Detection and Differentiation of Frontotemporal Dementia and Related Disorders From Alzheimer Disease Using the Montreal Cognitive Assessment.
The objectives were: (1) to determine whether the MoCA detects cognitive impairment (CI) in FTD subjects; (2) to determine whether Alzheimer disease (AD) and FTD subtypes and related disorders can be parsed using the MoCA; and (3) describe longitudinal MoCA performance by subtype. We extracted demographic and testing data from a database of patients referred to a cognitive neurology clinic who met criteria for probable AD or FTD (N=192). Logistic regression was used to determine whether dementia subtypes were associated with overall scores, subscores, or combinations of subscores on the MoCA. Initial MoCA results demonstra...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Global Data Sharing in Alzheimer Disease Research.
Authors: Ashish N, Bhatt P, Toga AW Abstract Many investigators recognize the importance of data sharing; however, they lack the capability to share data. Research efforts could be vastly expanded if Alzheimer disease data from around the world was linked by a global infrastructure that would enable scientists to access and utilize a secure network of data with thousands of study participants at risk for or already suffering from the disease. We discuss the benefits of data sharing, impediments today, and solutions to achieving this on a global scale. We introduce the Global Alzheimer's Association Interactive Netw...
Source: Alzheimer Disease and Associated Disorders - November 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cross-Validation of a Shortened Battery for the Assessment of Dysexecutive Disorders in Alzheimer Disease.
The objective was to derive a shortened battery by using the GREFEX population as a training dataset and by cross-validating the results in the REFLEX population. A total of 102 AD patients of the GREFEX study (MMSE=23.2±2.9) and 72 patients of the REFLEX study (MMSE=20.8±3.5) were included. Tests were selected and receiver operating characteristic curves were generated relative to the performance of 780 controls from the GREFEX study. Stepwise logistic regression identified 3 cognitive tests (Six Elements Task, categorical fluency and Trail Making Test B error) and behavioral disorders globally referred as g...
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Predictive Factors for the Uptake of Coping Strategies by Spousal Dementia Caregivers: A Systematic Review.
Authors: Roche L, MacCann C, Croot K Abstract An understanding of spousal dementia caregivers' coping strategies and their predictive factors is imperative for caregivers' well-being. Although several reviews have explored the relationship between coping strategies and outcomes, no review has investigated factors that predict caregivers' use of one type of coping strategy over another. The current review aimed to identify factors that predict caregivers' coping strategies. Within this, we attempted to identify caregivers who are more likely to adopt dysfunctional coping strategies and be at risk of adverse outcomes...
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Results From the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study.
DISCUSSION: The recommended new tests are well correlated with the previous tests. The equipercentile equating method produced conversion tables that provide a useful reference for clinicians and researchers. PMID: 26485498 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Improvement of Dream Enactment Behavior Associated With Levetiracetam Treatment in Dementia With Lewy Bodies.
Authors: Batalini F, Avidan A, Moseley BD, Ringman JM PMID: 26485499 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Consider the Source: The Implications of Informant Type on Outcome Assessments.
Authors: Grill JD, Karlawish J PMID: 26485500 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Editorial Transition at Alzheimer's Disease and Associated Disorders.
Authors: DeCarli C PMID: 26492327 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy.
Authors: Iacono D, Volkmann I, Nennesmo I, Pedersen NL, Fratiglioni L, Johansson B, Karlsson D, Winblad B, Gatz M PMID: 26492328 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs.
Authors: Callahan CM, Hendrie HC PMID: 26492329 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease.
DISCUSSION: In this sample, we found neither a higher prevalence of latent toxoplasmosis in the AD group compared with the control group nor differences in serum anti-T. gondii IgG titers between groups. PMID: 26421353 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 3, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Consider the Source: The Implications of Informant Type on Outcome Assessments
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Semantic Corticobasal Dementia: Challenging Nosology in Frontotemporal Lobe Degeneration
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Conscious Knowledge and Decision Making Under Ambiguity in Mild Cognitive Impairment and Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Does Alzheimer Disease Pathologic Change Underlie Subjective Cognitive Complaints?
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Cerebral Amyloid Angiopathy–related Inflammation Presenting With Rapidly Progressive Dementia, Responsive to IVIg
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Caregiver Burden: Looking Beyond the Unidimensional Total Score
This study aims to determine the agreement between unidimensional (UD) and multidimensional (MD) classification of burden, and differences in predictors among identified groups. We studied 165 dyads of dementia patients and primary caregivers. Caregivers were dichotomized into low-burden and high-burden groups based upon: (1) UD score using quartile cutoffs; and (2) MD model via exploratory cluster analysis. We compared UD versus MD 2×2 classification of burden using κ statistics. Caregivers not showing agreement by either definition were classified as “intermediate” burden. We performed binary logi...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Diagnostic Pathways to Alzheimer Disease: Costs Incurred in a Medicare Population
Despite its implications on the personal and policy level, little is currently known about the specific diagnostic pathways that patients with cognitive impairment (CI) pass through before being diagnosed with Alzheimer disease (AD). Four major diagnostic pathways were identified in the Medicare claims records for 2001 to 2006: AD as initial diagnosis, cognitive disturbance followed by AD; dementia with suspected etiologies followed by AD; dementia without known cause followed by AD; and 1 triple pathway, cognitive disturbance followed by dementia without known cause followed by AD. For all of these pathways, previously lo...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Comparison of an Electronic and Paper-based Montreal Cognitive Assessment Tool
This pilot study compared a novel electronic Montreal Cognitive Assessment (eMoCA) tool to the original paper-based MoCA. Potential participants were approached at primary care practices, a geriatric day hospital, and a university campus. Each of the 401 participants were randomly assigned to either the eMoCA (N=182) or MoCA (N=219). Scores were adjusted by self-reported demographic and health information using regression analysis. The difference in average scores (26.21±3.11 for the MoCA group and 24.84±4.21 for the eMoCA group) was found to be statistically significant. Controlling for the effect of potenti...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Evaluation of a Brief Survey Instrument for Assessing Subtle Differences in Cognitive Function Among Older Adults
Most measures of cognitive function used in large-scale surveys of older adults have limited ability to detect subtle differences across cognitive domains, and standard clinical instruments are impractical to administer in general surveys. The Montreal Cognitive Assessment (MoCA) can address this need, but has limitations in a survey context. Therefore, we developed a survey adaptation of the MoCA, called the MoCA-SA, and describe its psychometric properties in a large national survey. Using a pretest sample of older adults (n=120), we reduced MoCA administration time by 26%, developed a model to accurately estimate full M...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

A Prospective Comparison of Informant-based and Performance-based Dementia Screening Tools to Predict In-Hospital Delirium
Dementia is an important risk factor for delirium, but the optimal strategy for incorporating cognitive impairment into delirium risk assessment at the time of hospital admission is unknown. We compared 2 informant-based screening tools for dementia and mild cognitive impairment [AD8 and D=(MC)2] to the Mini Mental State Examination (MMSE) and Mini-cog in predicting hospital-acquired delirium. This prospective cohort study at an academic medical center consisted of 162 medical inpatients over age 50 years without delirium upon admission. Each participant was evaluated using the MMSE, Mini-cog, AD8, and D=(MC)2 upon admissi...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Variability in Obstacle Clearance May (Not) Indicate Cognitive Disorders in Alzheimer Disease
In conclusion, individuals with AD had increased gait variability while approaching an obstacle during walking, indicating a deficit in planning to avoid obstacles that could be related to cognitive disorders. However, gait variability during the crossing phase may not be indicative of cognitive disorders in AD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Deficits in Everyday Function Differ in AD and FTD
Alzheimer disease (AD) and frontotemporal dementia (FTD) are 2 neurodegenerative diseases with differing cognitive and neuropathologic profiles. Although both diseases ultimately result in functional disability, differences in the profiles of everyday functioning between the 2 groups have not been well characterized. The present study examines potential differences in the types of everyday functional limitations present in these 2 dementias. The present study compared individuals with AD (N=240) or FTD (N=13). The Everyday Cognition (ECog) scale was used to measure distinct domains of everyday cognition: everyday memory, e...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Is Mild Dementia Related to Unsafe Street-Crossing Decisions?
The overrepresentation of very old people (75 or older) in pedestrian crash statistics raises the issue of the effects of normal and pathologic ageing on gap-selection difficulties during street crossing. The present study focused on Alzheimer disease, a condition commonly associated with cognitive declines detrimental to daily life activities such as crossing the street. Twenty-five participants with mild dementia and 33 controls carried out a street-crossing task in a simulated environment. They also took a battery of cognitive tests. The mild-dementia group was more likely than the control group to make decisions that l...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort
Objective: Vascular risk factors in mid-life predict late life cognitive decline in previously normal populations. We sought to investigate the contribution of vascular risk factors in late life to cognitive decline in a cohort of normal elderly individuals. Methods: Cognitively normal subjects were identified from the longitudinal cohort of participants in the National Alzheimer Coordinating Center (NACC) database (n=2975). The association between a composite score of vascular risk factors (based on the Framingham Stroke Risk Profile) and cognitive function was tested at baseline visit and estimated in longitudinal analys...
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness: A Study Among 1777 Cognitively Normal Subjects
Conclusions: Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Editorial Transition at Alzheimer’s Disease and Associated Disorders
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2015 Category: Geriatrics Tags: Editorial Source Type: research

Olfactory Deficits Predict Cognitive Improvement on Donepezil in Patients With Depression and Cognitive Impairment: A Randomized Controlled Pilot Study.
Authors: Pelton GH, Soleimani L, Roose SP, Tabert MH, Devanand DP PMID: 26398910 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia.
Authors: Wang C, Gao S, Hendrie HC, Kesterson J, Campbell NL, Shekhar A, Callahan CM Abstract A retrospective cohort study was conducted including 3688 patients age 60 years or older without dementia enrolled in a depression screening study in primary care clinics. Information on antidepressant use and incident dementia during follow-up was retrieved from electronic medical records. The Cox proportional hazard models were used to compare the risk for incident dementia among 5 participant groups: selective serotonin re-uptake inhibitors (SSRI) only, non-SSRI only (non-SSRI), mixed group of SSRI and non-SSRI, not on ...
Source: Alzheimer Disease and Associated Disorders - August 24, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive and Functional Correlates of NPI-Q Scores and Symptom Clusters in Mildly Demented Alzheimer Patients.
Authors: Travis Seidl JN, Massman PJ Abstract Previous research has demonstrated an association between the emotional and behavioral symptoms of dementia, known as neuropsychiatric symptoms, and cognitive and functional decline among patients with Alzheimer disease (AD). The present study aimed to identify associations between neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory-Questionnaire (NPI-Q) and cognitive and functional performance. Participants were 256 AD patients enrolled in the Alzheimer's Disease and Memory Disorders Center at Baylor College of Medicine. An exploratory factor analys...
Source: Alzheimer Disease and Associated Disorders - August 19, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Editorial Transition at Alzheimer's Disease and Associated Disorders.
Authors: Luchsinger JA PMID: 26284739 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - August 19, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Systematic Review of the Public's Knowledge and Understanding of Alzheimer's Disease and Dementia.
Authors: Cahill S, Pierce M, Werner P, Darley A, Bobersky A Abstract This paper reports findings from a systematic review of the literature on the general public's knowledge and understanding of dementia/Alzheimer's disease. The key purpose of the review was to evaluate existing literature with specific attention paid to conceptual and methodological issues and to key findings. Over a 20-year period, 40 published articles satisfied the inclusion criteria. Only 4 of these were qualitative and 5 were cross-national. The review revealed a lack of consistency across studies regarding how knowledge was operationalized, ...
Source: Alzheimer Disease and Associated Disorders - July 26, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Correlation Between Caregiver Reports of Physical Function and Performance-based Measures in a Cohort of Older Adults With Alzheimer Disease.
The objectives of this report are to determine the association between performance-based measures of physical function with caregiver reports of physical function in older adults with Alzheimer disease (AD) and to examine whether those associations vary by the level of patients' cognitive functioning. Subjects included 180 patient-caregiver dyads who are enrolled in a clinical trial testing the impact of an occupational therapy intervention plus guideline-level care to delay functional decline among older adults with AD. The primary caregiver-reported measure is the Alzheimer's Disease Cooperative Study Group Activities of...
Source: Alzheimer Disease and Associated Disorders - July 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Embedded Online Questionnaire Measures are Sensitive to Identifying Mild Cognitive Impairment.
We examined whether passive aspects of responding to a remotely monitored weekly online questionnaire discriminated between older adults with and without MCI. METHODS: Participants were 83 independent, community-dwelling older adults enrolled in a longitudinal study of in-home monitoring technologies, which included completion of a short weekly online questionnaire of health and life events. RESULTS: In longitudinal analyses, time to complete the online questionnaire decreased over 1 year in both MCI and cognitively intact participants (P
Source: Alzheimer Disease and Associated Disorders - July 23, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Systematic Review of the Public’s Knowledge and Understanding of Alzheimer’s Disease and Dementia
This paper reports findings from a systematic review of the literature on the general public’s knowledge and understanding of dementia/Alzheimer’s disease. The key purpose of the review was to evaluate existing literature with specific attention paid to conceptual and methodological issues and to key findings. Over a 20-year period, 40 published articles satisfied the inclusion criteria. Only 4 of these were qualitative and 5 were cross-national. The review revealed a lack of consistency across studies regarding how knowledge was operationalized, approaches to sampling, response rates, and data collection instr...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Review Article Source Type: research

Predictive Testing for Alzheimer’s Disease: Suicidal Ideation in Healthy Participants
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

First Report of PSEN2 Mutation Presenting as Posterior Cortical Atrophy
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Frequency and Impact of Informant Replacement in Alzheimer Disease Research
Informants serve an essential role in Alzheimer disease research. Were an informant to be replaced during a longitudinal study, this could have negative implications. We used data from the National Alzheimer’s Coordinating Center Uniform Data Set to examine the frequency of informant replacement among Alzheimer disease dementia participants, whether patient and informant characteristics were associated with replacement, and how replacement affected research outcome measures. Informant replacement was common (15.5%) and typically occurred after the first or the second research visit. Adult child (24%) and other (38%) ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Anxiety in Family Caregivers of Hospitalized Persons With Dementia: Contributing Factors and Responses
Conclusions: Routine evaluation of caregiver strain and baseline patient function is integral to informing the transitional planning for persons with dementia. The FCG responses suggest that a multifactorial approach (family-centered policies of partnership in care, staff education addressing the specialized needs of patients and family members, and attention to promoting functional recovery) may benefit both hospitalized patients with dementia as well as FCGs and warrants future research. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Prospective Memory in Subjective Cognitive Decline: A Preliminary Study on the Role of Early Cognitive Marker in Dementia
Accumulating evidence shows that subjective cognitive decline (SCD) without impairment on conventional neuropsychological tests may indicate increased risk for Alzheimer disease. Previous studies of mild cognitive impairment have demonstrated the potential role of prospective memory (PM) in the early detection of cognitive decline. We thus aimed to investigate the performance of people with SCD on PM tasks relative to their healthy controls (HCs). Forty-one participants with SCD and demographically matched HCs received regular cognitive testing as well as 2 single-trial naturalistic time-based and event-based PM tasks. Sta...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

The Utility of the Dementia Severity Rating Scale in Differentiating Mild Cognitive Impairment and Alzheimer Disease From Controls
The current study investigated the utility of the Dementia Severity Rating Scale (DSRS) total score to identify individuals at the earliest stage of impairment (ie, mild cognitive impairment/MCI). In addition, the authors sought to investigate how well the measure correlates with an expanded battery of cognitive tests and other measures of functional abilities. Of the 320 participants included in this study, 85 were normal controls, 96 had single-domain or multiple-domain amnestic MCI, and 139 had possible or probable Alzheimer disease (AD). Each participant underwent a thorough cognitive, neurological, and physical examin...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

C-TOC (Cognitive Testing on Computer): Investigating the Usability and Validity of a Novel Self-administered Cognitive Assessment Tool in Aging and Early Dementia
Discussion: In general, C-TOC had good validity in detecting cognitive impairment. Ensuring test-takers’ understanding of the tasks, and considering their computer knowledge appear important steps towards C-TOC’s implementation. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Does Type 2 Diabetes Increase Rate of Cognitive Decline in Older Mexican Americans?
We examined baseline and new-onset diabetes and cognitive decline with joint longitudinal-survival models to account for death. At baseline, 32.4% of participants had diabetes and 15.8% developed diabetes during the study. During the study period, 22.8% of participants died. In joint longitudinal-survival models, those with baseline diabetes experienced faster cognitive decline (P=0.003) and higher mortality (hazards ratio=1.88; 95% confidence interval, 1.48-2.38) than those without diabetes. Cognitive decline and mortality were similar for those with new-onset diabetes and those without diabetes. For a typical person, 3MS...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Mid-Life Proteinuria and Late-Life Cognitive Function and Dementia in Elderly Men: The Honolulu-Asia Aging Study
Conclusion: Mid-life proteinuria was an independent predictor for late-life incident all-cause dementia and cognitive decline over 8 years. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Adaptive, Dose-finding Phase 2 Trial Evaluating the Safety and Efficacy of ABT-089 in Mild to Moderate Alzheimer Disease
ABT-089, an α4β2 neuronal nicotinic receptor partial agonist, was evaluated for efficacy and safety in mild to moderate Alzheimer disease patients receiving stable doses of acetylcholinesterase inhibitors. This phase 2 double-blind, placebo-controlled, proof-of-concept, and dose-finding study adaptively randomized patients to receive ABT-089 (5, 10, 15, 20, 30, or 35 mg once daily) or placebo for 12 weeks. The primary efficacy endpoint was the Alzheimer’s Disease Assessment Scale, cognition subscale (ADAS-Cog) total score. A Bayesian response-adaptive randomization algorithm dynamically assigned allocation...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Long-term Dantrolene Treatment Reduced Intraneuronal Amyloid in Aged Alzheimer Triple Transgenic Mice
In this study, we investigated the long-term treatment of dantrolene on amyloid and tau neuropathology, brain volume, and cognitive function in aged triple transgenic Alzheimer (3xTg-AD) mice. Fifteen-month old 3xTg-AD mice and wild-type controls were treated with oral dantrolene (5 mg/kg) or vehicle control twice a week for 6 months. Learning and memory were examined using the Morris Water Maze at 21 and 22 months of age. After the behavioral testing, hippocampal and cortical brain volumes were calculated with magnetic resonance imaging and motor function was evaluated using the rotorod. The amyloid burden and tau neurofi...
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Editorial Transition at Alzheimer’s Disease and Associated Disorders
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2015 Category: Geriatrics Tags: Editorial Source Type: research

NSAID Use and Incident Cognitive Impairment in a Population-based Cohort.
This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were use...
Source: Alzheimer Disease and Associated Disorders - June 20, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research