Surveillance of Core Cellular Pathways in C. elegans for Pathogen Assaults
CCR Eminent Lectures
The Ruvkun lab uses C. elegans molecular genetics and genomics to study miRNA and RNAi pathways. Using genetic and RNA interference approaches, we have identified many genes that positively or negatively regulate RNAi and microRNA pathways. These genes reveal the trajectory of siRNAs and miRNAs as they target mRNAs, as well as components that may be developed as drug targets to enhance RNAi in mammals.
Over the past decade, we discovered that like mammals, C. elegans uses an insulin signaling pathway to control its metabolism and longevity. This analysis has revealed striking congruence of molecular me...
Source: Videocast - All Events - October 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Wednesday Afternoon Lecture Series – Special Tuesday Lecture
NIH Director's Wednesday Afternoon Lecture Series
The major interest of Dr. Hotamisligil's laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. His lab's biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.For more information go tohttps://oir.nih.gov/walsAir date: 11/13/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Lipsett Lecture: " Oncofertility: From Bench to Bedside to Babies "
The Lipsett Lecture is an annual lecture held by NICHD to honor Dr. Mortimer B. Lipsett, Director of the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health (NIH), who died of cancer on November 10, 1985 at the Clinical Center. This year's speaker will be Dr. Teresa K. Woodruff, Dean and Associate Provost for Graduate Education in The Graduate School at Northwestern University and Thomas J. Watkins Professor of Obstetrics& Gynecology, the Vice Chair for Research and the Chief of the Division of Reproductive Science in Medicine in the Department of Obstetrics and Gynec...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Reversing the Tide: Diagnosis and Prevention of Type 2 Diabetes in African Descent Populations and 2) Race/Ethnic Variations in Diabetes Risk Prediction: Insights from Metabolic Studies
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 6/6/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDDK Advisory Council - May 2018
NIDDK Advisory Council May 2018 covers (a) report from NIDDK Director, (b)Lectures on Regenerative Research and Presentations fby eminent Scientist Dr. Maike Sander from University of California, San Diego on the topic of " Harnessing Insights into Beta Cell Plasticity for Regenerative Therapies " and " Balancing Multi-Disciplinary Team Science and Individual Lab Science " by NIDDK Program officer Dr. Blondel and Reports from NIDDK Scientific Director Review Committee Meeting by Dr. Evan Abel.For more information go tohttps://sp-web.niddk.nih.gov/about-niddk/advisory-coordinating-committees/national-diabetes-digestive-kidn...
Source: Videocast - All Events - April 27, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
John E. Anderson, MD - Exploring Advances in GLP-1 Agonist Therapy: Practical Insights to Individualize Care in Diabetes
Exploring Advances in GLP-1 Agonist Therapy: Practical Insights to Individualize Care in Diabetes (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - March 15, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Sugar and the beating heart: the conundrum of heart failure in diabetes
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Abel's current research interests focus on elucidating the molecular mechanisms leading to cardiac dysfunction in diabetes and the regulation of myocardial growth and metabolism by insulin signaling.For more information go tohttps://oir.nih.gov/wals/2017-2018/sugar-beating-heart-conundrum-heart-failure-diabetesAir date: 2/7/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Extension of Hydroxyl Radical-Based Footprinting Coupled with Mass Spectrometry for In Cell and In Vivo Protein Analysis
Proteomics Interest Group
In recent years, protein footprinting coupled with mass spectrometry has been used to identify protein-protein interaction sites and regions of conformational change through modification of solvent accessible sites in proteins. Hydroxyl radical-based footprinting (HRBF) approaches utilize hydroxyl radicals to oxidatively modify the side chains of solvent accessible amino acids. There are several approaches to generate radicals for oxidation including synchrotron radiation and electrochemistry. One HRBF method, fast photochemical oxidation of proteins (FPOP), utilizes an excimer laser for photolysi...
Source: Videocast - All Events - November 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Demystifying Medicine: Diabetes and artificial sweeteners
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 3/6/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series
Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Training and Mentoring the Next Generation of Health Equity Researchers: Insights from the Field
The Center for Translation Research and Implementation Science (CTRIS), a part of the National Heart, Lung and Blood Institute (NHLBI), fosters and supports an integrated portfolio of late-stage T4 translation research, implementation science, and related research training in heart, lung, blood, and sleep (HLBS) disorders. CTRIS serves as a strategic focal point at NHLBI to identify optimal research strategies for the delivery of evidence-based interventions which, when scaled up, will improve population level health for all and reduce related health inequities. An important part of the CTRIS mission is the commitment to r...
Source: Videocast - All Events - August 22, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Training the Next Generation of Implementation Researchers for Health Equity
The Center for Translation Research and Implementation Science (CTRIS), a part of the National Heart, Lung and Blood Institute (NHLBI), fosters and supports an integrated portfolio of late-stage T4 translation research, implementation science, and related research training in heart, lung, blood, and sleep (HLBS) disorders. CTRIS serves as a strategic focal point at NHLBI to identify optimal research strategies for the delivery of evidence-based interventions which, when scaled up, will improve population level health for all and reduce related health inequities. An important part of the CTRIS mission is the commitment to r...
Source: Videocast - All Events - August 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDDK Advisory Council - September 2017
Established by law and charter, the National Diabetes and Digestive and Kidney Diseases Advisory Council meets three times annually to advise the NIDDK about its research portfolio. The Council typically undertakes broad issues of science policy. Members of the Advisory Council are drawn from the scientific and lay communities and represent all areas within the Institute's research mission. Video cast will cover budget update from NIDDK director, scientific talk ‘ Molecular Biology of Fertilization ’ by Dr. Jurrien Dean, and other scientific presentations and talks which support NIDDK community's research effortsFor mo...
Source: Videocast - All Events - July 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Accelerating Translation: Strategies for High-Throughput Drug Combination Discovery
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Craig Thomas received his B.S. from the University of Indianapolis in 1995 and received his Ph. D. from Syracuse University in 2000. Dr. Thomas then undertook post-doctoral work in the laboratories of Dr. Sidney Hecht where he earned a fellowship through the American Cancer Society. In 2003, Dr. Thomas moved to the NIH as director of the chemical biology core of the National Institute of Diabetes and Digestive and Kidney Diseases. In 2007, Dr. Thomas moved to the NIH Chemical Genomics Center. Currently, Dr. Thomas serves as the chemistry technology section group ...
Source: Videocast - All Events - June 5, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Production, characterization, and application of stem cell-derived photoreceptors
NEI AGI Seminar in Neuroregenerative Medicine
3-D organoids are the next big thing in disease modeling, drug screening, and tissue sourcing for transplantation. These miniature organs can be grown from patient-derived stem cells, providing a theoretically unlimited supply.
David Gamm, M.D., Ph.D., will summarize efforts to develop retinal organoids derived from human pluripotent stem cells. The retina is the light-sensitive tissue in the back of the eye that sends visual signals to the brain. The most common blinding conditions in the U.S. affect the retina, including age-related macular degeneration, diabetic retinopathy,...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
