Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Oct 31;43(10):BSR20222591. doi: 10.1042/BSR20222591.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled replication forks and...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Phenotype reversion as “natural gene therapy” in Fanconi anemia by a gene conversion event
Somatic mosaicism appears as a recurrent phenomenon among patients suffering from Fanconi anemia (FA), but its direct prognostic significance mostly remains an open question. The clinical picture of FA mosaic subjects could indeed vary from just mild features to severe hematologic failure. Here, we illustrate the case of a proband whose FA familiarity, modest signs (absence of hematological anomalies and fertility issues), and chromosome fragility test transition to negative overtime were suggestive of somatic mosaicism. In line with this hypothesis, genetic testing on patient’s peripheral blood and buccal swab reported ...
Source: Frontiers in Genetics - September 18, 2023 Category: Genetics & Stem Cells Source Type: research
OTUD5 limits replication fork instability by organizing chromatin remodelers
Nucleic Acids Res. 2023 Sep 15:gkad732. doi: 10.1093/nar/gkad732. Online ahead of print.ABSTRACTProper regulation of replication fork progression is important for genomic maintenance. Subverting the transcription-induced conflicts is crucial in preserving the integrity of replication forks. Various chromatin remodelers, such as histone chaperone and histone deacetylases are known to modulate replication stress, but how these factors are organized or collaborate are not well understood. Here we found a new role of the OTUD5 deubiquitinase in limiting replication stress. We found that OTUD5 is recruited to replication forks,...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Angelo de Vivo Hongseon Song Yujin Lee Neysha Tirado-Class Anthony Sanchez Sandy Westerheide Huzefa Dungrawala Younghoon Kee Source Type: research
Correction to: Multiparametric analysis of etoposide exposed mesenchymal stem cells and Fanconi anemia cells: implications in development of secondary myeloid malignancy
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 9, 2023 Category: Research Source Type: research
Research progress of the Fanconi anemia pathway and premature ovarian insufficiency
Biol Reprod. 2023 Sep 5:ioad110. doi: 10.1093/biolre/ioad110. Online ahead of print.ABSTRACTThe Fanconi anemia (FA) pathway is a key pathway involved in the repair of DNA interstrand crosslinking (ICL) damage, which chiefly includes the following four modules: lesion recognition, FA core complex recruitment, FANCD2-FANCI complex monoubiquitination, and downstream events (nucleolytic incision, translesion synthesis, and homologous recombination). Mutations or deletions of multiple FA genes in this pathway can damage the ICL repair pathway and disrupt primordial germ cell development and oocyte meiosis, thereby leading to ab...
Source: Biology of Reproduction - September 5, 2023 Category: Reproduction Medicine Authors: Jingyu Zhao Yixin Zhang Wenbo Li Mengmeng Yao Chuqi Liu Zihan Zhang Caiqin Wang Xiaomei Wang Kai Meng Source Type: research
Research progress of the Fanconi anemia pathway and premature ovarian insufficiency
Biol Reprod. 2023 Sep 5:ioad110. doi: 10.1093/biolre/ioad110. Online ahead of print.ABSTRACTThe Fanconi anemia (FA) pathway is a key pathway involved in the repair of DNA interstrand crosslinking (ICL) damage, which chiefly includes the following four modules: lesion recognition, FA core complex recruitment, FANCD2-FANCI complex monoubiquitination, and downstream events (nucleolytic incision, translesion synthesis, and homologous recombination). Mutations or deletions of multiple FA genes in this pathway can damage the ICL repair pathway and disrupt primordial germ cell development and oocyte meiosis, thereby leading to ab...
Source: Reproductive Biology - September 5, 2023 Category: Reproduction Medicine Authors: Jingyu Zhao Yixin Zhang Wenbo Li Mengmeng Yao Chuqi Liu Zihan Zhang Caiqin Wang Xiaomei Wang Kai Meng Source Type: research
Insulin-Like Growth Factor 2 mRNA Binding Protein 3 Suppresses Ferroptosis in Non-Small Cell Lung Cancer via Stabilizing m6A Modification of Fanconi Anemia Group D2 Protein
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - September 1, 2023 Category: Nanotechnology Authors: Zhang, Haotian Tang, Junjie Gong, Xiaowei Huang, Chenjun Tags: research-article Source Type: research
Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia
AbstractMutations inTDP2, encoding tyrosyl-DNA phosphodiesterase 2, have been associated with a syndromal form of autosomal recessive spinocerebellar ataxia, type 23 (SCAR23). This is a very rare and progressive neurodegenerative disorder described in only nine patients to date, and caused by splice site or nonsense mutations that result in greatly reduced or absent TDP2 protein. TDP2 is required for the rapid repair of DNA double-strand breaks induced by abortive DNA topoisomerase II (TOP2) activity, important for genetic stability in post-mitotic cells such as neurons. Here, we describe a sibship that is homozygous for t...
Source: Human Genetics - September 1, 2023 Category: Genetics & Stem Cells Source Type: research
LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease
Biochem Cell Biol. 2023 Aug 29. doi: 10.1139/bcb-2023-0134. Online ahead of print.ABSTRACTThe cGAS-STING axis integrates DNA damage and cellular stress with type I interferon (IFN) signalling to facilitate transcriptional changes underlying inflammatory stress responses. The cGAS-STING pathway responds to cytosolic DNA in the form of dsDNA, micronuclei, and LINE-1 (L1) retroelements. L1 retroelements are a class of self-propagating non-LTR transposons that have remained highly active in our genomes. L1 retroelements are emerging as important inducers of cGAS-STING and interferon signalling, which are often dysregulated in ...
Source: Biochemistry and Cell Biology - August 29, 2023 Category: Biochemistry Authors: Sabateeshan Mathavarajah Graham Dellaire Source Type: research
