Empagliflozin treatment rescues abnormally reduced Na currents in ventricular cardiomyocytes from dystrophin-deficient mdx mice
Am J Physiol Heart Circ Physiol. 2023 Dec 15. doi: 10.1152/ajpheart.00729.2023. Online ahead of print.ABSTRACTCardiac arrhythmias significantly contribute to mortality in Duchenne muscular dystrophy (DMD), a severe muscle illness caused by mutations in the gene encoding for the intracellular protein dystrophin. A major source for arrhythmia vulnerability in patients with DMD is impaired ventricular impulse conduction, which predisposes for ventricular asynchrony, decreased cardiac output and the development of reentrant circuits. Using the dystrophin-deficient mdx mouse model for human DMD, we previously reported that the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 15, 2023 Category: Physiology Authors: Jakob Sauer Jessica Marksteiner Elena Lilliu Benjamin Hackl Hannes Todt Helmut Kubista Christopher Dostal Bruno K Podesser Attila Kiss Xaver Koenig Karlheinz Hilber Source Type: research
Empagliflozin treatment rescues abnormally reduced Na currents in ventricular cardiomyocytes from dystrophin-deficient mdx mice
Am J Physiol Heart Circ Physiol. 2023 Dec 15. doi: 10.1152/ajpheart.00729.2023. Online ahead of print.ABSTRACTCardiac arrhythmias significantly contribute to mortality in Duchenne muscular dystrophy (DMD), a severe muscle illness caused by mutations in the gene encoding for the intracellular protein dystrophin. A major source for arrhythmia vulnerability in patients with DMD is impaired ventricular impulse conduction, which predisposes for ventricular asynchrony, decreased cardiac output and the development of reentrant circuits. Using the dystrophin-deficient mdx mouse model for human DMD, we previously reported that the ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 15, 2023 Category: Physiology Authors: Jakob Sauer Jessica Marksteiner Elena Lilliu Benjamin Hackl Hannes Todt Helmut Kubista Christopher Dostal Bruno K Podesser Attila Kiss Xaver Koenig Karlheinz Hilber Source Type: research
Empagliflozin alleviates atherosclerotic calcification by inhibiting osteogenic differentiation of vascular smooth muscle cells
Front Pharmacol. 2023 Nov 29;14:1295463. doi: 10.3389/fphar.2023.1295463. eCollection 2023.ABSTRACTSGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE-/- mice were fed with western diet and empagliflozin was added to the drinking water for 24 weeks. Empagliflozin treatment significantly alleviated arterial calcification assessed by alizarin red and von kossa staining in aortic roots and reduced the lipid levels, while had little effe...
Source: Atherosclerosis - December 14, 2023 Category: Cardiology Authors: Junping Li Changping Li Zhaoqi Huang Chunling Huang Juanzhang Liu Tao Wu Shuwan Xu Peibiao Mai Dengfeng Geng Shuxian Zhou Kun Zhang Zhaoyu Liu Source Type: research
Empagliflozin alleviates atherosclerotic calcification by inhibiting osteogenic differentiation of vascular smooth muscle cells
Front Pharmacol. 2023 Nov 29;14:1295463. doi: 10.3389/fphar.2023.1295463. eCollection 2023.ABSTRACTSGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE-/- mice were fed with western diet and empagliflozin was added to the drinking water for 24 weeks. Empagliflozin treatment significantly alleviated arterial calcification assessed by alizarin red and von kossa staining in aortic roots and reduced the lipid levels, while had little effe...
Source: Atherosclerosis - December 14, 2023 Category: Cardiology Authors: Junping Li Changping Li Zhaoqi Huang Chunling Huang Juanzhang Liu Tao Wu Shuwan Xu Peibiao Mai Dengfeng Geng Shuxian Zhou Kun Zhang Zhaoyu Liu Source Type: research
Insulin Resistance/Diabetes and Schizophrenia: Potential Shared Genetic Factors and Implications for Better Management of Patients with Schizophrenia
The objective of this narrative review was to synthesize important studies, including Mendelian randomization (MR) analyses that have integrated genome-wide association studies (GWAS), as well as results from in vitro models, in vivo models, and observational studies of patients with schizophrenia. Both GWAS and MR studi es have found that schizophrenia and T2D/insulin resistance share genetic risk factors, and this may mediate a connection between peripheral or brain insulin resistance and T2D with cognition impairment and an increased risk of developing prediabetes and T2D in schizophrenia. Moreover, accumulating evidenc...
Source: CNS Drugs - December 14, 2023 Category: Neurology Source Type: research
Cardioprotective Effects of Sodium-Glucose Cotransporter 2 Inhibitors and Their Possible Association With Normalization of the Circadian Index of Heart Rhythm
CONCLUSION: The use of SGLT2 inhibitors during early treatment can favorably affect both autonomic dysfunction and functional effort capacity of patients with type 2 diabetes with ischemic HFrEF.PMID:38083821 | DOI:10.14503/THIJ-23-8196 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - December 12, 2023 Category: Cardiology Authors: Nazile Bilgin Dogan Hamiyet Yilmaz Yasar Baris Kilicaslan Source Type: research
Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury
Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulat... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - December 12, 2023 Category: Neurology Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su and Yehong Zhuo Tags: Research Source Type: research
Protective effects of empagliflozin on methotrexate induced hepatotoxicity in rats
This study was aimed to evaluate the effect of Empagliflozin on liver injury induced by MTX in rats. The rats were divided into five groups as control, MTX (20 mg/kg; i.p.), Empagliflozin (30 mg/kg/day; i.p.), MTX and Empagliflozin (10 and 30 mg/kg/day; i.p.). Histopathologic alterations were examined for assessment of the liver injury. Furthermore, the levels of tissue malondialdehyde (MDA) and activity of anti-oxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, as well as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were evaluated. Our results rev...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2023 Category: Drugs & Pharmacology Authors: Elham Kalantari Naime Majidi Zolbanin Morteza Ghasemnejad-Berenji Source Type: research
RNA-Seq Analysis of ceRNA-Related Networks in the Regulatory Metabolic Pathway of Mice with Diabetic Nephropathy Subjected to Empagliflozin Intervention
CONCLUSIONS: The analysis of DEGs and key core genes in this study enhanced our understanding of the effect of empagliflozin on the pathogenesis of DN and provided more potential gene targets and application ideas for DN treatment.PMID:38053423 | DOI:10.56434/j.arch.esp.urol.20237609.83 (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - December 6, 2023 Category: Urology & Nephrology Authors: Ting Wu Zhiqin Zhang Haowen Huang Xiaoyan Wu Source Type: research
