Distinct Patterns and Clinical Implications of Semantic Memory Deterioration Among Patients With MCI
This study examined the cognitive performance of 181 participants from various MCI subgroups, a group of mildly impaired individuals with dementia of the Alzheimer type (DAT) and a group of individuals with subjective memory impairment on various semantic memory tasks. The aMCI-single domain (aMCI-sd) group displayed poor performance on a semantic memory task requiring relatively higher degrees of effortful retrieval, and participants in the aMCI-multiple domain (aMCI-md) group, who also suffered with mild executive dysfunction displayed poor performance on all semantic memory tasks, similar to the DAT group. The nonamnest...
Source: Alzheimer Disease and Associated Disorders - April 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study
Conclusions: Middle-aged healthy adults with cardiovascular risk factors including diabetes, history of smoking, and ApoE4 positivity were found to have greater later-life memory impairments. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

A 24-Week, Open-Label Extension Study to Investigate the Long-term Safety, Tolerability, and Efficacy of 13.3 mg/24 h Rivastigmine Patch in Patients With Severe Alzheimer Disease
The long-term safety, tolerability, and efficacy of high-dose 13.3 mg/24 h rivastigmine patch in severe Alzheimer disease was evaluated in a 24-week, open-label extension to the double-blind ACTION study. Safety and tolerability, and efficacy on the Alzheimer’s Disease Cooperative Study-Activities of Daily Living scale-Severe Impairment Version (ADCS-ADL-SIV), Severe Impairment Battery (SIB), and ADCS-Clinical Global Impression of Change (ADCS-CGIC) were assessed. Overall, 197 patients continued on 13.3 mg/24 h patch; 199 uptitrated from 4.6 mg/24 h to 13.3 mg/24 h patch. The incidence of adverse events (AEs), seriou...
Source: Alzheimer Disease and Associated Disorders - April 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI
Conclusion: These findings provide information about biomarker enrichment and outcome measurements that could be employed to reduce MCI patient samples and treatment duration in future clinical trials. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Determinants of Activity Levels in African Americans With Mild Cognitive Impairment.
Authors: Rovner BW, Casten RJ, Leiby BE Abstract Engaging in cognitive, social, and physical activities may prevent cognitive decline. In a sample of older African Americans with mild cognitive impairment (MCI; N=221), we investigated the cross-sectional relationships between activity levels and participants' demographic, clinical, and neuropsychological characteristics. The average age of participants was 75.4 years (SD, 7.0); 177 (80.1%) were women. Participation in cognitive/social activities was positively associated with education, depression, literacy, mobility, instrumental activities of daily living (IADL),...
Source: Alzheimer Disease and Associated Disorders - March 28, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A "Real-Life" Study.
CONCLUSIONS: Cognition and behaviour of AD patients deteriorated accompanied with an increase in care-dependency during 3.5 years. Nevertheless, compared with the precholinesterase inhibitor era, current pharmacological and nonpharmacological interventions appear to slow cognitive decline, which emphasizes that they seem to have a favorable effect. PMID: 25756604 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 12, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Episodic Memory in Alzheimer Disease, Frontotemporal Dementia, and Dementia With Lewy Bodies/Parkinson Disease Dementia: Disentangling Retrieval From Consolidation.
We examined the memory performance of 106 AD patients, 51 FTD patients, 26 DLB/PDD patients, and 37 controls using the Five-Words Test, a 5-item memory test that facilitates encoding. RESULTS:: The patient groups did not differ in modified Mini Mental State Examination scores. AD patients scored lowest on the Five-Words Test overall, and showed the greatest reduction from immediate total recall to delayed free recall relative to the other 2 groups, consistent with a predominantly consolidation deficit. DLB/PDD patients showed the largest improvement from delayed free to delayed total recall relative to the other 2 grou...
Source: Alzheimer Disease and Associated Disorders - March 5, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cerebral Amyloid Angiopathy-related Inflammation Presenting With Rapidly Progressive Dementia, Responsive to IVIg.
Authors: Cenina AR, De Leon J, Tay KY, Wong CF, Kandiah N PMID: 25710131 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 25, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cancer and Dementia: It's Complicated.
Authors: Ganguli M Abstract The relationship between dementia and cancer is complex. A wealth of observational data suggest (1) reduced risk of certain cancers in Alzheimer and Parkinson diseases; and (2) increased risk of other cancers in Parkinson disease. These relationships persist despite correcting for reporting artifacts and survival bias. Several potential mechanisms have been proposed and warrant further investigation. Aging is a risk factor for both. Common environmental exposures, such as smoking, may play roles. Common mechanisms such as chronic inflammation and immunosenescence, and common risk factors...
Source: Alzheimer Disease and Associated Disorders - February 25, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Caregiver Burden: Looking Beyond the Unidimensional Total Score.
This study aims to determine the agreement between unidimensional (UD) and multidimensional (MD) classification of burden, and differences in predictors among identified groups. We studied 165 dyads of dementia patients and primary caregivers. Caregivers were dichotomized into low-burden and high-burden groups based upon: (1) UD score using quartile cutoffs; and (2) MD model via exploratory cluster analysis. We compared UD versus MD 2×2 classification of burden using κ statistics. Caregivers not showing agreement by either definition were classified as "intermediate" burden. We performed binary logist...
Source: Alzheimer Disease and Associated Disorders - February 25, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study.
Authors: Paganini-Hill A, Kawas CH, Corrada MM Abstract Dementia incidence increases exponentially with age even in people aged 90 years and above. Because therapeutic regimens are limited, modification of lifestyle behaviors may offer the best means for disease control. To test the hypotheses that lifestyle factors are related to lower risk of dementia in the oldest-old, we analyzed data from The 90+ Study, a population-based longitudinal cohort study initiated in 2003. This analysis included 587 participants (mean age=93 y) seen in-person and determined not to have dementia at enrollment. Information on lifestyle...
Source: Alzheimer Disease and Associated Disorders - February 25, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Long-term Dantrolene Treatment Reduced Intraneuronal Amyloid in Aged Alzheimer Triple Transgenic Mice.
In this study, we investigated the long-term treatment of dantrolene on amyloid and tau neuropathology, brain volume, and cognitive function in aged triple transgenic Alzheimer (3xTg-AD) mice. Fifteen-month old 3xTg-AD mice and wild-type controls were treated with oral dantrolene (5 mg/kg) or vehicle control twice a week for 6 months. Learning and memory were examined using the Morris Water Maze at 21 and 22 months of age. After the behavioral testing, hippocampal and cortical brain volumes were calculated with magnetic resonance imaging and motor function was evaluated using the rotorod. The amyloid burden and tau neurofi...
Source: Alzheimer Disease and Associated Disorders - February 6, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Does Type 2 Diabetes Increase Rate of Cognitive Decline in Older Mexican Americans?
We examined baseline and new-onset diabetes and cognitive decline with joint longitudinal-survival models to account for death. At baseline, 32.4% of participants had diabetes and 15.8% developed diabetes during the study. During the study period, 22.8% of participants died. In joint longitudinal-survival models, those with baseline diabetes experienced faster cognitive decline (P=0.003) and higher mortality (hazards ratio=1.88; 95% confidence interval, 1.48-2.38) than those without diabetes. Cognitive decline and mortality were similar for those with new-onset diabetes and those without diabetes. For a typical person, 3MS...
Source: Alzheimer Disease and Associated Disorders - February 6, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort.
Authors: Viswanathan A, Macklin EA, Betensky R, Hyman B, Smith EE, Blacker D Abstract OBJECTIVE:: Vascular risk factors in mid-life predict late life cognitive decline in previously normal populations. We sought to investigate the contribution of vascular risk factors in late life to cognitive decline in a cohort of normal elderly individuals. METHODS:: Cognitively normal subjects were identified from the longitudinal cohort of participants in the National Alzheimer Coordinating Center (NACC) database (n=2975). The association between a composite score of vascular risk factors (based on the Framingham Stroke Ri...
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness: A Study Among 1777 Cognitively Normal Subjects.
CONCLUSIONS:: Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness. PMID: 25626634 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Mid-Life Proteinuria and Late-Life Cognitive Function and Dementia in Elderly Men: The Honolulu-Asia Aging Study.
CONCLUSION:: Mid-life proteinuria was an independent predictor for late-life incident all-cause dementia and cognitive decline over 8 years. PMID: 25626635 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diagnostic Pathways to Alzheimer Disease: Costs Incurred in a Medicare Population.
Authors: Gilden DM, Kubisiak JM, Sarsour K, Hunter CA Abstract Despite its implications on the personal and policy level, little is currently known about the specific diagnostic pathways that patients with cognitive impairment (CI) pass through before being diagnosed with Alzheimer disease (AD). Four major diagnostic pathways were identified in the Medicare claims records for 2001 to 2006: AD as initial diagnosis, cognitive disturbance followed by AD; dementia with suspected etiologies followed by AD; dementia without known cause followed by AD; and 1 triple pathway, cognitive disturbance followed by dementia witho...
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Anxiety in Family Caregivers of Hospitalized Persons With Dementia: Contributing Factors and Responses.
CONCLUSIONS:: Routine evaluation of caregiver strain and baseline patient function is integral to informing the transitional planning for persons with dementia. The FCG responses suggest that a multifactorial approach (family-centered policies of partnership in care, staff education addressing the specialized needs of patients and family members, and attention to promoting functional recovery) may benefit both hospitalized patients with dementia as well as FCGs and warrants future research. PMID: 25635341 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Effectiveness of a Fotonovela for Reducing Depression and Stress in Latino Dementia Family Caregivers.
In conclusion, a culturally tailored FN can be an effective tool for Latino CGs given their high unmet needs for assistance and various barriers in accessing resources. PMID: 25590939 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 21, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Deficits in Everyday Function Differ in AD and FTD.
Authors: Park LQ, Harvey D, Johnson J, Farias ST Abstract Alzheimer disease (AD) and frontotemporal dementia (FTD) are 2 neurodegenerative diseases with differing cognitive and neuropathologic profiles. Although both diseases ultimately result in functional disability, differences in the profiles of everyday functioning between the 2 groups have not been well characterized. The present study examines potential differences in the types of everyday functional limitations present in these 2 dementias. The present study compared individuals with AD (N=240) or FTD (N=13). The Everyday Cognition (ECog) scale was used to ...
Source: Alzheimer Disease and Associated Disorders - January 21, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Dantrolene, A Treatment for Alzheimer Disease?
Authors: Liang L, Wei H Abstract Alzheimer disease (AD) is a fatal progressive disease and the most common form of dementia without effective treatments. Previous studies support that the disruption of endoplasmic reticulum Ca through overactivation of ryanodine receptors plays an important role in the pathogenesis of AD. Normalization of intracellular Ca homeostasis could be an effective strategy for AD therapies. Dantrolene, an antagonist of ryanodine receptors and an FDA-approved drug for clinical treatment of malignant hyperthermia and muscle spasms, exhibits neuroprotective effects in multiple models of neurod...
Source: Alzheimer Disease and Associated Disorders - January 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Frequency and Impact of Informant Replacement in Alzheimer Disease Research.
Authors: Grill JD, Zhou Y, Karlawish J, Elashoff D Abstract Informants serve an essential role in Alzheimer disease research. Were an informant to be replaced during a longitudinal study, this could have negative implications. We used data from the National Alzheimer's Coordinating Center Uniform Data Set to examine the frequency of informant replacement among Alzheimer disease dementia participants, whether patient and informant characteristics were associated with replacement, and how replacement affected research outcome measures. Informant replacement was common (15.5%) and typically occurred after the first or...
Source: Alzheimer Disease and Associated Disorders - January 4, 2015 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Progressive Changes in Hippocampal Resting-state Connectivity Across Cognitive Impairment: A Cross-sectional Study From Normal to Alzheimer Disease: Erratum
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Erratum Source Type: research

Proinflammatory Cytokines and the Clinical Features of Dementia With Lewy Bodies
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Clinical Amyloid Imaging in Logopenic Progressive Aphasia
The introduction of florbetapir (Amyvid) positron emission tomography biomarkers could dramatically change how we clinically evaluate young patients who present with nonamnestic cognitive complaints for possible Alzheimer disease (AD). Logopenic progressive aphasia (LPA) may be the most common example of this type of clinical problem. In most, but not all, cases, LPA is an early-onset AD variant presenting with language changes that can be difficult to distinguish from other progressive aphasias. We clinically evaluated 3 patients with LPA, in comparison with age-matched and severity-matched patients with typical amnestic ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Early-onset Alzheimers and Cortical Vision Impairment in a Woman With Valosin-containing Protein Disease Associated With 2 APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 Genotype
In conclusion, we report a unique patient with an APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 genotype and atypical VCP disease associated with early Alzheimer disease and severe vision impairment. Future studies will elucidate the interaction of VCP mutations and APOE [Latin Small Letter Open E]4 alleles in understanding common mechanisms in AD and VCP disease. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Whipple’s Disease Masquerades as Dementia With Lewy Bodies
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

A Case of Globular Glial Tauopathy Presenting Clinically as Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Brief Reports Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs
Conclusions: Use of self-report data in clinical trials of Alzheimer disease treatments may inflate sample size needs. Even when adequate power is achieved by increasing sample size, reporting errors can result in a biased estimate of the true effect size of the intervention. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Why are Spousal Caregivers More Prevalent than Nonspousal Caregivers as Study Partners in AD Dementia Clinical Trials?
This study examines the association between caregiver relationship to the patient and willingness to enroll in an AD clinical trial and how caregiver burden and research attitudes modify willingness. Design: Interviews with 103 AD caregivers who met criteria for ability to serve as a study partner. Results: A total of 54% of caregivers were spouses or domestic partners and the remaining were adult children. Willingness to enroll a patient in a clinical trial was associated with being a spouse [odds ratio (OR)=2.53, P=0.01], increasing age (OR=1.39, P=0.01), and increasing scores on the Research Attitudes Questionnaire (OR=...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Alterations in Cholesterol and Ganglioside GM1 Content of Lipid Rafts in Platelets From Patients With Alzheimer Disease
The aim of this study was to investigate the changes in the protein, cholesterol, and ganglioside GM1 content of lipid rafts in platelets from patients with Alzheimer disease (AD), and identify potential blood biomarkers of the disease. A total of 31 Chinese patients with AD and 31 aged-matched control subjects were selected. Lipid rafts were isolated from platelets using Optiprep gradient centrifugation. The protein content of lipid rafts was evaluated using Micro BCA assay, the cholesterol content using molecular probes, ganglioside GM1 content using colorimetry and dot-blotting analysis. The results showed that the chol...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Cognitive Intervention in Semantic Dementia: Maintaining Words Over Time
Patients with semantic dementia (SD) can improve their naming ability through cognitive intervention, with good retention 1 month later. Beyond this time, improvements often fade, yet no studies have investigated how to maintain performance. Nine SD patients completed a 2-month word training program and were then monitored over 6 months: firstly for 2 months without training, followed by a further 4 months, where additional training was provided to revise words, if required. All patients improved their naming immediately postintervention (P (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Quality of Life in Alzheimer Disease: A Comparison of Patients’ and Caregivers’ Points of View
This study identified variables related to patients’ QoL and examined the agreement between patients’ and caregivers’ QoL ratings. A total of 135 dyads (patient and principal caregiver) were enrolled in the study. Patients’ QoL evaluations showed a negative relationship with depressive mood and a positive relationship with Activities of Daily Living (ADL), whereas caregivers’ QoL ratings showed a negative relationship with patients’ depressive mood and behavioral disturbances. Caregivers tended to underestimate patients’ QoL compared with the patients’ own self-evaluations, w...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

The Rest-Activity Rhythm and Physical Activity in Early-Onset Dementia
Background: A substantial part of elderly persons with dementia show rest-activity rhythm disturbances. The rest-activity rhythm is important to study in people with early-onset dementia (EOD) for rest-activity rhythm disturbances are predictive of institutionalization, and caregivers of young patients suffer from high distress. Objective: The aim of this study was to study (1) whether EOD patients have more rest-activity rhythm disturbances compared with cognitively intact adults; and (2) which factors contribute to a disturbed rhythm. Methods: We included 61 patients with EOD [mean age 61.9 (4.9) y, 41 (67%) men] and 68 ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Normative Data for 8 Neuropsychological Tests in Older Blacks and Whites From the Atherosclerosis Risk in Communities (ARIC) Study
This study provides age, race, and education-specific normative data for 8 cognitive tests derived from 320 black and 392 white participants aged 61 to 82 years (mean 71 y) in the Atherosclerosis Risk in Communities (ARIC) study without clinical or subclinical/latent neurological disease. Normative data are provided for the Delayed Word Recall Test, Logical Memory Parts I and II, the Word Fluency Test, Animal Naming, the Trail Making Test Parts A and B and the Digit Symbol Substitution Test. Age, race, and education-specific mean and −1.5 SD scores are given in tabular form and graphically, as well as regression-base...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Mild Cognitive Impairment Due to Alzheimer Disease is Less Likely Under the Age of 65
Patients with amnestic mild cognitive impairment (aMCI) are considered to have a high risk for Alzheimer dementia (AD). Even high positive predictive values, however, cannot be guaranteed even by tests with high sensitivity and specificity when disease prevalence is low. If we regard the clinical criteria for aMCI as a test for predicting aMCI due to AD, the positive predictive value of the criteria will be low by definition in young patients with aMCI (age below 65 years) because of the low prevalence of AD in this age group. To test this hypothesis, we compared CSF biomarkers for AD between young (age below 65 years) and...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Vascular Disease and Risk Factors are Associated With Cognitive Decline in the Alzheimer Disease Spectrum
We investigated the relationship between vascular disease and risk factors versus cognitive decline cross-sectionally and longitudinally in normal older control, mild cognitive impairment, and mild Alzheimer disease (AD) dementia subjects. A total of 812 participants (229 normal older control, 395 mild cognitive impairment, 188 AD) underwent cognitive testing, brain magnetic resonance imaging, and clinical evaluations at baseline and over a period of 3 years. General linear, longitudinal mixed-effects, and Cox proportional hazards models were used. Greater homocysteine level and white matter hyperintensity volume were asso...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Intracranial Stenosis, Cerebrovascular Diseases, and Cognitive Impairment in Chinese
Extracranial carotid artery disease has been shown to be related to cognitive deficits. However, limited data are available on intracranial stenosis (ICS) and cognitive impairment. We investigate the association between ICS and cognitive impairment in Chinese. Subjects (n=278), recruited from the Epidemiology of Dementia in Singapore Study, underwent comprehensive clinical evaluation, neuropsychological testing, and brain magnetic resonance imaging (MRI), including 3-dimensional-time-of-flight magnetic resonance angiography (MRA). Cognitive function was expressed as composite and domain-specific Z-scores. Cognitive impairm...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Angina Pectoris Severity Among Coronary Heart Disease Patients is Associated With Subsequent Cognitive Impairment
Conclusions: In people with preexisting CHD, severity of AP is associated with late-life poorer cognitive performance, independent of other vascular risk factors. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Original Articles Source Type: research

Dantrolene, A Treatment for Alzheimer Disease?
Alzheimer disease (AD) is a fatal progressive disease and the most common form of dementia without effective treatments. Previous studies support that the disruption of endoplasmic reticulum Ca2+ through overactivation of ryanodine receptors plays an important role in the pathogenesis of AD. Normalization of intracellular Ca2+ homeostasis could be an effective strategy for AD therapies. Dantrolene, an antagonist of ryanodine receptors and an FDA-approved drug for clinical treatment of malignant hyperthermia and muscle spasms, exhibits neuroprotective effects in multiple models of neurodegenerative disorders. Recent preclin...
Source: Alzheimer Disease and Associated Disorders - January 1, 2015 Category: Geriatrics Tags: Review Article Source Type: research

Is Mild Dementia Related to Unsafe Street-Crossing Decisions?
Authors: Dommes A, Wu YH, Aquino JP, Pitti-Ferrandi H, Soleille M, Martineau-Fleury S, Samson M, Rigaud AS Abstract The overrepresentation of very old people (75 or older) in pedestrian crash statistics raises the issue of the effects of normal and pathologic ageing on gap-selection difficulties during street crossing. The present study focused on Alzheimer disease, a condition commonly associated with cognitive declines detrimental to daily life activities such as crossing the street. Twenty-five participants with mild dementia and 33 controls carried out a street-crossing task in a simulated environment. They als...
Source: Alzheimer Disease and Associated Disorders - December 12, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A 24-Week, Open-Label Extension Study to Investigate the Long-term Safety, Tolerability, and Efficacy of 13.3 mg/24 h Rivastigmine Patch in Patients With Severe Alzheimer Disease.
Authors: Farlow MR, Grossberg GT, Sadowsky CH, Meng X, Velting DM Abstract The long-term safety, tolerability, and efficacy of high-dose 13.3 mg/24 h rivastigmine patch in severe Alzheimer disease was evaluated in a 24-week, open-label extension to the double-blind ACTION study. Safety and tolerability, and efficacy on the Alzheimer's Disease Cooperative Study-Activities of Daily Living scale-Severe Impairment Version (ADCS-ADL-SIV), Severe Impairment Battery (SIB), and ADCS-Clinical Global Impression of Change (ADCS-CGIC) were assessed. Overall, 197 patients continued on 13.3 mg/24 h patch; 199 uptitrated from 4.6...
Source: Alzheimer Disease and Associated Disorders - December 6, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI.
CONCLUSION:: These findings provide information about biomarker enrichment and outcome measurements that could be employed to reduce MCI patient samples and treatment duration in future clinical trials. PMID: 25437302 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 6, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Reply to the letter by nagai m. Et Al.
Authors: Lattanzi S, Silvestrini M PMID: 25386684 [PubMed - in process] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 13, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

A Prospective Comparison of Informant-based and Performance-based Dementia Screening Tools to Predict In-Hospital Delirium.
Authors: Zeng L, Josephson SA, Fukuda KA, Neuhaus J, Douglas VC Abstract Dementia is an important risk factor for delirium, but the optimal strategy for incorporating cognitive impairment into delirium risk assessment at the time of hospital admission is unknown. We compared 2 informant-based screening tools for dementia and mild cognitive impairment [AD8 and D=(MC)] to the Mini Mental State Examination (MMSE) and Mini-cog in predicting hospital-acquired delirium. This prospective cohort study at an academic medical center consisted of 162 medical inpatients over age 50 years without delirium upon admission. Each p...
Source: Alzheimer Disease and Associated Disorders - October 30, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Help-Seeking for Dementia: A Systematic Review of the Literature.
CONCLUSIONS:: Although the body of literature in the area of HS and dementia is growing, several conceptual and methodological limitations still have to be resolved to advance knowledge in the area. PMID: 25321607 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 18, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Variability in Obstacle Clearance May (Not) Indicate Cognitive Disorders in Alzheimer Disease.
In conclusion, individuals with AD had increased gait variability while approaching an obstacle during walking, indicating a deficit in planning to avoid obstacles that could be related to cognitive disorders. However, gait variability during the crossing phase may not be indicative of cognitive disorders in AD. PMID: 25291460 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 9, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Semantic Corticobasal Dementia: Challenging Nosology in Frontotemporal Lobe Degeneration.
Authors: Luzzi S, Fabi K, Cafazzo V, Fringuelli FM, Reverberi C, Baldinelli S, Silvestrini M, Provinciali L, Ascoli G, Pickering-Brown S, Mann D, Neary D, Snowden JS PMID: 25291461 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 9, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Reply to the Letter by Nagai M. et al
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Letters to the Editor Source Type: research

BP Variability and Cognitive Impairment: Vascular Risk Factors for Alzheimer Disease?
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Letters to the Editor Source Type: research