Fight Aging! Newsletter, April 10th 2017
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined age-associated DNA methylation changes at the whole-genome, single-nucleotide level in mouse liver and tested the impact of longevity-promoting interventions, specifically the Ames dwarf Prop1 df/df mutation, calorie restriction, and rapamycin. In wild-type mice fed an unsupplemented ad libitum diet, age-associated hypomethylation was enriched at super-enhancers in highly expressed genes critical for liver function. Genes harbouring hypomethylated enhancers were enriched for genes that change expression with age. Hypermethylation was enriched at CpG islands marked with bivalent activating and repressing histone modifications and resembled hypermethylation in liver cancer. Age-associated methylation changes are suppressed in Ames dwarf and calorie restricted mice and more selectively and less specifically in rapamycin treated mice. Dietary restriction ...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More News: Academia | Alzheimer's | Babies | Babies Heart Conditions | Biochemistry | Biology | Biotechnology | Brain | Cancer | Cancer & Oncology | Cardiology | Chemistry | Child Development | Childhood Cancer | Cholesterol | Chronic Obstructive Pulmonary | Clinical Trials | Coronary Heart Disease | Cytomegalovirus | Dementia | DEXA Scan | Diabetes | Down's Syndrome | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Funding | Fundraising | Gastroschisis Repair | Gene Therapy | Genetics | Glomeruli | Harvard | Health Medicine & Bioethics Commentators | Heart | Heart Disease | Heart Transplant | Hypertension | Immunotherapy | Infertility | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Liver | Liver Disease | Liver Transplant | Men | Miscarriage | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Nutrition | Obesity | Orthopaedics | Osteoporosis | Ovarian Cancer | Ovaries | Pathology | PET Scan | Physiology | Pregnancy | Reproduction Medicine | Research | Science | Spirometry | Sports Medicine | Stem Cell Therapy | Stem Cells | Stroke | Study | Toxicology | Transplant Surgery | Transplants | Urology & Nephrology | Women