Identification of a Novel IGSF1 Variant in Two Malaysian Male Siblings with Central Hypothyroidism and Macroorchidism
J Clin Res Pediatr Endocrinol. 2024 Apr 22. doi: 10.4274/jcrpe.galenos.2024.2023-12-1. Online ahead of print.ABSTRACTIGSF1 mutation is the commonest cause of mild to moderate isolated central congenital hypothyroidism and has an X-linked recessive inheritance, primarily affecting males. Other notable clinical features are macroorchidism with delayed pubertal testosterone rise, large birth weight, increased body mass index, low prolactin, transient growth hormone deficiency and low prolactin. Two male siblings with central hypothyroidism were found to have a novel IGSF1 c.3467T>A variant that was likely pathogenic based ...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 22, 2024 Category: Endocrinology Authors: Yee Lin Lee Tzer Hwu Ting Chong Teik Lim Karuppiah Thilakavathy Nurul Huda Musa King Hwa Ling Source Type: research
Trips Through the Skin: Reviewing Cutaneous Drug Reactions to Psychedelics and Hallucinogens
Dermatitis. 2024 Apr 17. doi: 10.1089/derm.2023.0292. Online ahead of print.ABSTRACT Although psychedelic and hallucinogenic substances have gained popularity for therapeutic use, their dermatologic adverse effects are poorly characterized. This review characterizes the cutaneous reactions associated with psychedelic and hallucinogenic drugs. A review of PubMed and Scopus was conducted from the inception of databases to August 31, 2023. Search terms included drug names and classes (cannabis, MDMA, ecstasy, 3,4-methylenedioxymethamphetamine, psychedelics, hallucinogens, peyote, marijuana, lysergic acid diethylamide, LSD, ke...
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Syed Minhaj Rahman Yousef Salem Aamir Hussain Source Type: research
Trips Through the Skin: Reviewing Cutaneous Drug Reactions to Psychedelics and Hallucinogens
Dermatitis. 2024 Apr 17. doi: 10.1089/derm.2023.0292. Online ahead of print.ABSTRACT Although psychedelic and hallucinogenic substances have gained popularity for therapeutic use, their dermatologic adverse effects are poorly characterized. This review characterizes the cutaneous reactions associated with psychedelic and hallucinogenic drugs. A review of PubMed and Scopus was conducted from the inception of databases to August 31, 2023. Search terms included drug names and classes (cannabis, MDMA, ecstasy, 3,4-methylenedioxymethamphetamine, psychedelics, hallucinogens, peyote, marijuana, lysergic acid diethylamide, LSD, ke...
Source: Dermatitis - April 18, 2024 Category: Dermatology Authors: Syed Minhaj Rahman Yousef Salem Aamir Hussain Source Type: research
Serous cystic neoplasm of pancreas with surgical obstructive jaundice and double duct sign: Cystadenoma or cystadenocarcinoma?
(Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 18, 2024 Category: Gastroenterology Source Type: research
Robotic Biliary Stricturoplasty and Roux-en-Y Hepaticojejunostomy After Hepatic Artery Infusion Pump Injury
CONCLUSIONS: Robotic biliary stricturoplasty with RY hepaticojejunostomy for treatment of biliary sclerosis after HAIP chemotherapy is safe and feasible. Appropriate experience in minimally invasive hepatobiliary surgery is necessary to achieve this goal.PMID:38632219 | DOI:10.1245/s10434-024-15258-0 (Source: Ann Oncol)
Source: Ann Oncol - April 17, 2024 Category: Cancer & Oncology Authors: Emanuel Shapera Sharona Ross Tara Pattilachan Maria Christodoulou Iswanto Sucandy Source Type: research
ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review
J Nephrol. 2024 Apr 17. doi: 10.1007/s40620-024-01924-9. Online ahead of print.ABSTRACTLeukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis. Membranous nephropathy and diabetic nephropathy are common causes of nephrotic syndrome. Here we report a 49-year-old Hispanic male patient with diabetes mellitus who presented with jaundice and pruritus. IgG4-related autoimmune pancreatitis was diagnosed through laboratory workup and ampulla biopsy. He...
Source: Journal of Nephrology - April 17, 2024 Category: Urology & Nephrology Authors: Muhammad Shaheen Anchit Bharat Allon N Friedman Shunhua Guo Source Type: research
Robotic Biliary Stricturoplasty and Roux-en-Y Hepaticojejunostomy After Hepatic Artery Infusion Pump Injury
CONCLUSIONS: Robotic biliary stricturoplasty with RY hepaticojejunostomy for treatment of biliary sclerosis after HAIP chemotherapy is safe and feasible. Appropriate experience in minimally invasive hepatobiliary surgery is necessary to achieve this goal.PMID:38632219 | DOI:10.1245/s10434-024-15258-0 (Source: Ann Oncol)
Source: Ann Oncol - April 17, 2024 Category: Cancer & Oncology Authors: Emanuel Shapera Sharona Ross Tara Pattilachan Maria Christodoulou Iswanto Sucandy Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China
Int J Food Microbiol. 2024 Mar 25;417:110682. doi: 10.1016/j.ijfoodmicro.2024.110682. Online ahead of print.ABSTRACTHepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned. An epidemiological investigation was conducted on all individuals in the nursing home, including demographic...
Source: International Journal of Food Microbiology - April 16, 2024 Category: Food Science Authors: Ziping Miao Kexin Cao Xiaoyue Wu Chenye Zhang Jian Gao Yin Chen Zhou Sun Xiaobin Ren Yijuan Chen Mengya Yang Can Chen Daixi Jiang Yuxia Du Xin Lv Shigui Yang Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China
Int J Food Microbiol. 2024 Mar 25;417:110682. doi: 10.1016/j.ijfoodmicro.2024.110682. Online ahead of print.ABSTRACTHepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned. An epidemiological investigation was conducted on all individuals in the nursing home, including demographic...
Source: International Journal of Food Microbiology - April 16, 2024 Category: Food Science Authors: Ziping Miao Kexin Cao Xiaoyue Wu Chenye Zhang Jian Gao Yin Chen Zhou Sun Xiaobin Ren Yijuan Chen Mengya Yang Can Chen Daixi Jiang Yuxia Du Xin Lv Shigui Yang Source Type: research
Precirrhotic Primary Biliary Cholangitis with Portal Hypertension: Bile Duct Injury Correlate
CONCLUSIONS: : Approximately 24.2% of precirrhotic PBC patients have PH, which is histologically related to the injury of bile ducts. High alkaline phosphatase levels, low white blood cell counts, high Mayo scores, and high FIB-4 index values are associated with increased risk of precirrhotic PBC with PH.PMID:38623061 | DOI:10.5009/gnl230468 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Yi-Fan Hu Shun-Xin Li Hong-Li Liu Zhi-Xiang Du Shuang-Shuang Wang Miao-Yang Chen Li Wang Qing-Fang Xiong Yan-Dan Zhong Du-Xian Liu Yong-Feng Yang Source Type: research
Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis
ConclusionsFindings recommend that leptospirosis patients be treated with antibiotics, which significantly reduced the leptospirosis defervescence time. Cephalosporins, doxycycline, and penicillin are suggested, and azithromycin may be a suitable alternative for drug-resistant cases.Systematic review registrationPROSPERO CRD42022354938. (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2024 Category: International Medicine & Public Health Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
