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Can personalized medicine live up to its hype in health care?
The genius of Henry Ford was in his perfection of mass production. Ford’s assembly lines produced oodles of Model T, with economies of scale so that the cost of each car fell to the point that even those working in those lines could afford them. His method was copied by other car manufacturers and ultimately Read more… Can personalized medicine live up to its hype in health care? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 18, 2023 Category: General Medicine Authors: Tags: Meds Oncology/Hematology Source Type: blogs

MLKL Knockout Slows Some Aspects of Immune Aging
Researchers here report on the results of disabling the MLKL gene involved in necroptosis, a form of programmed cell death. This reduces age-related inflammation in female mice, and delays loss of lymphocyte production in male mice. The changes are not enough to produce differences in apparent signs of aging, such as mortality rate, however. The scientific challenge here lies in linking reduced necroptosis to the observed changes in immune aging, as is usually the case in any change that is broadly related cell survival or fundamental cell activities such as replication. This sort of activity can keep research teams busy f...
Source: Fight Aging! - February 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing the Development of Senotherapeutics
Today's open access paper is a very readable tour of the present state of research and development of therapies targeting senescent cells, whether to destroy them or alter their function in favorable ways. In both cases the primary goal is to reduce the senescence-associated secretory phenotype (SASP), the pro-growth, pro-inflammatory signaling that contributes to degenerative aging as the number of senescent cells rises over the course of later life. It is hoped that clearance of senescent cells will produce a sizable positive impact for late life health, reducing chronic inflammation, slowing the onset of near all age-re...
Source: Fight Aging! - February 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Primary PCI and its silent encounter with “ myocardial neutrophilia ”
Myocardial infarction,  a gross pathological entity renamed now as STEMI for clinical purposes, is the most famous medical emergency that triggers a series of calls. Right from 911/First medical contact, the ER, that ends up in CCU or a 24/7 cath lab. The heart, can’t wait for all these external responses when it is challenged with a vascular accident. The moment ATO occurs, two things happen. The endogenous fibrinolytic led by native tissue PA (Tpa) tries to get rid of the thrombotic plug by all its means. It succeeds in 15%. We call it spontaneous lysis or aborted MI. Many lives are lost in the remaining before th...
Source: Dr.S.Venkatesan MD - February 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized myocardial neutrophilia Source Type: blogs

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Improving cancer care through integrated care [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! In this episode, we will be discussing the role of health system specialty pharmacies in improving patient outcomes. Our guest, Chelsey Lindner, is a clinical pharmacist who will share her insights on the unique combination of expertise and resources that these pharmacies offer to Read more… Improving cancer care through integrated care [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 26, 2023 Category: General Medicine Authors: Tags: Podcast Oncology/Hematology Source Type: blogs

Fecal Microbiota Transplant From Young to Old Mice Reduces Inflammation and Improves Hematopoiesis
In this study, we performed fecal microbiota transplantation (FMT) from young mice to aged mice and observed significant increment in lymphoid differentiation and decrease in myeloid differentiation in aged recipient mice. Further, FMT from young mice rejuvenated aged HSCs with enhanced short-term and long-term hematopoietic repopulation capacity. Mechanistically, single-cell RNA sequencing deciphered that FMT from young mice mitigated inflammatory signals, upregulated FoxO signaling pathway and promoted lymphoid differentiation of HSCs during aging. Finally, integrated microbiome and metabolome analyses uncovered that FMT...
Source: Fight Aging! - January 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cancer as a model of diversity: To be an ally, ask
I was brought to tears today, suddenly, unexpectedly, by the ringing of a bell. I had passed a small sign earlier, and I knew that the ringing signified the completion of someone’s chemotherapy. As I heard cheers, I thought how amazing this group of individuals (who I could not see, closeted as I was behind Read more… Cancer as a model of diversity: To be an ally, ask originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 22, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Breast cancer surgery: Liking my doctor mitigates the feeling of violation
On waking up from anesthesia-induced unconsciousness, I was dressed in an unfamiliar pink surgical bra with multiple Velcro straps. As if I were a doll, someone had clothed my limp body without my knowledge, and I had no idea who. Even then, I had a vague sense, groggy and feeling an odd lack of sensation Read more… Breast cancer surgery: Liking my doctor mitigates the feeling of violation originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 15, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Caught in the middle: How health insurance companies influence cancer drug selection
Patients may find themselves caught in the middle between their health insurance company and their oncologist when it comes to selecting the drugs used to treat their cancer. Why is this? The American Cancer Society explains biologic drugs (derived from living organisms such as yeast, bacteria, or animal cells) and biosimilar drugs, which behave similarly Read more… Caught in the middle: How health insurance companies influence cancer drug selection originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 12, 2023 Category: General Medicine Authors: Tags: Meds Oncology/Hematology Source Type: blogs

Learn to earn end-of-life respect
Pele, the famous Brazilian soccer star, reportedly stopped medical treatment for colon cancer. Media outlets stated he was receiving various iterations of comfort, hospice, and palliative care which were perceived as criminal and disrespectful. His daughter denied these allegations on Instagram. How often are those with serious illnesses treated like criminals for wrongdoing? When medical Read more… Learn to earn end-of-life respect originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 6, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Palliative Care Source Type: blogs

From cough to cancer: one woman ’ s determination to find answers and relief
My mom is putting garlic oil in her ears because her house cleaner told her it would help with her recent hearing loss. When I asked her why she was continuing to do this even after being assessed by two physicians, including an ear, nose, and throat specialist, she just shrugged and told me she Read more… From cough to cancer: one woman’s determination to find answers and relief originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 3, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Which one is worse: cancer or loneliness?  
If my grandfather were alive, he would be the same age as Mr. Hendricks. Seventy-eight years old. That’s why when I first met him, he introduced himself as John, but I preferred to call him Mr. Hendricks. That’s how I was taught as one of the ways to give respect to the elderly. The “American” Read more… Which one is worse: cancer or loneliness?  originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 30, 2022 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

The vampire, phlebotomy, and advocating for my care
Every five weeks, I see a different vampire from the phlebotomy and give this collective of blood-suckers consent to take my blood. The crimson-filled, turquoise-capped vacutainer is destined for analysis to see how fast my blood coagulates. If the vampires read my chart, they would see the graph showing values dating back to 2015, marking Read more… The vampire, phlebotomy, and advocating for my care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 25, 2022 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs