Her Brother ’s Cord Blood Saved Her Life
Just after she was born, Cameron was diagnosed with Fanconi Anemia (FA), an inherited genetic disorder that attacks cells in bone marrow, eventually leading to bone marrow failure. The prognosis she was given by her doctors caused her family great concern, as most children with this condition do not live into adulthood.
At 9 years old, Cameron’s health began to rapidly decline. Her doctors agreed that she should undergo a stem cell transplant in order to remove the FA-infected blood cells and replace them with new, healthy blood cells. Her family was relieved to hear that stem cells could be used for treatment because th...
Source: Cord Blood News - July 2, 2019 Category: Perinatology & Neonatology Authors: Maze Cord Blood Tags: blood disorder Cord Blood medical research Source Type: blogs
Fight Aging! Newsletter, June 10th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 9, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Progress Towards Blocking Alternative Lengthening of Telomeres in Cancer
Well, this is promising news. Researchers have found that inhibition of FANCM activity is a potential point of intervention to shut down alternative lengthening of telomeres (ALT) in cancer. This goal is one half of the ultimate cancer therapy, a form of treatment that is (a) capable of shutting down all forms of cancer, without exception, where (b) cancers cannot evolve resistance to its mechanisms, and (c) it requires little to no expensive, time-consuming adaptation for delivery to different cancer types. The other half is a method of blocking the ability of telomerase to lengthen telomeres, and several research groups ...
Source: Fight Aging! - June 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
aka Tropical Travel Trouble 009
The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
A Semi-Automated Benchtop System to Produce Genetically Modified Stem Cells: Interview with Professor Jennifer Adair
Scientists at the Fred Hutchinson Cancer Research Center and the University of Washington have developed a semi-automated benchtop system to produce clinical-grade genetically modified haematopoietic stem cells (HSCs). The research was recently published in Nature Communications. Genetically modified HSCs have significant therapeutic potential for patients with bone marrow disorders. However, producing such cells so they remain contamination-free and fit for purpose usually requires cell handling and manipulation at sophisticated Good Manufacturing Practices facilities, which limits the availability of these cells. The re...
Source: Medgadget - November 11, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Genetics Medicine Oncology Pathology Source Type: blogs
An Interview with Noted Pancreas Surgeon Dr. Charles J. Yeo
Recently, InsideSurgery had a chance to speak with Dr. Charles J. Yeo about his career as a top Whipple and pancreas surgeon and his ongoing role as a surgical leader and educator.
As the Samuel D. Gross Professor of Surgery and Chair of the Department of Surgery, you welcomed your second intern class to Thomas Jefferson University in Philadelphia, Pennsylvania last month. What one piece advice do you have for your new trainees?
One piece of advice….that’s tough! Several pieces of advice….enjoy the challenges and experiences of internship; read and increase your knowledge base outside of that 80 hours; ...
Source: Inside Surgery - August 12, 2016 Category: Surgery Authors: Editor Tags: Interviews Source Type: blogs
Is it ethical for parents to create a savior sibling?
<p>Savior siblings are children who are born to provide HLA compatible
body parts, typically umbilical cord blood to be used for bone marrow
transplantation, in order to save the life of their older sibling. They
are created using IVF so that the embryos can be screened in order to
find and implant one that is a match to the existing child. The first
savior sibling, Adam Nash, was born in the US was born in 2000. Lisa and
Jack Nash decided to create a savior sibling after their doctor
suggested it might be the best option for a cure for their daughter
Molly, who was born with a severe type of Fanconi anemia...
Source: blog.bioethics.net - October 1, 2015 Category: Medical Ethics Authors: Hayley Dittus-Doria Tags: Health Care Reproductive Medicine assisted reproduction genetic testing syndicated Source Type: blogs
What Rare Diseases Teach Us About the Cellular Basis of Aging
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Chapter 4 explains that much what we think we know about the aging process comes from studying rare diseases of premature aging, such as Hutchinson–Gilford progeria syndrome, Bloom syndrome, Werner syndrome, Cockayne syndrome, dyskeratosis congenita, Fanconi anemia, Wolfram syndrome, and xeroderma pigmentosum. Lessons learned from these rare...
Source: Specified Life - July 4, 2014 Category: Pathologists Tags: ageing aging biology of aging cancer cause of aging cell renewal common disease genetic disease orphan disease orphan drugs rare disease Source Type: blogs
What is the Fundamental Biological Process that Causes Aging?
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Chapter 4 explains that much what we think we know about the aging process comes from studying rare diseases of premature aging, such as Hutchinson–Gilford progeria syndrome, Bloom syndrome, Werner syndrome, Cockayne syndrome, dyskeratosis congenita, Fanconi anemia, Wolfram syndrome, and xeroderma pigmentosum. From Chapter 4: Based on the obs...
Source: Specified Life - July 3, 2014 Category: Pathologists Tags: ageing aging biology of aging common disease DNA repair orphan disease orphan drugs rare disease Source Type: blogs
Wrinkling and Sagging are Chronic Toxic Processes Not Directly Caused by Aging
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Chapter 4 tackles the subject of human aging. Much of what we know about the aging process comes from studying rare diseases of premature aging, such as Hutchinson–Gilford progeria syndrome, Bloom syndrome, Werner syndrome, Cockayne syndrome, dyskeratosis congenita, Fanconi anemia, Wolfram syndrome, and xeroderma pigmentosum. The relationshi...
Source: Specified Life - July 2, 2014 Category: Pathologists Tags: ageing aging common disease complex disease genetic disease orphan disease orphan drugs premature aging rare disease sagging skin aging wrinkling Source Type: blogs
NIH, FDA and Academic Institutions: Announce Industry Academic Collaborations
Several recent announcements have discussed new industry-academic collaborations as well as new funding opportunities to help translate scientific discoveries to improve patient care and health.
Harvard and AstraZeneca
AstraZeneca and Harvard University's Wyss Institute for Biologically Inspired Engineering recently announced a partnership "to use its organs-on-chips technology--miniature human organs made of a clear, flexible polymer that contain tiny tubes lined with living human cells--to help improve the way it tests drugs for humans," according to a press release.
"The chips are translucent, which could provide ...
Source: Policy and Medicine - November 27, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs
An Interview with Noted Pancreas Surgeon Dr. Charles J. Yeo
Recently, InsideSurgery had a chance to speak with Dr. Charles J. Yeo about his career as a top Whipple and pancreas surgeon and his ongoing role as a surgical leader and educator.
As the Samuel D. Gross Professor of Surgery and Chair of the Department of Surgery, you welcomed your second intern class to Thomas Jefferson University in Philadelphia, Pennsylvania last month. What one piece advice do you have for your new trainees?
One piece of advice….that’s tough! Several pieces of advice….enjoy the challenges and experiences of internship; read and increase your knowledge base outside of that 80 hours; practice kno...
Source: Inside Surgery - August 12, 2013 Category: Surgeons Authors: Editor Tags: Interviews Source Type: blogs
