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Novel APOE Mutation in a Moroccan Subject Suffering from Alzheimer Disease: A Case Study and Exploration of Pathogenic Implication
In this study, we report a novel pathogenic mutation, Arg160Leu, in APOE that was identified in a Moroccan patient. The magnetic resonance imaging of this 67-year-old woman revealed hippocampal shrinkage, and the results of her cognition testing revealed that she is suffering from severe AD. The current study may increase awareness of the genetic risk factors for AD caused by APOE4 mutations.PMID:38015425 | DOI:10.1097/WAD.0000000000000590 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 28, 2023 Category: Psychiatry Authors: Youssef Razouqi Ihssane El Bouchikhi Hassan El-Abid Soukayna Baammi Ayoub Nedbour Ahmed Omar Touhami Ahami Achraf El Allali Laila Bouguenouch Source Type: research

Alzheimer Disease: A New Beginning in Therapeutics
Alzheimer Dis Assoc Disord. 2023 Oct-Dec 01;37(4):267-269. doi: 10.1097/WAD.0000000000000592. Epub 2023 Nov 28.NO ABSTRACTPMID:38015422 | DOI:10.1097/WAD.0000000000000592 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 28, 2023 Category: Psychiatry Authors: Lawrence S Honig Source Type: research

Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia
DISCUSSION: Results show that greater regional WMH volume relates to poorer cognitive functioning-even among those with normal cognition. Together with results from previous studies, our findings raise the possibility that WMH may be a useful therapeutic target and/or important effect modifier in treatment or prevention dementia trials.PMID:38015423 | PMC:PMC10664788 | DOI:10.1097/WAD.0000000000000585 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 28, 2023 Category: Psychiatry Authors: Rachel Membreno Kelsey R Thomas Amanda T Calcetas Lauren Edwards Maria Bordyug Maya Showell Morgan Stanfill Einat K Brenner Kayla S Walker Lindsay J Rotblatt Adam M Brickman Emily C Edmonds Katherine J Bangen Alzheimer ’s Disease Neuroimaging Initiative Source Type: research

Proteomic Analysis Reveals Potential Exosomal Biomarkers in Patients With Sporadic Alzheimer Disease
CONCLUSIONS: These findings lend further support for exosomal changes in neurodegenerative disorders, and particularly in sAD. Further proteomic research could decisively advance our knowledge of sAD pathophysiology as much as it could foster the development of clinically meaningful biomarkers.PMID:38015424 | DOI:10.1097/WAD.0000000000000589 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 28, 2023 Category: Psychiatry Authors: Konstanze Plaschke J ürgen Kopitz Johannes Gebert Nadine D Wolf Robert Christian Wolf Source Type: research