The effect of epigallocatechin gallate on laying performance, egg quality, immune status, antioxidant capacity, and hepatic metabolome of laying ducks reared in high temperature condition
In conclusion, 300 mg/kg dietary EGCG showed protection effects on the laying ducks reared in high temperature by improving the immune and antioxidant capacities, which contributed to the increase of laying performance of ducks. The potential mechanism could be that EGCG modulate the synthesis of key metabolites and associated metabolic pathways.PMID:37921498 | DOI:10.1080/01652176.2023.2280041 (Source: Veterinary Quarterly)
Source: Veterinary Quarterly - November 3, 2023 Category: Veterinary Research Authors: Yang Liu Xu Zhang Yaling Yao Xuan Huang Chuang Li Ping Deng Guitao Jiang Qiuzhong Dai Source Type: research
The effect of epigallocatechin gallate on laying performance, egg quality, immune status, antioxidant capacity, and hepatic metabolome of laying ducks reared in high temperature condition
In conclusion, 300 mg/kg dietary EGCG showed protection effects on the laying ducks reared in high temperature by improving the immune and antioxidant capacities, which contributed to the increase of laying performance of ducks. The potential mechanism could be that EGCG modulate the synthesis of key metabolites and associated metabolic pathways.PMID:37921498 | DOI:10.1080/01652176.2023.2280041 (Source: Veterinary Quarterly)
Source: Veterinary Quarterly - November 3, 2023 Category: Veterinary Research Authors: Yang Liu Xu Zhang Yaling Yao Xuan Huang Chuang Li Ping Deng Guitao Jiang Qiuzhong Dai Source Type: research
The effect of epigallocatechin gallate on laying performance, egg quality, immune status, antioxidant capacity, and hepatic metabolome of laying ducks reared in high temperature condition
In conclusion, 300 mg/kg dietary EGCG showed protection effects on the laying ducks reared in high temperature by improving the immune and antioxidant capacities, which contributed to the increase of laying performance of ducks. The potential mechanism could be that EGCG modulate the synthesis of key metabolites and associated metabolic pathways.PMID:37921498 | DOI:10.1080/01652176.2023.2280041 (Source: Veterinary Quarterly)
Source: Veterinary Quarterly - November 3, 2023 Category: Veterinary Research Authors: Yang Liu Xu Zhang Yaling Yao Xuan Huang Chuang Li Ping Deng Guitao Jiang Qiuzhong Dai Source Type: research
Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis
Int J Biol Macromol. 2023 Oct 13:127377. doi: 10.1016/j.ijbiomac.2023.127377. Online ahead of print.ABSTRACTTAs, including hyoscyamine and scopolamine, were used to treat neuromuscular disorders ranging from nerve agent poisoning to Parkinson's disease. Tropinone reductase I (TR-I; EC 1.1.1.206) catalyzed the conversion of tropinone into tropine in the biosynthesis of TAs, directing the metabolic flow towards hyoscyamine and scopolamine. Tropinone reductase II (TR-II; EC 1.1.1.236) was responsible for the conversion of tropinone into pseudotropine, diverting the metabolic flux towards calystegine A3. The regulation of meta...
Source: International Journal of Biological Macromolecules - October 15, 2023 Category: Biochemistry Authors: Xiaoxiang Hu Wenjing Liu Yi Yan Huaxiang Deng Yujie Cai Source Type: research
Tropinone reductase: A comprehensive review on its role as the key enzyme in tropane alkaloids biosynthesis
Int J Biol Macromol. 2023 Oct 13:127377. doi: 10.1016/j.ijbiomac.2023.127377. Online ahead of print.ABSTRACTTAs, including hyoscyamine and scopolamine, were used to treat neuromuscular disorders ranging from nerve agent poisoning to Parkinson's disease. Tropinone reductase I (TR-I; EC 1.1.1.206) catalyzed the conversion of tropinone into tropine in the biosynthesis of TAs, directing the metabolic flow towards hyoscyamine and scopolamine. Tropinone reductase II (TR-II; EC 1.1.1.236) was responsible for the conversion of tropinone into pseudotropine, diverting the metabolic flux towards calystegine A3. The regulation of meta...
Source: International Journal of Biological Macromolecules - October 15, 2023 Category: Biochemistry Authors: Xiaoxiang Hu Wenjing Liu Yi Yan Huaxiang Deng Yujie Cai Source Type: research
Simultaneous quantification of hyoscyamine and scopolamine using HPLC-DAD in four Solanaceae: < em > Hyoscyamus niger, Datura stramonium, Atropa belladonna < /em > and < em > Mandragora officinarum < /em >
Nat Prod Res. 2023 Oct 13:1-6. doi: 10.1080/14786419.2023.2269595. Online ahead of print.ABSTRACTAlkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from Hyoscyamus niger, Datura stramonium, Atropa belladonna, Mandragora officinarum. In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. A. bellad...
Source: Natural Product Research - October 13, 2023 Category: Biochemistry Authors: Diletta Piatti Riccardo Marconi Simone Angeloni Giovanni Caprioli Filippo Maggi Emanuele Ribatti Vittorio Cattaneo Gianni Sagratini Source Type: research
Simultaneous quantification of hyoscyamine and scopolamine using HPLC-DAD in four Solanaceae: < em > Hyoscyamus niger, Datura stramonium, Atropa belladonna < /em > and < em > Mandragora officinarum < /em >
Nat Prod Res. 2023 Oct 13:1-6. doi: 10.1080/14786419.2023.2269595. Online ahead of print.ABSTRACTAlkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from Hyoscyamus niger, Datura stramonium, Atropa belladonna, Mandragora officinarum. In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. A. bellad...
Source: Natural Product Research - October 13, 2023 Category: Biochemistry Authors: Diletta Piatti Riccardo Marconi Simone Angeloni Giovanni Caprioli Filippo Maggi Emanuele Ribatti Vittorio Cattaneo Gianni Sagratini Source Type: research
Simultaneous quantification of hyoscyamine and scopolamine using HPLC-DAD in four Solanaceae: < em > Hyoscyamus niger, Datura stramonium, Atropa belladonna < /em > and < em > Mandragora officinarum < /em >
Nat Prod Res. 2023 Oct 13:1-6. doi: 10.1080/14786419.2023.2269595. Online ahead of print.ABSTRACTAlkaloids are a group of secondary metabolites that generate great interest since ancient times. Numerous Solanaceae plants are rich sources of tropane alkaloids as hyoscyamine and scopolamine which are obtained mainly from Hyoscyamus niger, Datura stramonium, Atropa belladonna, Mandragora officinarum. In the present study it was developed an HPLC-DAD using an XBridge Phenyl column for the quantification of scopolamine and hyoscyamine, molecules used in pharmaceutical industry to treat stomach or intestinal disorders. A. bellad...
Source: Natural Product Research - October 13, 2023 Category: Biochemistry Authors: Diletta Piatti Riccardo Marconi Simone Angeloni Giovanni Caprioli Filippo Maggi Emanuele Ribatti Vittorio Cattaneo Gianni Sagratini Source Type: research
Viral inhibitory potential of hyoscyamine in Japanese encephalitis virus –infected embryonated chicken eggs involving multiple signaling pathways
In this study, we investigated the antiviral effect of hyoscyamine against JEV and its immunomodulatory activity in embryonated chicken eggs. Pretreatment with hyoscyamine sulphate resulted in a significant decrease in the viral load in both chorioallantoic membrane (CAM) and brain tissues at 48 and 96 hours postinfection.In silico studies showed stable binding and interaction between hyoscyamine and non-structural protein 5 (NS5), suggesting that this could be the basis of its antiviral effect. Embryonated eggs pretreated with hyoscyamine sulphate showed upregulation of Toll-like receptor 3 (TLR3), TLR7, TLR8, interleuk...
Source: Archives of Virology - October 3, 2023 Category: Virology Source Type: research
Dicycloverine/hyoscyamine/sucralfate
(Source: Reactions Weekly)
Source: Reactions Weekly - June 30, 2023 Category: Drugs & Pharmacology Source Type: research
Hyoscyamine induces developmental toxicity by disrupting metabolism in zebrafish embryo (Danio rerio)
In this study, an untargeted metabolomics approach was used to investigate the toxic mechanisms of hyoscyamine in zebrafish embryos. The LC10 and MNLC of hyoscyamine in zebrafish embryos were determined to be 350 and 313 μg/mL, respectively. Moreover, hyoscyamine exposure increased the accumulation of ROS and MDA, and altered the activity of antioxidant enzymes (CAT, SOD, and GSH) in zebrafish embryos. After exposure, the embryos were extracted, derivatized and analyzed by UHPLC-Q-Orbitrap-HRMS for 3551 metabolites to identify 38 significantly changed metabolites based on the VIP, p value, and fold change results. Metabol...
Source: Food and Chemical Toxicology - June 1, 2023 Category: Food Science Authors: Yinni Lv Zhanyu Lin Jingpei Chen Kecheng Jiang Anli Wang Binjie Wang Yuanzhao Wu Zhongshi Xu Jiye Wang Weixuan Yao Source Type: research
Hyoscyamine induces developmental toxicity by disrupting metabolism in zebrafish embryo (Danio rerio)
In this study, an untargeted metabolomics approach was used to investigate the toxic mechanisms of hyoscyamine in zebrafish embryos. The LC10 and MNLC of hyoscyamine in zebrafish embryos were determined to be 350 and 313 μg/mL, respectively. Moreover, hyoscyamine exposure increased the accumulation of ROS and MDA, and altered the activity of antioxidant enzymes (CAT, SOD, and GSH) in zebrafish embryos. After exposure, the embryos were extracted, derivatized and analyzed by UHPLC-Q-Orbitrap-HRMS for 3551 metabolites to identify 38 significantly changed metabolites based on the VIP, p value, and fold change results. Metabol...
Source: Food and Chemical Toxicology - June 1, 2023 Category: Food Science Authors: Yinni Lv Zhanyu Lin Jingpei Chen Kecheng Jiang Anli Wang Binjie Wang Yuanzhao Wu Zhongshi Xu Jiye Wang Weixuan Yao Source Type: research
The evolutionary pattern of cocaine and hyoscyamine biosynthesis provides strategies to produce tropane alkaloids
Chembiochem. 2023 May 30:e202300234. doi: 10.1002/cbic.202300234. Online ahead of print.ABSTRACTCocaine and hyoscyamine are two tropane alkaloids (TA) from Erythroxylaceae and Solanaceae, respectively. These famous compounds possess anticholinergic properties that can be used to treat neuromuscular disorders. While the hyoscyamine biosynthetic pathway has been fully elucidated allowing its de novo synthesis in yeast, the cocaine pathway remained partially elucidated. Recently, the Huang research group has completed the cocaine biosynthetic route by characterizing its two missing enzymes. This allowed transferring this whol...
Source: Chembiochem - May 30, 2023 Category: Biochemistry Authors: Duchesse-Lacours Zamar Nicolas Papon Vincent Courdavault Source Type: research
