Integrative Omics Approaches to Identify New Therapeutic Cancer Targets

CCR Grand Rounds Kimberly Stegmaier, M.D., Professor of Pediatrics at Harvard Medical School and the Ted Williams Chair at Dana-Farber Cancer Institute, has advanced the application of genomics to drug and protein target discovery for pediatric cancers. She is the Vice Chair for Pediatric Oncology Research, co-director of the Pediatric Hematologic Malignancy Program and an attending physician providing clinical care in Pediatric Oncology at the Dana-Farber Cancer Institute and Boston Children ’ s Hospital. Dr. Stegmaier is also an Institute Member of the Broad Institute of Harvard and MIT. She has served as a Council Member with the Society for Pediatric Research from 2013-2016 and now as the Chair for the American Association for Cancer Research (AACR) Pediatric Cancer Working Group. The Stegmaier Lab develops and integrates chemical and functional genomic approaches to identify new protein targets and small-molecule modulators of malignancy with an eye toward clinical translation. The laboratory has focused on pediatric malignancies notable for an aberrancy of differentiation and/or oncogenic activation of transcription factors: the acute leukemias, neuroblastoma and Ewing sarcoma. Multiple clinical trials have resulted from her laboratory ’ s research. Dr. Stegmaier is the recipient of numerous awards such as the Joanne Levy, M.D., Memorial Award for Outstanding Achievement from the American Society of Hematology, the Society for Pediatric Research Young Investigator A...
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