Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this.
There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Has Bitcoin Succeeded?
Lawrence H. WhiteThe answer depends on what you mean. Succeeded at what?With the US dollar price of Bitcoin reaching an all-time high above $23,000 this month, and its market cap reaching an all-time high above $400 billion, there has been much celebration among Bitcoin holders about their success at investing. The run-up has accompanied the announcements by large institutionalinvestors Grayscale, MicroStrategy, and MassMutual that they are acquiring hundreds of millions of dollars in Bitcoin for their investment portfolios. There isn ' t much doubt that the Bitcoin project has succeeded remarkably at creating a new type o...
Source: Cato-at-liberty - December 28, 2020 Category: American Health Authors: Lawrence H. White Source Type: blogs
Diffuse Midline Glioma, H3 K27M Mutation
is not a phrase you want to hear from a doctor. It’s a type of tumour that most commonly affects people under about the age of 25 years but over 3 years. It’s very rare – 100 people in the UK annually – but always lethal, sadly. The tumour grows rapidly within the Central Nervous System and has a devastating effect on the spinal cord or the brain depending on precisely where it grows.
I must admit I’d heard of spinal tumours, but don’t think I’d heard this full phrase until a friend posted about it on social media as their daughter had started a fundraiser to raise funds for rese...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 15, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Midline Glioma – research fundraiser
UPDATE: Since posting, the fundraiser has gone from 57% to 62% target reached! Thank you! Keep those donations coming in.
Diffuse Midline Glioma, H3 K27M Mutation is not a phrase you want to hear from a doctor. It’s a type of tumour that most commonly affects people under about the age of 25 years but over 3 years. It’s very rare – 100 people in the UK annually – but always lethal, sadly. The tumour grows rapidly within the Central Nervous System and has a devastating effect on the spinal cord or the brain depending on precisely where it grows.
I must admit I’d heard of spinal tumours, but do...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 15, 2020 Category: Science Authors: David Bradley Tags: Cancer Source Type: blogs
Bionano Genomics: A Belated Update
Back before I can remember -- as in January of this year -- I wrote a piece on the challenging situation of BioNano Genomics. I got an important detail wrong in that piece, missing some important fundraising, but in general from the point-of-view I took I thought it was a decent piece, meant to convey the challenge of a really amazing technology having its original market disappear. Some commenters took strong excepti on to the piece and suggested I had not-so-pure motives for writing it. They're wrong -- but at AGBT I got a chance to learn more about the company's new direction and how I hadn't been loo...
Source: Omics! Omics! - November 14, 2020 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
What presidential elections can teach us about losing gracefully
For the winner of any election, the moment of victory brings joy, applause, laughter, relief, and often champagne. Losing the presidency, however, is felt like a crushing defeat. The hours of travel, giving speeches, campaigning, fundraising, stress, and sleepless nights are all for naught. The feeling of defeat is experienced by the candidate and their […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 13, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/anjani-amladi" rel="tag" > Anjani Amladi, MD < /a > < /span > Tags: Physician Public Health & Policy Source Type: blogs
Fight Aging! Newsletter, November 9th 2020
In this study, young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
We found that injured muscles from endurance-exercised mice display improved regenerative capacity, demonstrated through higher densities of newly formed myofibres compared with controls (evidenced by an increase in embryonic myosin heavy chain expression), as well as lower inflammation (evidenced by quantifying CD68-marked macrophages), and reduced fibrosis. Enhanced myogenic function was accompanied by an increased ...
Source: Fight Aging! - November 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SENS Research Foundation 2020 Year End Fundraiser: Donate to Fund the Foundational Science Needed for New Rejuvenation Therapies
We live in the early, formative years of the era of rejuvenation, in which medicine will target the mechanisms of aging, increasingly effectively as the years pass, in order to make the old physiologically young once again. The first, crude rejuvenation therapies worthy of the name are under development or already available to the adventurous. These are senolytic treatments that selectively destroy the accumulated senescent cells that contribute to aging. Senescent cells produce chronic inflammation, tissue dysfunction, and age-related disease. By removing even just a third to a half of senescent cells in just some tissues...
Source: Fight Aging! - November 2, 2020 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Research at risk: mitigating the impact of Covid-19 on health R & D investment
This report reveals the impact of Covid-19 on health charities. It reveals that medical research charities are expected to lose almost 38 per cent of their fundraising income last academic year, and over 25 per cent this academic next year. It recommends that the government should introduce a new, three year life sciences charity partnership fund to support medical research charities.ReportInstitute for Public Policy Research - publications (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - October 23, 2020 Category: UK Health Authors: The King ' s Fund Library Source Type: blogs
He was the best I could ask for
Dad passed away about a month and a half ago. I’ve been struggling to write this ever since. Many of you knew dad, at least in a way, but probably didn’t realize it. I’ll talk more about that soon.
He was 70 and fighting liver disease. He responded well to treatment for a while. But after a few bumps in the road, he didn’t bounce back the way anyone hoped, and his quality of life suffered. Another turn for the worse, and it went downhill quickly after that. Of course, we miss him terribly. But if it’s going to happen, quickly is best. He was at peace letting go, and so were we. My sister an...
Source: Scott's Diabetes Blog - October 20, 2020 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
A symptom, not the cause
I came across this piece in The Baffler by Rick Perlstein, written in 2012 and occasioned by the Romney campaign for president. How soon we forget, but Romney lied continually and atrociously. His lying was actually pretty much on a par with the current Liar in Chief. People tried to count them all and found the task overwhelming. But Perlstein ' s point is that constant, remorseless, outrageous lying was a necessary condition for Romney to be accepted by the conservative movement, because lying is central to conservative culture. It ' s a long piece but please do read it all. Perlstein subscribed to some conservative...
Source: Stayin' Alive - October 6, 2020 Category: American Health Source Type: blogs
What is (and Do You Have) Imposter Syndrome?
Do you have a constant feeling of self doubt or fraudulence despite evidence to the contrary? You may have a very common condition: Imposter syndrome. In today’s Not Crazy podcast, we discuss what this syndrome is and why so many people feel like they are swindling others with their personal success.
What is the difference between imposter syndrome and negative self-talk? And how can we start thinking more positively about ourselves? Join us for a great discussion. Click on the player below to listen now!
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Source: World of Psychology - September 22, 2020 Category: Psychiatry & Psychology Authors: Gabe Howard Tags: General Not Crazy Podcast Peer Support Perfectionism Self-Esteem Source Type: blogs
Resurrected Schools, and More COVID-19 Private Ed News
Neal McCluskeyBad news grabs a lot more attention than good, and Cato’sCOVID-19 Permanent Private School Closures tracker mainly communicates bad – private schools going out of business, leaving thousands of children educationally homeless. But today we offer some good news, coupled with some news of less clear character.The good news is that 3 schools have been removed from the tracker, bringing closures down from 118 to 115.On September 1 it wasannounced that the Crotched Mountain School in New Hampshire, which serves students with disabilities, was revived after being acquired by an organization called Gersh A...
Source: Cato-at-liberty - September 10, 2020 Category: American Health Authors: Neal McCluskey Source Type: blogs
A History of Crowdfunding in the Wake of Violence
Will DuffieldIn the days following a vigilante shooting in Kenosha, WI, activists and supporters launched GoFundMe pages soliciting donations for the families of the dead, the medical expenses of the injured, and the costs of the shooter ’s legal defense. GoFundMe has sinceremoved the legal defense fundraiser for Kyle Rittenhouse. For those who see the shooting as a case of self-defense, GoFundMe isattempting to deny a young man legal assistance for partisan reasons. Others, proceeding from the belief that Rittenhouse is a mass shooter,looked askance at Facebook ’s initial failure to remove statements supporting him, l...
Source: Cato-at-liberty - September 9, 2020 Category: American Health Authors: Will Duffield Source Type: blogs
