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5 myths of treating sickle cell disease with automated red blood cell exchange
Not all transfusion therapies are the same. Unlike other transfusion therapies, automated red blood cell exchange (RBCX) efficiently and rapidly removes a patient’s hemoglobin S (HbS)-containing RBCs and replaces them with healthy RBCs. You may be surprised to learn that there are a few misperceptions surrounding automated RBCX. How do you think about automated RBCX Read more… 5 myths of treating sickle cell disease with automated red blood cell exchange originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 19, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

How to Construct Measures of Biological Age
This paper provides an introduction to the several different methodological approaches that can be used to assemble a measure of biological age from data sets that exhibit changes with age. In recent years, many varied aging clocks have been produced and tested. Where such clocks are derived from epigenetic, transcriptomic, proteomic, and similar data, it remains unclear as to which processes of aging they reflect, and to what level of sensitivity. Clocks that use very few data points can produce good measures in a naturally aging population, but are unlikely to be useful when assessing the outcome of a potential rejuvenat...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The deadly consequences of a shortage: The Pluvicto crisis leaves metastatic prostate cancer patients in limbo
You’ve recently been diagnosed with metastatic cancer. You started the recommended first-line therapy, but it isn’t cutting it. There is another available treatment, but your hopes are crushed upon learning that you will have to wait at least three months before the life-extending medication can be produced for you and reach your location. All the Read more… The deadly consequences of a shortage: The Pluvicto crisis leaves metastatic prostate cancer patients in limbo originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 12, 2023 Category: General Medicine Authors: Tags: Meds Oncology/Hematology Source Type: blogs

An inspiring tribute to an exceptional radiologist who made a lasting impact
“He had an intuitive gift as a physician in diagnosing and managing breast cancer. His expertise helped countless patients, and he was deeply appreciated by those he cared for. He felt an enormous sense of gratitude to be able to help his patients and be an integral part of their care.” I didn’t want to Read more… An inspiring tribute to an exceptional radiologist who made a lasting impact originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 11, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Reviewing T Cell Immunotherapies to Treat Cancer
The use of immunotherapies will most likely replace chemotherapy and radiation therapy for the treatment near all cancers over the next twenty years, and has already done so for many types of cancer. We should expect immunotherapies to in turn be replaced by approaches that target the telomere lengthening essential to all cancers. The wheel turns slowly, but this progress will lead steadily to an end to the suffering and loss of life accompanying cancer. Cancer will become a mild, annoying but controllable condition within a matter of decades, within the lifetimes of most of those reading this now. The review paper noted h...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The miracle cure: the world ’ s first successful bone marrow transplant for aplastic anemia
An excerpt from Living Medicine: Don Thomas, Marrow Transplantation, and the Cell Therapy Revolution. Late in the summer of 1960, Dr. Clem Finch invited Dr. Don Thomas to Seattle to give a talk about his early experience with transplantation. Clem, who had been Thomas’s hematology fellowship instructor at the Brigham in Boston, had since moved Read more… The miracle cure: the world’s first successful bone marrow transplant for aplastic anemia originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 6, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Unwavering faith: a woman ’ s journey through cancer and beyond
Her back was mottled, and she could barely sit up. She was weak from her invasive cancer. I visited her on Easter Sunday. Perhaps it was God’s will that I didn’t have an elaborate Easter dinner with ham, rolls, pies, and house decor filled with decorative bunnies. Instead, I went to visit this dear friend Read more… Unwavering faith: a woman’s journey through cancer and beyond originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 5, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

A Second Cancer
It’s been a long time since I posted anything.   Recently I was diagnosed with a second primary cancer.  I’ve had surgery and am well on the way to recovery. My hematologist and the head and neck cancer specialist agreed it wasn’t necessary for me to undergo aggressive surgery for this cancer, so I didn’t have … (Source: beth's myeloma blog)
Source: beth's myeloma blog - May 4, 2023 Category: Cancer & Oncology Authors: Beth Tags: Cancer Source Type: blogs

Against all odds: 17-month-old defies death and improves neurologically after craniospinal irradiation
Three months ago, a case was discussed in the multidisciplinary tumor board. A 17-month-old child was admitted through the ER with a posterior fossa tumor (brain tumor) and multi-level spinal cord compression due to tumor deposits. The tumor was so extensive that only a biopsy could be performed rather than maximum safe resection. The biopsy Read more… Against all odds: 17-month-old defies death and improves neurologically after craniospinal irradiation originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 1, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Breakthrough trial shows MRI-guided radiation can reduce prostate cancer treatment toxicity
Nearly 290,000 American men will be diagnosed with prostate cancer in 2023. Thankfully, the vast majority will be diagnosed with clinically localized disease and can be cured with either surgery or radiotherapy. Emerging clinical trial data have cemented stereotactic body radiotherapy (SBRT), a form of radiation in which ≤5 daily doses are delivered with high Read more… Breakthrough trial shows MRI-guided radiation can reduce prostate cancer treatment toxicity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 29, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Why poor diets are contributing to a surge in colorectal cancer cases among young people
An alarming trend has emerged in my medical practice in recent years: I’m seeing more and more young adults with colorectal cancer. When I began practicing as a family physician 21 years ago, I never saw patients in their 40s and 50s with the disease, much less ones in their 30s. Now, I diagnose two Read more… Why poor diets are contributing to a surge in colorectal cancer cases among young people originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 26, 2023 Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs

A veteran ’ s battle against possible lung cancer
During my night shift at the emergency department, I encountered a 72-year-old decorated war veteran named Mr. Sun. Accompanied by his concerned wife, he came to address a year-long struggle with fatigue and a non-productive cough he’d been experiencing in recent weeks. Initially resistant to seeking medical attention, Mr. Sun finally gave in to his Read more… A veteran’s battle against possible lung cancer originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 22, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

The insurance denial process: one oncologist ’ s fight against a broken system
It is 4:15 p.m. in my clinic, and I’m running an hour behind. One of my morning patients arrived acutely ill and thus required more of my time and attention than the schedule allotted for. Accordingly, every patient after that has ended up waiting for me. And, as I’m a cancer physician, each of them Read more… The insurance denial process: one oncologist’s fight against a broken system originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 16, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Finding hope in the face of cancer
“My best friend’s mother arrived at our oncology outpatient department. She had recently been diagnosed with locally advanced breast cancer and was understandably apprehensive, filled with numerous questions. I took her medical history and performed an examination. She didn’t have any relatives with cancer, so all the treatments and terminology were completely unfamiliar to her. Read more… Finding hope in the face of cancer originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 9, 2023 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs