Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors.
PRRX1 as a Possible Point of Control for Remyelination
https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/
Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operati...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Trump-Xi Meeting at G-20: Kicking the Can Down the Road
Much was expected of the discussion at the 2018 G-20 meeting in Buenos Aires between the United States and China on their ongoing trade war. However, nothing of significance emerged. With signs of a global economic slowdown surfacing earlier than expected, the failed outcomes of this meeting could come back to haunt world leaders. (Source: The RAND Blog)
Source: The RAND Blog - December 14, 2018 Category: Health Management Authors: Rafiq Dossani Source Type: blogs
MedPAC ’s Proposed “Reforms” Should Be Tested Before They’re Implemented: CMS’s Hospital Readmissions Reduction Program Is Exhibit A | Part II
Conclusions reached by Gupta et al. and MedPAC
In November of 2017 Ankur Gupta and 10 other experts in cardiovascular medicine published an article in JAMA Cardiology entitled, “Association of the Hospital Readmissions Reduction Program implementation with readmission and mortality outcomes in heart failure.” The authors were affiliated with well-known universities, and three of them were also editors of JAMA Cardiology [4]. Their research was financed by grants from the NIH and Get With the Guidelines-Heart Failure (GWTG-HF), a “voluntary quality improvement program” sponsored by the American Heart Association.
...
Source: The Health Care Blog - December 7, 2018 Category: Consumer Health News Authors: matthew holt Tags: Medicare Politics CMS Congress hospital readmissions HRRP Kip Sullivan MedPAC P4P Pay for Performance Source Type: blogs
Part II | MedPAC ’s Proposed “Reforms” Should Be Tested Before They’re Implemented: CMS’s Hospital Readmissions Reduction Program Is Exhibit A
Conclusions reached by Gupta et al. and MedPAC
In November of 2017 Ankur Gupta and 10 other experts in cardiovascular medicine published an article in JAMA Cardiology entitled, “Association of the Hospital Readmissions Reduction Program implementation with readmission and mortality outcomes in heart failure.” The authors were affiliated with well-known universities, and three of them were also editors of JAMA Cardiology [4]. Their research was financed by grants from the NIH and Get With the Guidelines-Heart Failure (GWTG-HF), a “voluntary quality improvement program” sponsored by the American Heart Association.
...
Source: The Health Care Blog - December 7, 2018 Category: Consumer Health News Authors: matthew holt Tags: Medicare Politics CMS Congress hospital readmissions HRRP Kip Sullivan MedPAC P4P Pay for Performance Source Type: blogs
Fight Aging! Newsletter, November 12th 2018
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records.
The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - November 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Researchers find the most plausible cause of wellbeing decline in youth is increased screen time
A new paper analyses wellbeing and lifestyle data from over a million US youth
By Alex Fradera
Have young people never had it so good, or do they face more challenges than any generation? Our current era in the West is one of high wealth and relatively free of deprivation, meaning minors enjoy material benefits and legal protections that would be the envy of those living in the past. But there is an increasing suspicion that all is not well for our youth, and one of the most popular explanations, among some experts and the popular media, is that excessive “screen time” is to blame (all the attention young people devot...
Source: BPS RESEARCH DIGEST - October 2, 2018 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Mental health Technology Source Type: blogs
Fight Aging! Newsletter, September 10th 2018
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
The Price of Progress or the Waste...
Source: Fight Aging! - September 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making Sense of the Health Care Merger Scene
By JEFF GOLDSMITH
In the past 12 months, there has been a raft of multi-billion-dollar mergers in health care. What do these deals tell us about the emerging health care landscape, and what will they mean for patients/consumers and the incumbent actors in the health system?
Health Systems
There have been a few large health system mergers in the past year, notably the $11 billion multi-market combinations of Aurora Health Care and Advocate Health Care Network in Milwaukee and suburban Chicago, as well as the proposed (but not yet consummated) $28 billion merger of Catholic Health Initiatives and Dignity Health. However, the...
Source: The Health Care Blog - July 23, 2018 Category: Consumer Health News Authors: matthew holt Tags: Hospitals Physicians The Business of Health Care Healthcare merger Healthcare systems the future of healthcare Source Type: blogs
The Fed's Recent Defense of Interest on Reserves
As regularAlt-Mreaders know, I ’ve been saying for over a year now that, despite their promise to “normalize” monetary policy, Fed officials have been determined to maintain the Fed’s post-crisis “floor” system of monetary control, in which changes to the Fed’s monetary policy stance are mainly achieved by means of adjustments to the rate of interest the Fed pays on banks’ excess reserve balances, or the IOER rate, for short.Until recently the Fed ’s intentions had to be inferred by reading between the lines of its official press releases, or by referring to personal preferences expressed by leading Fed o...
Source: Cato-at-liberty - July 13, 2018 Category: American Health Authors: George Selgin Source Type: blogs
Price Level Targeting: A Step in the Right Direction
The Federal Reserve plans to review its inflation growth rate target and potentially select a new monetary policy target.Many Fed officials are in favor of the idea, includingChair Powell. And the latest FOMC minutes show that the Fed ’s policy setting committeehas discussed new targets.This is good news, because inflation rate targeting suffers from serious shortcomings. With a growth rate target, a central bank writes off past errors. Instead of deliberately correcting those errors, it “lets bygones be bygones,” allowing its mistakes to permanently alter the value of its policy target. For example, the Fed haspersi...
Source: Cato-at-liberty - June 12, 2018 Category: American Health Authors: Tate Lacey Source Type: blogs
What If We All Lived Beyond 130 Years?
Life expectancy is continuously growing but how far could it be stretched? Could you imagine that the average person lived beyond 130 years of age? How would longevity transform societies and our ways of life?
Based on the book, My Health: Upgraded.
The quest for immortality
Humanity has been yearning for the secret of immortality since the first temple for the ever-living Gods was built, which might have been 12,000 years ago in Gobekli Tepe, according to the current state of archeology. The ancient legends and myths are full of tales about how men on Earth wanted to join the community of immortals. However, sometimes t...
Source: The Medical Futurist - June 9, 2018 Category: Information Technology Authors: nora Tags: Future of Medicine aging digital innovation Healthcare immortality longevity Personalized medicine society technology Source Type: blogs
Congress Tees Up an $867 Billion Farm Bill
If you thought that the congressional spending orgy would slow down after thebloated omnibus bill passed in March, you were wrong. Republicans are preparing to bring to the House floor a farm bill that willcost taxpayers at least $867 billion over 10 years.While this is a “farm bill,” one-quarter of the spending will be for farm subsidies and three-quarters for food stamps. The latter is officially called “nutrition” spending. But since almost one-quarter of food stamp spendingis for junk food, that label is as absurd as calling Social Security ’s Ponzi-style accounting a “trust fund.”The essence of the farm ...
Source: Cato-at-liberty - May 7, 2018 Category: American Health Authors: Chris Edwards Source Type: blogs
Fight Aging! Newsletter, May 7th 2018
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Heart r...
Source: Fight Aging! - May 6, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of a Mitochondrially Targeted Antioxidant
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of mitochondrially targeted antioxidants, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis.
A standard blood test, with inflammatory markers.
An oxidized LDL cholesterol assessment.
Resting heart rate and blood pressure.
Heart r...
Source: Fight Aging! - May 1, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs
