Maurice B. Burg Lecture 2016: The Kidney and New Therapies for Diabetes

In the early 20th century Homer Smith demonstrated that glucose was freely filtered by the human kidney, no glucose was lost in the urine, and phlorizin completely blocked glucose reabsorption. Despite the fact that glycosuria is a hallmark of diabetes, a new class of drugs derived from phlorizin have been introduced to lower hyperglycemia in these patients by increasing glycosuria. Dr. Wright will review the kidney physiology and preclinical studies that led to this unexpected new treatment for diabetes.Air date: 10/17/2016 2:00:00 PM
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