Fanconi anemia: Insight from a green plant
(American Society of Plant Biologists) Fanconi anemia is a human genetic disorder with severe effects, including an increased risk of cancer and infertility. Research in plants helps us understand the disease in humans, showing how a key protein functions in the exchange of genetic material.
Conclusion: This paper addresses the clinical implications of performing numerous CT examinations in patients with cancer, providing clinicians with information regarding methods to reduce risk factors in this patient population.Blood Purif 2018;46:56 –69
Conclusions: RDLs are frequently observed in high-risk patients for gastric cancer after eradication. M-NBI demonstrated significantly superior diagnostic efficacy with respect to RDL.Digestion 2018;98:48 –55
This study showed that ESE-16 exposure leads to the aggregation of acidic vesicles, identified as lysosomes, not accompanied by an induction of autophagy. Therefore, ESE-16 disrupts normal endocytic vesicle maturation likely through the inhibition of the microtubule function.Pharmacology 2018;102:9 –16
Preclinical and clinical studies have shown that viral-based immunotherapy has the potential to overcome resistance to immune checkpoint blockade (ICB) and to fill the unmet needs of many cancer patients. Poxviruses, such as modified vaccinia virus Ankara (MVA), have the potential as cancer immunotherapeutic agents. We recently showed that intratumoral (IT) delivery of inactivated modified vaccinia virus Ankara (iMVA) induces antitumor systemic immunity via the STING-mediated cytosolic DNA-sensing pathway and Batf3 –dependent CD103+/CD8+ dendritic cells (DCs).
Skin cancer is one of the most preventable forms of cancer. Roughly, 85% of skin cancer cases could be avoided by reducing UV exposure, especially during adolescence. We conducted a pilot study to evaluate sun safety behaviors in this age group, as well as, the effects of an innovative intervention in changing sun protection attitudes and behaviours. Methods: Participants were recruited from 8 secondary schools in Vancouver, BC. Participants were segregated into the control arm (N=38) or intervention arm (N=138).
Annabelle Y. Guo, PhD1, Indra Neil Sarkar, PhD1,3, Elizabeth S. Chen, PhD1,3,Joanna Walker, MD2, Paul Stey, PhD3, Wen Qing Li, PhD2, Eunyoung Cho, ScD2, Abrar A. Qureshi, MD21The Warren Alpert Medical School; 2Department of Dermatology; 3Center for Biomedical Informatics, Brown University, Providence, RI. Merkel Cell Carcinoma (MCC) is an aggressive malignant skin cancer with a high mortality rate. The effect of ultraviolet (UV) exposure on MCC patients long-term survival is not fully understood.
Background: The high keratinocyte carcinoma (KC) incidence in Western countries puts pressure on healthcare systems and urges to identify areas for improvement. Aim: To describe current KC care based on routinely collected data in primary and secondary care in the Netherlands. Methods: A retrospective cohort study using the Integrated Primary Care Information database and for specialist care the nationwide Netherlands Cancer Registry. In primary care 1736 records of patients with suspicious KC lesions were included (2009-2013).
Frequent use of sun-protection factor (SPF)>15 sunscreen is an important skin cancer prevention strategy, but little is known about users of SPF15 SPF versus
Atopic dermatitis (AD), a chronic inflammatory skin disease, affects between 2-10% of the adult population in industrialized nations. AD is primarily treated with topical emollients and anti-inflammatory agents such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI), though more severe cases require systemic immunosuppressive agents. TCIs currently carry a black box warning label for a possible association with cutaneous malignancy, including melanoma and keratinocyte carcinomas (KCs), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
Fanconi anemia (FA) is a relatively rare genetic condition with primary sequelae of bone marrow failure, hematologic malignancies, and squamous cell cancers (SCC) of head/neck, breast, and anogenital tract. Many patients require hematopoietic stem cell transplant (bone marrow transplant, BMT) to treat marrow dysfunction, but risk of future malignancies remains. Female patients are at risk of reproductive complications, including infertility related to primary ovarian insufficiency (POI) and gynecologic cancers.