Fanconi anemia: Insight from a green plant
(American Society of Plant Biologists) Fanconi anemia is a human genetic disorder with severe effects, including an increased risk of cancer and infertility. Research in plants helps us understand the disease in humans, showing how a key protein functions in the exchange of genetic material. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 19, 2018 Category: Cancer & Oncology Source Type: news
Medical News Today: New cancer-causing syndrome uncovered
Researchers reveal that mutations in the FANCM gene do not cause Fanconi anemia, as previous studies suggest. They actually cause early-onset cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 25, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Discovery of a new genetic syndrome which predisposes the body to cancer
(Universitat Autonoma de Barcelona) A new syndrome caused by biallelic mutations -- those produced in both gene copies inherited from the mother and father -- in the FANCM gene predisposes the body to the appearance of tumors and causes rejection to chemotherapy treatments. Contrary to what scientists believed, the gene does not cause Fanconi anaemia. Researchers recommend modifying the clinical monitoring of patients with these mutations. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 22, 2017 Category: Cancer & Oncology Source Type: news
New gene mutation associated with Fanconi anemia
(University of W ü rzburg) Fanconi anemia is a rare genetic disease characterized by high cancer risk. Researchers of the University of W ü rzburg now have revealed a new Fanconi anemia gene that is involved in complex DNA repair processes and may also play a relevant role in cancer prevention. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2017 Category: International Medicine & Public Health Source Type: news
Study identifies new gene mutation associated with defective DNA repair and Fanconi anemia
(JCI Journals) Fanconi anemia is a rare genetic disease characterized by hematologic symptoms and high cancer risk. Mutations in nearly 20 different genes have been identified in patients with Fanconi anemia. In a study published this week in the JCI, work from Detlev Schinder's group at the University of Wurzburg reveals a new Fanconi anemia gene, RFWD3, that is involved in complex DNA repair processes and may also play a relevant role in cancer risk. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 10, 2017 Category: Cancer & Oncology Source Type: news
What Causes Anemia?
Discussion
One of the most common problems in pediatrics is anemia. It is defined as “a lower than normal value for the related measurements of hemoglobin, hematocrit, and number of red blood cells”, usually 2 standard deviations below the normal for age. Normal hematological values change with age. For a discussion of which values are used click here.
The most common type of anemia in childhood is iron deficiency which is commonly caused by inadequate stores (e.g. premature infant), inadequate intake (e.g. poor nutrition) or blood loss (e.g. menses). Anemia screening is recommended at age 9-12 months, and for...
Source: PediatricEducation.org - May 15, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
URI scientist: Rare childhood disease linked to major cancer gene
(University of Rhode Island) A team of researchers led by a University of Rhode Island scientist has discovered an important molecular link between a rare childhood genetic disease, Fanconi anemia, and a major cancer gene called PTEN. The discovery improves the understanding of the molecular basis of Fanconi anemia and could lead to improved treatment outcomes for some cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 1, 2016 Category: Cancer & Oncology Source Type: news
New function of genes found linked to Fanconi anemia and certain types of cancer
An important new function of genes in the Fanconi anemia pathway has been identified by researchers – a finding that could have implications for development of new therapies to treat this disorder and some cancers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 3, 2016 Category: Science Source Type: news
UTSW identifies new function of genes linked to Fanconi anemia and certain types of cancer
(UT Southwestern Medical Center) Researchers from UT Southwestern Medical Center have identified an important new function of genes in the Fanconi anemia pathway -- a finding that could have implications for development of new therapies to treat this disorder and some cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2016 Category: Cancer & Oncology Source Type: news
What Are Common Causes of Congenital Aplastic Anemia?
Discussion
Aplastic anemia are disorders where there is inadequate production of erythrocytes, granulocytes and platelets caused by decreased bone marrow production leading to a peripheral blood pancytopenia. Most often it is acquired because of exposures to infections (especially viruses such as Epstein-Barr virus, rubella, herpes, etc.), drugs (e.g. chloramphenicol, chemotherapeutic agents, etc.), toxins or radiation.
Learning Point
The most common congenital bone marrow failure syndromes causing pancytopenia are (in this order) Fanconi anemia, Diamond-Blackfan anemia, and Shwachman-Diamond anemia. Most have a variety of...
Source: PediatricEducation.org - April 17, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Phil and Penny Knight pledge $10M for medical research in honor of David Frohnmayer
Phil and Penny Knight on Wednesday pledge $10 million to the David Frohnmayer Scientific Research Fund, according to a report in the Register-Guard. The fund is part of the Fanconi Anemia Research Fund.
Frohnmayer, a former University of Oregon president, died in May.
He and Knight had a very public spat in 2000, but eventually mended fences.
The Knights pledge is part of a $20 million campaign, according to the Register-Guard report.
Two of the three daughters of Lynn and Dave Frohnmayer died… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 6, 2016 Category: Biotechnology Authors: Matthew Kish Source Type: news
Phil and Penny Knight pledge $10M for medical research in honor of David Frohnmayer
Phil and Penny Knight on Wednesday pledge $10 million to the David Frohnmayer Scientific Research Fund, according to a report in the Register-Guard. The fund is part of the Fanconi Anemia Research Fund.
Frohnmayer, a former University of Oregon president, died in May.
He and Knight had a very public spat in 2000, but eventually mended fences.
The Knights pledge is part of a $20 million campaign, according to the Register-Guard report.
Two of the three daughters of Lynn and Dave Frohnmayer died… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 6, 2016 Category: Pharmaceuticals Authors: Matthew Kish Source Type: news
[This Week in Science] The real cause of cancer in Fanconi anemia
Author: Guy Riddihough (Source: ScienceNOW)
Source: ScienceNOW - February 19, 2016 Category: Science Authors: Guy Riddihough Tags: DNA Repair Source Type: news
Fanconi Anemia: Genetic disease breakthrough announced
A team of investigators has established the cause of a rare syndrome consistent with Fanconi Anemia, a chromosome instability disorder which is clinically typified by birth defects, bone marrow failure, leukemia, and susceptibility to solid tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 12, 2016 Category: Science Source Type: news
Scientists identify molecule that appears to fuel deadly genetic illness
(Cincinnati Children's Hospital Medical Center) Researchers have identified a molecular target and experimental treatment strategy for DNA repair defects behind Fanconi anemia -- a complex genetic disorder responsible for birth anomalies, organ damage, anemia and cancer. The findings, published Jan. 12, 2016, in Stem Cell Reports, also create a bit of molecular intrigue. It involves how cells used in the study -- which still had the Fanconi anemia (FA) DNA repair defect -- were able to recover and grow normally after targeted treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 12, 2016 Category: Cancer & Oncology Source Type: news
