Data-Driven Precision Medicine

National Library of Medicine Informatics Lecture Series There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab builds and applies computational tools to convert hundreds of trillions of points of molecular, clinical, and epidemiological data collected by researchers and clinicians worldwide over the past decade, now commonly known as “big data”, into new diagnostics, therapeutics, and insights into rare and common diseases. Dr. Butte, a bioinformatician and pediatric endocrinologist, will highlight how publicly-available molecular measurements to find new uses for drugs including drug repositioning for inflammatory bowel disease, discovering new treatable inflammatory mechanisms of disease in type 2 diabetes, and how the next generation of biotech companies might even start in your garage. Atul Butte, MD, PhD is the founding Director of the newly-established Institute of Computational Health Sciences at the University of California, San Francisco, and a Professor of Pediatrics. Prior to his new position, he was the chief of the Division of Systems Medicine and Associate Professor of Pediatrics at Stanford University and Lucile Packard Children’s Hospital, where he has been a faculty member for the past decade. Trained in both Computer Science and Medicine at Brown University, Dr...
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