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Rescreening on RBANS Delayed Memory Index? Forget About It!
CONCLUSIONS: The results from our analysis indicate that there is limited value in rescreening patients based on their initial RBANS DMI score.PMID:38277642 | DOI:10.1097/WAD.0000000000000606 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2024 Category: Psychiatry Authors: Marwan N Sabbagh Wojciech Michalak Charlotte Thim Hansen Christian Ahmad Wichmann Alice Clark Source Type: research

Application of Suggestive Biomarkers in Dementia With Lewy Bodies With Masking of Typical Clinical Symptoms by Alzheimer Disease-type Pathology
We describe the case of a 63-year-old woman who was initially diagnosed as having AD and later diagnosed with DLB based on suggestive biomarkers of DLB. In this case, transient sleep talking with physical movements for several days led to the assessment of suggestive biomarkers for DLB in the absence of the core clinical features of DLB. For clinicians, diagnosing DLB in patients with AD-type pathology is challenging. However, the application of biomarkers suggestive of DLB to all patients with dementia is not realistic. To overcome the difficulties of clinical diagnosis of DLB, further research is needed regarding strateg...
Source: Alzheimer Disease and Associated Disorders - January 16, 2024 Category: Psychiatry Authors: Ryota Kobayashi Daichi Morioka Shinobu Kawakatsu Kazutaka Sakamoto Akihito Suzuki Source Type: research

Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications
Alzheimer Dis Assoc Disord. 2024 Jan 17. doi: 10.1097/WAD.0000000000000599. Online ahead of print.ABSTRACTAlthough psychotic symptoms have been described in association with rare presenilin (PSEN) gene mutations underlying early-onset Alzheimer disease (AD), no contemporary reviews on this topic exist. The purpose of this review is to characterize the psychiatric phenotype (specifically with respect to psychosis) of PSEN1 and PSEN2 variant-associated AD. A PubMed search was completed in July 2023. Only articles that described individuals harboring a PSEN1 or PSEN2 mutation who experienced symptoms of psychosis were include...
Source: Alzheimer Disease and Associated Disorders - January 16, 2024 Category: Psychiatry Authors: Mark A Colijn Zahinoor Ismail Source Type: research

Identifying Stigmatizing Language Used by Israelis and Germans With a Mild Neurocognitive Disorder, Their Relatives, and Caregivers of People With Alzheimer's Disease
CONCLUSIONS: The study indicates that, despite culture and language differences, the use of stigmatic discourse and stigmatizing language is common among people with close exposure to dementia in Israel and Germany. Efforts should be increased to develop a person-centered and dementia-friendly language.PMID:38194484 | DOI:10.1097/WAD.0000000000000596 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 9, 2024 Category: Psychiatry Authors: Perla Werner Natalie Ulitsa Z ümrüt Alpinar-Sencan Daphna Shefet Silke Schicktanz Source Type: research

Risk of Neuropsychiatric Symptoms Among People Who Develop Cognitive Impairment With and Without a History of Post-traumatic Stress Disorder
Alzheimer Dis Assoc Disord. 2023 Dec 28. doi: 10.1097/WAD.0000000000000594. Online ahead of print.ABSTRACTWe aimed to prospectively assess the change in neuropsychiatric symptoms among people who develop cognitive impairment and have a history of post-traumatic stress disorder (PTSD). We analyzed longitudinal data from the National Alzheimer's Coordinating Center Unified Data Set (March 2015 to December 2021). Analyses included individuals who were cognitively normal and who had nonmissing assessment of PTSD at the initial visit and had at least 1 follow-up visit with cognitive impairment. We compared the difference in the...
Source: Alzheimer Disease and Associated Disorders - January 9, 2024 Category: Psychiatry Authors: Jaime Perales-Puchalt Kathryn Gauthreaux Jason D Flatt Oanh L Meyer Walter A Kukull Source Type: research

Cognitive Complaint Types Can Correlate With Cognitive Testing, Perceived Stress, and Symptom Distress in Older Adults With Normal Cognition and Dementia
CONCLUSION: CCTs showed a factor structure that was mostly robust between classification methods; however, some content-divergent CCTs shared factors, suggesting construct overlap. Relatively slight variations in content altered how CCTs correlated with diagnostic groups, perceived stress, and symptom distress. Most CCTs did not discern between impaired and unimpaired cognitive test scores. Research is needed to better understand CCTs as clinical markers and targets of clinical interventions.PMID:38133963 | DOI:10.1097/WAD.0000000000000595 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 22, 2023 Category: Psychiatry Authors: Shana D Stites Brian N Lee Jonathan D Rubright Kristin Harkins Dawn Mechanic-Hamilton Source Type: research