Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Doxorubicin ‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
Mol Med Rep. 2024 May;29(5):74. doi: 10.3892/mmr.2024.13198. Epub 2024 Mar 15.ABSTRACTDoxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation ...
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Akshi Malik Ashim K Bagchi Davinder S Jassal Pawan K Singal Source Type: research
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)
This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.PMID:38488029 | PMC:PMC10955520 | DOI:10.3892/mmr.2024.13197 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - March 15, 2024 Category: Molecular Biology Authors: Bixian Chen Jing Guo Hongmei Ye Xinyu Wang Yufei Feng Source Type: research
Identification of key genes increasing susceptibility to atrial fibrillation in nonalcoholic fatty liver disease and the potential mechanisms: mitochondrial dysfunction and systemic inflammation
Conclusion: Our study firstly discovered that AMOT, PDE11A, TYMS, TMEM98, and PTGS2 are associated with NAFLD-related AF and hold strong diagnostic values. Our study also indicates that mitochondrial dysfunction and systemic inflammation may be potential mechanisms bridging NAFLD and AF. Additionally, we identified empagliflozin as a potentially effective therapeutic agent for NAFLD-related AF at the molecular structure level. These novel insights contribute to the further understanding, diagnosis, and intervention of NAFLD-related AF. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
Nature and Magnitude of the Benefits of Dapagliflozin and Empagliflozin for Heart Failure
Circulation. 2024 Mar 12;149(11):839-842. doi: 10.1161/CIRCULATIONAHA.123.068089. Epub 2024 Mar 11.NO ABSTRACTPMID:38466791 | DOI:10.1161/CIRCULATIONAHA.123.068089 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: John G F Cleland Source Type: research
Nature and Magnitude of the Benefits of Dapagliflozin and Empagliflozin for Heart Failure
Circulation. 2024 Mar 12;149(11):839-842. doi: 10.1161/CIRCULATIONAHA.123.068089. Epub 2024 Mar 11.NO ABSTRACTPMID:38466791 | DOI:10.1161/CIRCULATIONAHA.123.068089 (Source: Circulation)
Source: Circulation - March 11, 2024 Category: Cardiology Authors: John G F Cleland Source Type: research
