Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia
Conclusions and Relevance: Flortaucipir uptake distinguished individuals with PCA and amnestic AD dementia early in the symptomatic course. The posterior brain regions appear to be uniquely vulnerable to tau deposition in PCA, aligning with clinical deficits that define this disease subtype. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - April 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Autoimmune Frontotemporal Dementia: A New Nosological Entity?
Authors: Borroni B, Manes MA, Alberici A, Cosseddu M, Bernasconi P, Archetti S, Pinelli L, Gasparotti R, Padovani A PMID: 28338508 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 27, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Temporal Trends and Rural-Urban Differences in Hospital Length of Stay for Alzheimer Disease and Related Disorders.
CONCLUSIONS: LOS for ADRD-related hospitalizations was found to be influenced mostly by patient-level demographic and clinical factors. Hospital-level factors were not associated with LOS. PMID: 28296666 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - March 16, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Functional Connectivity is Reduced in Early-Stage Primary Progressive Aphasia When Atrophy is not Prominent.
Authors: Bonakdarpour B, Rogalski EJ, Wang A, Sridhar J, Mesulam MM, Hurley RS Abstract Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent. ...
Source: Alzheimer Disease and Associated Disorders - March 15, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study.
DISCUSSION: Our results suggest CABG history is associated with long-term dementia risk. Further investigation is warranted to examine the causal mechanisms which may explain this relationship or whether the association reflects differences in coronary artery disease severity.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommo...
Source: Alzheimer Disease and Associated Disorders - March 7, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Change in Health-related Quality of Life After Referral to Memory Assessment Services.
Authors: Park MH, Smith SC, Chrysanthaki T, Neuburger J, Ritchie CW, Hendriks AA, Black N Abstract Despite strong support for the provision of memory assessment services (MASs) in England and other countries, their effectiveness in improving patient outcomes is uncertain. We aimed to describe change in patients' health-related quality of life (HRQL) 6 months after referral to MASs and to examine associations with patient characteristics and use of postdiagnostic interventions. Data from 883 patients referred to 69 MASs and their informal caregivers (n=569) were collected at referral and 6 months later. Multivariabl...
Source: Alzheimer Disease and Associated Disorders - March 3, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study.
Authors: Marden JR, Mayeda ER, Tchetgen Tchetgen EJ, Kawachi I, Glymour MM Abstract BACKGROUND: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. MATERIALS AND METHODS: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician's diagnosis of diabetes was self-reported in the same year. Composite memory (z scored) was assesse...
Source: Alzheimer Disease and Associated Disorders - February 24, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Time, Sex, Gender, History, and Dementia.
Authors: Rocca WA Abstract A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type. Third, I suggest some areas of future research...
Source: Alzheimer Disease and Associated Disorders - February 10, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Chorein Deficiency and Alzheimer Disease: An Intriguing, Yet Premature Speculation.
Authors: Velayos-Baeza A, Danek A PMID: 28121633 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Correlation of Histopathology and MRI in Prion Disease.
This study includes 11 cases of definite prion disease in which FDG-PET scans were obtained. There were 8 sporadic CJD cases, 2 genetic CJD cases, and 1 fatal familial insomnia case. Automated FDG-PET analysis revealed parietal region hypometabolism in all cases. Surprisingly, limbic and mesolimbic hypermetabolism were also present in the majority of cases. When FDG-PET hypometabolism was compared with neuropathologic changes (neuronal loss, astrocytosis, spongiosis), hypometabolism was predictive of neuropathology in 80.6% of cortical regions versus 17.6% of subcortical regions. The odds of neuropathologic changes were 2....
Source: Alzheimer Disease and Associated Disorders - January 26, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Heterozygous Deletion of Chorein Exons 70-73 and GNA14 Exons 3-7 in a Brazilian Patient Presenting With Probable Tau-Negative Early-Onset Alzheimer Disease.
Authors: Lazarczyk MJ, Haller S, Savioz A, Gimelli S, Bena F, Giannakopoulos P PMID: 28079535 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 14, 2017 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Thank You to Our Reviewers in 2016!
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Guest Reviewers Acknowledgement Source Type: research

Heterozygous Deletion of Chorein Exons 70-73 and GNA14 Exons 3-7 in a Brazilian Patient Presenting With Probable Tau-Negative Early-Onset Alzheimer Disease
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Chorein Deficiency and Alzheimer Disease: An Intriguing, Yet Premature Speculation
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Letters to the Editor Source Type: research

Time, Sex, Gender, History, and Dementia
A growing body of epidemiologic evidence indicates a decline in the incidence or prevalence of dementia in high income countries in the past 25 years. In this commentary, I first suggest that the decline in the incidence or prevalence of dementia is not explained completely by the factors considered so far, and that a broader historical perspective may be needed. Second, I suggest that the overall declining trend may conceal trends in opposite directions for the two major subtypes of dementia, the neurovascular and the neurodegenerative type. Third, I suggest some areas of future research to further elucidate the trends. T...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Review Article Source Type: research

Low-dose Lithium Treatment for Agitation and Psychosis in Alzheimer Disease and Frontotemporal Dementia: A Case Series
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals
We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/A&beta...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Brief Reports Source Type: research

The Effects of Computerized Cognitive Testing of Older Patients on Primary Care Physicians’ Approaches to Care: A Canadian Study
Conclusions: Our findings indicate that PCPs documented more care approaches in patients with greater cognitive impairment based on the CAMCI results and this was independent of their, the patients’, or families’ prior concerns about their patients’ cognition. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia
Conclusions: Specific functional deficits increased dementia risk and, with age and global cognition, constituted a validated clinical algorithm to estimate dementia risk. Clinicians can use this clinically important algorithm to personalize decision-making about further investigation and identify high-risk patients for early treatment or inclusion in clinical trials. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study
Background: Type 2 diabetes (T2D) is an established risk factor for dementia, but evidence for T2D and memory decline is less consistent. Understanding how T2D and blood glucose relate to memory decline is crucial to elucidating the mechanisms linking T2D and dementia. Materials and Methods: For 8888 Health and Retirement Study participants aged 50+, glycosylated hemoglobin (HbA1c) was measured in either 2006 or 2008 and physician’s diagnosis of diabetes was self-reported in the same year. Composite memory (z scored) was assessed biennially through 2012 using immediate and delayed word list recall or the Informant Q...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology. Diabetes [odds ratio (OR)=0.94; 95% conf...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

MRI Markers Predict Cognitive Decline Assessed by Telephone Interview: The Northern Manhattan Study
Conclusions: Telephone cognitive assessments can detect decline due to white matter lesions and smaller brain volumes. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

The Potential Value of β-Amyloid Imaging for the Diagnosis and Management of Dementia: A Survey of Clinicians
In conclusion, β-amyloid imaging can influence diagnosis, prescriptions, and patient management. (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials
Recent clinical trials in mild Alzheimer disease (AD) have enriched for amyloid-specific positron emission tomography (PET) imaging and used extended versions of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog) in an effort to increase the sensitivity to detect treatment effects. We used data from mild AD participants in the AD Neuroimaging Initiative to model trial effect sizes for 12- and 24-month trials using 3 versions of the ADAS-Cog and increased standardized uptake value ratio (SUVR) cutoffs for amyloid imaging inclusion criteria. For 12-month trials, extended ADAS-Cog versions improved effect sizes. The ADAS-C...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea
Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF biomarker concentrations were measured using enzyme-linked immunosorbent assay. CSF biomarkers differed significantly between the ADD and control g...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Cholinergic Changes in Aging and Alzheimer Disease: An [18F]-F-A-85380 Exploratory PET Study
The central cholinergic system undergoes changes during the physiological process of aging and the pathologic process of Alzheimer disease (AD). We aimed to analyze the impairment of cholinergic pathways by positron emission tomography using the [18F]-F-A-85380 (FA85) tracer, which has a high affinity for nicotinic acetylcholine receptors (nAChRs). Aging was assessed by comparing young (n=10) and elderly (n=4) healthy subjects, and the pathologic process of AD was assessed by comparing elderly controls and age-matched AD patients (n=8). We measured an index of the nAChR density in the cortex and the hippocampus and the tot...
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Correlation of Histopathology and MRI in Prion Disease
This study includes 11 cases of definite prion disease in which FDG-PET scans were obtained. There were 8 sporadic CJD cases, 2 genetic CJD cases, and 1 fatal familial insomnia case. Automated FDG-PET analysis revealed parietal region hypometabolism in all cases. Surprisingly, limbic and mesolimbic hypermetabolism were also present in the majority of cases. When FDG-PET hypometabolism was compared with neuropathologic changes (neuronal loss, astrocytosis, spongiosis), hypometabolism was predictive of neuropathology in 80.6% of cortical regions versus 17.6% of subcortical regions. The odds of neuropathologic changes were 2....
Source: Alzheimer Disease and Associated Disorders - January 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research

Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease in South Korea.
Authors: Park SA, Chae WS, Kim HJ, Shin HS, Kim S, Im JY, Ahn SI, Min KD, Yim SJ, Ye BS, Seo SW, Jeong JH, Park KW, Choi SH, Na DL Abstract Laboratory-specific reference values for cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers are necessary. Our objective was to apply well-known CSF biomarkers and redetermine their diagnostic cutoff values for AD in South Korea. CSF samples from matched control subjects (n=71), patients with AD dementia (ADD, n=76), and other neurological disorders with cognitive decline (OND, n=47) were obtained from 6 Korean dementia clinics according to a standardized protocol. CSF...
Source: Alzheimer Disease and Associated Disorders - December 30, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Neuropsychological Testing in Pathologically Verified Alzheimer Disease and Frontotemporal Dementia: How Well Do the Uniform Data Set Measures Differentiate Between Diseases?
CONCLUSIONS: Other than memory, numerical scores of neurocognitive performance on the UDS are of limited value in differentiating FTLD from AD at the initial visit. These results highlight the difficulty of obtaining an accurate early diagnosis of FTLD and argue for adding supplemental tests to those included in the UDS to assess cognition in FTD and AD patients. PMID: 28005562 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - December 25, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Attenuation of Choroidal Thickness in Patients With Alzheimer Disease: Evidence From an Italian Prospective Study.
DISCUSSION: CT in patients with AD showed a rate of thinning greater than what could be expected during the natural course of aging. PMID: 27875364 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 23, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Impairment and Dementia in Older Adults With Chronic Kidney Disease: A Review.
Authors: Zammit AR, Katz MJ, Bitzer M, Lipton RB Abstract Individuals with chronic kidney disease (CKD), especially older adults, are at more risk of experiencing cognitive impairment, possibly leading to mild cognitive impairment and/or dementia. Studies report associations between CKD and cognitive impairment; although unclear, there seems to be a graded association between stage of CKD and affected cognitive domains, with executive function being affected earlier in the process than episodic memory and global ability. In CKD, dysexecutive mild cognitive impairment and vascular dementia are also more prominent th...
Source: Alzheimer Disease and Associated Disorders - November 20, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Pneumonia, Intake Problems, and Survival Among Nursing Home Residents With Variable Stages of Dementia in the Netherlands: Results From a Prospective Observational Study.
DISCUSSION: Developing pneumonia and intake problems affects survival, and this is not limited to advanced dementia. The occurrence of pneumonia and intake problems are important signals to consider a palliative care approach in nursing home residents with dementia, and an active focus on advance care planning is needed. Future studies should investigate whether this is also relevant for patients in primary care. PMID: 27849637 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Role of APOE ε4 Allele and Incident Stroke on Cognitive Decline and Mortality.
Role of APOE ε4 Allele and Incident Stroke on Cognitive Decline and Mortality. Alzheimer Dis Assoc Disord. 2016 Nov 15; Authors: Rajan KB, Aggarwal NT, Schneider JA, Wilson RS, Everson-Rose SA, Evans DA Abstract BACKGROUND: The apolipoprotein E (APOE) ε4 allele and stroke increase the risk of cognitive decline. However, the association of the APOE ε4 allele before and after stroke is not well understood. METHODS: Using a prospective sample of 3444 (66% African Americans, 61% females, mean age=71.9 y) participants, we examined cognitive decline relative to stroke among those ...
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

WeCareAdvisor ™: The Development of a Caregiver-focused, Web-based Program to Assess and Manage Behavioral and Psychological Symptoms of Dementia.
CONCLUSIONS: The WeCareAdvisor was designed with input on functionality and content by end-users, family caregivers. The randomized controlled trial of WeCareAdvisor will test whether the tool improves outcomes including caregiver upset and burden and frequency and severity of BPSD.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativ...
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Rapidly Progressive Dementia: Prevalence and causes in a Neurologic Unit of a Tertiary Hospital in Brazil.
CONCLUSIONS: Immune-mediated diseases were the most common cause of RPD in this series. Timely evaluation and diagnosis along with institution of appropriate therapy are required in RPD, especially in view of potentially reversible causes. PMID: 27849640 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology.
CONCLUSIONS: These findings potentially explain some of the variation in whether a person with AD neuropathology expresses symptoms. Understanding why some people remain cognitively normal despite having AD neuropathology could identify pathways to disease heterogeneity and guide treatment trials. PMID: 27849641 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sarcopenia is Associated With Impairment of Activities of Daily Living in Japanese Patients With Early-Stage Alzheimer Disease.
Authors: Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T PMID: 27849642 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 18, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Closing-in is Related to Daily Living Functioning in Patients With Mild-to-Moderate Alzheimer Disease.
Authors: De Lucia N, Grossi D, Trojano L PMID: 27819839 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Repressive Coping Does Not Contribute to Anosognosia in First-Diagnosis Patients With Alzheimer Disease.
Authors: Verhülsdonk S, Lange-Asschenfeldt C, Höft B, Schwender H, Supprian T, Hellen F, Kalbe E Abstract Anosognosia is common in patients with Alzheimer disease (AD) even in early stages. Although neural correlates and the impact of cognitive dysfunctions have been described, possible psychodynamic processes such as a repressive coping style as described in other illnesses, have not been examined. Our study aimed to examine possible psychological influence factors on illness perception embracing a repressive coping style and cognitive functions in AD patients in the diagnostic process. Fifty-four subjec...
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Recruiting US Chinese Elders Into Clinical Research for Dementia.
This study described and evaluated the rapid recruitment of elderly Chinese into clinical research at the Mount Sinai Alzheimer's Disease Research Center (MSADRC). DESIGN AND METHODS: Methods of publicizing the study included lectures to local senior centers/churches and publications in local Chinese newspapers. The amount of time and success of these methods were evaluated. A "go to them" model of evaluation was used to enable participants to complete the study visit at locations where they were comfortable. RESULTS: From January to December 2015, we recruited 98 participants aged 65 years or older who p...
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Low-dose Lithium Treatment for Agitation and Psychosis in Alzheimer Disease and Frontotemporal Dementia: A Case Series.
Authors: Devanand DP, Pelton GH, D'Antonio K, Strickler JG, Kreisl WC, Noble J, Marder K, Skomorowsky A, Huey ED PMID: 27819842 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia.
CONCLUSIONS: Specific functional deficits increased dementia risk and, with age and global cognition, constituted a validated clinical algorithm to estimate dementia risk. Clinicians can use this clinically important algorithm to personalize decision-making about further investigation and identify high-risk patients for early treatment or inclusion in clinical trials. PMID: 27819843 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Sociodemographic Characteristics, Cognitive Function, and Health-related Quality of Life of Patients Referred to Memory Assessment Services in England.
The objectives were to: describe the characteristics (age, sex, ethnicity, socioeconomic deprivation, and comorbidity) of referred patients, and examine the relationships between these characteristics and cognitive function (tertiles of Mini-Mental State Examination score) and health-related quality of life (HRQL) (DEMQOL, DEMQOL-Proxy). We used multivariable regression methods to analyze data from 1420 patients from 73 MAS, and their lay carers (n=1020). The mean age of patients was 78 years; 42% had cognitive function equivalent to Mini-Mental State Examination
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

The Potential Value of β-Amyloid Imaging for the Diagnosis and Management of Dementia: A Survey of Clinicians.
In conclusion, β-amyloid imaging can influence diagnosis, prescriptions, and patient management. PMID: 27819845 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Validity of Death Certificate and Hospital Discharge ICD Codes for Dementia Diagnosis: The Multi-Ethnic Study of Atherosclerosis.
Authors: Fujiyoshi A, Jacobs DR, Alonso A, Luchsinger JA, Rapp SR, Duprez DA PMID: 27819846 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - November 9, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Willingness to Be a Brain Donor: A Survey of Research Volunteers From 4 Racial/Ethnic Groups.
DISCUSSION: The predictive factors identified in this study may be useful for researchers seeking to increase participation of diverse ethnic groups in brain donation. PMID: 27779492 [PubMed - as supplied by publisher] (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 27, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Modeling Alzheimer's Disease Through Functional Independence and Participation.
This study aimed at investigating such relationships along AD evolution by means of the Disability Assessment for Dementia (DAD). METHODS: Consecutive pairs of AD outpatients and their primary informal caregivers were enrolled. Patients were evaluated by means of the Mini Mental State Examination and neuropsychological tests. A clinician completed the Clinical Dementia Rating Scale to stage dementia severity and interviewed the caregivers to complete the Neuropsychiatric Inventory to assess behavioral disturbances and the DAD to evaluate patients' functional competence. RESULTS: A total of 158 dyads were enrolled; ...
Source: Alzheimer Disease and Associated Disorders - October 20, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology.
We examined the relationship of diabetes and hemoglobin A1C (A1C) to 2 common causes of dementia. The study included 1228 subjects who underwent annual clinical evaluations and a brain autopsy at death, as part of a Rush longitudinal cohort study of aging. A total of 433 subjects had A1C data available. Neuropathologic evaluations documented the size and location of infarcts. Modified silver stain-based Alzheimer disease (AD) measures included global and regional scores. We used regression analyses to examine associations of diabetes and A1C with overall and regional neuropathology. Diabetes [odds ratio (OR)=0.94; 95% conf...
Source: Alzheimer Disease and Associated Disorders - October 20, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

Cognitive Impairment and Dementia in Older Adults With Chronic Kidney Disease: A Review
Individuals with chronic kidney disease (CKD), especially older adults, are at more risk of experiencing cognitive impairment, possibly leading to mild cognitive impairment and/or dementia. Studies report associations between CKD and cognitive impairment; although unclear, there seems to be a graded association between stage of CKD and affected cognitive domains, with executive function being affected earlier in the process than episodic memory and global ability. In CKD, dysexecutive mild cognitive impairment and vascular dementia are also more prominent than other subtypes. Explanations are directed toward traditional an...
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Review Article Source Type: research

Progressive Language Impairment in an English-Italian Bilingual Woman With Alzheimer Disease: An 18-Month Follow-up
No abstract available (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - October 1, 2016 Category: Geriatrics Tags: Brief Report Source Type: research