Toddler's eyes have been stitched shut after being stretched by her enormous head
Nineteen-month-old Aubrey Jones, from Nuneaton, Warwickshire, suffers from the condition hydrocephalus, which has caused her head to grow, dragging her eyelids up so that they needed stitching. (Source: the Mail online | Health)
Source: the Mail online | Health - August 10, 2018 Category: Consumer Health News Source Type: news
Girl, 15, has a swollen 27-inch head which means she cannot walk or sit up by herself
Shivani Kumari, from Himachal Pradesh in northern India, has a huge head because she developed hydrocephalus – a build-up of fluid in the brain – after falling over three years ago. (Source: the Mail online | Health)
Source: the Mail online | Health - July 27, 2018 Category: Consumer Health News Source Type: news
ETV/CPC show positive outcomes in babies with hydrocephalus
Hydrocephalus, literally “water on the brain,” is an abnormal build-up of cerebrospinal fluid in the brain cavities known as ventricles. In infants, it can be congenital (it often accompanies spina bifida, for example), or it can be caused by brain hemorrhage or infection. The usual treatment is surgery to implant a shunt, which drains the excess fluid into the abdomen, relieving pressure on the brain.
But over time, shunts nearly always fail, requiring emergency neurosurgery to repair or replace them. But emergency neurosurgery is not something that’s readily available outside of metropolitan areas. Untreated, hydro...
Source: Mass Device - July 24, 2018 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog Vector Blog Source Type: news
Stem cell mutations linked to hydrocephalus
The mutations result in reduced brain volume that secondarily becomes filled with cerebrospinal fluid. (Source: Yale Science and Health News)
Source: Yale Science and Health News - July 11, 2018 Category: Universities & Medical Training Source Type: news
Pakistani baby with football-sized head has 12 pints of fluid drained
Amna Noor, from Abbottabad, Pakistan, suffers from the rare condition hydrocephalus, which left her immobile, unable to eat or sleep properly and with a head that measured 40 inches. (Source: the Mail online | Health)
Source: the Mail online | Health - June 27, 2018 Category: Consumer Health News Source Type: news
New discovery about the brain's water system may prove beneficial in stroke
(University of Copenhagen The Faculty of Health and Medical Sciences) Water is transported from the blood into the brain via an ion transporter, a new study on mice conducted at the University of Copenhagen reveals. If the mechanism can be targeted with medicine, it may prove relevant to all disorders involving increased intracranial pressure, including brain oedema in connection with stroke as well as hydrocephalus, also called 'water in the head'. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2018 Category: International Medicine & Public Health Source Type: news
Baby girl with a FOOTBALL-sized head is desperately awaiting surgery
Amna Noor, from Abbottabad, Pakistan, was born with hydrocephalus - a build-up of fluid inside his skull which can be deadly. The condition is believed to strike one in 1,000 babies. (Source: the Mail online | Health)
Source: the Mail online | Health - June 13, 2018 Category: Consumer Health News Source Type: news
Anuncia Announces Successful First-in-Human Use of the Alivio ReFlow(TM) Ventricular System for Treatment of Hydrocephalus
Novel product provides qualified clinicians with the option of non-invasive retrograde flushing of the ventricular catheter, to unblock occluded inlet holes or open a relief membrane to restore or increase cerebrospinal fluid (CSF) flow in a non-flowing sh... Devices, Neurosurgery Anuncia , Alivio ReFlow, Ventricular System, hydrocephalus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 22, 2018 Category: Pharmaceuticals Source Type: news
Brain cell's Achilles' heel may prompt hydrocephalus
(Duke University) Viruses may spark hydrocephalus by exploiting a surprising weakness of cells that circulate fluid in the brain, called ependymal cells, report Duke University scientists. The researchers discovered that ependymal cells from mice require a continuous production of a transcription factor called Foxj1 to maintain their shape and function. Viruses known to infect the brain have found a way to shut down the production of Foxj1 and disable the cells, the researchers show. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 25, 2018 Category: International Medicine & Public Health Source Type: news
Baby, 9 months, with a head the size of a football is unable to eat, sleep or move
Nine-month-old Muhammad Hammad, from Khuzdar in Pakistan, suffers from hydrocephalus, which caused his head to swell to 25 inches in circumference. (Source: the Mail online | Health)
Source: the Mail online | Health - April 3, 2018 Category: Consumer Health News Source Type: news
Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner
Catalytically activating mutations in Ptpn11, which encodes the protein tyrosine phosphatase SHP2, cause 50% of Noonan syndrome (NS) cases, whereas inactivating mutations in Ptpn11 are responsible for nearly all cases of the similar, but distinct, developmental disorder Noonan syndrome with multiple lentigines (NSML; formerly called LEOPARD syndrome). However, both types of disease mutations are gain-of-function mutations because they cause SHP2 to constitutively adopt an open conformation. We found that the catalytic activity of SHP2 was required for the pathogenic effects of gain-of-function, disease-associated mutations...
Source: Signal Transduction Knowledge Environment - March 20, 2018 Category: Science Authors: Zheng, H., Yu, W.-M., Waclaw, R. R., Kontaridis, M. I., Neel, B. G., Qu, C.-K. Tags: STKE Research Articles Source Type: news
Simple Walking Test Helps Diagnose Treatable Cause of Dementia Simple Walking Test Helps Diagnose Treatable Cause of Dementia
Idiopathic normal-pressure hydrocephalus is often misdiagnosed because its symptoms are similar to those of other neurologic conditions, but a new study finds a dual-task walking test greatly improves diagnostic accuracy.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 27, 2018 Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news
What is the Difference Between an Association and a Syndrome?
Discussion
VATER association was first described in the 1970s with additional congenital malformations being added to the association so it is most often called VACTERL association. It is a highly heterogeneous, overlapping condition estimated to occur in ~1/10,000-40,000 births. The cause is unknown. In animal models, some signaling pathway gene mutations have phenotypes of VACTERL association.
Experts suggest that patients having at least 2 components should be further evaluated (at least 3 for diagnosis) for VACTERL and other diseases in its differential diagnosis. There are more than 30 syndromes, mutations and diseas...
Source: PediatricEducation.org - February 5, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Toddler has a head the size of a football
Fifteen-month-old Muhammad Sanaullah,from Badin in Pakistan, suffers from a rare condition, known as hydrocephalus, which causes fluid to build-up inside his skull. (Source: the Mail online | Health)
Source: the Mail online | Health - January 12, 2018 Category: Consumer Health News Source Type: news
Indian baby's head tripled in size due to hydrocephalus
Ankit Minj, from India, suffers from hydrocephalus - a build-up of fluid inside his skull which can be deadly. Doctors have inserted a shunt to remove some fluid. (Source: the Mail online | Health)
Source: the Mail online | Health - December 28, 2017 Category: Consumer Health News Source Type: news
