SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
SOHO State of the Art Updates and Next Questions: Chronic Myeloid Leukemia and Pregnancy: "Per Aspera Ad Astra"
Clin Lymphoma Myeloma Leuk. 2023 Dec 12:S2152-2650(23)02189-4. doi: 10.1016/j.clml.2023.11.011. Online ahead of print.ABSTRACTChronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic disorder that can be treated with targeted drugs and allows survival expectations approaching age-matched controls. Thus, pregnancy and conception in CML should not be precluded anymore; however, to ensure the well-being of both the mother and the developing fetus careful planning and management are required. Tyrosine Kinase Inhibitors (TKIs) are not genotoxic or carcinogenic but can pose a risk to the developin...
Source: Clinical Lymphoma and Myeloma - December 27, 2023 Category: Cancer & Oncology Authors: Elisabetta Abruzzese Malgorzata Monika Trawinska Paolo De Fabritiis Simona Bernardi Source Type: research
The prevalence of hepatic and thyroid toxicity associated with imatinib treatment of chronic myeloid leukaemia: a systematic review
ConclusionHigh frequency of mild and severe hepatotoxicity, associated with imatinib in CML patients, was reported in the published literature. Low numbers of mild and manageable thyroid toxicity events were reported. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 26, 2023 Category: Drugs & Pharmacology Source Type: research
FBXW7 regulates the sensitivity of imatinib in gastrointestinal stromal tumors by targeting MCL1
ConclusionsFBXW7 regulates imatinib sensitivity by inhibiting MCL1 to enhance imatinib-induced apoptosis in GIST, and predicts efficacy of imatinib treatment in high-risk GIST patients treated with imatinib. (Source: Gastric Cancer)
Source: Gastric Cancer - December 24, 2023 Category: Gastroenterology Source Type: research
C-kit controls blood-brain barrier permeability by regulating caveolae-mediated transcytosis after chronic cerebral hypoperfusion
This study provides evidence that C-kit is a key BBB permeability regulator through caveolae-mediated transcytosis in EC after CCH.PMID:38141279 | DOI:10.1016/j.biopha.2023.115778 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 23, 2023 Category: Drugs & Pharmacology Authors: Junkui Shang Wei Li Huiwen Zhang Wan Wang Ning Liu Dandan Gao Fengyu Wang Xi Yan Chenhao Gao Ruihua Sun Haohan Zhang Kai Ma Fengmin Shao Jiewen Zhang Source Type: research
C-kit controls blood-brain barrier permeability by regulating caveolae-mediated transcytosis after chronic cerebral hypoperfusion
This study provides evidence that C-kit is a key BBB permeability regulator through caveolae-mediated transcytosis in EC after CCH.PMID:38141279 | DOI:10.1016/j.biopha.2023.115778 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 23, 2023 Category: Drugs & Pharmacology Authors: Junkui Shang Wei Li Huiwen Zhang Wan Wang Ning Liu Dandan Gao Fengyu Wang Xi Yan Chenhao Gao Ruihua Sun Haohan Zhang Kai Ma Fengmin Shao Jiewen Zhang Source Type: research
