Onset of Mild Cognitive Impairment in Parkinson Disease
Conclusions: Longitudinal disease-state models support a prodromal dementia stage (PD-MCI) marked by early declines in working memory and visuospatial processing beginning 5 years before clinical diagnosis of PDD. Cognitive declines in PD affect motor ability (bradykinesia), working memory, and processing speed (bradyphrenia) resulting in PD-MCI where visuospatial imagery and memory retrieval deficits manifest before eventual development of overt dementia. Tests of episodic memory may not be sufficient to detect and quantify cognitive decline in PD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease
Discussion: In this sample, we found neither a higher prevalence of latent toxoplasmosis in the AD group compared with the control group nor differences in serum anti-T. gondii IgG titers between groups. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Inverse Association Between Cancer and Dementia: A Population-based Registry Study in Taiwan
This study showed an inverse association between cancer and dementia. Further studies focusing on colon and prostate cancers may help elucidate the underlying mechanism and expand the therapeutic strategies. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Benzodiazepine Use and Cognitive Decline in Elderly With Normal Cognition
Benzodiazepine (BZD) use may be associated with dementia. However, differing opinions exist regarding the effect of BZDs on long-term changes in cognition. We evaluated the association between BZD use and cognitive decline in the elderly with normal cognition from the National Alzheimer’s Disease Coordinating Center’s Uniform Data Set. The study exposure, BZD use, was classified 2 ways: any-use [reported BZD use at a minimum of 1 Alzheimer's disease center (ADC) visit] and always-use (reported BZD use at all ADC visits). The reference group included participants without any declared BZD use at any Alzheimer's D...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

NSAID Use and Incident Cognitive Impairment in a Population-based Cohort
This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were use...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia
A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on antidepressants but depressed, and not on antidepressants and not depressed. SSRI and non-SSRI users h...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study
Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to participants (N=507; 71 developed incident aMCI; mean follow-up time=3.6 y, SD=2.0) who were aged 70 years and old...
Source: Alzheimer Disease and Associated Disorders - April 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients.
CONCLUSION: Our findings suggest that rs2075650 of TOMM40 could be involved in earlier presentation of LOAD in the Colombian population. PMID: 27023435 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 31, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Temporal Trends and Geographic Variations in Dementia Mortality in China Between 2006 and 2012: Multilevel Evidence From a Nationally Representative Sample.
CONCLUSIONS: Our findings indicate that regional inequalities in dementia mortality are salient, and the increase in mortality rates in rural areas is an emerging public health challenge in China. Tailored preventive health strategies should be in place to narrow down this avoidable and wholly unnecessary inequality. PMID: 26999577 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 22, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Reversion From Mild Cognitive Impairment to Normal Cognition: A Meta-Analysis.
Authors: Malek-Ahmadi M Abstract The initiation of Alzheimer disease (AD) prevention studies has placed greater emphasis on the need to accurately detect individuals with amnestic mild cognitive impairment (aMCI) given their increased risk for developing AD. Several studies reporting on the incidence and prevalence of aMCI have also found that a substantial number of aMCI cases at baseline assessments revert to normal cognition at subsequent assessments. This instability presents a major challenge to intervention studies aimed at preventing the onset of clinical symptoms associated with aMCI. Reversion rates from 2...
Source: Alzheimer Disease and Associated Disorders - February 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Both Financial and Cognitive Decline Predict Clinical Progression in MCI.
We examined patterns of financial and cognitive decline across the 2-year study period, and used these data and the 3 outcome variables to construct discrete predictor models of clinical progression in MCI. We found that both financial skills and cognitive abilities declined over the 2-year study period, were significantly associated with clinical progression, and contributed unique variance to all 3 predictor models. The resulting models accounted for 40% to 75% of variance in clinical progression across outcome variables. Taken together, our results indicate that changes in both cognitive abilities and higher order funct...
Source: Alzheimer Disease and Associated Disorders - February 25, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial.
Authors: Sevigny J, Suhy J, Chiao P, Chen T, Klein G, Purcell D, Oh J, Verma A, Sampat M, Barakos J Abstract Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or mild AD underwent florbetapir PET scanning at screening. PET, magnetic resonance imaging, and coregistered PET/magnetic resonance imaging scans were reviewed by 2 independent readers and binary visual readings tabula...
Source: Alzheimer Disease and Associated Disorders - February 19, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Misidentification Delusions: Prevalence in Different Types of Dementia and Validation of a Structured Questionnaire.
We examined 146 subjects with Alzheimer disease, 21 with Lewy body dementia, 6 with frontotemporal dementia, and 13 with vascular dementia (subcortical type), who were consecutively enrolled in the study from 2 Memory Clinics. Patients had a mean age of 78.7±6.4 years and an Mini-Mental State Examination average score of 16.9±6.1. The Neuropsychiatric Inventory delusion subscale and a new Misidentification Delusion Questionnaire aimed at specific assessment of 11 delusional misidentification syndromes were administrated to the caregivers. On the basis of the Neuropsychiatric Inventory, MDs were present in 33....
Source: Alzheimer Disease and Associated Disorders - February 10, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Progressive Language Impairment in an English-Italian Bilingual Woman With Alzheimer Disease: An 18-Month Follow-up.
Authors: D'Antonio F, Imbriano L, Campanelli A, de Lena C, Trebbastoni A PMID: 26840543 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 4, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Relationship Between Mobility Dysfunction Staging and Global Cognitive Performance.
Authors: Tolea MI, Galvin JE Abstract OBJECTIVES: To assess the relationship and the directionality between mobility and cognitive performance. METHOD: A cross-sectional analysis of a racially/ethnically diverse sample of 327 community-dwelling adults (mean age=68.9±9.9 y; range, 40 to 100 y) categorized as having no mobility dysfunction, upper-extremity (UE) impairment, lower-extremity (LE) impairment, or mobility limitation (both UE and LE impairments), and compared by global cognition with multiple hierarchical linear regression adjusted for sociodemographic, health, and mood factors. A bootstrapping ...
Source: Alzheimer Disease and Associated Disorders - February 4, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Default Mode Network Functional Connectivity in Early and Late Mild Cognitive Impairment: Results From the Alzheimer's Disease Neuroimaging Initiative.
CONCLUSIONS: Our results suggest that the breakdown of DMN connectivity may occur in the early stage of MCI. PMID: 26840545 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 4, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dementia and Cognitive Impairment Prevalence and Associated Factors in Indigenous Populations: A Systematic Review.
In this study, a systematic review of the literature on the subject "cognitive impairment in indigenous elderly population" in the databases MEDLINE via PubMed, Lilacs, and Scopus showed that the prevalence of dementia in indigenous populations between 45 and 94 years old, originally from different countries, varied between 0.5% and 26.8% for age 60 and older, whereas the prevalence of cognitive impairment not dementia varied between 4.4% and 17.7%. Early onset of the disease, older age, low education level, and several poor health conditions were associated with prevalence rates and conversion from normal to any...
Source: Alzheimer Disease and Associated Disorders - February 4, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Heterozygous Chorein Deficiency in Probable Tau-negative Early-onset Alzheimer Disease.
Authors: Lazarczyk MJ, Haller S, Gimelli S, Bena F, Giannakopoulos P PMID: 26825611 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 31, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

SNP Variation in MicroRNA Biogenesis Pathway Genes as a New Innovation Strategy for Alzheimer Disease Diagnostics: A Study of 10 Candidate Genes in an Understudied Population From the Eastern Mediterranean.
Authors: Görücü Yilmaz Ş, Erdal ME, Avci Özge A, Sungur MA Abstract Alzheimer disease (AD) is a common complex neurodegenerative disorder accounting for nearly 50% to 70% of dementias worldwide. Yet the current diagnostic options for AD are limited. New diagnostic innovation strategies focusing on novel molecules and pathways are sorely needed. In this connection, microRNAs (miRNAs) are conserved small noncoding RNAs that regulate posttranscriptional gene expression and are vital for neuronal development and its functional sustainability. Conceivably, biological pathways responsible for the bio...
Source: Alzheimer Disease and Associated Disorders - January 24, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Epileptic Seizures in Alzheimer Disease: A Review.
Authors: Horváth A, Szűcs A, Barcs G, Noebels JL, Kamondi A Abstract Alzheimer disease (AD) is the most frequent cause of major neurocognitive disorders with a huge economical and medical burden. Several studies pointed out that AD is associated with a high risk for developing epileptic seizures. The aims of our review were to evaluate and to summarize the current literature (ending in September 2015) of animal and human studies in the relation of AD and epileptic seizures. It seems likely that epileptic hyperexcitation could be partially responsible for the progression of AD due to the increased rate of am...
Source: Alzheimer Disease and Associated Disorders - January 16, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Cross-Sectional Analysis of Late-Life Cardiovascular Factors and Their Relation to Clinically Defined Neurodegenerative Diseases.
Authors: Dugger BN, Malek-Ahmadi M, Monsell SE, Kukull WA, Woodruff BK, Reiman EM, Beach TG, Wilson J Abstract Studies have demonstrated associations between cardiovascular factors and Alzheimer disease (AD) with minimal focus on other neurodegenerative diseases. Utilizing cross-sectional data from 17,532 individuals in the National Alzheimer's Coordinating Center, Uniform Data Set, we compared the presence of cardiovascular factors [body mass index (BMI), atrial fibrillation, hypertension, hyperlipidemia, and diabetes] in individuals carrying a diagnosis of Probable AD (ProbAD), Possible AD, vascular dementia, dem...
Source: Alzheimer Disease and Associated Disorders - January 16, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up.
Authors: Marden JR, Mayeda ER, Walter S, Vivot A, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM Abstract Evidence on whether genetic predictors of Alzheimer disease (AD) also predict memory decline is inconsistent, and limited data are available for African ancestry populations. For 8253 non-Hispanic white (NHW) and non-Hispanic black (NHB) Health and Retirement Study participants with memory scores measured 1 to 8 times between 1998 and 2012 (average baseline age=62), we calculated weighted polygenic risk scores [AD Genetic Risk Score (AD-GRS)] using the top 22 AD-associated loci, and an alternative score excluding ...
Source: Alzheimer Disease and Associated Disorders - January 16, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You to Our Reviewers in 2015!
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Guest Reviewers Acknowledgement Source Type: research

Predictive Factors for the Uptake of Coping Strategies by Spousal Dementia Caregivers: A Systematic Review
An understanding of spousal dementia caregivers’ coping strategies and their predictive factors is imperative for caregivers’ well-being. Although several reviews have explored the relationship between coping strategies and outcomes, no review has investigated factors that predict caregivers’ use of one type of coping strategy over another. The current review aimed to identify factors that predict caregivers’ coping strategies. Within this, we attempted to identify caregivers who are more likely to adopt dysfunctional coping strategies and be at risk of adverse outcomes. Several electronic databases...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Review Article Source Type: research

Aging Stereotypes Must be Taken Into Account for the Diagnosis of Prodromal and Early Alzheimer Disease
Because of a dramatic increase of older people worldwide, screening for prodromal state of Alzheimer disease (AD) is a major societal challenge. Many individuals diagnosed with prodromal AD, do not convert to AD, some remaining stable and others reversing back to normal. We argue that an important source of this overdiagnosis comes from negative aging stereotypes (eg, the culturally shared beliefs that aging inescapably causes severe cognitive decline and diseases). Many laboratory studies show that such stereotypes impair memory performance in healthy older adults, producing inflated age differences. Research is needed to...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Concepts, Conjectures, and Hypotheses in Dementia Source Type: research

Clinicopathologic and Genetic Studies of 2 Patients With Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer’s Disease: A Case Report
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Olfactory Deficits Predict Cognitive Improvement on Donepezil in Patients With Depression and Cognitive Impairment: A Randomized Controlled Pilot Study
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Trajectory of Mobility Decline by Type of Dementia
Cognitive and physical aspects of functionality are closely related. However, whether physical decline differs by dementia type and progression rate is debatable. To address these issues, we conducted a longitudinal study of 766 older adults whose physical performance and cognitive status were assessed annually with standard assessment tools [eg, Physical Performance Test, Clinical Dementia Rate (CDR)] for 8 years. Compared with participants who remained cognitively normal, those progressing to later-stage dementia (CDR=1) declined in their mobility by a factor of 2.82 (P (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A “Real-Life” Study
Conclusions: Cognition and behaviour of AD patients deteriorated accompanied with an increase in care-dependency during 3.5 years. Nevertheless, compared with the precholinesterase inhibitor era, current pharmacological and nonpharmacological interventions appear to slow cognitive decline, which emphasizes that they seem to have a favorable effect. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Episodic Memory in Alzheimer Disease, Frontotemporal Dementia, and Dementia With Lewy Bodies/Parkinson Disease Dementia: Disentangling Retrieval From Consolidation
We examined the memory performance of 106 AD patients, 51 FTD patients, 26 DLB/PDD patients, and 37 controls using the Five-Words Test, a 5-item memory test that facilitates encoding. Results: The patient groups did not differ in modified Mini Mental State Examination scores. AD patients scored lowest on the Five-Words Test overall, and showed the greatest reduction from immediate total recall to delayed free recall relative to the other 2 groups, consistent with a predominantly consolidation deficit. DLB/PDD patients showed the largest improvement from delayed free to delayed total recall relative to the other 2 groups, ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Determinants of Activity Levels in African Americans With Mild Cognitive Impairment
Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and participants’ demographic, clinical, and neuropsychological characteristics. The average age of participants was 75.4 years (SD, 7.0); 177 (80.1%) were women. Participation in cognitive/social activities was positively associated with education, depression, literacy, mobility, instrumental activities of daily living (IADL), verbal learning, and subcomponents of executive fu...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Emergency Department Use Among Older Adults With Dementia
Although persons with dementia are frequently hospitalized, relatively little is known about the health profile, patterns of health care use, and mortality rates for patients with dementia who access care in the emergency department (ED). We linked data from our hospital system with Medicare and Medicaid claims, Minimum Data Set, and Outcome and Assessment Information Set data to evaluate 175,652 ED visits made by 10,354 individuals with dementia and 15,020 individuals without dementia over 11 years. Survival rates after ED visits and associated charges were examined. Patients with dementia visited the ED more frequently, ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Both Financial and Cognitive Decline Predict Clinical Progression in MCI
We examined patterns of financial and cognitive decline across the 2-year study period, and used these data and the 3 outcome variables to construct discrete predictor models of clinical progression in MCI. We found that both financial skills and cognitive abilities declined over the 2-year study period, were significantly associated with clinical progression, and contributed unique variance to all 3 predictor models. The resulting models accounted for 40% to 75% of variance in clinical progression across outcome variables. Taken together, our results indicate that changes in both cognitive abilities and higher order funct...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study
Dementia incidence increases exponentially with age even in people aged 90 years and above. Because therapeutic regimens are limited, modification of lifestyle behaviors may offer the best means for disease control. To test the hypotheses that lifestyle factors are related to lower risk of dementia in the oldest-old, we analyzed data from The 90+ Study, a population-based longitudinal cohort study initiated in 2003. This analysis included 587 participants (mean age=93 y) seen in-person and determined not to have dementia at enrollment. Information on lifestyle factors (smoking, alcohol, caffeine, vitamin supplements, exerc...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study
Conclusions: Evidence from polygenic scores suggests that insulin sensitivity specifically may affect AD risk, more than T2D overall. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway
Conclusions: The present study found a lower performance of the biomarkers than reported previously. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial
Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or mild AD underwent florbetapir PET scanning at screening. PET, magnetic resonance imaging, and coregistered PET/magnetic resonance imaging scans were reviewed by 2 independent readers and binary visual readings tabulated. Semiquantitative values of cortical to whole cerebellar standard uptake value ratios were computed (threshold 1....
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-based, Aging Cohort.
CONCLUSIONS: Exposure to CMV, HSV-2, or TOX is associated with cognitive deterioration in older individuals, independent of general age-related variables. An increased understanding of the role of infectious agents in cognitive decline may lead to new methods for its prevention and treatment. PMID: 26710257 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 29, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Posterior Cortical Atrophy: A Case Report of a 6-Year Natural Progression.
Authors: Heber IA, Costa AS, Werner CJ, Schöne U, Reich A, Schulz JB, Reetz K PMID: 26704219 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Profiles on the Severe Impairment Battery are Similar in Alzheimer Disease and Down Syndrome With Dementia.
Authors: Dick MB, Doran E, Phelan M, Lott IT Abstract Previous research has revealed similarities in the neuropathology, clinical presentation, and risk factors between persons with Alzheimer disease from the general population (GP-AD) and those with Down syndrome (DS-AD). Less is known, however, about the extent of similarities and differences in the cognitive profiles of these 2 populations. Fifty-one moderate to severely demented GP-AD and 59 DS-AD individuals participated in this study which compared the cognitive profiles of these 2 populations on the Severe Impairment Battery (SIB), controlling for sex as wel...
Source: Alzheimer Disease and Associated Disorders - December 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
Authors: Katz MJ, Derby CA, Wang C, Sliwinski MJ, Ezzati A, Zimmerman ME, Zwerling JL, Lipton RB Abstract Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to ...
Source: Alzheimer Disease and Associated Disorders - December 16, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Aging Stereotypes Must be Taken Into Account for the Diagnosis of Prodromal and Early Alzheimer Disease.
Authors: Régner I, Mazerolle M, Alescio-Lautier B, Clarys D, Michel B, Paccalin M, Piolino P, Rigalleau F, Sambuchi N, Huguet P Abstract Because of a dramatic increase of older people worldwide, screening for prodromal state of Alzheimer disease (AD) is a major societal challenge. Many individuals diagnosed with prodromal AD, do not convert to AD, some remaining stable and others reversing back to normal. We argue that an important source of this overdiagnosis comes from negative aging stereotypes (eg, the culturally shared beliefs that aging inescapably causes severe cognitive decline and diseases). Many la...
Source: Alzheimer Disease and Associated Disorders - December 11, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study.
CONCLUSIONS: Evidence from polygenic scores suggests that insulin sensitivity specifically may affect AD risk, more than T2D overall. PMID: 26650880 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 11, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembé, Brazil.
Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembé, Brazil. Alzheimer Dis Assoc Disord. 2015 Dec 2; Authors: César KG, Brucki SM, Takada LT, Nascimento LF, Gomes CM, Almeida MC, Oliveira MO, Porto FH, Senaha ML, Bahia VS, Silva TB, Ianof JN, Spíndola L, Schmidt MT, Jorge MS, Vale PH, Cecchini MA, Cassimiro L, Soares RT, Gonçalves MR, Martins AC, Daré P, Smid J, Porto CS, Carthery-Goulart MT, Yassuda MS, Mansur LL, Nitrini R Abstract BACKGROUND: The prevalence of cognitive impairment is insufficiently determined in developing countries. The ai...
Source: Alzheimer Disease and Associated Disorders - December 5, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway.
CONCLUSIONS: The present study found a lower performance of the biomarkers than reported previously. PMID: 26629677 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 5, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Frontal Variant Alzheimer Disease or Frontotemporal Lobe Degeneration With Incidental Amyloidosis?
Authors: Scialò C, Ferrara M, Accardo J, Morbelli S, Picco A, Arnaldi D, Brugnolo A, Girtler N, Nobili F PMID: 26583500 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 21, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil.
Authors: Oliveira FF, Chen ES, Smith MC, Bertolucci PH Abstract Little is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. In this 44-month cohort study, 214 consecutive outpatients with late-onset AD were assessed for rates of cognitive and functional decline by way of Clinical Dementia Rating and Mini-Mental State Examination (MMSE) scores, keeping blinded assessment of APOE haplotypes. Subjects were evaluated for sex, schooling, age of dementia onse...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Emergency Department Use Among Older Adults With Dementia.
Authors: LaMantia MA, Stump TE, Messina FC, Miller DK, Callahan CM Abstract Although persons with dementia are frequently hospitalized, relatively little is known about the health profile, patterns of health care use, and mortality rates for patients with dementia who access care in the emergency department (ED). We linked data from our hospital system with Medicare and Medicaid claims, Minimum Data Set, and Outcome and Assessment Information Set data to evaluate 175,652 ED visits made by 10,354 individuals with dementia and 15,020 individuals without dementia over 11 years. Survival rates after ED visits and assoc...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Inverse Association Between Cancer and Dementia: A Population-based Registry Study.
This study showed an inverse association between cancer and dementia. Further studies focusing on colon and prostate cancers may help elucidate the underlying mechanism and expand the therapeutic strategies. PMID: 26523711 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research