Fanconi anemia: Insight from a green plant

(American Society of Plant Biologists) Fanconi anemia is a human genetic disorder with severe effects, including an increased risk of cancer and infertility. Research in plants helps us understand the disease in humans, showing how a key protein functions in the exchange of genetic material.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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CONCLUSION: There has been an overall improvement in cancer care service provision for Northland patients since the previous audit, however it still falls short of the national FCT targets. PMID: 29927915 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Medical consultant Dr Sarah Brewer and dietitian Juliette Kellow say eating a tablespoon of olive oil each day could reduce the risk of getting cancer or heart disease because it contains antioxidants.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Dual-energy CT (DECT) is an emerging technology that has potential to enhance diagnostic performance and radiologists ’ confidence in the evaluation of thoracic malignancies. DECT clinical applications include characterization of solitary pulmonary nodule, lung masses and mediastinal tumors. DECT-derived iodine uptake quantification may assist in characterization of tumor differentiation and gene expression. The use DECT in oncology has potential to improve lung cancer staging, therapy planning, and assessment of response to therapy as well as detection of incidental pulmonary embolism.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Many U.S. breast imaging facilities don't have structures in place to establish...Read more on AuntMinnie.comRelated Reading: What do women want in a breast imaging center? 6 tips for top-notch breast cancer risk assessment Tweets reveal women's perspectives on mammography NCBC: Breast centers must reach out to survive Will Etheridge's breast cancer up screening in gay community?
Source: Headlines - Category: Radiology Source Type: news
Fetal MRI brain scans can advance the detection of abnormalities due to severe...Read more on AuntMinnie.comRelated Reading: Fetal MRI can spot early brain abnormality MRI shows maternal depression meds affect babies' brains 3T MRI fetal scans should not affect newborns' hearing Gadolinium in fetuses almost entirely cleared via placenta MRI links blood flow to brain development in preterm babies
Source: Headlines - Category: Radiology Source Type: news
Abstract: The human papilloma virus (HPV) causes approximately 30,700 annual cancer cases of the cervix, vulva, vagina, penis, oral cavity, and anus. Nurse practitioners can use their unique relationships with patients to advocate for the HPV vaccine. The purpose of this article is to update NPs on current knowledge regarding the HPV vaccine while providing appropriate information necessary for counseling patients and parents.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: IMMUNIZATIONS Source Type: research
Can patients with rectal cancer safely avoid surgery? Jessamy Bagenal of The Lancet interviews Geerard Beets about findings from the International Watch&Wait Database.
Source: Listen to The Lancet - Category: General Medicine Authors: Source Type: podcasts
Scientists have discovered a new way in which bacteria residing in the human gut may be able to contribute to chemotherapy resistance.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Fanconi anemia (FA) is a relatively rare genetic condition with primary sequelae of bone marrow failure, hematologic malignancies, and squamous cell cancers (SCC) of head/neck, breast, and anogenital tract. Many patients require hematopoietic stem cell transplant (bone marrow transplant, BMT) to treat marrow dysfunction, but risk of future malignancies remains. Female patients are at risk of reproductive complications, including infertility related to primary ovarian insufficiency (POI) and gynecologic cancers.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
In this study, we generated Fancb mutant mice, the first mouse model of X-linked FA, and identified a novel function of the FA pathway in epigenetic regulation during mammalian gametogenesis. Fancb mutant mice were infertile and exhibited primordial germ cell (PGC) defects during embryogenesis. Further, Fancb mutation resulted in the reduction of undifferentiated spermatogonia in spermatogenesis, suggesting that FANCB regulates the maintenance of undifferentiated spermatogonia. Additionally, based on functional studies, we dissected the pathway in which FANCB functions during meiosis. The localization of FANCB on sex chrom...
Source: Human Molecular Genetics - Category: Genetics & Stem Cells Authors: Tags: ARTICLES Source Type: research
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