Nature PastCast, August 1975: Antibodies ’ ascendency to blockbuster drug status
This year, Nature celebrates its 150th birthday. To mark this anniversary we’re rebroadcasting episodes from our PastCast series, highlighting key moments in the history of science.They’re found in home-testing kits for pregnancy, hospital tests for MRSA, and in six out of ten of the best-selling drugs today. But monoclonal antibodies have kept a surprisingly low profile since their debut in a Nature paper in 1975. This podcast follows them from that time through patent wars, promising drug trials and finally to blockbuster status today.This episode was first broadcast in August 2013.From the archive:Continuous culture...
Source: Nature Podcast - August 30, 2019 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Nature PastCast, August 1975: Antibodies ’ ascendency to blockbuster drug status
This year, Nature celebrates its 150th birthday. To mark this anniversary we’re rebroadcasting episodes from our PastCast series, highlighting key moments in the history of science.They’re found in home-testing kits for pregnancy, hospital tests for MRSA, and in six out of ten of the best-selling drugs today. But monoclonal antibodies have kept a surprisingly low profile since their debut in a Nature paper in 1975. This podcast follows them from that time through patent wars, promising drug trials and finally to blockbuster status today.This episode was first broadcast in August 2013.From the archive:Continuous culture...
Source: Nature Podcast - August 30, 2019 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 559: Nectin connection what's your infection?
The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Fire Alarm at ASV Ebola outbreak sitrep(WHO) Ebola outbreak dashboard(WHO) Ebola outbreakDRC (MSF) Ebola articles at CIDRAP Ebola virus vaccine could run out(STAT news) Nectin mediated cytoplasmic transfer(J Cell S...
Source: This Week in Virology - MP3 Edition - August 4, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
04 July 2019: Machine learning in materials science, and sand ’s sustainability
This week, using an algorithm to find properties in materials science, and the global consequences of sand-mining.In this episode:00:47 Predicting propertiesA word-association algorithm is reading millions of abstracts to discover new properties of materials. Research article: Tshitoyan et al.; News and Views: Text mining facilitates materials discovery08:28 Research HighlightsTiny robot-jellyfish, and genome mutation hot-spots. Research Article:Multi-functional soft-bodied jellyfish-like swimming; Research Highlight:How DNA ‘hotspots’ snarl the search for cancer genes10:48 Sand under stra...
Source: Nature Podcast - July 3, 2019 Category: Science Authors: Springer Nature Limited Source Type: podcasts
04 July 2019: Machine learning in materials science, and sand ’s sustainability
This week, using an algorithm to find properties in materials science, and the global consequences of sand-mining.In this episode:00:47 Predicting propertiesA word-association algorithm is reading millions of abstracts to discover new properties of materials. Research article: Tshitoyan et al.; News and Views: Text mining facilitates materials discovery08:28 Research HighlightsTiny robot-jellyfish, and genome mutation hot-spots. Research Article:Multi-functional soft-bodied jellyfish-like swimming; Research Highlight:How DNA ‘hotspots’ snarl the search for cancer genes10:48 Sand under stra...
Source: Nature Podcast - July 3, 2019 Category: Science Authors: Springer Nature Limited Source Type: podcasts
04 July 2019: Machine learning in materials science, and sand ’s sustainability
This week, using an algorithm to find properties in materials science, and the global consequences of sand-mining.In this episode:00:47 Predicting propertiesA word-association algorithm is reading millions of abstracts to discover new properties of materials. Research article: Tshitoyan et al.; News and Views: Text mining facilitates materials discovery08:28 Research HighlightsTiny robot-jellyfish, and genome mutation hot-spots. Research Article:Multi-functional soft-bodied jellyfish-like swimming; Research Highlight:How DNA ‘hotspots’ snarl the search for cancer genes10:48 Sand under stra...
Source: Nature Podcast - July 3, 2019 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 542: Inside Microbiotix
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps by Jolene. Thanks! Listener Pick Islam- How to successfully collaborate with industry Intro music is by Ronald Jenkees. Se...
Source: This Week in Virology - MP3 Edition - April 7, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Mark S. Sulkowski, MD - Addressing the Evolving Opioid and HCV Epidemics Through Community Engagement and Education
Go online to PeerView.com/QYB860 to view the entire program with slides. In this activity, which is based on recent live meetings held in Baltimore and Cambridge, Maryland, clinicians practicing on the front-lines of the intersecting hepatitis C and opioid epidemics offer thought-provoking perspectives on identifying HCV among people with substance use disorders who live in urban and rural healthcare settings and successfully engaging them in care to achieve better patient and community outcomes. Upon completion of this activity, participants will be able to: Evaluate patients with, or at risk of, hepatitis C virus (HCV) i...
Source: PeerView CME/CE Audio Podcast - Primary Care - March 25, 2019 Category: Primary Care Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
"Mudicinal Properties" -- The Discovery Files
Arizona State University and Mayo Clinic researchers have found that one type of clay, Oregon blue clay, may help fight disease-causing bacteria in wounds, including treatment-resistant bacteria. In laboratory tests, the researchers found that the clay has antibacterial effects against bacteria such as Escherichia coli and Staphylococcus aureus, including strains such as carbapenem-resistant Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA). (Source: The Discovery Files)
Source: The Discovery Files - September 6, 2018 Category: Science Authors: National Science Foundation Source Type: podcasts
Have we misunderstood TB's timeline?
The number of people estimated to be latently infected with TB - that is infected with TB, which has not yet manifested symptoms - is around 2 billion. That is 1 in 3 people on the planet are infected by the bacteria. The World Health Organization ’s website notes that on average 5-10% of those infected with TB will develop active TB.
That number is terrifying, but a new analysis published in the BMJ, suggests that the assumption that latent TB often has a very long incubation period of many years may be wrong - and that may change how we calculate the number of people affected, and our whole approach to tackling the di...
Source: The BMJ Podcast - August 23, 2018 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Have we misunderstood TB ’s timeline?
The number of people estimated to be latently infected with TB - that is infected with TB, which has not yet manifested symptoms - is around 2 billion. That is 1 in 3 people on the planet are infected by the bacteria. The World Health Organization’s website notes that on average 5-10% of those infected with TB will develop active TB.
That number is terrifying, but a new analysis published in the BMJ, suggests that the assumption that latent TB often has a very long incubation period of many years may be wrong - and that may change how we calculate the number of people affected, and our whole approach to tackling the dis...
Source: The BMJ Podcast - August 23, 2018 Category: General Medicine Authors: BMJ Group Source Type: podcasts
TWiV 500: Keep virology weird
The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jinny Suh, Jason McClellan, and Jon Huibregtse Become a patron of TWiV! Links for this episode A big list of science podcasts Immunize Texas McClellan Lab Huibregtse Lab John Ring LaMontagne Center for Infectious Disease Video of this episode (YouTube) Weekly Science Picks Alan - The Airplane Cabin Microbiome Rich - Coalition for Epidemic Preparedness Innovations (CEPI)(wiki) ...
Source: This Week in Virology - MP3 Edition - July 1, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Sketching suspects with DNA, and using light to find Zika-infected mosquitoes
DNA fingerprinting has been used to link people to crimes for decades, by matching DNA from a crime scene to DNA extracted from a suspect. Now, investigators are using other parts of the genome —such as markers for hair and eye color—to help rule people in and out as suspects. Staff Writer Gretchen Vogel talks with Sarah Crespi about whether science supports this approach and how different countries are dealing with this new type of evidence.
Sarah also talks with Jill Fernandes of th e University of Queensland in Brisbane, Australia, about her Science Advances paper on a light-based technique for detecting Zika in mo...
Source: Science Magazine Podcast - May 24, 2018 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts
Sketching suspects with DNA, and using light to find Zika-infected mosquitoes
DNA fingerprinting has been used to link people to crimes for decades, by matching DNA from a crime scene to DNA extracted from a suspect. Now, investigators are using other parts of the genome —such as markers for hair and eye color—to help rule people in and out as suspects. Staff Writer Gretchen Vogel talks with Sarah Crespi about whether science supports this approach and how different countries are dealing with this new type of evidence. Sarah also talks with Jill Fernandes of the University of Queensland in Brisbane, Australia, about her Science Advances paper on a light-based technique for detecting Zika in mosq...
Source: Science Magazine Podcast - May 24, 2018 Category: Science Authors: Science Tags: Scientific Community Source Type: podcasts
