Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards More Broadly Effective Influenza Vaccines
Might it be possible to develop a vaccine that works on every strain of influenza, rather than going through a seasonal exercise of vaccination every year? Or at least many strains, rather than just a few? In today's research materials, scientists discuss a possible approach, identifying a novel part of the influenza virus to target, a part of the viral structure that may mutate less readily than the usual vaccine targets. Viruses mutate aggressively when they infect large population, a challenge to both vaccination and natural immunity. The immune system recognizes small parts of a virus, epitopes, and the epitopes most r...
Source: Fight Aging! - December 30, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Omicron (B.1.1529 COVID variant )
Last updated 1430 UK time 24th December 2021. Items added that day flagged NEW.Research literature and scientific informationPubMedLess sensitive strategy (finds 100 items as of 21st December - found 28 on 13th)More sensitive strategy - same as strategy above but have added Omicron lineages, BA.1 and BA.2(finds 140 items as of 21st December - found 67 on 13th. Note: results include work on any aspect of COVID from UK postcodes BA1 and BA2).PubMed COVID-19 Clinical Query Select aspect (diagnosis, treatment, etc.) from the drop down boxPreprintsCOVID preprints from medRxiv and bioRxiv (sorted...
Source: Browsing - November 27, 2021 Category: Databases & Libraries Tags: coronavirus COVID-19 Source Type: blogs
TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Click arrow to playDownload TWiV 832 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus vector adjuvant correlate of protection Covaxin COVID-19 inactivated vaccine influenza influenza oral vaccine mass cytometry pandemic SARS-CoV-2 smallpox vaccine efficacy vaccinia virus viral Source Type: blogs
Multistep Lateral Flow Devices Perform Advanced Assays
Researchers at Georgia Tech have developed a lateral flow test platform that can perform advanced assays that would otherwise require a laboratory. By controlling the flow of liquid through the lateral flow test, the research team designed it so that it can perform advanced multistep assays that do not require sophisticated lab equipment and significant periods of time. So far, they have designed advanced dipstick tests that can detect both COVID-19 and influenza simultaneously, and others that can perform immunoassays to detect Zika virus, HIV, hepatitis B virus, or malaria.
Lateral flow assays, otherwise ...
Source: Medgadget - November 10, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Pathology Public Health georgiatech Source Type: blogs
Wuhan spiny eel influenza virus
Influenza B viruses, unlike influenza A viruses, do not cause pandemics. There are many non-human animal reservoirs of influenza A viruses which provide gene segments that go towards making reassortant viruses that can infect humans. Influenza B viruses do not appear to have an animal reservoir other than humans – they have been isolated from […] (Source: virology blog)
Source: virology blog - October 29, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology HA influenza B virus influenza virus pandemic viral viruses Wuhan spiny eel virus Source Type: blogs
Trial By Error: BBC ’ s Problematic Coverage of New Long COVID Study
By David Tuller, DrPH Since the start of the coronavirus pandemic, suggesting an equivalence between COVID-19 and influenza has been a consistent approach among those seeking to downplay the current situation. So it’s not surprising to see something similar happen with comparisons between Long COVID and the delayed recovery some people experience after an acute […] (Source: virology blog)
Source: virology blog - October 4, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized BBC Long Covid PLoS Medicine Source Type: blogs
Trial By Error: BBC s Problematic Coverage of New Long COVID Study
By David Tuller, DrPH Since the start of the coronavirus pandemic, suggesting an equivalence between COVID-19 and influenza has been a consistent approach among those seeking to downplay the current situation. So its not surprising to see something similar happen with comparisons between Long COVID and the delayed recovery some people experience after an acute […] (Source: virology blog)
Source: virology blog - October 4, 2021 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS BBC Long Covid PLoS Medicine Source Type: blogs
Gain of function research explained
The term ‘gain of function’ is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an organism a new property or […] (Source: virology blog)
Source: virology blog - September 10, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology avian influenza virus coronavirus COVID-19 ferret gain of function research GOF pandemic viral viruses Source Type: blogs
Selfish Much?
By KIM BELLARD
In a week where we’ve seen the bungled Afghan withdrawal, had Texas show us its contempt for all sorts of rights, watched wildfires ravage the west and Ida wreak havoc on a third of the country, and, of course, witnessed COVID-19 continue its resurgence, I managed to find an article that depressed me further. Thank you, Aaron Carroll.
Dr. Carroll – pediatrician, long-time contributor to The New York Times, and now Chief Health Officer of I.U. Health — wrote a startling piece in The Atlantic: We’ve Never Protected the Vulnerable. He looks at the resistance to public health measur...
Source: The Health Care Blog - September 7, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy health equity Kim Bellard Source Type: blogs
COVID ’s lab leak theory obscures zoonosis and progression
Even as COVID-19 is found in apes, big cats, minks, domestic cats, other small mammals, and now in U.S. deer, some don ’t want to let go of the insultingly simplistic “lab leak” theory. Do they really think the 1918 influenza and AIDS pandemics (or Ebola, MERS, and SARS ) needed lab mendacity to exist? WeRead more …COVID’s lab leak theory obscures zoonosis and progression originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 7, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/martha-rosenberg" rel="tag" > Martha Rosenberg < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Acute Hemorrhagic Necrotizing Encephalopathy associated with COVID19
Sharing some keypoints about encephalopathy with COVID19 to help fellow Radiologists in the pandemic storm to identify the possibility. Reference article has been shared for further reading.Acute necrotizing encephalopathy is a rare complication of influenza and other viral infections and has been related to intracranial cytokine storms, which result in blood-brain barrier breakdown but without direct viral invasion or parainfectious demyelination. Although predominantly described in the pediatric population, acute necrotizing encephalopathy is known to occur in adults as well. The most characte...
Source: Sumer's Radiology Site - June 9, 2021 Category: Radiology Authors: Sumer Sethi Source Type: blogs
