What Was Causing a Toddler ’ s Vocal Problems? Not Any of the Usual Suspects

When a toddler presented with a raspy voice, pediatricians initially suspected respiratory infections, dysphonia and then acid reflux. But, as revealed in a “Mystery Diagnosis” column in the Washington Post, the problem was much more serious. A pediatrician initiated acid reflux treatment and referred the little girl, who had experienced voice problems since birth, to a a pediatric otolaryngologist.  The ENTs investigations revealed a diagnosis that shocked the girls’ parents: She had a rare disease—recurrent respiratory papillomatosis. Caused by two strains of the human papilloma virus (HPV)—a sexually transmitted infection acquired at or before birth—the incurable disease causes benign tumors in the respiratory tract, most commonly in the larynx. The papillomas interfere with the normal vibrations of the vocal folds and may block the airway. Many Future Physicians Don’t Connect HPV With Head and Neck Cancer Strategies For a New Generation of Oral Cancer Patients Blueprint for Creating a Successful Head and Neck Cancer Support Group Treatment includes surgery to shave off the tumors, which grow back. The procedure, which may need to be repeated two or three times a year, can damage the vocal cords. The article describes a newer method to remove the tumors, potassium titanyl phosphate laser, which can remove more tumor while minimizing vocal cord damage. Carol Polovoy is managing editor of The ASHA Leader. cpolovoy@asha.org The...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Health Care News Slider Speech-Language Pathology HPV Voice Disorders Source Type: blogs

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This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis. PMID: 31955147 [PubMed - in process]
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
This study aims to unveil the mechanisms underlying the pro-apoptotic effect of Cur-NLC on HepG2 cells. Evidence indicates that low expression of death receptors (DRs) on cancer cell membranes leads to attenuated apoptosis signaling. This study showed that Cur-NLC significantly increased total expression of DR5 protein while simultaneously upregulated cell membrane expression of DR5. Cur-NLC significantly increased caspase-8 and caspase-3 activities, accompanied by increased apoptosis. Furthermore, enhanced apoptosis was inhibited in the presence of a pan-caspase inhibitor, Z-VAD-FMK. Therefore, Cur-NLC induced activation ...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. Here, we describe the effects of polyphyllin D (PD) on proliferation and cell cycle modifications of PCa cells, and whether SOX7 participates in this process. PC-3 cells were cultured in complete medium containing PD for 12, 24, and 48 h. MTT assay was used to investigate the cytotoxic effects of PD. Cell cycle progression was analyzed using propidium iodide (PI) staining, and prote...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Conclusion: SliceTracker is modular and extensible open source platform for supporting image processing aspects of the tpMRgBx procedure. It has been successfully utilized to support clinical research procedures at our site.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 20 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Alicia Gutiérrez, Lorena Sambuco, Laura Álvarez, Mariel Núñez, Rosa Bergoc, Elsa Zotta, Gabriela Martín, Andrea RandiAbstractBreast cancer is currently the leading cause of cancer death among women worldwide. AP-1 (c-Fos/c-Jun) is associated with proliferation and survival, while cytoplasmic c-Fos activates phospholipid synthesis in cells induced to differentiate or grow. Estrogen receptor α 46 (ERα46) is a splice variant of full-length ERα66 and ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/C9CP06530J, PaperPablo Abreu Morais, Francisco Francin é Maia, Jr., Christian Solis-Calero, Ewerton Wagner Santos Caetano, Valder Nogueira Freire, Hernandes Faustino Carvalho Despite being recognized as a therapeutic target in the processes of cancer cell proliferation and metastasis for over 50 years, the interaction of the urokinase plasminogen activator uPA with its... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09214E, CommunicationMathew David Anker, Ryan James Schwamm, Martyn P Coles The reaction of the potassium aluminyl K[Al(NONDipp)] (NONDipp = [O(SiMe2NDipp)2]2 –, Dipp = 2,6-iPr2C6H3) with an organic azide generates the aluminium imide complex, K[Al(NONDipp)(NMes)] (Mes = mesityl = 2,4,6-Me3C6H2). DFT calculations... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
A new study casts doubt on the popular notion that smoking weed or using CBD may help cancer patients cope with pain.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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