Recent studies on non-invasive biomarkers useful in biliary atresia - a literature review
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6858. Online ahead of print.ABSTRACTThe aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urina...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Anna Lew-Tusk Marta P ęksa Teresa Stachowicz-Stencel Source Type: research
Osteosarcoma's genetic landscape painted by genes' mutations
CONCLUSIONS: Their role in cancerogenesis was confirmed by the analysis of available articles published previously. The results of the study indicate that examination of selected genes' mutations might help to identify patients' predisposition to OS development, as well as monitor the disease progression, and establish prognosis. However, to fully understand the pathogenesis of OS further studies are required.PMID:37717265 | DOI:10.18388/abp.2020_6869 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Wiktoria Urban Dagmara Krzysta ńska Micha ł Piekarz Jerzy Nazar Anna Jankowska Source Type: research
Impact of diet modification on body mass and kidney function in patients with diabetic nephropathy: a pilot study
CONCLUSIONS: The study shows that obesity is a common comorbid disease in patients with DN and that dietary intervention is associated with a significant reduction in body mass and stabilization of eGFR in these patients.PMID:37717272 | DOI:10.18388/abp.2020_6889 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Ma łgorzata Kaczkan Sylwia Czaja-Stolc Ma łgorzata Sikorska-Wiśniewska Micha ł Chmielewski Alicja D ębska-Ślizień Sylwia Ma łgorzewicz Source Type: research
Pheochromocytoma and paraganglioma in children and adolescents
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6955. Online ahead of print.ABSTRACTPheochromocytoma (PPC) and paraganglioma (PGL) are the tumors that rarely occur in the pediatric population (PPGL). Both originate from chromaffin cells, pheochromocytoma is localized in the adrenal gland, whereas paragangliomas are regarded as the tumors present in other localizations, from head to the pelvis. The clinical image is characterized by the presence of the sustained hypertension, headaches, sweating, palpitations. The symptoms are caused by the catecholamine secretion or are related to tumor mass pressure on different org...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Teresa Stachowicz-Stencel Natalia Pasikowska Anna Synakiewicz Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
Recent studies on non-invasive biomarkers useful in biliary atresia - a literature review
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6858. Online ahead of print.ABSTRACTThe aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urina...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Anna Lew-Tusk Marta P ęksa Teresa Stachowicz-Stencel Source Type: research
Osteosarcoma's genetic landscape painted by genes' mutations
CONCLUSIONS: Their role in cancerogenesis was confirmed by the analysis of available articles published previously. The results of the study indicate that examination of selected genes' mutations might help to identify patients' predisposition to OS development, as well as monitor the disease progression, and establish prognosis. However, to fully understand the pathogenesis of OS further studies are required.PMID:37717265 | DOI:10.18388/abp.2020_6869 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Wiktoria Urban Dagmara Krzysta ńska Micha ł Piekarz Jerzy Nazar Anna Jankowska Source Type: research
Impact of diet modification on body mass and kidney function in patients with diabetic nephropathy: a pilot study
CONCLUSIONS: The study shows that obesity is a common comorbid disease in patients with DN and that dietary intervention is associated with a significant reduction in body mass and stabilization of eGFR in these patients.PMID:37717272 | DOI:10.18388/abp.2020_6889 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Ma łgorzata Kaczkan Sylwia Czaja-Stolc Ma łgorzata Sikorska-Wiśniewska Micha ł Chmielewski Alicja D ębska-Ślizień Sylwia Ma łgorzewicz Source Type: research
Pheochromocytoma and paraganglioma in children and adolescents
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6955. Online ahead of print.ABSTRACTPheochromocytoma (PPC) and paraganglioma (PGL) are the tumors that rarely occur in the pediatric population (PPGL). Both originate from chromaffin cells, pheochromocytoma is localized in the adrenal gland, whereas paragangliomas are regarded as the tumors present in other localizations, from head to the pelvis. The clinical image is characterized by the presence of the sustained hypertension, headaches, sweating, palpitations. The symptoms are caused by the catecholamine secretion or are related to tumor mass pressure on different org...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Teresa Stachowicz-Stencel Natalia Pasikowska Anna Synakiewicz Source Type: research
A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia
CONCLUSION: The study results revealed a negative correlation as well as a protective factor for AML with the C481T and G857A polymorphisms in the NAT2 gene.PMID:37715989 | DOI:10.18388/abp.2020_6235 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Abdullah Farasani Source Type: research
Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development
In conclusion, the results of this study reveal the role of circMETTL15 in CRC and the underlying molecular mechanism, which provides potential data support for the development of future CRC drugs.PMID:37715994 | DOI:10.18388/abp.2020_6470 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Feng Guo Yang Luo GuangYao Ye WeiJun Tang Source Type: research
Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer
Acta Biochim Pol. 2023 Sep 16. doi: 10.18388/abp.2020_6501. Online ahead of print.ABSTRACTBrain metastases (BM) are associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). Considering that, LGAS8-AS1-mediated progression of BM was probed in NSCLC. The clinical characteristics of 60 NSCLC patients (30 without BM and 30 with BM) were analyzed. NSCLC patients with BM had higher levels of LGALS8-AS1 than NSCLC patients without BM. Depleting LGALS8-AS1 prevented NSCLC cell proliferation, migration, invasion, and angiogenesis in vitro, and NSCLC tumorigenesis and BM in vivo. LGALS8-AS1 targeted miR-88...
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Jian Zhong Bo Wang Source Type: research
Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis
This study aimed to investigate the efficacy and safety of vitamin D supplementation in the treatment of allergic rhinitis (AR) using mometasone. A total of 140 patients with moderate and severe AR treated at our hospital between January 2017 and August 2020 were recruited as subjects for this study. The patients were randomly divided into control and experimental groups, with 70 patients in each group. Mometasone nasal spray was used in both groups, and vitamin D was administered to the experimental group for four weeks. The total nasal symptom scores (TNSS) and rhinoconjunctivitis quality of life questionnaire (RQLQ) wer...
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Minfei Guo Source Type: research
In silico explorations of bacterial mercuric reductase as an ecofriendly bioremediator for noxious mercuric intoxications
In this study, a mercuric reductase was extracted from Pseudomonas aeruginosa. The sequence of the enzyme was retrieved from the literature and structural homologs were identified. The protein bonded with Mercuric compounds and their interaction was briefly studied. Autodock Vina was used to perform a molecular docking with the target protein. Results showed that the sequence consists of most of the random coil 44.74% followed by α-helix and B-turns. Moreover, the protein was predicted to have a FAD/NAD(P)-binding domain. The virulence factor prediction using different approaches of Virulentpred and VICMpred suggested tha...
Source: Acta Biochim Pol - September 7, 2023 Category: Biochemistry Authors: Muhammad Naveed Muhammad Aqib Shabbir Tariq Aziz Ayesha Saleem Rida Naveed Ayaz Ali Khan Taqweem Ul Haq Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
Design and development of new inhibitors against breast cancer, Monkeypox and Marburg virus by modification of natural Fisetin via in silico and SAR studies
Acta Biochim Pol. 2023 Sep 7. doi: 10.18388/abp.2020_6667. Online ahead of print.ABSTRACTThe natural Fisetin and its derivatives have been shown to have effective bioactivity and strong pharmacological profile, which is continuously drawing the interest of therapeutic applications to the development of new biomolecules against Breast cancer and Monkeypox, and Marburg viral infection, while computational approaches and the study of their structure-activity relationship (SAR) are the most eloquent and reliable platform for performing their hypothetical profile renovation. So, the main perspective of this investigation is to ...
Source: Acta Biochim Pol - September 7, 2023 Category: Biochemistry Authors: Shopnil Akash Md Mominur Rahman Clara Mariana Gon çalves Lima Talha Bin Emran Sharifa Sultana Sumaira Naz Tariq Aziz Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
