Imatinib
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Pulmonary Arterial Hypertension Associated to Tyrosine Kinase Inhibitor - A Case Report
We present the case of PAH in a 46-year-old woman treated with imatinib for Acute Lymphocytic Leukemia (ALL). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Papageorgiou, K. Jansson Source Type: research
ERS/EBMT clinical practice guidelines on treatment of pulmonary chronic graft-versus-host disease in adults
Chronic graft-versus-host disease (cGvHD) is a common complication after allogeneic haematopoietic stem cell transplantation, characterised by a broad disease spectrum that can affect virtually any organ. Although pulmonary cGvHD is a less common manifestation, it is of great concern due to its severity and poor prognosis. Optimal management of patients with pulmonary cGvHD is complicated and no standardised approach is available. The purpose of this joint European Respiratory Society (ERS) and European Society for Blood and Marrow Transplantation task force was to develop evidence-based recommendations regarding the treat...
Source: European Respiratory Journal - March 28, 2024 Category: Respiratory Medicine Authors: Bos, S., Murray, J., Marchetti, M., Cheng, G.-S., Bergeron, A., Wolff, D., Sander, C., Sharma, A., Badawy, S. M., Peric, Z., Piekarska, A., Pidala, J., Raj, K., Penack, O., Kulkarni, S., Beestrum, M., Linke, A., Rutter, M., Coleman, C., Tonia, T., Schoema Tags: Respiratory clinical practice Original Articles: ERS/EBMT guidelines Source Type: research
Imatinib pharmacokinetics and creatine kinase levels in chronic myeloid leukemia patients: implications for therapeutic response and monitoring
ConclusionThe study highlights the link between imatinib ’s pharmacokinetics and elevated CK levels, indicating a possible correlation between specific metabolites and improved treatment response. Individualized monitoring of CK levels and imatinib pharmacokinetics could enhance care for CML patients. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research
CRISPR-Cas9-Mediated Bioluminescent Tagging of Endogenous Proteins by Fluorescent Protein-Assisted Cell Sorting
Methods Mol Biol. 2024;2779:273-286. doi: 10.1007/978-1-0716-3738-8_12.ABSTRACTOncogenic fusion genes are attractive therapeutic targets because of their tumor-specific expression and central "driver" roles in various human cancers. However, oncogenic fusions involving transcription factors such as PAX3-FOXO1 in alveolar fusion gene-positive rhabdomyosarcoma (FP-RMS) have been difficult to inhibit due to the apparent lack of tractable drug-like binding sites comparable to that recognized by Gleevec (imatinib mesylate) on the BCR-ABL1 tyrosine kinase fusion protein. Toward the identification of novel small molecules that se...
Source: Mol Biol Cell - March 25, 2024 Category: Molecular Biology Authors: Robert G Hawley Teresa S Hawley Source Type: research
CRISPR-Cas9-Mediated Bioluminescent Tagging of Endogenous Proteins by Fluorescent Protein-Assisted Cell Sorting
Methods Mol Biol. 2024;2779:273-286. doi: 10.1007/978-1-0716-3738-8_12.ABSTRACTOncogenic fusion genes are attractive therapeutic targets because of their tumor-specific expression and central "driver" roles in various human cancers. However, oncogenic fusions involving transcription factors such as PAX3-FOXO1 in alveolar fusion gene-positive rhabdomyosarcoma (FP-RMS) have been difficult to inhibit due to the apparent lack of tractable drug-like binding sites comparable to that recognized by Gleevec (imatinib mesylate) on the BCR-ABL1 tyrosine kinase fusion protein. Toward the identification of novel small molecules that se...
Source: Mol Biol Cell - March 25, 2024 Category: Molecular Biology Authors: Robert G Hawley Teresa S Hawley Source Type: research
