FBXW7 regulates the sensitivity of imatinib in gastrointestinal stromal tumors by targeting MCL1

ConclusionsFBXW7 regulates imatinib sensitivity by inhibiting MCL1 to enhance imatinib-induced apoptosis in GIST, and predicts efficacy of imatinib treatment in high-risk GIST patients treated with imatinib.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research