Diagnosing Disorders of Hypopigmentation and Depigmentation in Patients with Skin of Color
Skin hypopigmentation and depigmentation disorders are a top concern for patients with skin of color seeking care from a dermatologist. The visual contrast between involved and uninvolved skin in these disorders makes them particularly burdensome for patients with skin of color. These disorders may have a wide differential of diagnosis, as patients with skin of color may present differently or more frequently than White patients for certain conditions. Clues from a comprehensive history and physical examination with standard lighting and a Wood ’s light are essential for clinching the diagnosis, although a biopsy may be ...
Source: Dermatologic Clinics - March 27, 2023 Category: Dermatology Authors: Marissa S. Ceresnie, Sarah Gonzalez, Iltefat H. Hamzavi Source Type: research
Clinical practice gaps in patients with extragenital lichen sclerosus: A retrospective review
To the Editor: Lichen sclerosus (LS) is a chronic inflammatory skin disorder characterized by progressive epidermal atrophy and hypopigmentation, usually of the anogenital area. Patients may also present with extragenital lesions, though only 6% of LS cases are isolated on extragenital skin.1 For patients first presenting with extragenital lichen sclerosus (EGLS), a thorough history and examination of both the extragenital and genital skin can prevent diagnostic delays and improve patient outcomes by identifying concomitant genital lesions. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 12, 2023 Category: Dermatology Authors: Subin Lim, Salvatore Daddario, Shawn Afvari, Nathaniel Goldman, Kevin Yang, Bina Kassamali, Neda Shahriari, Avery H. LaChance Tags: Research letter Source Type: research
Efficacy and safety of picosecond laser for the treatment of melasma: a systematic review and meta-analysis
AbstractMultiple laser modalities have been used for melasma treatment. However, the effectiveness of picosecond laser in treating melasma remains unclear. This meta-analysis investigated the effectiveness and safety of picosecond laser for melasma treatment. Randomized controlled trials (RCTs) comparing picosecond laser with conventional treatment for melasma were searched through five databases. The melasma area severity index (MASI)/modified MASI (mMASI) was used to quantify the degree of melasma improvement. Standardized mean differences and 95% confidence intervals were calculated using Review Manager for result stand...
Source: Lasers in Medical Science - March 10, 2023 Category: Laser Surgery Source Type: research
Anti-programmed death-1 inhibitor nivolumab-induced immune-related adverse events: hepatitis, renal insufficiency, myositis, vitiligo, and hypothyroidism: a case-based review
We present five immunological AEs in a single patient treated with NIVO. A 68-year-old male patient with metastatic renal cell carcinoma and right-sided nephrectomy received NIVO after pazopanib and sunitinib treatment. Two and a half months after starting NIVO, hepatocellular enzymes and creatinine were elevated. Concomitantl y, the patient noticed hypopigmentation of the hand skin and a change in voice and speech. Due to hepatitis, he has been treated with dexamethasone 16 mg daily for 22 days, after which hypothyroidism and increased creatine kinase were found without muscle pain and functional impairment. Dexametha...
Source: Rheumatology International - March 1, 2023 Category: Rheumatology Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
Large, linear pigmentation anomaly: an unusual dyspigmentation case
Dermatol Online J. 2022 Dec 15;28(6). doi: 10.5070/D328659729.ABSTRACTSegmental pigmentation anomalies can be further divided into segmental pigmentation disorder (SPD) complex and café-au-lait macules (CALMs). Both are congenital skin conditions characterized by hyper- or hypopigmentation. Segmental pigmentation disorder is a rare entity, whereas CALMs are common skin lesions that may be associated with various genetic conditions, especially when several are present and the patient has other indicators of a genetic abnormality. When the CALM is segmental, segmental neurofibromatosis (type V) may be considered in the diff...
Source: Dermatol Online J - February 22, 2023 Category: Dermatology Authors: Ashley Vander Does Catherine Motosko Gil Yosipovitch Source Type: research
