prevalence of cognitive impairment without dementia and dementia in community-dwelling elderly in Brazil. Methods: This was a single-phase cross-sectional survey of the elderly (aged 60 years and above) living in the municipality of Tremembé, Brazil. Twenty percent of the households with elderly persons were randomly selected from urban and rural areas, to obtain a homogenous representation of all socioeconomic and cultural levels. Results: We assessed 630 individuals ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Detection and Differentiation of Frontotemporal Dementia and Related Disorders From Alzheimer Disease Using the Montreal Cognitive Assessment
The objectives were: (1) to determine whether the MoCA detects cognitive impairment (CI) in FTD subjects; (2) to determine whether Alzheimer disease (AD) and FTD subtypes and related disorders can be parsed using the MoCA; and (3) describe longitudinal MoCA performance by subtype. We extracted demographic and testing data from a database of patients referred to a cognitive neurology clinic who met criteria for probable AD or FTD (N=192). Logistic regression was used to determine whether dementia subtypes were associated with overall scores, subscores, or combinations of subscores on the MoCA. Initial MoCA results demonstra...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Cognitive Profiles on the Severe Impairment Battery Are Similar in Alzheimer Disease and Down Syndrome With Dementia
Previous research has revealed similarities in the neuropathology, clinical presentation, and risk factors between persons with Alzheimer disease from the general population (GP-AD) and those with Down syndrome (DS-AD). Less is known, however, about the extent of similarities and differences in the cognitive profiles of these 2 populations. Fifty-one moderate to severely demented GP-AD and 59 DS-AD individuals participated in this study which compared the cognitive profiles of these 2 populations on the Severe Impairment Battery (SIB), controlling for sex as well as level of functional ability using a modified version of t...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil
Little is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. In this 44-month cohort study, 214 consecutive outpatients with late-onset AD were assessed for rates of cognitive and functional decline by way of Clinical Dementia Rating and Mini-Mental State Examination (MMSE) scores, keeping blinded assessment of APOE haplotypes. Subjects were evaluated for sex, schooling, age of dementia onset, and cerebrovascular risk factors (including Framingham risk scores). ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Predicting the Rate of Cognitive Decline in Alzheimer Disease: Data From the ICTUS Study
Conclusions: A slow progression of cognitive decline is common among AD patients. The influence of age and baseline cognitive impairment should always be carefully considered when designing AD trials and defining study populations. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

The Relationship Between Mobility Dysfunction Staging and Global Cognitive Performance
Objectives: To assess the relationship and the directionality between mobility and cognitive performance. Method: A cross-sectional analysis of a racially/ethnically diverse sample of 327 community-dwelling adults (mean age=68.9±9.9 y; range, 40 to 100 y) categorized as having no mobility dysfunction, upper-extremity (UE) impairment, lower-extremity (LE) impairment, or mobility limitation (both UE and LE impairments), and compared by global cognition with multiple hierarchical linear regression adjusted for sociodemographic, health, and mood factors. A bootstrapping mediation analysis investigated the directionalit...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases
Studies have demonstrated associations between cardiovascular factors and Alzheimer disease (AD) with minimal focus on other neurodegenerative diseases. Utilizing cross-sectional data from 17,532 individuals in the National Alzheimer’s Coordinating Center, Uniform Data Set, we compared the presence of cardiovascular factors [body mass index (BMI), atrial fibrillation, hypertension, hyperlipidemia, and diabetes] in individuals carrying a diagnosis of Probable AD (ProbAD), Possible AD, vascular dementia, dementia with Lewy bodies (DLB), frontotemporal dementia, Parkinson disease, progressive supranuclear palsy, or cort...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-based, Aging Cohort
Conclusions: Exposure to CMV, HSV-2, or TOX is associated with cognitive deterioration in older individuals, independent of general age–related variables. An increased understanding of the role of infectious agents in cognitive decline may lead to new methods for its prevention and treatment. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4
We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations with 5- to 7-year follow-up. Regression analyses investigated associations between baseline pulse pressure (systolic−diastolic pressure) and cognition, total cerebral volume and temporal horn ve...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

SNP Variation in MicroRNA Biogenesis Pathway Genes as a New Innovation Strategy for Alzheimer Disease Diagnostics: A Study of 10 Candidate Genes in an Understudied Population From the Eastern Mediterranean
Alzheimer disease (AD) is a common complex neurodegenerative disorder accounting for nearly 50% to 70% of dementias worldwide. Yet the current diagnostic options for AD are limited. New diagnostic innovation strategies focusing on novel molecules and pathways are sorely needed. In this connection, microRNAs (miRNAs) are conserved small noncoding RNAs that regulate posttranscriptional gene expression and are vital for neuronal development and its functional sustainability. Conceivably, biological pathways responsible for the biogenesis of miRNAs represent a veritable set of upstream candidate genes that can be potentially a...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up
Evidence on whether genetic predictors of Alzheimer disease (AD) also predict memory decline is inconsistent, and limited data are available for African ancestry populations. For 8253 non-Hispanic white (NHW) and non-Hispanic black (NHB) Health and Retirement Study participants with memory scores measured 1 to 8 times between 1998 and 2012 (average baseline age=62), we calculated weighted polygenic risk scores [AD Genetic Risk Score (AD-GRS)] using the top 22 AD-associated loci, and an alternative score excluding apolipoprotein E (APOE) (AD-GRSexAPOE). We used generalized linear models with AD-GRS-by-age and AD-GRS-by-age2...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

The Effects of Computerized Cognitive Testing of Older Patients on Primary Care Physicians' Approaches to Care: A Canadian Study.
CONCLUSIONS: Our findings indicate that PCPs documented more care approaches in patients with greater cognitive impairment based on the CAMCI results and this was independent of their, the patients', or families' prior concerns about their patients' cognition. PMID: 27341011 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You to Our Reviewers in 2015!
Authors: PMID: 27331232 [PubMed - in process] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - June 23, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia.
Authors: Galetta KM, Chapman KR, Essis MD, Alosco ML, Gillard D, Steinberg E, Dixon D, Martin B, Chaisson CE, Kowall NW, Tripodis Y, Balcer LJ, Stern RA Abstract The King-Devick (K-D) test is a 1 to 2 minute, rapid number naming test, often used to assist with detection of concussion, but also has clinical utility in other neurological conditions (eg, Parkinson disease). The K-D involves saccadic eye and other eye movements, and abnormalities thereof may be an early indicator of Alzheimer disease (AD)-associated cognitive impairment. No study has tested the utility of the K-D in AD and we sought to do so. The sampl...
Source: Alzheimer Disease and Associated Disorders - June 16, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Recruiting Dementia Caregivers Into Clinical Trials: Lessons Learnt From the Australian TRANSCENDENT Trial.
This study has generated new insights into the effective recruitment of dementia caregivers into clinical trials. We anticipate that these lessons learnt will assist in shaping the recruitment strategies of future studies of dementia caregivers. PMID: 27227995 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 27, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease.
In this study, we aimed to investigate the effect of age at onset and apoE genotype on white-matter changes in AD using diffusion tensor imaging. About 213 patients with AD and 66 normal individuals underwent diffusion tensor imaging, and apoE genotype was obtained in all AD patients and in 24 normal individuals. When multiple regression analysis was conducted, a younger age at onset was associated with lower fractional anisotropy in both deep-located long-range limbic and association fibers and superficial-located short-range association fibers in the frontal, the temporal, and the parietal lobes, and with a higher mean d...
Source: Alzheimer Disease and Associated Disorders - May 27, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease.
Authors: Tarrant SD, Bardach SH, Bates K, Nichols H, Towner J, Tamatha C, Caban-Holt A, Van-Eldik LJ, Murphy RR, Sperling R, Jicha GA Abstract Effective and practical recruitment strategies are needed to ensure successful recruitment into the Alzheimer disease clinical trials. To facilitate successful recruitment for the NIH-sponsored A4 (Anti-Amyloid treatment in Asymptomatic Alzheimer's disease, NCT02008357) trial for the secondary prevention of Alzheimer disease, we developed a small-group community information session to attract and recruit potential research participants. After a successful media campaign, 213...
Source: Alzheimer Disease and Associated Disorders - May 24, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials.
Authors: Chang TS, Teng E, Elashoff D, Grill JD, Alzheimer’s Disease Neuroimaging Initiative Abstract Recent clinical trials in mild Alzheimer disease (AD) have enriched for amyloid-specific positron emission tomography (PET) imaging and used extended versions of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog) in an effort to increase the sensitivity to detect treatment effects. We used data from mild AD participants in the AD Neuroimaging Initiative to model trial effect sizes for 12- and 24-month trials using 3 versions of the ADAS-Cog and increased standardized uptake value ratio (SUVR) cutoffs for a...
Source: Alzheimer Disease and Associated Disorders - May 21, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients.
Authors: Curto M, Martocchia A, Ferracuti S, Comite F, Scaccianoce S, Girardi P, Nicoletti F, Falaschi P PMID: 27196536 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 21, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Early-Onset Dementia: Frequency, Diagnostic Procedures, and Quality Indicators in Three European Tertiary Referral Centers.
CONCLUSIONS: In tertiary referral centers in Copenhagen, Stockholm, and Amsterdam, quality indicators were not always met for patients with EOD. Results partly reflect differences in referral pattern, the application of diagnostic criteria, and local best practices. Standardized international procedures for patients with EOD may reduce this variability. PMID: 27158877 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 11, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals.
We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/A&beta...
Source: Alzheimer Disease and Associated Disorders - April 30, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil.
CONCLUSIONS: The frequency of GRN mutations was 9.6% and that of MAPT mutations was 7.1%. Among familial cases of FTD, the frequency of GRN mutations was 31.5% and that of MAPT mutations was 10.5%. PMID: 27082848 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial: Erratum
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Erratum Source Type: research

Epileptic Seizures in Alzheimer Disease: A Review
Alzheimer disease (AD) is the most frequent cause of major neurocognitive disorders with a huge economical and medical burden. Several studies pointed out that AD is associated with a high risk for developing epileptic seizures. The aims of our review were to evaluate and to summarize the current literature (ending in September 2015) of animal and human studies in the relation of AD and epileptic seizures. It seems likely that epileptic hyperexcitation could be partially responsible for the progression of AD due to the increased rate of amyloid deposition. Pathologic changes in animal models of AD are similar to those seen...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Review Article Source Type: research

Frontal Variant Alzheimer Disease or Frontotemporal Lobe Degeneration With Incidental Amyloidosis?
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Improvement of Dream Enactment Behavior Associated With Levetiracetam Treatment in Dementia With Lewy Bodies
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Correlation Between Caregiver Reports of Physical Function and Performance-based Measures in a Cohort of Older Adults With Alzheimer Disease
The objectives of this report are to determine the association between performance-based measures of physical function with caregiver reports of physical function in older adults with Alzheimer disease (AD) and to examine whether those associations vary by the level of patients’ cognitive functioning. Subjects included 180 patient-caregiver dyads who are enrolled in a clinical trial testing the impact of an occupational therapy intervention plus guideline-level care to delay functional decline among older adults with AD. The primary caregiver-reported measure is the Alzheimer’s Disease Cooperative Study Group A...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Global Data Sharing in Alzheimer Disease Research
Many investigators recognize the importance of data sharing; however, they lack the capability to share data. Research efforts could be vastly expanded if Alzheimer disease data from around the world was linked by a global infrastructure that would enable scientists to access and utilize a secure network of data with thousands of study participants at risk for or already suffering from the disease. We discuss the benefits of data sharing, impediments today, and solutions to achieving this on a global scale. We introduce the Global Alzheimer’s Association Interactive Network (GAAIN), a novel approach to create a globa...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Embedded Online Questionnaire Measures Are Sensitive to Identifying Mild Cognitive Impairment
We examined whether passive aspects of responding to a remotely monitored weekly online questionnaire discriminated between older adults with and without MCI. Methods: Participants were 83 independent, community-dwelling older adults enrolled in a longitudinal study of in-home monitoring technologies, which included completion of a short weekly online questionnaire of health and life events. Results: In longitudinal analyses, time to complete the online questionnaire decreased over 1 year in both MCI and cognitively intact participants (P (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Cognitive and Functional Correlates of NPI-Q Scores and Symptom Clusters in Mildly Demented Alzheimer Patients
Previous research has demonstrated an association between the emotional and behavioral symptoms of dementia, known as neuropsychiatric symptoms, and cognitive and functional decline among patients with Alzheimer disease (AD). The present study aimed to identify associations between neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory-Questionnaire (NPI-Q) and cognitive and functional performance. Participants were 256 AD patients enrolled in the Alzheimer’s Disease and Memory Disorders Center at Baylor College of Medicine. An exploratory factor analysis of the NPI-Q indicated a 2-factor structure c...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Cross-validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease
The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE=23.2±2.9) and 72 patients of the REFLEX study (MMSE=20.8±3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as g...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study
Discussion: The recommended new tests are well correlated with the previous tests. The equipercentile equating method produced conversion tables that provide a useful reference for clinicians and researchers. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Onset of Mild Cognitive Impairment in Parkinson Disease
Conclusions: Longitudinal disease-state models support a prodromal dementia stage (PD-MCI) marked by early declines in working memory and visuospatial processing beginning 5 years before clinical diagnosis of PDD. Cognitive declines in PD affect motor ability (bradykinesia), working memory, and processing speed (bradyphrenia) resulting in PD-MCI where visuospatial imagery and memory retrieval deficits manifest before eventual development of overt dementia. Tests of episodic memory may not be sufficient to detect and quantify cognitive decline in PD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease
Discussion: In this sample, we found neither a higher prevalence of latent toxoplasmosis in the AD group compared with the control group nor differences in serum anti-T. gondii IgG titers between groups. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Inverse Association Between Cancer and Dementia: A Population-based Registry Study in Taiwan
This study showed an inverse association between cancer and dementia. Further studies focusing on colon and prostate cancers may help elucidate the underlying mechanism and expand the therapeutic strategies. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition
Benzodiazepine (BZD) use may be associated with dementia. However, differing opinions exist regarding the effect of BZDs on long-term changes in cognition. We evaluated the association between BZD use and cognitive decline in the elderly with normal cognition from the National Alzheimer’s Disease Coordinating Center’s Uniform Data Set. The study exposure, BZD use, was classified 2 ways: any-use [reported BZD use at a minimum of 1 Alzheimer's disease center (ADC) visit] and always-use (reported BZD use at all ADC visits). The reference group included participants without any declared BZD use at any Alzheimer's D...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

NSAID Use and Incident Cognitive Impairment in a Population-based Cohort
This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were use...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia
A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on antidepressants but depressed, and not on antidepressants and not depressed. SSRI and non-SSRI users h...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research