CC Grand Rounds: (1) Effect of Non-glycemic Factors on Hemoglobin A1c Measurements and (2) Moving Beyond A1C to Detect Glycemia in African Descent Populations
Presented by: (1) David B. Sacks, MB, ChB ,Chief, Clinical Chemistry Service, Department of Laboratory Medicine, CC, NIH and (2)Anne E. Sumner, MD, Section Chief, Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 01/20/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - January 20, 2016 Category: Journals (General) Tags: Past Events Source Type: video
CC Grand Rounds: (1) Homeostatic Control of Calorie Intake in Humans and its Role in Obesity Treatment and (2) Human Brown Adipose Tissue and Its Role in Treatment of Metabolic Diseases
Presented by: (1) Kevin Hall, PhD, Senior Investigator, Integrative Physiology Section, Laboratory of Biological Modeling, NIDDK, NIH and (2) Aaron M. Cypess, MD, PhD, Investigator and Acting Section Chief, Translational Physiology Section, Diabetes, EndocrinologCategory: Clinical Center Grand RoundsAired date: 01/06/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - January 7, 2016 Category: Journals (General) Tags: Past Events Source Type: video
CC Grand Rounds: 1) Fatty Liver Disease: Understanding and Developing Therapies for a Growing Epidemic and 2) Lipodystrophy, Leptin, and Liver Disease
Presented by: 1) Yaron Rotman, MD, Clinical Investigator, Liver Diseases Branch, NIDDK, NIH and 2) Rebecca Brown, MD, Clinical Investigator, Clinical and Cellular Biology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 10/28/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - October 30, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Aquaporin water channels - from transfusion medicine to malaria
NIH Director’s Wednesday Afternoon Lecture Series
Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. AQP1 has been characterized biophysically, and the atomic structure of AQP1 is known. Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. Thirteen homologous proteins exist in humans...
Source: Videocast - All Events - September 1, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
How to Die Young at a Very Old Age?
Trans-NIH GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its summer seminar, featuring Dr. Nir Barzilai. Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research...
Source: Videocast - All Events - July 15, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Contemporary Clinical Medicine: Great Teachers Twelfth Annual John Laws Decker Memorial Lecture: Impact of Selective Insulin Resistance on Cardiovascular Risk Reduction Strategies
Presented by: Ranganath Muniyappa, MD, PhD, Staff Clinician, Clinical Endocrinology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 06/10/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - June 11, 2015 Category: Journals (General) Tags: Past Events Source Type: video
CC Grand Rounds: (1) Obesity and Brown Fat: Of Mice and Men and (2) Obesity Management in Adults
Presented by: (1) Marc Reitman, MD, PhD Chief, Diabetes, Endocrinology, and Obesity Branch, NIDDK, NIH and (2) Susan Z. Yanovski, MD Co-Director, Office of Obesity Research, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 05/20/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - May 22, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Data-Driven Precision Medicine
National Library of Medicine Informatics Lecture Series
There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab builds and applies computational tools to convert hundreds of trillions of points of molecular, clinical, and epidemiological data collected by researchers and clinicians worldwide over the past decade, now commonly known as “big data”, into new diagnostics, therapeutics, and insights into rare and common diseases. Dr. Bu...
Source: Videocast - All Events - May 6, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Unraveling the multi-generational syndrome of diabetic embryopathy: from cell signaling to clinical care
Presented by: E. Albert Reece, M.D., Ph.D., MBA, Dean, University of Maryland School of Medicine; John Z. and Akiko K. Bowers Distinguished Professor and Vice President for Medical Affairs, University of MarylandCategory: WALS - Wednesday Afternoon LecturesAired date: 04/29/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - April 30, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Unraveling the multi-generational syndrome of diabetic embryopathy: from cell signaling to clinical care
Wednesday Afternoon Lecture Series
Successful fetal and maternal outcomes in the context of maternal pregestational diabetes (type 1 or type 2) largely depend on how well glycemic control is maintained, especially prior to conception and in the first trimester of pregnancy. Stringent metabolic control and monitoring, and nutritional management via supplements and antioxidants significantly reduce the risk for or can eliminate poor outcomes due to hyperglycemia on both the maternal and fetal side.
Experiments in animal models have shown that hyperglycemia induces oxidative stress within the developing cells and tissues ...
Source: Videocast - All Events - April 27, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Trial To Assess Chelation Therapy (TACT) - Connecting Silos of Scientific Information
The National Center for Complementary and Integrative Health (NCCIH; formerly NCCAM)presents the Integrative Medicine Research Lecture Series. The series provides overviews of the current state of research and practice involving complementary health approaches and explores perspectives on the emerging discipline of integrative medicine. Gervasio Lamas, M.D., F.A.C.C., F.A.H.A., F.E.S.C., is the chairman of medicine at Mount Sinai Medical Center and chief of the Columbia University Division of Cardiology at Mount Sinai Medical Center. Dr. Lamas is also professor of medicine at Columbia University College of Physicians and S...
Source: Videocast - All Events - April 16, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Unraveling the syndrome of diabetic embryopathy: From cell signaling to clinical care
His research focuses on diabetes in pregnancy, birth defects and prenatal diagnosis. He directs an NIH multi-million dollar research laboratory group studying the bio-molecular mechanisms of diabetes-induced birth defects. His laboratory has determined that there are specific cytoarchitectural changes at the epithelial level of the cell associated with these anomalies. Biochemical changes include depletion in membrane lipids and phospholipids as well as excess “free radicals." His group is now studying the molecular mechanisms, and methods to prevent these anomalies. He and his colleagues have also developed the techniqu...
Source: Videocast - All Events - March 25, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Use of spherical nucleic acid nanoconjugates to accelerate closure of diabetic wounds
NIH Director's Wednesday Afternoon Lecture Series
The Paller lab studies the role of gangliosides (sphingolipids), which regulate lipid raft-based signaling, in skin, particularly in diabetic wound healing and skin cancer. The lab uses DNA- and RNA-nanoconjugates as topical gene therapy to treat diabetic ulcers, psoriasis, skin cancer and other skin overgrowth disorders, and rare genetic skin problems. Dr. Paller is the PI of Northwestern's Skin Disease Research Center, which includes 3 Cores dedicated to providing service to researchers of skin biology. As a pediatric dermatologist, Dr. Paller specializes in genetic (esp...
Source: Videocast - All Events - March 25, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Inflammation, dysbiosis and chronic disease
Wednesday Afternoon Lecture Series
Dysregulation of the immune system and host-microbiota interaction has been associated with the development of a variety of inflammatory as well as metabolic diseases such as obesity and diabetes. Recent studies in Dr. Flavell's laboratory have elucidated the important function of inflammasomes as steady-state sensors and regulators of the gut microbiota. Mice with a disrupted inflammasome pathway have been shown to develop a colitogenic microbial community, which results in exacerbation of chemical-induced colitis and diet-induced steatohepatitis, obesity and type 2 diabetes.
These d...
Source: Videocast - All Events - March 17, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
NICHD Structural Birth Defects Working Group Meeting - December 2014
The mission of the Birth Defects Initiative is to capitalize on genomic and other biomedical discoveries to further understanding of the mechanisms responsible for structural birth defects, which affect almost 4% of all live births in the United States each year. The ultimate goal is the development of new, innovative, and valuable strategies for the molecular diagnosis, treatment, and prevention of human structural birth defects.
The Initiative and the related NICHD Structural Birth Defects Working Group were founded in 2000 by the NICHD and is coordinated by the Developmental Biology and Structural Variations Branch (DB...
Source: Videocast - All Events - November 3, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
