Screening Utility of the “Attended Alone” Sign for Subjective Memory Impairment
As awareness of dementia as a major public health issue grows, increasing numbers of individuals with subjective memory impairment (SMI) are presenting to memory services. Many with SMI are cognitively healthy and require only reassurance. In the absence of reliable and easily available biomarkers of dementia, clinical signs may be the most effective way of differentiating cognitively healthy SMI individuals from those with underlying brain disease. Collateral history is important in the assessment of memory complaints, so patients are routinely instructed to bring a relative, friend, or a carer to clinic with them. Attend...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Brief Reports Source Type: research

Erythrocyte Membrane Stability to Hydrogen Peroxide is Decreased in Alzheimer Disease
The brain and erythrocytes have similar susceptibility toward free radicals. Therefore, erythrocyte abnormalities might indicate the progression of the oxidative damage in Alzheimer disease (AD). The aim of this study was to investigate erythrocyte membrane stability and plasma antioxidant status in AD. Fasting blood samples (from 17 patients with AD and 14 healthy controls) were obtained and erythrocyte membrane stability against hydrogen peroxide and 2,2′-azobis-(2-amidinopropane) dihydrochloride (AAPH), serum Trolox equivalent antioxidant capacity (TEAC), residual antioxidant activity or gap (GAP), erythrocyte cat...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

The Role of Cerebellar Volume in Cognition in the General Elderly Population
Conclusions:We only found a minor relationship between larger cerebellar volume and better cognition in healthy older adults, which further attenuated after correcting for cerebral volume. Our findings support the notion that cerebellar volume has an influence on cognition in aging, but that it is not the major leading structure. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Visit-to-Visit Blood Pressure Variability in Alzheimer Disease
The aim of this study was to evaluate visit-to-visit blood pressure (BP) variability in a cohort of patients with Alzheimer disease (AD) and healthy controls. Patients with clinically diagnosed mild or moderate AD and cognitively normal controls matched for age and sex were recruited and followed up for 6 months. To characterize the BP status of each individual, mean, maximum and minimum values, SD, and coefficient of variation were obtained for both systolic BP (SBP) and diastolic BP (DBP). Seventy AD patients and 140 controls were enrolled. No meaningful differences were found in prevalence or treatments of various vascu...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Deficient Symbol Processing in Alzheimer Disease
Symbols and signs have been suggested to improve the orientation of patients suffering from Alzheimer disease (AD). However, there are hardly any studies that confirm whether AD patients benefit from signs or symbols and which symbol characteristics might improve or impede their symbol comprehension. To address these issues, 30 AD patients and 30 matched healthy controls performed a symbol processing task (SPT) with 4 different item categories. A repeated-measures analysis of variance was run to identify impact of different item categories on performance accuracy in both the experimental groups. Moreover, SPT scores were c...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

The Effects of Spaced Retrieval Combined With Errorless Learning in Institutionalized Elders With Dementia: Recall Performance, Cognitive Status, and Food Intake
The purpose of this study was to explore the effects on recall performance, cognitive status, and food intake when using accumulating cues in a spaced retrieval (SR) paradigm. In a double-blinded experimental design, 32 participants in the SR combined with errorless learning (SR/EL) group and 29 participants in the SR-only group were trained in a variety of eating-related actions. Accumulating cues were used within each SR trial in the SR/EL group. The participants’ recall performance, the Mini-Mental State Examination (MMSE) scores, and the portion of a meal that participants had eaten were measured. After the 8-wee...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Is Bilingualism Associated With a Lower Risk of Dementia in Community-living Older Adults? Cross-sectional and Prospective Analyses
Conclusions:We did not find any association between speaking>1 language and dementia. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Factors Associated With Primary Care Physicians’ Recognition of Cognitive Impairment in Their Older Patients
Although there are accurate screens for cognitive impairment, there is as yet no evidence that screening improves outcomes including primary care physicians’ (PCP) medical decision making. PCPs’ recognition of cognitive impairment being suboptimal, we investigated factors associated with improved recognition. Eligible patients were aged 65 years and above, without documented dementia or previous work-up for dementia, seen consecutively over 2 months by one of 13 PCPs. PCPs indicated whether they, the patient, or the family had concerns about each patient’s cognition. We enrolled 130 patients with any cogn...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Feasibility and Validity of the Self-administered Computerized Assessment of Mild Cognitive Impairment With Older Primary Care Patients
We investigated whether a validated computerized cognitive test, the Computerized Assessment of Mild Cognitive Impairment (CAMCI), could be independently completed by older primary care patients. We also determined the optimal cut-off for the CAMCI global risk score for mild cognitive impairment against an independent neuropsychological reference standard. All eligible patients aged 65 years and older, seen consecutively over 2 months by 1 family practice of 13 primary care physicians, were invited to participate. Patients with a diagnosis or previous work-up for dementia were excluded. Primary care physicians indicated wh...
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Help-Seeking for Dementia: A Systematic Review of the Literature
Conclusions:Although the body of literature in the area of HS and dementia is growing, several conceptual and methodological limitations still have to be resolved to advance knowledge in the area. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2014 Category: Geriatrics Tags: Review Article Source Type: research

Conscious Knowledge and Decision Making Under Ambiguity in Mild Cognitive Impairment and Alzheimer Disease.
Authors: Bayard S, Jacus JP, Raffard S, Gély-Nargeot MC PMID: 25222384 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 17, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Memory Profiles in Pathology or Biomarker Confirmed Alzheimer Disease and Frontotemporal Dementia.
CONCLUSIONS:: AD participants showed more rapid forgetting than bvFTD, and both groups showed more rapid forgetting than controls. In contrast, bvFTD did not conform to a more dysexecutive pattern of performance as patient groups committed similar number of intrusion errors and showed comparably low rates of improvement on cued recall and recognition trials. For patients with neuroimaging, there were no group differences in medial temporal volumes, which was the only significant predictor of consolidation for both dementia groups. PMID: 25203512 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 11, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion.
Authors: Suárez-Calvet M, Camacho V, Gómez-Ansón B, Antón S, Vives-Gilabert Y, Dols-Icardo O, Clarimón J, Alcolea D, Blesa R, Fortea J, Lleó A PMID: 25203513 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 11, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

C-TOC (Cognitive Testing on Computer): Investigating the Usability and Validity of a Novel Self-administered Cognitive Assessment Tool in Aging and Early Dementia.
DISCUSSION:: In general, C-TOC had good validity in detecting cognitive impairment. Ensuring test-takers' understanding of the tasks, and considering their computer knowledge appear important steps towards C-TOC's implementation. PMID: 25187218 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study.
CONCLUSIONS:: Middle-aged healthy adults with cardiovascular risk factors including diabetes, history of smoking, and ApoE4 positivity were found to have greater later-life memory impairments. PMID: 25187219 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Utility of the Dementia Severity Rating Scale in Differentiating Mild Cognitive Impairment and Alzheimer Disease From Controls.
Authors: Mitchell JC, Dick MB, Wood AE, Tapp AM, Ziegler R Abstract The current study investigated the utility of the Dementia Severity Rating Scale (DSRS) total score to identify individuals at the earliest stage of impairment (ie, mild cognitive impairment/MCI). In addition, the authors sought to investigate how well the measure correlates with an expanded battery of cognitive tests and other measures of functional abilities. Of the 320 participants included in this study, 85 were normal controls, 96 had single-domain or multiple-domain amnestic MCI, and 139 had possible or probable Alzheimer disease (AD). Each p...
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Distinct Patterns and Clinical Implications of Semantic Memory Deterioration Among Patients With MCI.
This study examined the cognitive performance of 181 participants from various MCI subgroups, a group of mildly impaired individuals with dementia of the Alzheimer type (DAT) and a group of individuals with subjective memory impairment on various semantic memory tasks. The aMCI-single domain (aMCI-sd) group displayed poor performance on a semantic memory task requiring relatively higher degrees of effortful retrieval, and participants in the aMCI-multiple domain (aMCI-md) group, who also suffered with mild executive dysfunction displayed poor performance on all semantic memory tasks, similar to the DAT group. The nonamnest...
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Prospective Memory in Subjective Cognitive Decline: A Preliminary Study on the Role of Early Cognitive Marker in Dementia.
Authors: Hsu YH, Huang CF, Tu MC, Hua MS Abstract Accumulating evidence shows that subjective cognitive decline (SCD) without impairment on conventional neuropsychological tests may indicate increased risk for Alzheimer disease. Previous studies of mild cognitive impairment have demonstrated the potential role of prospective memory (PM) in the early detection of cognitive decline. We thus aimed to investigate the performance of people with SCD on PM tasks relative to their healthy controls (HCs). Forty-one participants with SCD and demographically matched HCs received regular cognitive testing as well as 2 single-t...
Source: Alzheimer Disease and Associated Disorders - September 5, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Subtype of Mild Cognitive Impairment in Elderly Patients With Essential Tremor.
CONCLUSIONS:: ET is associated with MCI, particularly the nonamnestic subtype. These results suggest that cognitive change in patients with ET may have a different pathogenesis from that of Alzheimer disease. PMID: 25037029 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 19, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Intervention in Semantic Dementia: Maintaining Words Over Time.
Authors: Savage SA, Piguet O, Hodges JR Abstract Patients with semantic dementia (SD) can improve their naming ability through cognitive intervention, with good retention 1 month later. Beyond this time, improvements often fade, yet no studies have investigated how to maintain performance. Nine SD patients completed a 2-month word training program and were then monitored over 6 months: firstly for 2 months without training, followed by a further 4 months, where additional training was provided to revise words, if required. All patients improved their naming immediately postintervention (P
Source: Alzheimer Disease and Associated Disorders - July 19, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

BP Variability and Cognitive Impairment: Vascular Risk Factors for Alzheimer Disease?
Authors: Nagai M, Hoshide S, Kario K PMID: 25037031 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 19, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

First Report of PSEN2 Mutation Presenting as Posterior Cortical Atrophy.
Authors: Tremolizzo L, Susani E, Mapelli C, Isella V, Bertola F, Ferrarese C, Appollonio I PMID: 25010293 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 11, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Comparative Analysis of the Alzheimer Questionnaire (AQ) With the CDR Sum of Boxes, MoCA, and MMSE
The Alzheimer Questionnaire (AQ) has been established as a valid and accurate informant-based screening questionnaire for Alzheimer disease and amnestic mild cognitive impairment. Although the AQ’s validity and diagnostic accuracy has been established, its performance in comparison with other instruments has not. Thirty-nine amnestic mild cognitive impairment cases and 34 Alzheimer disease cases were matched on the basis of age, education, and sex to 73 cognitively normal individuals. The sample had a mean age of 82.54±7.77 years and a mean education level of 14.61±2.61 years. The diagnostic accuracy of...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Brief Reports Source Type: research

Rapidly Progressive Dementia as Presenting Feature in Inflammatory Bowel Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Brief Reports Source Type: research

Altered Levels of Amyloid Precursor Protein Intracellular Domain-interacting Proteins in Alzheimer Disease
Conclusions:This proteomic-based approach highlights the first step in finding the possible cellular pathways engaged in AD pathophysiology on the basis of interaction of one or more of their members with AICD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Cognitive Behavioral Group Intervention for Alzheimer Caregivers
This study aimed to explore the impact of cognitive and behavioral therapy (CBT) group intervention on AD patients’ caregivers. In particular, reduction in caregivers’ global care needs and in anxiety and depression has been investigated. About 100 caregivers were divided into the following groups: CBT group intervention, self-help manual, and control have been enrolled in the study. CBT group intervention seems to be more effective than the other 2 conditions in reducing caregivers’ anxiety. Furthermore, only caregivers of the CBT group showed significant needs related to reduction in care. The proposed ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Community Engagement in Diverse Populations for Alzheimer Disease Prevention Trials
The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or soliciting participation of older adults with a family history of AD from clinics and outreach efforts. However, high-risk groups, such as ethnic/racial minorities, are traditionally less likely to be recruited for AD prevention studies, thus limiting the ability to generalize findings for a significant proportion of the aging population. A community-engagement approach ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Social Relationships and Risk of Incident Mild Cognitive Impairment in US Alzheimer’s Disease Centers
Social relationships are hypothesized to prevent or slow cognitive decline. We sought to evaluate associations between social relationships and mild cognitive impairment (MCI). Participants from the National Alzheimer’s Coordinating Center database who were cognitively normal, aged 55 and older at baseline, and had at least 2 in-person visits (n=5335) were included. Multivariable Cox proportional hazard models evaluated the association between 4 social relationships at baseline (marital status, living situation, having children, and having siblings) and risk of developing MCI (on the basis of clinician diagnosis foll...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Progressive Changes in Hippocampal Resting-state Connectivity Across Cognitive Impairment: A Cross-sectional Study From Normal to Alzheimer Disease
In this study, we were able to quantify the deterioration of resting-state hippocampal connectivity with disease severity and formation of compensatory recruitment in the early stages of AD. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Distinctive RNA Expression Profiles in Blood Associated With Alzheimer Disease After Accounting for White Matter Hyperintensities
Conclusions:RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Genetics in Degenerative Dementia: Current Status and Applicability
An increasing number of hereditary neurodegenerative diseases, including autosomal-dominant Alzheimer disease (AD), familial autosomal-dominant frontotemporal dementia (FTD), and heritable Lewy body disease (LBD) have been defined at the molecular level in recent years, making it possible to determine the genotype before the onset of symptoms. The identification of deterministic genes for these common adult-onset genetic diseases is moving the field of genetic counseling toward a new and challenging direction. With the identification of genes associated with AD and FTD, there is considerable interest in the clinical applic...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Review Article Source Type: research

Alzheimer Disease Cerebrospinal Fluid Biomarkers Predict Cognitive Decline In Healthy Elderly Over 2 Years
Aim:The aim of this study is to check the ability of cerebrospinal fluid biomarkers of Alzheimer disease (CSF-BMK-AD) to make a discrimination checklist within a healthy group, according to their cognitive development at 2 years of obtaining the sample. Materials and Methods:Between 2008 and 2010, 67 subjects without cognitive or behavioral disorders were included as a control group in a study on CSF-AD-BMK. Neuropsychological assessment at baseline and at follow-up had been carried out 2 years later. CSF was obtained at the inclusion. It was analyzed by Innotest reagents to measure amyloid-β (Aβ1-42), total-&tau...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement
Conclusions:The proposed criteria for VCD provide a coherent approach to the diagnosis of this diverse group of disorders, with a view to stimulating clinical and pathologic validation studies. These criteria can be harmonized with the DSM-5 criteria such that an international consensus on the criteria for VCD may be achieved. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Practice Effects and Amyloid Deposition: Preliminary Data on a Method for Enriching Samples in Clinical Trials
Clinical trials in Alzheimer disease are moving toward prevention studies in prodromal individuals with amyloid burden. However, methods are needed to identify individuals expected to be amyloid positive for these studies to be feasible and cost-effective. The current study sought to determine whether short-term practice effects on cognitive tests can identify those with notable uptake on amyloid imaging. Twenty-five, nondemented older adults (15 cognitively intact, 10 with mild cognitive impairment) underwent amyloid imaging through 18F-flutemetamol and 2 cognitive testing sessions across 1 week to determine practice effe...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Can Mirtazapine Counteract the Weight Loss Associated With Alzheimer Disease? A Retrospective Open-label Study
Weight loss is a frequent complication of Alzheimer disease (AD), associated with increased morbidity and mortality. Increased appetite and weight gain are known side effects of the antidepressant mirtazapine. This analysis was undertaken to assess the safety and potential utility of mirtazapine to counteract weight loss in patients with AD or mixed AD (AD with cerebrovascular lesions). We performed a retrospective analysis of the clinical records of all outpatients attending our memory clinic for AD or mixed AD, who had received mirtazapine (30 mg daily) with the specific purpose of inducing weight or appetite gain. Data ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Brief Reports Source Type: research

Personality Changes in Dementia: Are They Disease Specific and Universal?
Previous studies about personality changes in dementia suggest that they may be due to the disruption of the biological basis of personality traits, and hence, that they are disease specific and universal. However, evidence about its specificity is still limited and scarce regarding culturally diverse populations. Accordingly, our aim was to compare personality changes in Argentinean patients with Alzheimer disease, behavioral variant of frontotemporal dementia, and primary progressive aphasia. The closest living relatives of patients diagnosed with Alzheimer disease (n=19), behavioral variant of frontotemporal dementia (n...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Association Between Neuropathology and Brain Volume in The Framingham Heart Study
Studies of clinical and community cohorts have shown that antemortem imaging measures of hippocampal volume have correlated with postmortem Alzheimer pathology. Fewer studies have examined the relationship between both Alzheimer and cerebrovascular pathology, and antemortem brain imaging. The aim of this study was to correlate antemortem brain magnetic resonance imaging (MRI) volumes with postmortem brain pathology (both Alzheimer-related and cerebrovascular) in a community-derived cohort from the Framingham Heart Study. Participants (n=59) from the Framingham Heart Study were included if they were enrolled in the brain au...
Source: Alzheimer Disease and Associated Disorders - July 1, 2014 Category: Geriatrics Tags: Original Articles Source Type: research

Quality of Life in Alzheimer Disease: A Comparison of Patients' and Caregivers' Points of View.
This study identified variables related to patients' QoL and examined the agreement between patients' and caregivers' QoL ratings. A total of 135 dyads (patient and principal caregiver) were enrolled in the study. Patients' QoL evaluations showed a negative relationship with depressive mood and a positive relationship with Activities of Daily Living (ADL), whereas caregivers' QoL ratings showed a negative relationship with patients' depressive mood and behavioral disturbances. Caregivers tended to underestimate patients' QoL compared with the patients' own self-evaluations, with patients' dependency in performing ADL and b...
Source: Alzheimer Disease and Associated Disorders - June 19, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Errors in Self-Reports of Health Services Use: Impact on Alzheimer Disease Clinical Trial Designs.
CONCLUSIONS:: Use of self-report data in clinical trials of Alzheimer disease treatments may inflate sample size needs. Even when adequate power is achieved by increasing sample size, reporting errors can result in a biased estimate of the true effect size of the intervention. PMID: 24845761 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 23, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old.
Authors: Ghoshal N, Perry A, McKeel D, Schmidt RE, Carter D, Norton J, Zou WQ, Xiao X, Puoti G, Notari S, Gambetti P, Morris JC, Cairns NJ PMID: 24845762 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - May 23, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Effect of APOE ε4 Allele on Cholinesterase Inhibitors in Patients With Alzheimer Disease: Evaluation of the Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging.
The Effect of APOE ε4 Allele on Cholinesterase Inhibitors in Patients With Alzheimer Disease: Evaluation of the Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging. Alzheimer Dis Assoc Disord. 2014 Apr-Jun;28(2):122-7 Authors: Wang L, Day J, Roe CM, Brier MR, Thomas JB, Benzinger TL, Morris JC, Ances BM Abstract This work is to determine whether apolipoprotein E (APOE) genotype modulates the effect of cholinesterase inhibitor (ChEI) treatment on resting state functional connectivity magnetic resonance imaging (rs-fcMRI) in patients with Alzheimer disease (AD). We ret...
Source: Alzheimer Disease and Associated Disorders - May 17, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Genetics in Degenerative Dementia: Current Status and Applicability.
Authors: Bruni AC, Conidi ME, Bernardi L Abstract An increasing number of hereditary neurodegenerative diseases, including autosomal-dominant Alzheimer disease (AD), familial autosomal-dominant frontotemporal dementia (FTD), and heritable Lewy body disease (LBD) have been defined at the molecular level in recent years, making it possible to determine the genotype before the onset of symptoms. The identification of deterministic genes for these common adult-onset genetic diseases is moving the field of genetic counseling toward a new and challenging direction. With the identification of genes associated with AD and ...
Source: Alzheimer Disease and Associated Disorders - May 10, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Why are Spousal Caregivers More Prevalent than Nonspousal Caregivers as Study Partners in AD Dementia Clinical Trials?
This study examines the association between caregiver relationship to the patient and willingness to enroll in an AD clinical trial and how caregiver burden and research attitudes modify willingness. DESIGN:: Interviews with 103 AD caregivers who met criteria for ability to serve as a study partner. RESULTS:: A total of 54% of caregivers were spouses or domestic partners and the remaining were adult children. Willingness to enroll a patient in a clinical trial was associated with being a spouse [odds ratio (OR)=2.53, P=0.01], increasing age (OR=1.39, P=0.01), and increasing scores on the Research Attitudes Questionnaire (OR=1.39, P
Source: Alzheimer Disease and Associated Disorders - May 10, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Vascular Disease and Risk Factors are Associated With Cognitive Decline in the Alzheimer Disease Spectrum.
Authors: Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Viswanathan A, Marshall GA, for the Alzheimer’s Disease Neuroimaging Initiative Abstract We investigated the relationship between vascular disease and risk factors versus cognitive decline cross-sectionally and longitudinally in normal older control, mild cognitive impairment, and mild Alzheimer disease (AD) dementia subjects. A total of 812 participants (229 normal older control, 395 mild cognitive impairment, 188 AD) underwent cognitive testing, brain magnetic resonance imaging, and clinical evaluations at baseline and over a period of 3 yea...
Source: Alzheimer Disease and Associated Disorders - May 3, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Dementia Severity Rating Scale Predicts Clinical Dementia Rating Sum of Boxes Scores.
Authors: Moelter ST, Glenn MA, Xie SX, Chittams J, Clark CM, Watson M, Arnold SE PMID: 24770371 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 29, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Alterations in Cholesterol and Ganglioside GM1 Content of Lipid Rafts in Platelets From Patients With Alzheimer Disease.
Authors: Liu L, Zhang K, Tan L, Chen YH, Cao YP Abstract The aim of this study was to investigate the changes in the protein, cholesterol, and ganglioside GM1 content of lipid rafts in platelets from patients with Alzheimer disease (AD), and identify potential blood biomarkers of the disease. A total of 31 Chinese patients with AD and 31 aged-matched control subjects were selected. Lipid rafts were isolated from platelets using Optiprep gradient centrifugation. The protein content of lipid rafts was evaluated using Micro BCA assay, the cholesterol content using molecular probes, ganglioside GM1 content using colori...
Source: Alzheimer Disease and Associated Disorders - April 25, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Normative Data for 8 Neuropsychological Tests in Older Blacks and Whites From the Atherosclerosis Risk in Communities (ARIC) Study.
This study provides age, race, and education-specific normative data for 8 cognitive tests derived from 320 black and 392 white participants aged 61 to 82 years (mean 71 y) in the Atherosclerosis Risk in Communities (ARIC) study without clinical or subclinical/latent neurological disease. Normative data are provided for the Delayed Word Recall Test, Logical Memory Parts I and II, the Word Fluency Test, Animal Naming, the Trail Making Test Parts A and B and the Digit Symbol Substitution Test. Age, race, and education-specific mean and -1.5 SD scores are given in tabular form and graphically, as well as regression-based equa...
Source: Alzheimer Disease and Associated Disorders - April 25, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Mild Cognitive Impairment Due to Alzheimer Disease is Less Likely Under the Age of 65.
Authors: Shin S, Kim JH, Cho JH, Kim GS, Choi SA, Lee JH, For the Alzheimer’s Disease Neuroimaging Initiative Abstract Patients with amnestic mild cognitive impairment (aMCI) are considered to have a high risk for Alzheimer dementia (AD). Even high positive predictive values, however, cannot be guaranteed even by tests with high sensitivity and specificity when disease prevalence is low. If we regard the clinical criteria for aMCI as a test for predicting aMCI due to AD, the positive predictive value of the criteria will be low by definition in young patients with aMCI (age below 65 years) because of the low ...
Source: Alzheimer Disease and Associated Disorders - April 25, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Distinctive RNA Expression Profiles in Blood Associated With Alzheimer Disease After Accounting for White Matter Hyperintensities.
CONCLUSIONS:: RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain. PMID: 24731980 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 17, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Intracranial Stenosis, Cerebrovascular Diseases, and Cognitive Impairment in Chinese.
Authors: Hilal S, Saini M, Tan CS, Catindig JA, Dong YH, Holandez RL, Niessen WJ, Vrooman HA, Ting E, Wong TY, Chen C, Venketasubramanian N, Ikram MK Abstract Extracranial carotid artery disease has been shown to be related to cognitive deficits. However, limited data are available on intracranial stenosis (ICS) and cognitive impairment. We investigate the association between ICS and cognitive impairment in Chinese. Subjects (n=278), recruited from the Epidemiology of Dementia in Singapore Study, underwent comprehensive clinical evaluation, neuropsychological testing, and brain magnetic resonance imaging (MRI), inc...
Source: Alzheimer Disease and Associated Disorders - April 17, 2014 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research