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Compassion Versus Accuracy: Lenient Scoring of the Spatial Orientation Items on the Mini-mental State Exam Lowers Sensitivity
We examined the effect of lenient SOE scoring on MMSE classification accuracy in a consecutive case series of 103 older adults (age 60 or above) clinically referred for neuropsychological evaluation. Lenient scoring of SOEs on the MMSE occurred in 53 (51.4%) patients and lowered the sensitivity by 7% to 18%, with variable gains in specificity (0% to 11%) to psychometrically operationalized cognitive impairment. Results are consistent with previous reports that lenient scoring is widespread and attenuates the sensitivity of the MMSE. Given the higher clinical priority of correctly detecting early cognitive decline over spec...
Source: Alzheimer Disease and Associated Disorders - February 1, 2024 Category: Psychiatry Authors: Katrina Kent Nesrine Adly Ibrahim Kristoffer Romero Shannon Baker Matthew Greenacre Chantal M Boucher Robert M Roth Laszlo A Erdodi Source Type: research

The Carer Assessment of MedicaTion Management GuidanCe for People With Dementia at Hospital Discharge (CATCH) Tool: Exploratory Factor Analysis
CONCLUSIONS: The CATCH tool can give the patient and carer an opportunity to provide feedback on key elements of medication management guidance delivered at discharge.PMID:38300882 | DOI:10.1097/WAD.0000000000000602 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2024 Category: Psychiatry Authors: Mouna Sawan Alexander Clough Ardalan Mirzaei Gabrielle J Widjaja Carl Schneider Yun-Hee Jeon Timothy Chen Sarah N Hilmer Danijela Gnjidic Source Type: research

Focusing on Earlier Management of Alzheimer Disease: Expert Opinion Based on a Modified Nominal Group Technique
CONCLUSIONS: Consensus was achieved regarding the need for educating primary care physicians on identifying people with cognitive impairment and for better diagnostic tools for its detection and early management. Management of mild cognitive impairment due to AD should encompass an adequate follow-up schedule aiming to maintain function for as long as possible, and primary care physicians and patients should be aware of the benefits of nonpharmacological interventions.PMID:38300883 | DOI:10.1097/WAD.0000000000000600 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2024 Category: Psychiatry Authors: Kristian Steen Frederiksen Xavier Morat ó Henrik Zetterberg Serge Gauthier Merc è Boada Vanesa Pytel Soeren Mattke Source Type: research

The Influence of Traffic Lights Presentation of Dementia Risk Screening Information on Older Adults' Motivations for Risk Reduction in Primary Care Settings
CONCLUSIONS: Traffic light presentation increases patient motivation to reduce dementia risk. Green-light information increases self-efficacy. Maximizing motivation through information presentation can decrease dementia prevalence.PMID:38300886 | DOI:10.1097/WAD.0000000000000598 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - February 1, 2024 Category: Psychiatry Authors: Diana Matovic Malene Ahern Xiaojing Lei Viviana M Wuthrich Source Type: research

Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness
DISCUSSION: AD with TBI represents a distinct group from AD, likely with distinct pathologic contributions beyond gray matter loss. This finding has important implications for the diagnosis and treatment of AD in the presence of TBI and indicates that models of AD, aging, and neural loss should account for TBI history.PMID:38285961 | DOI:10.1097/WAD.0000000000000607 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 29, 2024 Category: Psychiatry Authors: Gina M D'Souza Nathan W Churchill Dylan X Guan Marc A Khoury Simon J Graham Sanjeev Kumar Corinne E Fischer Tom A Schweizer Source Type: research

The Technology in Caring Questionnaire: Development and Psychometric Properties
CONCLUSION: The TCQ has good psychometric properties for the assessment of technology-based care strategies among dementia caregivers. Findings imply that the use of technologies may aid in symptom management and finding support and information but may also increase caregiver strain.PMID:38277628 | DOI:10.1097/WAD.0000000000000604 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2024 Category: Psychiatry Authors: Andrew M Kiselica Shayne S H Lin Rylea Ranum Cynthia M Mikula Greta Hermann Anna Boone Michael Scullin Dawn Mechanic-Hamilton Timothy Wolf Alan Stevens Jared F Benge Source Type: research

Delirium Severity and Physical Function in Hospitalized Persons Living With Dementia: Moderation by Age, Sex, and Race
CONCLUSIONS: Our findings suggest that age and sex may have differential effects on physical function across different levels of delirium severity in hospitalized persons living with dementia.PMID:38277635 | DOI:10.1097/WAD.0000000000000601 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2024 Category: Psychiatry Authors: Ashley Kuzmik Marie Boltz Barbara Resnick Rachel McPherson Marleny Rodriguez Brittany F Drazich Elizabeth Galik Source Type: research

Caregivers of People With Mild Cognitive Impairment and Dementia: Characterizing Social and Psychological Outcomes
CONCLUSIONS: Early life factors are relevant for caregivers of those with cognitive impairment and targeted prevention and early intervention may be helpful in alleviating caregiver burden and stress.PMID:38277636 | DOI:10.1097/WAD.0000000000000603 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2024 Category: Psychiatry Authors: Oanh L Meyer Shichen Zheng Raquel Alto Duyen Tran San Luu Uyen Vu Ladson Hinton Danielle Harvey Source Type: research

Rescreening on RBANS Delayed Memory Index? Forget About It!
CONCLUSIONS: The results from our analysis indicate that there is limited value in rescreening patients based on their initial RBANS DMI score.PMID:38277642 | DOI:10.1097/WAD.0000000000000606 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 26, 2024 Category: Psychiatry Authors: Marwan N Sabbagh Wojciech Michalak Charlotte Thim Hansen Christian Ahmad Wichmann Alice Clark Source Type: research

Application of Suggestive Biomarkers in Dementia With Lewy Bodies With Masking of Typical Clinical Symptoms by Alzheimer Disease-type Pathology
We describe the case of a 63-year-old woman who was initially diagnosed as having AD and later diagnosed with DLB based on suggestive biomarkers of DLB. In this case, transient sleep talking with physical movements for several days led to the assessment of suggestive biomarkers for DLB in the absence of the core clinical features of DLB. For clinicians, diagnosing DLB in patients with AD-type pathology is challenging. However, the application of biomarkers suggestive of DLB to all patients with dementia is not realistic. To overcome the difficulties of clinical diagnosis of DLB, further research is needed regarding strateg...
Source: Alzheimer Disease and Associated Disorders - January 16, 2024 Category: Psychiatry Authors: Ryota Kobayashi Daichi Morioka Shinobu Kawakatsu Kazutaka Sakamoto Akihito Suzuki Source Type: research

Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications
Alzheimer Dis Assoc Disord. 2024 Jan 17. doi: 10.1097/WAD.0000000000000599. Online ahead of print.ABSTRACTAlthough psychotic symptoms have been described in association with rare presenilin (PSEN) gene mutations underlying early-onset Alzheimer disease (AD), no contemporary reviews on this topic exist. The purpose of this review is to characterize the psychiatric phenotype (specifically with respect to psychosis) of PSEN1 and PSEN2 variant-associated AD. A PubMed search was completed in July 2023. Only articles that described individuals harboring a PSEN1 or PSEN2 mutation who experienced symptoms of psychosis were include...
Source: Alzheimer Disease and Associated Disorders - January 16, 2024 Category: Psychiatry Authors: Mark A Colijn Zahinoor Ismail Source Type: research

Identifying Stigmatizing Language Used by Israelis and Germans With a Mild Neurocognitive Disorder, Their Relatives, and Caregivers of People With Alzheimer's Disease
CONCLUSIONS: The study indicates that, despite culture and language differences, the use of stigmatic discourse and stigmatizing language is common among people with close exposure to dementia in Israel and Germany. Efforts should be increased to develop a person-centered and dementia-friendly language.PMID:38194484 | DOI:10.1097/WAD.0000000000000596 (Source: Alzheimer Disease and Associated Disorders)
Source: Alzheimer Disease and Associated Disorders - January 9, 2024 Category: Psychiatry Authors: Perla Werner Natalie Ulitsa Z ümrüt Alpinar-Sencan Daphna Shefet Silke Schicktanz Source Type: research

Risk of Neuropsychiatric Symptoms Among People Who Develop Cognitive Impairment With and Without a History of Post-traumatic Stress Disorder
Alzheimer Dis Assoc Disord. 2023 Dec 28. doi: 10.1097/WAD.0000000000000594. Online ahead of print.ABSTRACTWe aimed to prospectively assess the change in neuropsychiatric symptoms among people who develop cognitive impairment and have a history of post-traumatic stress disorder (PTSD). We analyzed longitudinal data from the National Alzheimer's Coordinating Center Unified Data Set (March 2015 to December 2021). Analyses included individuals who were cognitively normal and who had nonmissing assessment of PTSD at the initial visit and had at least 1 follow-up visit with cognitive impairment. We compared the difference in the...
Source: Alzheimer Disease and Associated Disorders - January 9, 2024 Category: Psychiatry Authors: Jaime Perales-Puchalt Kathryn Gauthreaux Jason D Flatt Oanh L Meyer Walter A Kukull Source Type: research