Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Was Causing a Toddler ’ s Vocal Problems? Not Any of the Usual Suspects
When a toddler presented with a raspy voice, pediatricians initially suspected respiratory infections, dysphonia and then acid reflux. But, as revealed in a “Mystery Diagnosis” column in the Washington Post, the problem was much more serious.
A pediatrician initiated acid reflux treatment and referred the little girl, who had experienced voice problems since birth, to a a pediatric otolaryngologist. The ENTs investigations revealed a diagnosis that shocked the girls’ parents: She had a rare disease—recurrent respiratory papillomatosis. Caused by two strains of the human papilloma virus (HPV)—a sexually tran...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - March 29, 2019 Category: Speech-Language Pathology Authors: Carol Polovoy Tags: Health Care News Slider Speech-Language Pathology HPV Voice Disorders Source Type: blogs
Simple Ways To Boost Health Care Access for People With Communication Disorders
The objectives—and perhaps even more interesting, the disparities within the objectives according to sex, educational attainment and disability status—are tracked by the Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics. We can search the CDC’s database by topic area for additional data on health care disparities.
While the government works toward the Healthy People initiative, we can help improve health care access for those with communication disorders in our communities. I started by considering people’s social determinants of health in my community and surrounding areas....
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - March 25, 2019 Category: Speech-Language Pathology Authors: Shelley D. Hutchins Tags: Audiology Health Care Private Practice Slider Speech-Language Pathology hearing loss Language Disorders Speech Disorders Source Type: blogs
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent well known to cause coronary vasospasm:Correct answer: c) 5-fluorouracil
5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrh...
Source: Cardiophile MD - February 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Creating an Easier Path for Patients With Head/Neck Cancer
Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care.
How did I create this pathway?
The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—und...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - February 4, 2019 Category: Speech-Language Pathology Authors: Stacey Brill Tags: Health Care Slider Speech-Language Pathology Dysphagia Source Type: blogs
Creating an Easier Path for Head/Neck Cancer Patients
Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care.
How did I create this pathway?
The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—und...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - February 4, 2019 Category: Speech-Language Pathology Authors: Stacey Brill Tags: Health Care Slider Speech-Language Pathology Dysphagia Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: November 2018
By BISHAL GYAWALI MD
Keynote speech
There was a very sobering piece in NEJM by the FDA last month in which the authors try to explore what went wrong with the Keynote-183, Keynote-185 and checkmate 602 trials testing PD-1 inhibitors combinations with pomalidomide or lenalidomide and dexamethasone in multiple myeloma. Interim analysis of Keynote 183 and 185 revealed detrimental effects on overall survival (OS) with hazard ratios of 1.61 and 2.06, not explained by differences in toxicities alone. The checkmate 602 trial was also halted in light of these findings and also showed higher mortality in the nivolumab combina...
Source: The Health Care Blog - December 17, 2018 Category: Consumer Health News Authors: matthew holt Tags: Pharmaceuticals Physicians Bishal Gyawali Cancer drugs cancer immunotherapy Clinical Trials FDA Oncology PD-1 inhibitors Source Type: blogs
10 things a pediatric oncologist wants you to know
1. Cancer is not rare. Technically, childhood cancer is rare compared to adult cancer, but it’s not as rare as you think. Outside of my work, I can think of 3 people who I know personally that had a childhood cancer. A teammate on my high school basketball team, my sister-in-law, and a high school debate teammate. My guess is that you also know someone from church, a coworker’s kid, or one of your kids’ classmates who has been affected by this disease.
2. Curing cancer and preventing cancer is not the same thing. We do have a cure for the majority of childhood cancers. Nearly 90 percent of children dia...
Source: Kevin, M.D. - Medical Weblog - September 17, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/wendy-a-rhoades" rel="tag" > Wendy A. Rhoades, MD < /a > Tags: Conditions Oncology/Hematology Pediatrics Source Type: blogs
Make Asbestos Great Again? - Trump Once Claimed " Movement Against by Asbestos was Led by the Mob, " Now is EPA Wants to Relax Asbestos Regulation
Introduction: An Old Public Health MenaceThis is somewhat personal. In the early 1980s, as a general internal medicine fellow, I gave a series of talks about important medical problems that generalist physicians often missed. One was asbestos related disease. Although asbestos had been heavily regulated since 1973, there were stilll large numbers of people exposed to it alive in the 1980s. One of my primitive slides, seemingly a picture of type writing, stated that around then, 2 to 4 million people who had histories of significant asbestos exposure were likely alive. Asbestos is known t...
Source: Health Care Renewal - August 10, 2018 Category: Health Management Tags: asbestos cancer conflicts of interest Donald Trump public health Source Type: blogs
Practical and Applicable Solutions: How SLPs Benefited from ASHA Health Care Connect
SLPs came to ASHA’s Health Care Connect conference ready to learn about dysphagia, head and neck cancer, Parkinson’s disease, concussion, delirium—and much more. Across three days of sessions, SLPs heard how their unique skills and training prepared them to work as an integral part of multidisciplinary teams.
Editor’s note: This is part two of a series on tips SLPs learned at ASHA Connect 2018. Read part one for insights heard from attendees of the schools’ sessions.
Ruth Snyder, an SLP and solo practitioner in Jacksonville, Florida, began her Friday morning at Vivian Sisskin’s session, “Differential ...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - July 24, 2018 Category: Speech-Language Pathology Authors: Jillian Kornak Tags: Academia & Research Events Health Care Private Practice Schools Slider Speech-Language Pathology dementia Dysphagia Parkinson's Speech Disorders Source Type: blogs
The Lie of Precision Medicine
My next blog post will be entitled " The Lie of Precision Medicine "— sarcastic_f (@sarcastic_f)June 23, 2018This post will be my own personalized rant about the false promises of personalized medicine. It will not be about neurological or psychiatric diseases, the typical topics for this blog. It will be about oncology, for very personal reasons: misery, frustration, and grief. After seven months of research on immunotherapy clinical trials, I couldn ' t find a single [acceptable] one1 in either Canada or the US that would enroll my partner with stage 4 cancer. For arbitrary reasons, for financial reasons, because ...
Source: The Neurocritic - June 24, 2018 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
The Not-Quite Annual ASCO Round-Up - 2018 edition
by Drew RosielleTheAmerican Society of Clinical Oncology annual meeting, besides being a feast for the pharmaceutical business news pages (google ' ASCO ' and most of the hits will be about how announcement X affected drug company Y ' s stock), is also one of the premiere platforms for publishing original palliative-oncology research. So every year I try to at least scan the abstracts to see what ' s happening, and I figure I might as well blog about it. It ' s tough to analyze abstracts, so I ' ll mostly just be summarizing ones that I think will be of interest to hospice and palliative care folks. I imagine I ' ve missed...
Source: Pallimed: A Hospice and Palliative Medicine Blog - June 6, 2018 Category: Palliative Care Tags: artificial nutrition ASCO cannabanoid code status conference reviews fatigue hpmglobal marijuana mindfulness mucositis neuropathic oncology pain race rosielle scrambler Source Type: blogs
Tips for Teaching Graduate Students About Dysphagia
“When I was in graduate school, we didn’t even have a class on dysphagia,” I sometimes tell my students. But before you hold this against me, I did realize this gap in my education during my clinical fellowship back in 1993, so I attended a course taught by Jeri Logemann.
The course helped me connect the dots, but I did my fellowship in an outpatient department for a children’s hospital, so I needed to learn quickly. Fortunately, Joan Arvedson, Bob Beecher and Monica Wojcik continued to shape my pediatric dysphagia knowledge.
Now I’m a clinical instructor and guest lecturer teaching a pediatric dysphagia course t...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - May 14, 2018 Category: Speech-Language Pathology Authors: Jennifer WIlson Tags: Academia & Research Health Care Slider Speech-Language Pathology Dysphagia Feeding Disorders NICU Swallowing Disorders Source Type: blogs
