Fight Aging! Newsletter, May 1st 2017
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation."
In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create molec...
Source: Fight Aging! - April 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 24th 2017
This study identified 1,497 genes with significantly different expression at different ages. Gene sets with a defined age-associated expression pattern provide information about molecular processes with altered activity during aging and provide a valuable diagnostic tool for determining individual biological rate of aging and predicting risk of age-associated disease, as demonstrated in follow-up analyses. On a gene-by-gene basis, differential expression alone is insufficient to distinguish between genes that play a causative role in aging and genes that merely respond to the altered physiological environment in an aging o...
Source: Fight Aging! - April 23, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Internet Speech 2016: More Regulation Needed?
Election law expert Nathaniel Persily has writtenan interesting article about the Internet and the 2016 election. The problems Nate (and others) see in 2016 will inform the debate about free speech now and in future elections.Persily notes that the 2016 campaign saw an “online explosion of campaign-relevant communication from all corners of cyberspace.” Here’s his description of the Trump campaign’s social media efforts:Employing traditional web-based communication, event promotions, new apps, native advertising (in which web ads are designed to look like articles in the publication containing them), and new uses o...
Source: Cato-at-liberty - April 21, 2017 Category: American Health Authors: John Samples Source Type: blogs
Show Your Appreciation for the Fundraising Work of Lifespan.io
The Lifespan.io and Life Extension Advocacy Foundation (LEAF) volunteers have over the past few years put together and maintained a crowdfunding infrastructure used to successfully raise hundreds of thousands of dollars for rejuvenation research projects. They have carried the message that aging can be effectively treated as a medical condition out to new audiences, expanded our community of supporters, and helped to connect researchers and entrepreneurs to new patrons. The LEAF volunteers are presently running a small fundraiser in search of monthly donors to help expand their present advocacy for the cause of rejuvenatio...
Source: Fight Aging! - April 20, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 17th 2017
This study assessed the prevalence of grey hair in patients with coronary artery disease and whether it was an independent risk marker of disease.
This was a prospective, observational study which included 545 adult men who underwent multi-slice computed tomography (CT) coronary angiography for suspected coronary artery disease. Patients were divided into subgroups according to the presence or absence of coronary artery disease, and the amount of grey/white hair. The amount of grey hair was graded using the hair whitening score: 1 = pure black hair, 2 = black more than white, 3 = black equals white, 4 = white more t...
Source: Fight Aging! - April 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Discrimination Against Patients With Substance Use Disorders Remains Prevalent And Harmful: The Case For 42 CFR Part 2
The authors of a recent Health Affairs Blog post argue that 42 CFR Part 2, the law designed to protect confidentiality of patients with substance use disorders, is outdated and unnecessary. We could not disagree more. 42 CFR Part 2 provides bedrock protections for people with substance use disorders that are as critical now as they were in the 1970s when the law was first enacted. The purpose of the confidentiality law is to ensure that a person with a substance use disorder is not made more vulnerable to discriminatory practices and legal consequences as a result of seeking treatment. Unfortunately, patients with substan...
Source: Health Affairs Blog - April 13, 2017 Category: Health Management Authors: Karla Lopez and Deborah Reid Tags: Featured Population Health Public Health Quality 42 CFR Part 2 HIPAA opioid epidemic patient discrimination patient privacy substance use treatment Source Type: blogs
Fight Aging! Newsletter, April 10th 2017
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers.
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions
Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined age-assoc...
Source: Fight Aging! - April 9, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
You Ought to Have a Look: The Catastrophe of Climate Catastrophizing and Fun at the House Science Committee
You Ought to Have a Look is a regular feature from the Center for the Study of Science. While this section will feature all of the areas of interest that we are emphasizing, the prominence of the climate issue is driving a tremendous amount of web traffic. Here we post a few of the best in recent days, along with our color commentary.—This time around You Ought to Have a Look at abrilliant analysis of the profound illogic of “climate catastrophizing” appearing, in all places, in Foreign Affairs, arguably the most important international contributor to precisely just that.Written by the Manhattan Institute ’s Oren ...
Source: Cato-at-liberty - April 3, 2017 Category: American Health Authors: Patrick J. Michaels Source Type: blogs
Mikhail Batin and the Open Longevity Project
The Life Extension Advocacy Foundation folk recently spoke to Mikhail Batin, long-standing advocate for radical life extension, and noted the latest venture from the Russian community, Open Longevity. In keeping with the spirit of the times, this is focused on setting up the infrastructure to run public human trials of interventions that may slow aging, on actually getting something done. That is admirable; we certainly need more of that in this era of stifling, overbearing regulation of every aspect of medical progress. I hope to see this effort succeed and grow. That said, I can't say as I think their initial choices are...
Source: Fight Aging! - March 4, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Ichor Therapeutics Announces Lysoclear SENS Rejuvenation Therapy and Series A Fundraising for Further Development
As regular readers will be aware, the company Ichor Therapeutics has for the past year or so been actively developing one of the results of the LysoSENS medical bioremediation program in order to produce a viable therapy. Today there is news of progress, and the work is moving on to the next stage of development and funding. This line of research sought to find bacterial enzymes that can degrade forms of metabolic waste that our cellular biochemistry struggles with, particular the constituents of lipofuscin. Lipofuscin compounds, varying in type from tissue to tissue, accumulate in the cellular recycling system known as th...
Source: Fight Aging! - February 15, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Positive Animal Trial Results for Reversible Male Contraceptive
Researchers at the University of California have published positive results of a trial in rhesus monkeys for Vasalgel, a long-term, reversible, non-hormonal male contraceptive injection.
Vasalgel is injected in a similar manner to the no-scalpel vasectomy. In a vasectomy, the vas deferens, a small tube transporting sperm from the testes, is cut and results in sterilization. Vasalgel is instead injected into the lumen of the vas deferens where the gel forms a blockage that does not allow sperm to penetrate. The temporary reduction in sperm count can then be reversed after months or years with a separate injection that dis...
Source: Medgadget - February 9, 2017 Category: Medical Equipment Authors: Tom Peach Tags: Reproductive Medicine Urology Source Type: blogs
Fight Aging! Newsletter, January 30th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - January 29, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
I saw how my family, including me, really felt about my husband ’s cancer
In 2000, my husband Brian was diagnosed with Stage III B Hodgkin lymphoma, which has since become a prominent part of our lives. My children and I belong to Gilda’s Club, a cancer support community. And recently, we were asked to help record a promotional video to be featured at a fundraising gala for the local chapter and on the club’s website.
I’m not a “spotlight” kind of girl, and I don’t feel drawn to video cameras or speeches, but I’ve been going to two Gilda’s Club programs—a caregiver support group, and a writing group — for nearly five years. Everyone is nurturin...
Source: Kevin, M.D. - Medical Weblog - January 24, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/melanie-di-stante" rel="tag" > Melanie Di Stante, RDN < /a > Tags: Physician Source Type: blogs
Why Rejuvenation Research Startups Go Quiet Following Launch
There are a number of young startup biotechnology companies presently working on the basis for rejuvenation therapies. Many of the interesting ones are focused on senescent cell clearance, the class of therapy that is arguably closest to the clinic. Some of those, like Oisin Biotechnologies, are supported by our community: seed funding from non-profits like the Methuselah Foundation and SENS Research Foundation, and angel funding from some of the same folk as put up matching funds for the yearly SENS rejuvenation research fundraisers. Typically, however, after the initial declaration of intent these companies go silent. Un...
Source: Fight Aging! - January 12, 2017 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A Look Back at 2016 in Longevity Science
Well, another year passes and here we are again, one step closer to the defeat of aging and age-related disease. Ours is an era of revolutionary progress in biotechnology, and it is starting to show. The past year was characterized by both significant fundraising and significant progress towards the clinical translation of the first complete SENS rejuvenation therapy: clearance of senescent cells from aged tissue. This is hopefully the first of numerous other SENS therapies based on repair of molecular damage to arrive over the next few years. I recently updated my predictions for the near future, looking over the parts of...
Source: Fight Aging! - December 31, 2016 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
