Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity (Day 2)
Obesity is a major contributor to serious health conditions in children and adults. The prevalence of obesity in the United States and globally has grown rapidly in the last three decades; thus, there is a pressing need to help people achieve and maintain a healthy weight.
Obesity is commonly defined as having a body mass index (BMI) greater than or equal to 30. In 2014, more than one-third (37.7%) of U.S. adults (Flegal, 2016 ) and 17% of U.S. children and young adults under the age of 20 (Ogden, 2016 ) met this definition, accounting for about 55% of the total U.S. population. There are also persistent disparities among ...
Source: Videocast - All Events - May 2, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity (Day 1)
Obesity is a major contributor to serious health conditions in children and adults. The prevalence of obesity in the United States and globally has grown rapidly in the last three decades; thus, there is a pressing need to help people achieve and maintain a healthy weight.
Obesity is commonly defined as having a body mass index (BMI) greater than or equal to 30. In 2014, more than one-third (37.7%) of U.S. adults (Flegal, 2016 ) and 17% of U.S. children and young adults under the age of 20 (Ogden, 2016 ) met this definition, accounting for about 55% of the total U.S. population. There are also persistent disparities among ...
Source: Videocast - All Events - May 2, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Stem Cells, Aging & Aging Stem Cells
NIH Director ’ s Wednesday Afternoon Lecture Series
A leader in the field of stem cell biology, Dr. Wagers ’ groundbreaking research has uncovered new migratory pathways and signaling networks that regulate the functioning of hematopoietic stem cells. Understanding how these cells function could lead to better treatments for a range of diseases, including cancer, anemia and diabetes.Air date: 4/5/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 29, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Aire: new tricks from an old dog
Immunology Interest Group Seminar Series
Aire is a transcriptional regulator that controls immunological tolerance. Its primary modus operandi is the induction – specifically in thymic medullary epithelial cells – of a battery of transcripts encoding proteins characteristic of terminally differentiated peripheral cell-types, and consequently negative selection of T cells that recognize these proteins. After briefly reviewing the classical findings, this presentation will focus on more recently discovered facets of Aire function, including positive selection of a perinatal population of regulatory T cells, inhibition of...
Source: Videocast - All Events - February 22, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: (1) SGLT2 Inhibitors: A Case Study in Developing Innovative Therapies for Diabetes and (2) Clinical Studies into Biological Mechanisms Mediating SGLT2 Inhibitors' Adverse Effects on Bone Health
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 2/22/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 26, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Using human stem cells to understand and treat diabetes
NIH Director's Wednesday Afternoon Lecture Series
We study how the pancreas normally develops and use that information to grow and develop pancreatic cells (Islets of Langerhans). Our laboratory focuses on the directed differentiation of stem cells to create functional pancreatic beta cells that can be used for research on the cause(s) of diabetes as well as exploring the use of stem cell-derived islets for transplantation.For more information go tohttps://oir.nih.gov/walsAir date: 12/15/2016 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 6, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
NIH Research Festival Plenary Session I - Super enhancers in cell identity and disease
Super enhancers, as the name may connote, offer seemingly heroic regulation of gene expression. While snippets of DNA known as enhancers have long been appreciated to bind with transcription factors to ramp up gene activity, regions of DNA called super enhancers are exceptionally busy parts of the genome that control lineage-defining genes — to paraphrase the movie Spinal Tap, they turn their volume up to 11 just when that extra push is needed. Mutations in super enhancers have been noted in various diseases, and they may play important roles in the dysregulation of gene expression in cancer.
NIH researchers have been at...
Source: Videocast - All Events - September 12, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Maurice B. Burg Lecture 2016: The Kidney and New Therapies for Diabetes
In the early 20th century Homer Smith demonstrated that glucose was freely filtered by the human kidney, no glucose was lost in the urine, and phlorizin completely blocked glucose reabsorption. Despite the fact that glycosuria is a hallmark of diabetes, a new class of drugs derived from phlorizin have been introduced to lower hyperglycemia in these patients by increasing glycosuria. Dr. Wright will review the kidney physiology and preclinical studies that led to this unexpected new treatment for diabetes.Air date: 10/17/2016 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 30, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Persistent Effect of Intensive Glycemic Control on Diabetic Retinopathy in Type 2 Diabetes and 2) Dysglycemia, Vasculopenia, and the Chronic Consequences of Diabetes
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 9/28/2016 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 29, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Sayer Lecture
The National Eye Institute (NEI) and the Foundation for the National Institutes of Health (FNIH) present the 9th Sayer Vision Research Lecture: "Sequencing 10,000s of Human Genomes: Analytical Challenges and Opportunities,” by Dr. Gonçalo Abecasis.
June 28, 2016
2:00 PM
Natcher Conference Center/Building 45, main auditorium National Institutes of Health Campus
Dr. Abecasis is the Felix E. Moore Collegiate Professor of Biostatistics and the Chair of the Department of Biostatistics at the University of Michigan’s Center for Statistical Genetics, School of Public Health. He is a world-renowned leader in the design of c...
Source: Videocast - All Events - June 27, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Genomics and Health Disparities Lecture Series: Genomics in Mexico: Implications for Health Care and the Bioeconomy
Gerardo Jiménez-Sánchez MD, PhD is Professor of Genomic Medicine, Adjunct Professor of Epidemiology, and Program Director, Genomic Medicine and Bioeconomy, at the Harvard T.H. Chan School of Public Health. He also Executive President of Global Biotech Consulting Group. He was the founding Director of the National Institute of Genomic Medicine (INMEGEN) in Mexico, and director of the Mexican Genomic Diversity Project.
The Genomics and Health Disparities Lecture Series was formed to enhance opportunities for dialogue about how innovations in genomics research and technology can impact health disparities. The lecture series...
Source: Videocast - All Events - April 6, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Role of PTPN22 in Autoimmunity and Viral Immunity.
Dr. Linda Sherman received her Ph.D. from M.I.T. in Biology, and did postdoctoral research in immunology at Albert Einstein Medical College and Harvard Medical School, after which she started her laboratory at The Scripps Research Institute, where she remained throughout her career. She has served on advisory panels for the National Science Foundation, The American Cancer Society, The Juvenile Diabetes Foundation, and The National Institutes of Health. She was a member of the Advisory Council to the National Institute of Diabetes and Digestive and Kidney Disease from 2002-2006. She has served on numerous committees for t...
Source: Videocast - All Events - March 24, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Exploring Genetic Dependencies in Ras Mutant Cancer Cells
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Ji Luo received his B.A. in Natural Sciences from the University of Cambridge, UK in 1998. He completed his Ph.D. training as an HHMI Predoctoral Fellow in the laboratory of Dr. Lewis Cantley at Harvard University, Boston. His Ph.D. research focused on the role of PI 3-kinase in development, diabetes and cancer. Ji Luo undertook his postdoctoral training as an AACR Fellow in the laboratory of Dr. Stephen Elledge at Harvard Medical School, Boston. His postdoctoral research focused on the development of bar-coded shRNA library technologies for genome-wide RNAi syn...
Source: Videocast - All Events - February 29, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: Thyroid Cancer: Diagnostic and Therapeutic Paradigm Shift: When Less is More and (2) Facts and Myths on the Role of Thyroid Stimulating Hormone (TSH) in Thyroid Cancer
Presented by: (1) Monica Skarulis, MD, Chief, Clinical Endocrine Section, Diabetes, Endocrinology and Obesity Branch, NIDDK, NIH and (2) Joanna Klubo-Gwiezdzinska, MD, PhD Clinical Fellow, Clinical Endocrine Section, Endocrinology and Obesity Branch, NIDDK, NIHCategory: Clinical Center Grand RoundsAired date: 02/24/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - February 25, 2016 Category: Journals (General) Tags: Past Events Source Type: video
How to make pancreatic beta cells for diabetics
Wednesday Afternoon Lecture Series
Dr. Melton is interested in the developmental biology of the pancreas and in understanding the stem cells that give rise to the pancreas. In the lecture, he will discuss the challenges of making stem-cell-derived pancreatic beta cells. A primary problem for insulin-dependent diabetics is the absence (in type 1 diabetes) or dysfunction (in type 2 diabetes) of pancreatic beta cells. The ability to direct the differentiation human stem cells into beta cells opens up the possibility of using these cells for research into the causes of beta-cell loss. In addition, stem-cell-derived beta cell...
Source: Videocast - All Events - January 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
