Anti-malarial humoral immunity: the long and short of it
Publication date: Available online 5 March 2021Source: Microbes and InfectionAuthor(s): Kai J. Rogers, Rahul Vijay, Noah S. Butler (Source: Microbes and Infection)
Source: Microbes and Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Bacterial and fungal co-infections among COVID-19 patients in intensive care unit
Publication date: Available online 5 March 2021Source: Microbes and InfectionAuthor(s): Siyuan Yang, Mingxi Hua, Xinzhe Liu, Chunjing Du, Lin Pu, Pan Xiang, Linghang Wang, Jingyuan Liu (Source: Microbes and Infection)
Source: Microbes and Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

A machine learning approach to predict healthcare-associated infections at intensive care unit admission: findings from the SPIN-UTI project
Publication date: Available online 5 March 2021Source: Journal of Hospital InfectionAuthor(s): Martina Barchitta, Andrea Maugeri, Giuliana Favara, Paolo Marco Riela, Giovanni Gallo, Ida Mura, Antonella Agodi, Paola Murgia, Maria Dolores Masia, Silvio Brusaferro, Daniele Celotto, Luca Arnoldo, Emanuela Bissolo, Alberto Rigo, Stefano Tardivo, Francesca Moretti, Alberto Carli, Diana Pascu, Lorella Tessari, Mara Olga Bernasconi (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Case for diagnosis. Erythematous and infiltrated plaques in the infrahyoid region,
This report describes the case of a 46-year-old man who had hypoesthetic lesions in the infrahyoid region for 30 days. The bacilloscopy was negative. The anatomopathological examination showed alterations corresponding to the tuberculoid pole (epithelioid histiocytes) and virchowian pole (foamy histiocytes), compatible with borderline-virchowian leprosy (Ridley and Jopling classification). Rapid tests for HIV I, II, and syphilis were positive, with a CD4 count of 223. The patient started treatment with multibacillary multidrug therapy, antiretroviral therapy, and benzathine penicillin, with marked clinical improvement in t...
Source: Anais Brasileiros de Dermatologia - March 5, 2021 Category: Dermatology Source Type: research

HIV/AIDS cast a dark shadow on 1980s London gay culture
Publication date: Available online 3 March 2021Source: The Lancet HIVAuthor(s): Talha Burki (Source: The Lancet HIV)
Source: The Lancet HIV - March 5, 2021 Category: Infectious Diseases Source Type: research

Clinical characteristics and risk factors for the isolation of multi-drug-resistant Gram-negative bacteria from critically ill patients with COVID-19
Publication date: April 2021Source: Journal of Hospital Infection, Volume 110Author(s): A. Baiou, A.A. Elbuzidi, D. Bakdach, A. Zaqout, K.M. Alarbi, A.A. Bintaher, M.M.B. Ali, A.M. Elarabi, G.A.M. Ali, J. Daghfal, M.A. Almaslamani, A.S.S. Ibrahim, A. Alkhal, A.S. Omrani (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Rapid detection and differentiation of mobile colistin resistance (mcr-1 to mcr-10) genes by real-time PCR and melt-curve analysis
Publication date: April 2021Source: Journal of Hospital Infection, Volume 110Author(s): M. Mentasti, S. David, K. Sands, S. Khan, L. Davies, L. Turner, M. Wootton (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

The accuracy of fully automated algorithms for surveillance of healthcare-associated urinary tract infections in hospitalized patients
Publication date: April 2021Source: Journal of Hospital Infection, Volume 110Author(s): S.D. van der Werff, E. Thiman, H. Tanushi, J.K. Valik, A. Henriksson, M. Ul Alam, H. Dalianis, A. Ternhag, P. Nauclér (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Flexible gastrointestinal endoscope processing challenges, current issues and future perspectives
Publication date: April 2021Source: Journal of Hospital Infection, Volume 110Author(s): N. Omidbakhsh, S. Manohar, R. Vu, K. Nowruzi (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Effect of skin antiseptic solutions on the incidence of catheter-related bloodstream infection: a systematic review and network meta-analysis
Publication date: April 2021Source: Journal of Hospital Infection, Volume 110Author(s): T. Masuyama, H. Yasuda, M. Sanui, A.K. Lefor (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

SARS-CoV-2 decontamination of skin with disinfectants active during and after application
Publication date: Available online 10 February 2021Source: Journal of Hospital InfectionAuthor(s): R.K. Campos, D. Mirchandani, G. Rafael, N. Saada, R. McMahon, S.C. Weaver (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

Glucose - The X factor for the survival of human fungal pathogens and disease progression in the host
Publication date: June 2021Source: Microbiological Research, Volume 247Author(s): Hafsa Qadri, Munazah Fazal Qureshi, Manzoor Ahmad Mir, Abdul Haseeb Shah (Source: Microbiological Research)
Source: Microbiological Research - March 5, 2021 Category: Infectious Diseases Source Type: research

The chemical profile of activated secondary metabolites by overexpressing LaeA in Aspergillus niger
Publication date: Available online 3 March 2021Source: Microbiological ResearchAuthor(s): Bin Wang, Xuejie Li, Jioji Tabudravu, Shan Wang, Hai Deng, Li Pan (Source: Microbiological Research)
Source: Microbiological Research - March 5, 2021 Category: Infectious Diseases Source Type: research

Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: A retrospective study
Publication date: Available online 3 March 2021Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Paige C. Grossman, David A. Schneider, David R. Herndon, Donald P. Knowles, Margaret A. Highland (Source: Comparative Immunology, Microbiology and Infectious Diseases)
Source: Comparative Immunology, Microbiology and Infectious Diseases - March 5, 2021 Category: Infectious Diseases Source Type: research

Human epigenetics may play role in MRSA infection outcomes
DNA-methylation signatures can distinguish between persistent and resolving MRSA infections (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - March 5, 2021 Category: Chemistry Source Type: research

Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis
Publication date: Available online 3 March 2021Source: Journal of Pharmaceutical AnalysisAuthor(s): Surajit Mistry, Subhasish Burman, Subhasis Roy, Nilendu Jyoti Maitra, Rajiv Roy, Abhijit Chanda (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - March 5, 2021 Category: Drugs & Pharmacology Source Type: research

Method and Computer System for Dialog Optimization of Aging Biomarker Panels for Biological Age Assessment
A concept, method, algorithm, and computer system (CS) of step-by-step dialog optimization of biomarker (BM) panels for assessing human biological age (BA) according to a number of universal criteria based on incomplete and noisy data have been developed. This system provides the ability to automatically build BM panels for BA assessment and to increase the accuracy of BA determination while reducing the number of measured BMs. The optimization criteria are as follows: high correlation of BMs with chronological age (CA); minimum size of BM panels, obtained by rejecting highly cross-correlated BMs; high accuracy of BA asses...
Source: Frontiers in Genetics - March 5, 2021 Category: Genetics & Stem Cells Source Type: research

Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease
The significance of microbiology and immunology with regard to caries and periodontal disease gained substantial clinical or research consideration in the mid 1960's. This enhanced emphasis related to several simple but elegant experiments illustrating the relevance of bacteria to oral infections. Since that point, the understanding of oral diseases has become increasingly sophisticated and many of the original hypotheses related to disease causality have either been abandoned or amplified. The COVID pandemic has reminded us of the importance of history relative to infectious diseases and in the words of Churchill “t...
Source: Frontiers in Microbiology - March 5, 2021 Category: Microbiology Source Type: research

Viruses, Vol. 13, Pages 411: Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Korea, 2012 –2019
This study provides information on the AFP surveillance situation in Korea and highlights the polio eradication stage in the monitoring and characterization of NPEV against the outbreak of neurological infectious diseases such as polio. (Source: Viruses)
Source: Viruses - March 5, 2021 Category: Virology Authors: Youngsil Yoon Yong-Pyo Lee Deog-Yong Lee Hye-Jin Kim June-Woo Lee Sangwon Lee Chun Kang Wooyoung Choi Joong Hyun Bin Young Hoon Kim Myung-Guk Han Hae Ji Kang Tags: Article Source Type: research

Clinical and epidemiological data of COVID-19 from Regensburg, Germany: a retrospective analysis of 1084 consecutive cases
We report data on type and duration of symptoms, and clinical severity of nearly all (99.5%) patients with SARS-CoV-2 recorded from March 2020 to May 2020 in Regensburg. A broad range of symptoms and symptom duration was seen, some of them lasting several weeks in a considerable number of cases. The case-fatality ratio was 2.1%. Asymptomatic cases may be underrepresented due to the nature of the study. (Source: Infection)
Source: Infection - March 5, 2021 Category: Infectious Diseases Source Type: research

HIV-related stigma and health-related quality of life in women living with HIV in developed countries: a systematic review
. (Source: AIDS Care)
Source: AIDS Care - March 5, 2021 Category: Infectious Diseases Authors: Ditte Scofield Ellen Moseholm Source Type: research

Polysubstance use and adherence to antiretroviral treatment in the Miami Adult Studies on HIV (MASH) cohort
. (Source: AIDS Care)
Source: AIDS Care - March 5, 2021 Category: Infectious Diseases Authors: Abraham Degarege Karl Krupp Javier Tamargo Sabrina Sales Martinez Adriana Campa Marianna Baum Source Type: research

Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
Starting from March 2020, nasopharyngeal swabs collected in three provinces (Chieti, L ’Aquila and Teramo) of Abruzzo, a central Region of Italy, are daily tested for the presence of SARS-CoV-2 RNA at the Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale” (IZSAM) (Danzetta et al, 2020). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Paolo Calistri, Laura Amato, Ilaria Puglia, Francesca Cito, Alessandra Di Giuseppe, Maria Luisa Danzetta, Daniela Morelli, Marco Di Domenico, Marialuigia Caporale, Silvia Scialabba, Ottavio Portanti, Valentina Curini, Fabrizia Perletta, Cesare Camm à, Ma Tags: Short Communication Source Type: research

Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
The most prominent clinical manifestations of acute chikungunya virus (CHIKV) infection are joint pain and fever (Weaver and Lecuit, 2015). As the disease evolves, the clinical picture is didactically divided into three stages: acute, subacute and chronic (Brasil, 2017; de Brito et al., 2016). The acute stage may last up to 10-14 days and is characterized by the presence of fever and polyarthralgia, but other manifestations, such as headache, myalgia, rash, conjunctivitis, and joint edema are commonly observed. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Mona íse M.O. Silva, Mariana Kikuti, Rosângela O. Anjos, Moyra M. Portilho, Viviane C. Santos, Thaiza S.F. Gonçalves, Laura B. Tauro, Patrícia S.S. Moreira, Leile C. Jacob-Nascimento, Perla M. Santana, Gúbio S. Campos, André M. Siqueira, Uriel Kitro Source Type: research

In-house crowding on childhood hospital admissions for acute respiratory infection: A matched case-control study in Bangladesh
Globally, acute respiratory infections (ARIs) are a leading cause of morbidity and mortality in under-five children [WHO and UNICEF, 2013; GBD Chronic Respiratory Disease Collaborators, 2020]. Pneumonia alone is responsible for approximately 20% of children deaths globally, a majority of which occur in sub-Saharan Africa and South Asia [GBD Chronic Respiratory Disease Collaborators, 2020; WHO and UNICEF, 2013]. Multiple studies show that 40% of children's ARI deaths occur in Bangladesh, India, Indonesia and Nepal [WHO Regional Office for Africa, 2015; Smith et al., 2000; Fischer et al., 2013]. (Source: International Journa...
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Moktarul Islam, Zeeba Zahra Sultana, Adiba Iqbal, Mohammad Ali, Ahmed Hossain Source Type: research

Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis
D-4-amino-3-isoxazolidinone, or D-cycloserine (cycloserine) was first discovered and synthesized by Hidy et al almost 70 years ago (Hidy et al., 1955). The neuropsychiatric toxicity (including depression and psychosis) was first reported with the earliest known use of cycloserine, and subsequent early treatment reports (Kendig et al., 1956; Murray, 1956). Cycloserine-associated peripheral neuropathy has been less frequently reported (Kendig et al., 1956; Murray, 1956; Desmeules et al., 1957; Conradie et al., 2014). (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Richard Court, Chad M. Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron Source Type: research

Main Differences Between the First and Second Waves of COVID-19 in Madrid, Spain
The outbreak and global rapid spreading of SARS-CoV-2 infection from Wuhan, China, at the end of 2019 represent an unprecedented phenomenon in medicine. COVID-19 continues challenging health services and disrupting social and economic activities globally. In Spain, the arrival of the first wave began in mid-March 2020 and lasted with high numbers for 3 months. It was finally abated thanks to strict lockdown and home confinement. Following relaxing of measures during summer, a second wave began in mid-September and extended until Christmas 2020. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Vicente Soriano, Pilar Ganado-Pinilla, Miguel Sanchez-Santos, Felix G ómez-Gallego, Pablo Barreiro, Carmen de Mendoza, Octavio Corral Tags: Short Communication Source Type: research

Peripheral neuropathy due to neuroborreliosis: Insensitivity for CXCL13 as early diagnostic marker
Lyme borreliosis is a multi-organ disease primarily transmitted by ticks. The condition is endemic in different parts of Europe and North America, and is caused by the spirochetes Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii. Nervous system manifestations termed Lyme neuroborreliosis (LNB) are seen in 10 –15% of all borrelia infections in adults. The most common manifestations are meningoradiculitis and cranial neuritis (Summer and Rupprecht, 2019). Rarer neurological complications include brain and spinal cord involvement, cerebral vasculitis and peripheral neuropathies (Moser, Bubel et ...
Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Kristina Gubanova, Julia Lang, Juliane Latzko, Bianka Novotna, Julian Perneczky, Stefan Pingitzer, Petra Purer, Bianca Wuchty, Christoph Wai ß, Johann Sellner Tags: Case Report Source Type: research

Lack of significant association between dyslipidemia and COVID-19 mortality
Recently, Aung et al reported that distribution frequency of angiotensin converting enzyme (ACE) insertion/insertion (II) genotype had a significant impact on coronavirus disease 2019 (COVID-19) mortality1. Dyslipidemia is one of the most comorbidities among COVID-19 patients, however, the conclusions from published articles on the relationship between dyslipidemia and COVID-19 mortality are still controversial. For instance, several studies found that there was a significant relationship between dyslipidemia and an increased risk for mortality among COVID-19 patients2 –4, while other studies reported dyslipidemia wa...
Source: Journal of Infection - March 5, 2021 Category: Infectious Diseases Authors: Haiyan Yang, Hongjie Hou, Xuan Liang, Jie Xu, Yadong Wang Tags: Letter to the Editor Source Type: research

Correction to: Impact of environmental cleaning on the colonization and infection rates of multidrug-resistant Acinetobacter baumannii in patients within the intensive care unit in a tertiary hospital
An amendment to this paper has been published and can be accessed via the original article. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 5, 2021 Category: Infectious Diseases Source Type: research

Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling
Publication date: June 2021Source: Molecular Immunology, Volume 134Author(s): Helene M.S. Eld, Emilie M. Nielsen, Peter R. Johnsen, Mauro Marengo, Ida W. Kamper, Lise Frederiksen, Francesco Bonomi, Dorte Frees, Stefania Iametti, Hanne Frøkiær (Source: Molecular Immunology)
Source: Molecular Immunology - March 4, 2021 Category: Allergy & Immunology Source Type: research

Sustained Low Incidence Rates of Central Line-Associated Blood Stream Infections in the Intensive Care Unit
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 4, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

In vitro and in vivo Effect of Antimicrobial Agent Combinations Against Carbapenem-Resistant Klebsiella pneumoniae with Different Resistance Mechanisms in China
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 4, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Knowledge, Attitude and Practice Toward COVID-19 Pandemic Among Population Visiting Dessie Health Center for COVID-19 Screening, Northeast Ethiopia
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 4, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Renal Involvement in COVID-19: A Review of the Literature
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 4, 2021 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Colloidal Silver combating Pathogenic Pseudomonas aeruginosa and MRSA in Chronic Rhinosinusitis
Publication date: Available online 4 March 2021Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sholeh Feizi, Clare M. Cooksley, George S. Bouras, Clive A. Prestidge, Tom Coenye, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde (Source: Colloids and Surfaces B: Biointerfaces)
Source: Colloids and Surfaces B: Biointerfaces - March 4, 2021 Category: Biochemistry Source Type: research

Sleeping Beauty and Hepatitis B: An Evidence-Based Guide for Dermatologists
Skinmed. 2021 Feb 1;19(1):37-41. eCollection 2021.ABSTRACTThe association between immunosuppressive therapy for dermatologic conditions and the subsequent reactivation of hepatitis B is of major medical concern. It remains a point of interest across multiple disciplines, including hepatology, dermatology, rheumatology, and infectious disease. Accordingly, we present an evidence-based practice algorithm on how best to approach a patient with presumptively cleared hepatitis B infection when anticipating the initiation of immunosuppressive therapy. This guide delineates the risk of reactivation by taking into account the immu...
Source: Skinmed - March 4, 2021 Category: Dermatology Authors: Virendra Sehgal Maya Firsowicz F Blaine Hollinger Gagan K Sood Harry Dao Source Type: research

A top scoring pairs classifier for recent HIV infections
Stat Med. 2021 Mar 3. doi: 10.1002/sim.8920. Online ahead of print.ABSTRACTAccurate incidence estimation of HIV infection from cross-sectional biomarker data is crucial for monitoring the epidemic and determining the impact of HIV prevention interventions. A key feature of cross-sectional incidence testing methods is the mean window period, defined as the average duration that infected individuals are classified as recently infected. Two assays available for cross-sectional incidence estimation, the BED capture immunoassay, and the Limiting Antigen (LAg) Avidity assay, measure a general characteristic of antibody response;...
Source: Topics in HIV Medicine - March 4, 2021 Category: Infectious Diseases Authors: Athena Chen Oliver Laeyendecker Susan H Eshleman Daniel R Monaco Kai Kammers Harry Benjamin Larman Ingo Ruczinski Source Type: research

Liver infection and COVID-19: the electron microscopy proof and revision of the literature
CONCLUSIONS: Although most studies in COVID-19 have been focused on the lungs, recently, cholestatic liver pathology has been introduced in the spectrum of pathological changes related to COVID-19. To the best of our knowledge, those presented in this paper are the first images of hepatic SARS-CoV-2 infected liver cells. Our findings suggest a role for cholangiocytes and biliary structures in the COVID-19.PMID:33660834 | DOI:10.26355/eurrev_202102_25120 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M Pirisi C Rigamonti S D'Alfonso M Nebuloni D Fanni C Gerosa G Orr ù E Venanzi Rullo P Pavone G Faa L Saba R Boldorini Source Type: research

COVID-19 fatality rates in hospitalized patients: systematic review and meta-analysis
CONCLUSION: High COVID-19 mortality among general admitted patients and critical care cases should guide resources allocations and economic burden calculations during the pandemics.PMID:33662494 | DOI:10.1016/j.annepidem.2021.02.012 (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - March 4, 2021 Category: Epidemiology Authors: Ana Macedo Nilza Gon çalves Cl áudia Febra Source Type: research

Droplet digital PCR as an emerging tool in detecting pathogens nucleic acids in infectious diseases
Clin Chim Acta. 2021 Mar 1:S0009-8981(21)00049-8. doi: 10.1016/j.cca.2021.02.008. Online ahead of print.ABSTRACTThe microbial infectious diseases (infectious diseases) represent the leading global public health problem, and the effective treatment depends on rapid and accurate detection of pathogens. Droplet digital PCR (ddPCR), a new assay that combines microfluidics technology with TaqMan-based PCR, provides absolute quantification without the need of the standard curves. With the development of ddPCR, it has become an ideal tool for microorganism detection. In this review, we summarized the major literature with regard ...
Source: International Journal of Clinical Chemistry - March 4, 2021 Category: Chemistry Authors: Biao Chen Yufeng Jiang Xiaohua Cao Chen Liu Ning Zhang Dongmei Shi Source Type: research

A WiFi scanner in conjunction with disposable multiplex paper assay for the quantitation of disease markers in blood plasma
Anal Bioanal Chem. 2021 Mar 4. doi: 10.1007/s00216-021-03234-6. Online ahead of print.ABSTRACTHerein we report a quantitative, multiplex assay for disease markers in plasma based on an integrated setup of a portable scanner and a disposable paper-based analytical device (PAD). The quantitative analysis relies on the digital colorimetric reading of the three-layer PAD with 30 assay sites for performing respective chromogenic reactions for plasma uric acid, glucose, and triglyceride, which are considered as important risk factors for cardiovascular diseases. A portable scanner with WiFi transmission capability was used to pr...
Source: Analytical and Bioanalytical Chemistry - March 4, 2021 Category: Chemistry Authors: Pengfei Hou Rong Deng Jiqiang Guo Weiyi Chen Xiaochun Li Hua-Zhong Yu Source Type: research

Sustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel
In this study, AMB was incorporated in a thermosensitive gel for intrathecal injection. We first synthesized AMB-loaded thermogel, investigated its in vitro cumulative release, and in vivo neurotoxicity, and therapeutic effect. The thermosensitive gel was comprised of 25 wt% poly (lactic acid-co-glycolic acid)-poly (ethylene glycol)-poly (lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock polymer aqueous solution. The AMB loaded in the thermosensitive gel (AMB in gel) had low viscosity at low temperature and resulted in the formation of a non-flowing gel at 37 °C (physiological temperature). AMB loading in gel sust...
Source: Drug Delivery - March 4, 2021 Category: Drugs & Pharmacology Authors: Wenting Lin Tao Xu Zhongzhi Wang Jianghan Chen Source Type: research

The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease
Int J Med Microbiol. 2021 Feb 25;311(3):151487. doi: 10.1016/j.ijmm.2021.151487. Online ahead of print.ABSTRACTThe glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as well as chronic disease. In this review, we focus on the interplay between host glycosylation, the intestinal microbiota and susceptibility to gastrointestinal pathogens based on studies of two exemplary blood group-relat...
Source: International Journal of Medical Microbiology - March 4, 2021 Category: Microbiology Authors: Alibek Galeev Abdulhadi Suwandi Aleksa Cepic Meghna Basu John F Baines Guntram A Grassl Source Type: research

Using core genome multilocus sequence typing (cgMLST) for vancomycin-resistant Enterococcus faecium isolates to guide infection control interventions and end an outbreak
Publication date: March 2021Source: Journal of Global Antimicrobial Resistance, Volume 24Author(s): Sanne Kjær Hansen, Lise Andersen, Mette Detlefsen, Anette Holm, Louise Roer, Panagiotis Antoniadis, Marianne Nielsine Skov, Anette M. Hammerum, Michael Kemp (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - March 4, 2021 Category: Infectious Diseases Source Type: research

Risk of adverse coronavirus disease 2019 outcomes for people living with HIV
Conclusion: Emerging evidence suggests a moderately increased risk of COVID-19 mortality among PLWH. Further investigation into the relationship between COVID-19 outcomes and CD4+ T-cell count, HIV viral load, ART and the use of tenofovir disoproxil fumarate is warranted. (Source: AIDS)
Source: AIDS - March 4, 2021 Category: Infectious Diseases Tags: FAST TRACK Source Type: research

HIV in Iran: onset, responses, and future directions
Iran, a country in the Middle East and North Africa (MENA) region, has been actively involved in the fight against HIV/AIDS over the past three decades. The unique features of the HIV epidemic in Iran are reflected by the modes of transmission and its recent changes to improve management and prevention programs. In this review, we recount the initial onset and subsequent spread of HIV infection in Iran, beginning with the first case diagnosed to the ongoing responses and most recent achievements in controlling this epidemic. Although in the MENA region, Iran is one of the pioneers in implementing pertinent policies includi...
Source: AIDS - March 4, 2021 Category: Infectious Diseases Tags: EDITORIAL REVIEW Source Type: research

Apolipoprotein A-I mimetics attenuate macrophage activation in chronic treated HIV
Conclusion: Given that gut barrier dysfunction and macrophage activation are contributors to comorbidities like cardiovascular disease in HIV, apoA-I mimetics should be tested as therapy for morbidity in chronic treated HIV. (Source: AIDS)
Source: AIDS - March 4, 2021 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research

Maternal HIV, antiretroviral timing, and spontaneous preterm birth in an urban Zambian cohort: the role of local and systemic inflammation
Conclusion: Women not receiving ART at entry into pregnancy care had more vaginal inflammation than women entering on treatment. They also experienced an increase in vaginal inflammation between the two sampling timepoints, possibly as a consequence of ART initiation. Vaginal (but not systemic) inflammation was associated with sPTB and offers a potential mechanistic insight into this important adverse birth outcome. (Source: AIDS)
Source: AIDS - March 4, 2021 Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research

Maintenance of statin therapy among people living with HIV
Conclusion: Maintenance of statin therapy is poor among PLHIV on ART but is not associated with using contraindicated antiretroviral/statin combinations. A better understanding of statin use in PLHIV will aid clinicians treating individuals and policy makers designing interventions for population-level ASCVD risk reduction. (Source: AIDS)
Source: AIDS - March 4, 2021 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research