Predictive Factors for the Uptake of Coping Strategies by Spousal Dementia Caregivers: A Systematic Review
An understanding of spousal dementia caregivers’ coping strategies and their predictive factors is imperative for caregivers’ well-being. Although several reviews have explored the relationship between coping strategies and outcomes, no review has investigated factors that predict caregivers’ use of one type of coping strategy over another. The current review aimed to identify factors that predict caregivers’ coping strategies. Within this, we attempted to identify caregivers who are more likely to adopt dysfunctional coping strategies and be at risk of adverse outcomes. Several electronic databases...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Review Article Source Type: research

Aging Stereotypes Must be Taken Into Account for the Diagnosis of Prodromal and Early Alzheimer Disease
Because of a dramatic increase of older people worldwide, screening for prodromal state of Alzheimer disease (AD) is a major societal challenge. Many individuals diagnosed with prodromal AD, do not convert to AD, some remaining stable and others reversing back to normal. We argue that an important source of this overdiagnosis comes from negative aging stereotypes (eg, the culturally shared beliefs that aging inescapably causes severe cognitive decline and diseases). Many laboratory studies show that such stereotypes impair memory performance in healthy older adults, producing inflated age differences. Research is needed to...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Concepts, Conjectures, and Hypotheses in Dementia Source Type: research

Clinicopathologic and Genetic Studies of 2 Patients With Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer’s Disease: A Case Report
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Olfactory Deficits Predict Cognitive Improvement on Donepezil in Patients With Depression and Cognitive Impairment: A Randomized Controlled Pilot Study
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Brief Reports Source Type: research

Trajectory of Mobility Decline by Type of Dementia
Cognitive and physical aspects of functionality are closely related. However, whether physical decline differs by dementia type and progression rate is debatable. To address these issues, we conducted a longitudinal study of 766 older adults whose physical performance and cognitive status were assessed annually with standard assessment tools [eg, Physical Performance Test, Clinical Dementia Rate (CDR)] for 8 years. Compared with participants who remained cognitively normal, those progressing to later-stage dementia (CDR=1) declined in their mobility by a factor of 2.82 (P (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A “Real-Life” Study
Conclusions: Cognition and behaviour of AD patients deteriorated accompanied with an increase in care-dependency during 3.5 years. Nevertheless, compared with the precholinesterase inhibitor era, current pharmacological and nonpharmacological interventions appear to slow cognitive decline, which emphasizes that they seem to have a favorable effect. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Episodic Memory in Alzheimer Disease, Frontotemporal Dementia, and Dementia With Lewy Bodies/Parkinson Disease Dementia: Disentangling Retrieval From Consolidation
We examined the memory performance of 106 AD patients, 51 FTD patients, 26 DLB/PDD patients, and 37 controls using the Five-Words Test, a 5-item memory test that facilitates encoding. Results: The patient groups did not differ in modified Mini Mental State Examination scores. AD patients scored lowest on the Five-Words Test overall, and showed the greatest reduction from immediate total recall to delayed free recall relative to the other 2 groups, consistent with a predominantly consolidation deficit. DLB/PDD patients showed the largest improvement from delayed free to delayed total recall relative to the other 2 groups, ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Determinants of Activity Levels in African Americans With Mild Cognitive Impairment
Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and participants’ demographic, clinical, and neuropsychological characteristics. The average age of participants was 75.4 years (SD, 7.0); 177 (80.1%) were women. Participation in cognitive/social activities was positively associated with education, depression, literacy, mobility, instrumental activities of daily living (IADL), verbal learning, and subcomponents of executive fu...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Emergency Department Use Among Older Adults With Dementia
Although persons with dementia are frequently hospitalized, relatively little is known about the health profile, patterns of health care use, and mortality rates for patients with dementia who access care in the emergency department (ED). We linked data from our hospital system with Medicare and Medicaid claims, Minimum Data Set, and Outcome and Assessment Information Set data to evaluate 175,652 ED visits made by 10,354 individuals with dementia and 15,020 individuals without dementia over 11 years. Survival rates after ED visits and associated charges were examined. Patients with dementia visited the ED more frequently, ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Both Financial and Cognitive Decline Predict Clinical Progression in MCI
We examined patterns of financial and cognitive decline across the 2-year study period, and used these data and the 3 outcome variables to construct discrete predictor models of clinical progression in MCI. We found that both financial skills and cognitive abilities declined over the 2-year study period, were significantly associated with clinical progression, and contributed unique variance to all 3 predictor models. The resulting models accounted for 40% to 75% of variance in clinical progression across outcome variables. Taken together, our results indicate that changes in both cognitive abilities and higher order funct...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study
Dementia incidence increases exponentially with age even in people aged 90 years and above. Because therapeutic regimens are limited, modification of lifestyle behaviors may offer the best means for disease control. To test the hypotheses that lifestyle factors are related to lower risk of dementia in the oldest-old, we analyzed data from The 90+ Study, a population-based longitudinal cohort study initiated in 2003. This analysis included 587 participants (mean age=93 y) seen in-person and determined not to have dementia at enrollment. Information on lifestyle factors (smoking, alcohol, caffeine, vitamin supplements, exerc...
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study
Conclusions: Evidence from polygenic scores suggests that insulin sensitivity specifically may affect AD risk, more than T2D overall. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway
Conclusions: The present study found a lower performance of the biomarkers than reported previously. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial
Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or mild AD underwent florbetapir PET scanning at screening. PET, magnetic resonance imaging, and coregistered PET/magnetic resonance imaging scans were reviewed by 2 independent readers and binary visual readings tabulated. Semiquantitative values of cortical to whole cerebellar standard uptake value ratios were computed (threshold 1....
Source: Alzheimer Disease and Associated Disorders - January 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Temporal Cognitive Decline Associated With Exposure to Infectious Agents in a Population-based, Aging Cohort.
CONCLUSIONS: Exposure to CMV, HSV-2, or TOX is associated with cognitive deterioration in older individuals, independent of general age-related variables. An increased understanding of the role of infectious agents in cognitive decline may lead to new methods for its prevention and treatment. PMID: 26710257 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 29, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Posterior Cortical Atrophy: A Case Report of a 6-Year Natural Progression.
Authors: Heber IA, Costa AS, Werner CJ, Schöne U, Reich A, Schulz JB, Reetz K PMID: 26704219 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Profiles on the Severe Impairment Battery are Similar in Alzheimer Disease and Down Syndrome With Dementia.
Authors: Dick MB, Doran E, Phelan M, Lott IT Abstract Previous research has revealed similarities in the neuropathology, clinical presentation, and risk factors between persons with Alzheimer disease from the general population (GP-AD) and those with Down syndrome (DS-AD). Less is known, however, about the extent of similarities and differences in the cognitive profiles of these 2 populations. Fifty-one moderate to severely demented GP-AD and 59 DS-AD individuals participated in this study which compared the cognitive profiles of these 2 populations on the Severe Impairment Battery (SIB), controlling for sex as wel...
Source: Alzheimer Disease and Associated Disorders - December 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
Authors: Katz MJ, Derby CA, Wang C, Sliwinski MJ, Ezzati A, Zimmerman ME, Zwerling JL, Lipton RB Abstract Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to ...
Source: Alzheimer Disease and Associated Disorders - December 16, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Aging Stereotypes Must be Taken Into Account for the Diagnosis of Prodromal and Early Alzheimer Disease.
Authors: Régner I, Mazerolle M, Alescio-Lautier B, Clarys D, Michel B, Paccalin M, Piolino P, Rigalleau F, Sambuchi N, Huguet P Abstract Because of a dramatic increase of older people worldwide, screening for prodromal state of Alzheimer disease (AD) is a major societal challenge. Many individuals diagnosed with prodromal AD, do not convert to AD, some remaining stable and others reversing back to normal. We argue that an important source of this overdiagnosis comes from negative aging stereotypes (eg, the culturally shared beliefs that aging inescapably causes severe cognitive decline and diseases). Many la...
Source: Alzheimer Disease and Associated Disorders - December 11, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study.
CONCLUSIONS: Evidence from polygenic scores suggests that insulin sensitivity specifically may affect AD risk, more than T2D overall. PMID: 26650880 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 11, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembé, Brazil.
Prevalence of Cognitive Impairment Without Dementia and Dementia in Tremembé, Brazil. Alzheimer Dis Assoc Disord. 2015 Dec 2; Authors: César KG, Brucki SM, Takada LT, Nascimento LF, Gomes CM, Almeida MC, Oliveira MO, Porto FH, Senaha ML, Bahia VS, Silva TB, Ianof JN, Spíndola L, Schmidt MT, Jorge MS, Vale PH, Cecchini MA, Cassimiro L, Soares RT, Gonçalves MR, Martins AC, Daré P, Smid J, Porto CS, Carthery-Goulart MT, Yassuda MS, Mansur LL, Nitrini R Abstract BACKGROUND: The prevalence of cognitive impairment is insufficiently determined in developing countries. The ai...
Source: Alzheimer Disease and Associated Disorders - December 5, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Performance of Cerebrospinal Fluid Biomarkers of Alzheimer Disease in a Memory Clinic in Norway.
CONCLUSIONS: The present study found a lower performance of the biomarkers than reported previously. PMID: 26629677 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 5, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Frontal Variant Alzheimer Disease or Frontotemporal Lobe Degeneration With Incidental Amyloidosis?
Authors: Scialò C, Ferrara M, Accardo J, Morbelli S, Picco A, Arnaldi D, Brugnolo A, Girtler N, Nobili F PMID: 26583500 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 21, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil.
Authors: Oliveira FF, Chen ES, Smith MC, Bertolucci PH Abstract Little is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. In this 44-month cohort study, 214 consecutive outpatients with late-onset AD were assessed for rates of cognitive and functional decline by way of Clinical Dementia Rating and Mini-Mental State Examination (MMSE) scores, keeping blinded assessment of APOE haplotypes. Subjects were evaluated for sex, schooling, age of dementia onse...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Emergency Department Use Among Older Adults With Dementia.
Authors: LaMantia MA, Stump TE, Messina FC, Miller DK, Callahan CM Abstract Although persons with dementia are frequently hospitalized, relatively little is known about the health profile, patterns of health care use, and mortality rates for patients with dementia who access care in the emergency department (ED). We linked data from our hospital system with Medicare and Medicaid claims, Minimum Data Set, and Outcome and Assessment Information Set data to evaluate 175,652 ED visits made by 10,354 individuals with dementia and 15,020 individuals without dementia over 11 years. Survival rates after ED visits and assoc...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Inverse Association Between Cancer and Dementia: A Population-based Registry Study.
This study showed an inverse association between cancer and dementia. Further studies focusing on colon and prostate cancers may help elucidate the underlying mechanism and expand the therapeutic strategies. PMID: 26523711 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Detection and Differentiation of Frontotemporal Dementia and Related Disorders From Alzheimer Disease Using the Montreal Cognitive Assessment.
The objectives were: (1) to determine whether the MoCA detects cognitive impairment (CI) in FTD subjects; (2) to determine whether Alzheimer disease (AD) and FTD subtypes and related disorders can be parsed using the MoCA; and (3) describe longitudinal MoCA performance by subtype. We extracted demographic and testing data from a database of patients referred to a cognitive neurology clinic who met criteria for probable AD or FTD (N=192). Logistic regression was used to determine whether dementia subtypes were associated with overall scores, subscores, or combinations of subscores on the MoCA. Initial MoCA results demonstra...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Global Data Sharing in Alzheimer Disease Research.
Authors: Ashish N, Bhatt P, Toga AW Abstract Many investigators recognize the importance of data sharing; however, they lack the capability to share data. Research efforts could be vastly expanded if Alzheimer disease data from around the world was linked by a global infrastructure that would enable scientists to access and utilize a secure network of data with thousands of study participants at risk for or already suffering from the disease. We discuss the benefits of data sharing, impediments today, and solutions to achieving this on a global scale. We introduce the Global Alzheimer's Association Interactive Netw...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cross-Validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease.
The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE=23.2±2.9) and 72 patients of the REFLEX study (MMSE=20.8±3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as g...
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictive Factors for the Uptake of Coping Strategies by Spousal Dementia Caregivers: A Systematic Review.
Authors: Roche L, MacCann C, Croot K Abstract An understanding of spousal dementia caregivers' coping strategies and their predictive factors is imperative for caregivers' well-being. Although several reviews have explored the relationship between coping strategies and outcomes, no review has investigated factors that predict caregivers' use of one type of coping strategy over another. The current review aimed to identify factors that predict caregivers' coping strategies. Within this, we attempted to identify caregivers who are more likely to adopt dysfunctional coping strategies and be at risk of adverse outcomes...
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study.
DISCUSSION: The recommended new tests are well correlated with the previous tests. The equipercentile equating method produced conversion tables that provide a useful reference for clinicians and researchers. PMID: 26485498 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Improvement of Dream Enactment Behavior Associated With Levetiracetam Treatment in Dementia With Lewy Bodies.
Authors: Batalini F, Avidan A, Moseley BD, Ringman JM PMID: 26485499 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Consider the Source: The Implications of Informant Type on Outcome Assessments.
Authors: Grill JD, Karlawish J PMID: 26485500 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Editorial Transition at Alzheimer's Disease and Associated Disorders.
Authors: DeCarli C PMID: 26492327 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy.
Authors: Iacono D, Volkmann I, Nennesmo I, Pedersen NL, Fratiglioni L, Johansson B, Karlsson D, Winblad B, Gatz M PMID: 26492328 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs.
Authors: Callahan CM, Hendrie HC PMID: 26492329 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease.
DISCUSSION: In this sample, we found neither a higher prevalence of latent toxoplasmosis in the AD group compared with the control group nor differences in serum anti-T. gondii IgG titers between groups. PMID: 26421353 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 3, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Consider the Source: The Implications of Informant Type on Outcome Assessments
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Semantic Corticobasal Dementia: Challenging Nosology in Frontotemporal Lobe Degeneration
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Conscious Knowledge and Decision Making Under Ambiguity in Mild Cognitive Impairment and Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Does Alzheimer Disease Pathologic Change Underlie Subjective Cognitive Complaints?
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Cerebral Amyloid Angiopathy–related Inflammation Presenting With Rapidly Progressive Dementia, Responsive to IVIg
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Caregiver Burden: Looking Beyond the Unidimensional Total Score
This study aims to determine the agreement between unidimensional (UD) and multidimensional (MD) classification of burden, and differences in predictors among identified groups. We studied 165 dyads of dementia patients and primary caregivers. Caregivers were dichotomized into low-burden and high-burden groups based upon: (1) UD score using quartile cutoffs; and (2) MD model via exploratory cluster analysis. We compared UD versus MD 2×2 classification of burden using κ statistics. Caregivers not showing agreement by either definition were classified as “intermediate” burden. We performed binary logi...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Diagnostic Pathways to Alzheimer Disease: Costs Incurred in a Medicare Population
Despite its implications on the personal and policy level, little is currently known about the specific diagnostic pathways that patients with cognitive impairment (CI) pass through before being diagnosed with Alzheimer disease (AD). Four major diagnostic pathways were identified in the Medicare claims records for 2001 to 2006: AD as initial diagnosis, cognitive disturbance followed by AD; dementia with suspected etiologies followed by AD; dementia without known cause followed by AD; and 1 triple pathway, cognitive disturbance followed by dementia without known cause followed by AD. For all of these pathways, previously lo...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Comparison of an Electronic and Paper-based Montreal Cognitive Assessment Tool
This pilot study compared a novel electronic Montreal Cognitive Assessment (eMoCA) tool to the original paper-based MoCA. Potential participants were approached at primary care practices, a geriatric day hospital, and a university campus. Each of the 401 participants were randomly assigned to either the eMoCA (N=182) or MoCA (N=219). Scores were adjusted by self-reported demographic and health information using regression analysis. The difference in average scores (26.21±3.11 for the MoCA group and 24.84±4.21 for the eMoCA group) was found to be statistically significant. Controlling for the effect of potenti...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Evaluation of a Brief Survey Instrument for Assessing Subtle Differences in Cognitive Function Among Older Adults
Most measures of cognitive function used in large-scale surveys of older adults have limited ability to detect subtle differences across cognitive domains, and standard clinical instruments are impractical to administer in general surveys. The Montreal Cognitive Assessment (MoCA) can address this need, but has limitations in a survey context. Therefore, we developed a survey adaptation of the MoCA, called the MoCA-SA, and describe its psychometric properties in a large national survey. Using a pretest sample of older adults (n=120), we reduced MoCA administration time by 26%, developed a model to accurately estimate full M...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

A Prospective Comparison of Informant-based and Performance-based Dementia Screening Tools to Predict In-Hospital Delirium
Dementia is an important risk factor for delirium, but the optimal strategy for incorporating cognitive impairment into delirium risk assessment at the time of hospital admission is unknown. We compared 2 informant-based screening tools for dementia and mild cognitive impairment [AD8 and D=(MC)2] to the Mini Mental State Examination (MMSE) and Mini-cog in predicting hospital-acquired delirium. This prospective cohort study at an academic medical center consisted of 162 medical inpatients over age 50 years without delirium upon admission. Each participant was evaluated using the MMSE, Mini-cog, AD8, and D=(MC)2 upon admissi...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research