Contributions made to the proteasome by substrate receptors
Biowulf 20th Anniversary Seminar Series
Regulated protein degradation in eukaryotes is performed by the proteasome, which contains a 20S catalytic core particle (CP) capped at either end by a 19S regulatory particle (RP). Proteasome activity is dysregulated in myriad diseases, and specific inhibitors of the CP used to treat hematological cancers. Substrates for the proteasome are typically marked by post-translational addition of ubiquitin chain(s). The proteasome captures such substrates through receptors located in
the RP that bind directly to ubiquitin, or to shuttle factors that bind the proteasome with UBL domains an...
Source: Videocast - All Events - October 2, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
2019 Maurice B. Burg Lecture
Maurice B. Burg, the legendary kidney researcher who spent his entire career in the intramural program of NHLBI, was known for innovation in the development of techniques for the study of transport and osmotic regulation in kidney epithelia. His work resulted in a virtual rewriting of renal physiology and nephrology textbooks. One of his early trainees, Robert A. Star, MD, Director of the Division of Kidney, Urologic, and Hematologic Diseases at NIDDK and an intramural investigator himself, will review Burg ’ s technological innovations and show how Burg ’ s work set the stage for breathtaking contemporary innovations ...
Source: Videocast - All Events - September 9, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Integrative Omics Approaches to Identify New Therapeutic Cancer Targets
CCR Grand Rounds
Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council Mem...
Source: Videocast - All Events - June 17, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Chimeric Antigen Receptor T-cell Therapies for Hematological Malignancies
CCR Grand Rounds
James Kochenderfer, M.D., is a tenure-track investigator in the Experimental Transplantation and Immunology Branch (ETIB) of the National Cancer Institute (NCI). For the past 12 years, Dr. Kochenderfer has focused on a full range of chimeric antigen receptor (CAR) research from designing and cons tructing new CARs to conducting clinical trials. Dr. Kochenderfer designed and constructed a novel anti-CD19 CAR and then participated in a clinical trial of this CAR. This clinical trial was the first to demonstrate antigen-specific activity of anti-CD19 CARs in humans. This work in anti-CD19 CAR T cells led to...
Source: Videocast - All Events - June 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
John C. Byrd, MD - BTK Inhibition as an Anti-Cancer Strategy: Exploring a Model for Modern Targeted Therapy in Hematologic Malignancies and Beyond
Go online to PeerView.com/EQY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. This PeerView CME/CNE-certified activity—based on a live event conducted in a MasterClass format held in conjunction with the 2019 meeting of the AACR—discusses how Bruton tyrosine kinase (BTK) inhibitors effectively target aspects of B-cell receptor signaling and covers key evidence and clinical issues related to the use of BTK inhibitors in hematologic malignancies (including agent selection, potential combination regimens, and strategies for overcoming drug intolerance or resistance). ...
Source: Peerview CME/CE Video Podcast - Internal Medicine International - May 22, 2019 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Mitchell S. Cairo, MD - Attacking the Clinical Problem of VOD/SOS in HCT Recipients: Insights on Pathophysiology, Diagnosis, and Treatment
In this activity, based on a live symposium held during the 2019 Transplantation and Cellular Therapy (TCT) Meetings of the American Society of Blood and Marrow Transplantation (ASBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR), experts in hematology-oncology explore new developments related to the changing clinical consensus for managing veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) as a post-transplant complication. In this program, the panelists will share their views on VOD pathophysiology and proposed revisions to diagnostic and severity grading criteria, while ...
Source: Peerview CME/CE Video Podcast - Internal Medicine International - April 17, 2019 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
NCI Support for Cancer Immunology
Immunonology IG Seminar
Norman E. “ Ned ” Sharpless, M.D., was officially sworn in as the 15th director of the National Cancer Institute (NCI) on October 17, 2017. Prior to his appointment, Dr. Sharpless served as the director of the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center, a position he held since January 2014. Dr. Sharpless was a Morehead Scholar at UNC – Chapel Hill and received his undergraduate degree in mathematics. He went on to pursue his medical degree from the UNC School of Medicine, graduating with honors and distinction in 1993. He then completed his internal medicine res...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
PD-1 Cancer Immunotherapy
NCI Center for Cancer Research Eminent Lecture Series
Gordon J. Freeman, PhD works in the Department of Medical Oncology at Dana-Farber Cancer Institute and is Professor of Medicine at Harvard Medical School. Dr. Freeman earned his BA in Biochemistry and Molecular Biology, and PhD in Microbiology and Molecular Genetics from Harvard University. His research has identified the major pathways that control the immune response by inhibiting T cell activation (PD-1/PD-L1 and B7-2/CTLA-4) or stimulating T cell activation (B7-2/CD28).
In 2000, Dr. Freeman discovered PD-L1 and PD-L2, and showed they were ligands for PD-1, thus def...
Source: Videocast - All Events - March 16, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Hematopoietic stem cells in stress, disease, and aging
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Passagu é 's research investigates the biology of blood-forming hematopoietic stem cells in normal and deregulated contexts such as development of hematological malignancies and physiological aging.For more information go tohttps://oir.nih.gov/wals/2017-2018Air date: 2/21/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Stem Cell Aging
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its fall seminar, featuring Dr. Sean Morrison. Dr. Morrison is the Director of the Children ’ s Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested in the mechanisms that regulate stem cel...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Prevention of Progression in Multiple Myeloma
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Irene Ghobrial is an Associate Professor at Dana-Farber Cancer Institute (DFCI), Harvard Medical School, Boston, MA and an Associate member of the Broad Institute, Cambridge, MA. She is the director of the Michele& Stephen Kirsch Laboratory and co-director of the Center for Prevention of Progression of Blood Cancers (CPOP) at DFCI. In addition, she is the co-leader of the Blood Cancer Research Partnership (BCRP), a consortium for innovative clinical trials of community oncology sites coordinated by DFCI.
Dr. Ghobrial received her medical degree from Cairo University S...
Source: Videocast - All Events - October 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Screening of Discovery's First in Human
Between September 2015 and June 2016, Discovery film crews followed patients, their families, doctors and researchers, and NIH clinical and care staff to provide a personal and realistic look at the challenges of carrying out cutting edge, experimental medicine. The endeavor was a massive undertaking, with Discovery crews capturing over 1,000 hours of footage in the hospital. More than 1,000 staff members consented to be filmed.
The film is a shining moment for the NIH as a whole and the Clinical Center in particular, and provides an unprecedented glimpse into the triumphs and setbacks that are part of being at the forefro...
Source: Videocast - All Events - August 3, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Hijacking of immune regulatory mechanisms in lymphoid malignancies
Immunology Interest Group Seminar Series
Signalling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signalling in human lymphoma has only come to light recently. Roles for antigen-dependent and antigen-independent, or tonic, BCR signalling have now been described for several different lymphoma subtypes. Furthermore, correlative data implicat...
Source: Videocast - All Events - April 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Prevention of Progression in Multiple Myeloma
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Irene Ghobrial is an Associate Professor at Dana-Farber Cancer Institute (DFCI), Harvard Medical School, Boston, MA and an Associate member of the Broad Institute, Cambridge, MA. She is the director of the Michele& Stephen Kirsch Laboratory and co-director of the Center for Prevention of Progression of Blood Cancers (CPOP) at DFCI. In addition, she is the co-leader of the Blood Cancer Research Partnership (BCRP), a consortium for innovative clinical trials of community oncology sites coordinated by DFCI.
Dr. Ghobrial received her medical degree from Cairo Universi...
Source: Videocast - All Events - April 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
