Broad complex rhythm in neonates: is it always a cause for concern?
A baby born at 37 weeks’ gestation was noted to have premature beats in utero. He was born in good condition. The premature beats were heard intermittently in the first few hours of life. There was no significant family history. He remained well with normal observations and was discharged home after reassurance was provided. At 9 days of age an irregular pulse was noted again during an assessment for jaundice. On initial assessment, he appeared well. He had an irregular pulse but no other abnormalities in his cardiovascular examination. He required phototherapy for the jaundice. There were no electrolyte abnormalitie...
Source: Archives of Disease in Childhood - Education and Practice - March 19, 2024 Category: Pediatrics Authors: Oswal, A., Bharmappanavara, G., Spentzou, G. Tags: Epilogue Source Type: research
A pilot study for biliary atresia diagnosis: Fluorescent Imaging of Indocyanine Green in stool
Biliary atresia is the most common cause of obstructive jaundice in infants and conventional cholangiography is the current diagnostic gold standard. Fluorescent cholangiography with indocyanine green can enhance biliary tree visualization during surgery because it is exclusively excreted into the bile ducts and eventually into the intestine. Therefore, we hypothesized that indocyanine green presence in stool could confirm bile duct patency in infants. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 19, 2024 Category: Surgery Authors: Yi Zou Lim, Kevin Mutore, Maria Valencia Bradd, Samir Pandya, Natasha Corbitt Source Type: research
Intra ‐biliary hydatid cyst rupture: A rare case report with superinfection
Abdominal CT (coronal) scan demonstrating elongated left lobe of the liver mimicking a beaver's tail (blue arrow) with the normal right lobe of the liver (red arrow); a beaver tail appearance liver. Key Clinical MessageHydatid cysts, primarily found in the liver (70%), are caused by parasitic infections and can lead to severe complications such as cyst rupture. This case report describes a unique instance of a hydatid liver cyst occupying the right lobe with a communicating part with the biliary tree that ruptured showing a concurrent superinfection.AbstractHydatid cysts are a clinical pathology resulting from parasitic in...
Source: Clinical Case Reports - March 18, 2024 Category: General Medicine Authors: Hanan Al ‐Asbahi,
Jaber H. Jaradat,
Mohammad Abu‐Jeyyab,
Ruba Al‐Dwairi,
Bara'a W. Tailakh,
Rand A. Almadadha,
Ibraheem M. Alkhawaldeh,
Abdulqadir J. Nashwan Tags: CASE REPORT Source Type: research
Targeting IL-1 in severe alcohol-related hepatitis; how many frogs will we need to kiss to find an effective therapy?
Alcohol-related hepatitis (AH) is an acute presentation of alcohol-related liver disease characterised by jaundice and features of liver failure on a background of heavy and recent alcohol consumption.1 In the severe form, defined by Maddrey ’s Discriminant Function ≥32 or Model for End Stage Liver Disease (MELD) score ≥20 the mortality is around 30% at 90 days after presentation. Although corticosteroids are frequently used as specific treatment for severe AH, meta-analysis of numerous clinical trials demonstrates only a short te rm, 1 month, survival benefit which is lost by 3 months. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 16, 2024 Category: Gastroenterology Authors: Mark Thursz, Philippe Mathurin Tags: Editorial Source Type: research
Cajanus cajan induces mitochondrial-mediated apoptosis via caspase activation and cytochrome c release
ConclusionsThese findings suggest thatC. cajan-induced mitochondrial-mediated apoptosis in normal rat liver through the induction of mPT and eventual release of cytochrome c which is a prelude to the progression of apoptosis. Hence, certain bioactive components ofC. cajan may be useful in chemoprevention and management of conditions associated with insufficient apoptosis. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - March 16, 2024 Category: Pathology Source Type: research
Targeting IL-1 in severe alcohol-related hepatitis: How many frogs will we need to kiss to find an effective therapy?
Alcohol-related hepatitis (AH) is an acute presentation of alcohol-related liver disease characterised by jaundice and features of liver failure on a background of heavy and recent alcohol consumption.1 In the severe form, defined by Maddrey ’s discriminant function ≥32 or model for end-stage liver disease score (MELD) ≥20, mortality is around 30% at 90 days after presentation. Although corticosteroids are frequently used as specific treatment for severe AH, a meta-analysis of numerous clinical trials demonstrated only a short ter m (1 month) survival benefit which was lost by 3 months. (Source: Journal of Hepatology)
Source: Journal of Hepatology - March 16, 2024 Category: Gastroenterology Authors: Mark Thursz, Philippe Mathurin Tags: Editorial Source Type: research
