Childhood dyspraxia predicts adult-onset nonaffective–psychosis-spectrum disorder
Research Articles Jason Schiffman, Vijay Mittal, Emily Kline, Erik L. Mortensen, Niels Michelsen, Morten Ekstrøm, Zachary B. Millman, Sarnoff A. Mednick, Holger J. Sørensen, Development and Psychopathology, Volume 27 Issue 4pt1, pp 1323-1330Abstract (Source: Development and Psychopathology)
Source: Development and Psychopathology - October 7, 2015 Category: Child Development Source Type: research
Behavioral, Cognitive, and Motor Preparation Deficits in a Visual Cued Spatial Attention Task in Autism Spectrum Disorder.
In this study we used behavioral measures, event-related potentials (ERP), and lateralized readiness potential (LRP) to study cognitive and motor preparation deficits contributing to the dyspraxia of autism. A modified Posner cueing task was used to analyze motor preparation abnormalities in children with autism and in typically developing children (N = 30/per group). In this task, subjects engage in preparing motor response based on a visual cue, and then execute a motor movement based on the subsequent imperative stimulus. The experimental conditions, such as the validity of the cue and the spatial location of the targ...
Source: Applied Psychophysiology and Biofeedback - September 16, 2015 Category: Psychiatry & Psychology Authors: Sokhadze EM, Tasman A, Sokhadze GE, El-Baz AS, Casanova MF Tags: Appl Psychophysiol Biofeedback Source Type: research
Behavioral, Cognitive, and Motor Preparation Deficits in a Visual Cued Spatial Attention Task in Autism Spectrum Disorder
In this study we used behavioral measures, event-related potentials (ERP), and lateralized readiness potential (LRP) to study cognitive and motor preparation deficits contributing to the dyspraxia of autism. A modified Posner cueing task was used to analyze motor preparation abnormalities in children with autism and in typically developing children (N = 30/per group). In this task, subjects engage in preparing motor response based on a visual cue, and then execute a motor movement based on the subsequent imperative stimulus. The experimental conditions, such as the validity of the cue and the spatial location of the targ...
Source: Applied Psychophysiology and Biofeedback - September 16, 2015 Category: Psychiatry Source Type: research
Developmental Dyspraxia and the Play Skills of Children With Autism.
CONCLUSION: Praxis problems in children with ASD greatly affect their successful participation in play and leisure activities.
PMID: 26356662 [PubMed - in process] (Source: The American Journal of Occupational Therapy)
Source: The American Journal of Occupational Therapy - September 1, 2015 Category: Occupational Health Authors: Bodison SC Tags: Am J Occup Ther Source Type: research
Resistance to thyroid hormone due to defective thyroid receptor alpha
Publication date: Available online 30 July 2015 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Carla Moran, Krishna Chatterjee Thyroid hormones act via nuclear receptors (TRα1, TRβ1, TRβ2) with differing tissue distribution; the role of α2 protein, derived from the same gene locus as TRα1, is unclear. Resistance to thyroid hormone alpha (RTHα) is characterised by tissue-specific hypothyroidism associated with near-normal thyroid function tests. Clinical features include dysmorphic facies, skeletal dysplasia (macrocephaly, epiphyseal dysgenesis), growth retardati...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 15, 2015 Category: Endocrinology Source Type: research
Resistance to Thyroid Hormone due to defective thyroid receptor alpha
Thyroid hormones act via nuclear receptors (TRα1, TRβ1, TRβ2) with differing tissue distribution; the role of α2 protein, derived from the same gene locus as TRα1, is unclear.Resistance to thyroid hormone alpha (RTHα) is characterised by tissue-specific hypothyroidism associated with near-normal thyroid function tests. Clinical features include dysmorphic facies, skeletal dysplasia (macrocephaly, epiphyseal dysgenesis), growth retardation, constipation, dyspraxia and intellectual deficit. Biochemical abnormalities include low/low-normal T4 and high/high-normal T3 concentrations, a subnormal T4/T3 ratio, variably redu...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - July 30, 2015 Category: Endocrinology Authors: Carla Moran, Krishna Chatterjee Source Type: research
A 13-year follow-up of Finnish patients with Salla disease
Conclusions
Younger SD patients performed better in almost every task measuring mental abilities that then seem to remain fairly constant till early sixties. Thus, the results indicate better prognosis in cognitive skills than earlier assumed. There is an apparent decline in motor skills after the age of 20 years. The early neurocognitive development predicts the later course of motor and cognitive development. (Source: Journal of Neurodevelopmental Disorders)
Source: Journal of Neurodevelopmental Disorders - July 13, 2015 Category: Neurology Source Type: research
A 13-year follow-up of Finnish patients with Salla disease
Conclusions:
Younger SD patients performed better in almost every task measuring mental abilities that then seem to remain fairly constant till early sixties. Thus, the results indicate better prognosis in cognitive skills than earlier assumed. There is an apparent decline in motor skills after the age of 20 years. The early neurocognitive development predicts the later course of motor and cognitive development. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - July 13, 2015 Category: Epidemiology Authors: Liisa PaavolaAnne RemesMarika HarilaTarja VarhoTapio KorhonenKari Majamaa Source Type: research
Health care professionals’ understanding of the use of a metered-dose inhaler
We read with interest the letter by Bonds et al1 on the misuse of inhalational devices for asthma and anaphylaxis among patients in Texas. From an asthma standpoint, the problems with the use of a pressurized metered-dose inhaler (pMDI) include inability to coordinate inhalation with actuation, inadequate breath hold, fast inspiratory flow rate, hand strength, and ideomotor dyspraxia. Although swapping inhalers or the use of a spacer can help, proper education of patients is needed to improve technique. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 26, 2015 Category: Allergy & Immunology Authors: Rachel Mercer, Louise Parker, A. Sheikh, K. Suresh Babu Tags: Correspondence Source Type: research
Do women with eating disorders who have social and flexibility difficulties really have autism? A case series
Conclusions
A substantial proportion of women with EDs who present with social and flexibility difficulties may have an unrecognised ASD, indicated by a constellation of autistic difficulties that appears to predate the onset of their eating problems. The ADOS is a useful component of an ASD assessment for adult women with ED. (Source: Molecular Autism)
Source: Molecular Autism - May 13, 2015 Category: Molecular Biology Source Type: research
Common childhood neurodevelopmental disorders are associated with increased risk of psychotic experiences in early adolescence
ABSTRACT FROM: Khandaker G, Stochl J, Zammit S, et al. A population-based longitudinal study of childhood neurodevelopmental disorders, IQ and subsequent risk of psychotic experiences in adolescence. Psychol Med 2014;44:3229–38. What is already known on this topic The disturbance of normal brain development, dating from the prenatal or perinatal period, is a key tenet of the neurodevelopmental hypothesis of schizophrenia.1 Similarities exist between schizophrenia and certain neurodevelopmental disorders (NDDs) of childhood, such as autism and intellectual disability, which both increase the risk of psychotic outcomes...
Source: Evidence-Based Mental Health - April 23, 2015 Category: Psychiatry & Psychology Authors: Hussain, H., Murray, G. K. Tags: Epidemiologic studies, Neurology, Autism, Pervasive developmental disorder, Schizophrenia spectrum, Epidemiology Causes and risk factors Source Type: research
Early-onset cerebellar ataxia due to novel mutations in ACO2 (P2.224)
CONCLUSIONS: Defect in mitochondrial aconitase was associated with an infantile neurodegenerative disorder affecting cerebellum and retina. We report one case of aconitase deficiency with milder phenotype confined to cerebellum, thus suggesting that aconitase mutation must be considered in differential diagnosis of childhood-onset cerebellar ataxias, even when retinal involvement is not present.Disclosure: Dr. Barca has nothing to disclose. Dr. Neil has nothing to disclose. Dr. Naini has nothing to disclose. Dr. De Vivo has received personal compensation for activities with Isis Pharmaceuticals as a consultant. Dr. DiMauro...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Barca, E., Neil, H., Naini, A., De Vivo, D., DiMauro, S. Tags: Child Neurology and Developmental Neurology: Genetics Source Type: research
Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping
Sensorimotor impairments are common in autism spectrum disorder (ASD), but they are not well understood. Here we examined force control during initial pulses and the subsequent rise, sustained, and relaxation phases of precision gripping in 34 individuals with ASD and 25 healthy control subjects. Participants pressed on opposing load cells with their thumb and index finger while receiving visual feedback regarding their performance. They completed 2- and 8-s trials during which they pressed at 15%, 45%, or 85% of their maximum force. Initial pulses guided by feedforward control mechanisms, sustained force output controlled...
Source: Journal of Neurophysiology - April 1, 2015 Category: Neurology Authors: Wang, Z., Magnon, G. C., White, S. P., Greene, R. K., Vaillancourt, D. E., Mosconi, M. W. Tags: Control Of Movement Source Type: research
A Randomized Controlled Trial for children with Childhood Apraxia of Speech comparing Rapid Syllable Transition Treatment and the Nuffield Dyspraxia Programme (3rd edition).
Conclusions: ReST and NDP3 have strong evidence of treatment and generalization gains in children with CAS when delivered intensively. Overall ReST has greater external evidence from multiple sources but both treatments have support for clinical use.
PMID: 25807891 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - March 24, 2015 Category: Speech Therapy Authors: Murray E, McCabe P, Ballard KJ Tags: J Speech Lang Hear Res Source Type: research
GRIN2A: An aptly named gene for speech dysfunction
Conclusions:
Distinctive features of dysarthria and dyspraxia are found in individuals with GRIN2A mutations, often in the setting of epilepsy-aphasia syndromes; dysarthria has not been previously recognized in these disorders. Of note, the speech phenotype may occur in the absence of a seizure disorder, reinforcing an important role for GRIN2A in motor speech function. Our findings highlight the need for precise clinical speech assessment and intervention in this group. By understanding the mechanisms involved in GRIN2A disorders, targeted therapy may be designed to improve chronic lifelong deficits in intelligibility. (Source: Neurology)
Source: Neurology - February 9, 2015 Category: Neurology Authors: Turner, S. J., Mayes, A. K., Verhoeven, A., Mandelstam, S. A., Morgan, A. T., Scheffer, I. E. Tags: Epilepsy semiology ARTICLE Source Type: research
