Current Status and Associated Factors of Post-Hemorrhagic Hydrocephalus in Infants of 22 to 28 Weeks Gestation With Severe Intraventricular Hemorrhage in Korea: A Nationwide Cohort Study
CONCLUSION: It is necessary to maintain meticulous monitoring and neurological intervention for infants with PHH not only during admission but also after discharge. In addition, identifying the clinical factors that increase the likelihood of developing PHH from severe IVH is crucial.PMID:38651224 | DOI:10.3346/jkms.2024.39.e139 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Misun Yang Sumin Kim Se In Sung Yun Sil Chang Won Soon Park So Yoon Ahn Source Type: research
Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage
ConclusionThere is a marked immune cell response at the ChP in IVH involving epiplexus cells, T lymphocytes and neutrophils. The blood components iron and Prx-2 may play a role in eliciting that response. Reduction of ChP macrophages with clodronate liposomes reduced iron-induced ventriculomegaly suggesting that ChP macrophages may be a promising therapeutic target for managing IVH-induced hydrocephalus. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - April 23, 2024 Category: Neuroscience Source Type: research
Low surgical weight associated with ETV failure in pediatric hydrocephalus patients
In this study, younger patients experienced higher ETV failure rates, but multivariate regression found that weight was a more robust pr edictor of ETV failure than chronologic age or gestational age, with an optimal cutoff of 4.9 kg in our small cohort. Given the limited sample size, further study is needed to elucidate the independent role of weight as a peri-operative variable in determining ETV candidacy in young infants.Previous presentations: Poster Presentation, Congress of Neurological Surgeons. (Source: Neurosurgical Review)
Source: Neurosurgical Review - April 22, 2024 Category: Neurosurgery Source Type: research
Cancers, Vol. 16, Pages 1574: The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience
io Melcarne
Diego Garbossa
Given the importance of maximizing resection for prognosis in patients with HGG and the potential risks associated with ventricle opening, this study aimed to assess the actual increase in post-surgical complications related to lateral ventricle opening and its influence on OS and PFS. A retrospective study was conducted on newly diagnosed HGG, dividing the patients into two groups according to whether the lateral ventricle was opened (69 patients) or not opened (311 patients). PFS, OS, subependymal dissemination, distant parenchymal recurrences, the development of hydrocephalus and CSF lea...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Fabio Cofano Andrea Bianconi Raffaele De Marco Elena Consoli Pietro Zeppa Francesco Bruno Alessia Pellerino Flavio Panico Luca Francesco Salvati Francesca Rizzo Alberto Morello Roberta Rud à Giovanni Morana Antonio Melcarne Diego Garbossa Tags: Article Source Type: research
Rare vermian pilocytic astrocytoma with recurrent spontaneous hemorrhage in the elderly: A case report and review of literature
CONCLUSION: PA in the elderly is a rare disease with distinct histologic and genetic peculiarities. This case review showed one of the oldest cases of cerebellar vermian PA presenting with recurrent spontaneous intratumoral hemorrhage, an extremely rare occurrence in benign glioma. Although complete surgical excision is recommended, partial resection is advocated for morbidly adherent tumors. Overall prognosis is worse in elderly PA.PMID:38628526 | PMC:PMC11021065 | DOI:10.25259/SNI_978_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Campbell Chukwuebuka Francis Kohei Kanaya Kohei Nagamine Tetsuya Goto Tetsuyoshi Horiuchi Samuel Chukwunonyerem Ohaegbulam Source Type: research
Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report
CONCLUSION: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement.PMID:38628523 | PMC:PMC11021090 | DOI:10.25259/SNI_32_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Yusuke Tomita Shoichi Fukuda Aiko Kobashi Yoshihiro Okada Keigo Makino Naoya Kidani Kenichiro Muraoka Nobuyuki Hirotsune Shigeki Nishino Source Type: research
Temporal bone squamous cell carcinoma: Aggressive behavior coursing with cerebellar invasion and hydrocephalus
CONCLUSION: We report a case of advanced TBSCC with poor prognosis despite surgical treatment and radiotherapy. More data are necessary to provide new and better treatment to these patients.PMID:38628504 | PMC:PMC11021098 | DOI:10.25259/SNI_1017_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Maria Eduarda Ros ário Viveiros de Castro Pedro Henrique Costa Ferreira-Pinto Dom ênica Baroni Coelho de Oliveira Ferreira Ana Carolina Gon çalves Brito Maud Parise Eduardo Mendes Correa Thaina Zanon Cruz Wesley Klein Nunes de Freitas Pedro Luiz Ribeir Source Type: research
Multimodal radionuclide shuntography for device patency: New procedural tips for anuncommon historical technique
Hell J Nucl Med. 2024 Apr 18:s002449912705. doi: 10.1967/s002449912705. Online ahead of print.ABSTRACTCerebrospinal fluid (CSF) shunting is an established long-term treatment option for hydrocephalus, and is one of the most commonly performed neurosurgical procedures in western countries.Despite advances in CSF shunt design and management, its failure rates remain high and is most commonly due to obstruction and infection.Cerebrospinal fluidshunt failure diagnosis should be prompt and accurate in establishing timely if its revision is appropriate. Radionuclide shuntography with technetium-99m-diethylenetriaminepetaacetic a...
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Antonio Rosario Pisani Dino Rubini Corinna Altini Nicola Lucarelli Angela Gaudiano Cristina Ferrari Giuseppe Rubini Source Type: research
GSE241018 SMARCA4 loss and mutated β-catenin induce proliferative lesions in the murine embryonic cerebellum [scRNA-seq]
Contributors : Carolin G öbel ; Melanie Schoof ; Dörthe Holdhof ; Michael Spohn ; Ulrich SchüllerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlmost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20% of WNT MB, but their functional role is mostly unknown. We therefore amended previously described Blbp cre::Ctnnb1(ex3)fl/wt mice by the introduction of a floxed Smarc...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE240627 SMARCA4 loss and mutated β-catenin induce proliferative lesions in the murine embryonic cerebellum
Contributors : Carolin G öbel ; Melanie Schoof ; Dörthe Holdhof ; Michael Spohn ; Ulrich SchüllerSeries Type : Methylation profiling by arrayOrganism : Mus musculusAlmost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) subgroup are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20 % of WNT MB but their functional role is mostly unknown. We therefore amended previously described Blbp-cre::Ctnnb1(ex3)fl/wt mice by the introduction of a floxed Smarca4 allele. In co...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by array Mus musculus Source Type: research
Comparison of decline in different cognitive domain in patients with normal pressure hydrocephalus
AbstractWe sought to describe the cognitive profile of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) using a comprehensive neuropsychological battery. Based on age and education correlated norms, we aimed to compare performance in each measured cognitive domain: executive functions (EFs), verbal memory (VM), non-verbal memory (nVM), visuoconstructional abilities (VA) and attention/psychomotor speed (A/PS). Patients diagnosed with iNPH underwent comprehensive neuropsychological evaluation before shunting. Their performance was compared to the age and education correlated norms. Correlation of different cogni...
Source: Neurosurgical Review - April 17, 2024 Category: Neurosurgery Source Type: research
Erratum: Neuroendoscopic Lavage and Third Ventriculostomy for the Treatment of Intraventricular Hemorrhage and Hydrocephalus in Neonates. A Prospective Study with 18 Months of Follow-Up
J Neurol Surg A Cent Eur Neurosurg 2024; 85: e1-e1 DOI: 10.1055/s-0044-1786193 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - April 16, 2024 Category: Neurosurgery Authors: Islas-Aguilar, Mario Alberto Torrez-Corzo, Jaime Gerardo Alberto Chalita-Williams, Juan Carlos Cervantes, Dominic Shelby Vinas-Rios, Juan Tags: Erratum Source Type: research
Ventriculoperitoneal Shunt Surgery in Pediatrics: Does Preoperative Skin Antisepsis with Chlorhexidine/Alcohol Reduce Postoperative Shunt Infection Rate?
Conclusions Two steps of preoperative skin antisepsis, first using chlorhexidine/alcohol and then povidone-iodine scrub solution, may significantly reduce the infection rate in pediatric VP shunt surgeries. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - April 15, 2024 Category: Neurosurgery Authors: Ammar, Ahmed Shawky Elnoamany, Hossam Elkholy, Hany Tags: Original Article Source Type: research
Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome
ConclusionsCPTII deficiency may be suspected in newborns showing cardiac arrhythmias, associated or not with hypertrophic cardiomyopathy, polycystic kidneys, brain malformations, hepatomegaly. Its diagnosis should be even more suspected and investigated in cases of increased plasmatic levels of creatine phosphokinase and acylcarnitines in addition to kidney, heart and liver dysfunctions, as occurred in the present patient. Accurate family history, extended metabolic screening, and multidisciplinary approach are necessary for diagnosis and adequate management of affected subjects. Next generation sequencing (NGS) techniques...
Source: Italian Journal of Pediatrics - April 14, 2024 Category: Pediatrics Source Type: research
