Dynamic changes of serum miR-105-3p expression and prognostic value evaluation of postoperative thyroid cancer
CONCLUSIONS: The level of serum miR-105-3p is closely related to the degree of differentiation and lymph node metastasis in patients with thyroid cancer. Its level gradually decreases with the passage of time after surgery. It has a good diagnostic value for the prognosis of thyroid cancer after surgery and when it is expected to become a thyroid cancer surgery. Potential biomarkers for post-diagnosis.PMID:38112227 | DOI:10.18388/abp.2018_6398 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 19, 2023 Category: Biochemistry Authors: JianPing Zhou XiaoLong Song YuFang Li Yu Song Long Wei Ru Yang Source Type: research
Dynamic changes of serum miR-105-3p expression and prognostic value evaluation of postoperative thyroid cancer
CONCLUSIONS: The level of serum miR-105-3p is closely related to the degree of differentiation and lymph node metastasis in patients with thyroid cancer. Its level gradually decreases with the passage of time after surgery. It has a good diagnostic value for the prognosis of thyroid cancer after surgery and when it is expected to become a thyroid cancer surgery. Potential biomarkers for post-diagnosis.PMID:38112227 | DOI:10.18388/abp.2018_6398 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 19, 2023 Category: Biochemistry Authors: JianPing Zhou XiaoLong Song YuFang Li Yu Song Long Wei Ru Yang Source Type: research
JNK promotes the progression of castration-resistant prostate cancer
CONCLUSIONS: JNK overexpression promotes the development of CRPC via the regulation of ERK and MMP1.PMID:38099475 | DOI:10.18388/abp.2020_6610 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Yigeng Feng Hongwen Cao Dan Wang Lei Chen Renjie Gao Peng Sun Source Type: research
MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein
CONCLUSION: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.PMID:38099479 | DOI:10.18388/abp.2020_6660 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Xingyou Chen Chen Feng Jiliang Zha Zihao Shen Wei Ji Source Type: research
JNK promotes the progression of castration-resistant prostate cancer
CONCLUSIONS: JNK overexpression promotes the development of CRPC via the regulation of ERK and MMP1.PMID:38099475 | DOI:10.18388/abp.2020_6610 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Yigeng Feng Hongwen Cao Dan Wang Lei Chen Renjie Gao Peng Sun Source Type: research
MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein
CONCLUSION: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.PMID:38099479 | DOI:10.18388/abp.2020_6660 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Xingyou Chen Chen Feng Jiliang Zha Zihao Shen Wei Ji Source Type: research
JNK promotes the progression of castration-resistant prostate cancer
CONCLUSIONS: JNK overexpression promotes the development of CRPC via the regulation of ERK and MMP1.PMID:38099475 | DOI:10.18388/abp.2020_6610 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Yigeng Feng Hongwen Cao Dan Wang Lei Chen Renjie Gao Peng Sun Source Type: research
MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein
CONCLUSION: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.PMID:38099479 | DOI:10.18388/abp.2020_6660 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Xingyou Chen Chen Feng Jiliang Zha Zihao Shen Wei Ji Source Type: research
JNK promotes the progression of castration-resistant prostate cancer
CONCLUSIONS: JNK overexpression promotes the development of CRPC via the regulation of ERK and MMP1.PMID:38099475 | DOI:10.18388/abp.2020_6610 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Yigeng Feng Hongwen Cao Dan Wang Lei Chen Renjie Gao Peng Sun Source Type: research
MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein
CONCLUSION: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.PMID:38099479 | DOI:10.18388/abp.2020_6660 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Xingyou Chen Chen Feng Jiliang Zha Zihao Shen Wei Ji Source Type: research
JNK promotes the progression of castration-resistant prostate cancer
CONCLUSIONS: JNK overexpression promotes the development of CRPC via the regulation of ERK and MMP1.PMID:38099475 | DOI:10.18388/abp.2020_6610 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Yigeng Feng Hongwen Cao Dan Wang Lei Chen Renjie Gao Peng Sun Source Type: research
MicroRNA-508-3p regulates the proliferation of human lung cancer cells by targeting G1 to S phase transition 1 (GSPT1) protein
CONCLUSION: Our study identifies miR-508-3p as a pivotal regulator of lung cancer cell proliferation by targeting the GSPT1 protein. This highlights its potential as a tumor suppressor and a therapeutic target for lung cancer. Our findings offer mechanistic insights into miRNA-mediated cancer progression, prompting further research in this intricate regulatory network.PMID:38099479 | DOI:10.18388/abp.2020_6660 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - December 15, 2023 Category: Biochemistry Authors: Xingyou Chen Chen Feng Jiliang Zha Zihao Shen Wei Ji Source Type: research
Mapping the substrate-binding subsite specificity of a Porphyromonas gingivalis Tpr peptidase
Acta Biochim Pol. 2023 Dec 8. doi: 10.18388/abp.2020_6904. Online ahead of print.ABSTRACTCalcium-dependent peptidases of the calpain family are widespread in eukaryotes but uncommon in prokaryotes. A few bacterial calpain homologs have been discovered but none of them have been characterized in detail. Here we present an in-depth substrate specificity analysis of the bacterial calpain-like peptidase Tpr from Porphyromonas gingivalis. Using the positional scanning hybrid combinatorial substrate library method, we found that the specificity of Tpr peptidase differs substantially from the papain family of cysteine proteases, ...
Source: Acta Biochim Pol - December 8, 2023 Category: Biochemistry Authors: Dominika Staniec Wioletta Rut Marcin Drag Michal Burmistrz Michael Kitching Jan Potempa Source Type: research
LncRNA MIR31HG promotes cell proliferation and invasive properties of the MCF-7 cell line by regulation of receptor-interacting serine-threonine kinase 4
Acta Biochim Pol. 2023 Dec 8. doi: 10.18388/abp.2020_6842. Online ahead of print.ABSTRACTLncRNA MIR31HG is involved in many types of cancers, while its roles in breast cancer are still unknown. The current study aimed to explore the function of lncRNA MIR31HG in breast cancer and the underlying mechanisms. Stable expression cell lines were constructed by using lentivirus particles. MTT assay was used to determine cell viability. Wound healing and Transwell assay were used to determine cell migration and invasion, respectively. The changes in biomarkers were determined by using qPR-PCT and Western blotting, respectively. BA...
Source: Acta Biochim Pol - December 8, 2023 Category: Biochemistry Authors: Jingwei Tang Xiaojing Zhang Chunchun Chen Binbin Wang Yansong Chen Hao Zhang Mengxiang Qiao Xianfu Liu Wei Guo Gongsheng Jin Source Type: research
Mapping the substrate-binding subsite specificity of a Porphyromonas gingivalis Tpr peptidase
Acta Biochim Pol. 2023 Dec 8. doi: 10.18388/abp.2020_6904. Online ahead of print.ABSTRACTCalcium-dependent peptidases of the calpain family are widespread in eukaryotes but uncommon in prokaryotes. A few bacterial calpain homologs have been discovered but none of them have been characterized in detail. Here we present an in-depth substrate specificity analysis of the bacterial calpain-like peptidase Tpr from Porphyromonas gingivalis. Using the positional scanning hybrid combinatorial substrate library method, we found that the specificity of Tpr peptidase differs substantially from the papain family of cysteine proteases, ...
Source: Acta Biochim Pol - December 8, 2023 Category: Biochemistry Authors: Dominika Staniec Wioletta Rut Marcin Drag Michal Burmistrz Michael Kitching Jan Potempa Source Type: research
