Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards the Regrowth of Lost Sensory Hair Cells in the Inner Ear
Age-related deafness arises from some combination of (a) the loss of sensory hair cells in the inner ear, and (b) the loss of connections between those cells and the brain. There is some disagreement in the literature as to which of these mechanisms is the most relevant, but most recent efforts in the field are focused on trying to coerce the body into producing new hair cells. If that production of new hair cells in the inner ear follows the normal developmental processes, then it might solve both of the above mentioned issues, providing both cells and connections to the brain.
Today's research materials illustrate...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Up Your Game With NIH Kahoot! Quizzes
NIH is now a premium partner with Kahoot! Credit: NIGMS.
We’re excited to announce our new partnership with Kahoot! Although we aren’t new Kahoot! gamers, we’ve recently partnered with them to provide you quizzes from across the National Institutes of Health (NIH) in a single place. “Reaching young people to teach them about biomedical science and inspire them to pursue careers in science is critically important to ensuring a diverse and vibrant biomedical research enterprise,” says NIGMS Director Jon Lorsch, Ph.D. “Our partnership with Kahoot! expands NIH’s STEM offerings, providing educators with free, in...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 23, 2023 Category: Research Authors: Chrissa Chverchko Tags: STEM Education Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stimulating the Olfactory System as a Way to Improve Late Life Cognitive Function
The research noted here adds to evidence for the lack of use of the senses to contribute to age-related declines in cognitive function: a sort of "use it or lose it" proposition for the brain that becomes especially pronounced in later life. This effect is better studied in the context of age-related deafness, given the sizable amount of data on hearing aid use. Here, however, researchers focus on the sense of smell, and find that cognitive function can be improved by stimulation via scents.
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed....
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sensory Hair Cells of the Inner Ear Can Repair Themselves to Some Degree
Hearing loss involves either damage or loss of sensory hair cells in the inner ear, or loss of their connections to the brain. It remains somewhat unclear as to whether cell damage, cell death, or connection loss is the primary mechanism of interest in mammals. Researchers here investigate the way in which hair cells repair themselves. Where a mechanism like this exists and is understood, there is the potential to increase its efficiency as a basis for therapy. This may prove to be a useful treatment for some forms of deafness, but only those in which the cells and their connections remain, where hearing loss results from ...
Source: Fight Aging! - July 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Matthew ’s health care tidbits: Hedge Funds that Do Health Care on the Side
Each time I send out the THCB Reader, our newsletter that summarizes the best of THCB (Sign up here!) I include a brief tidbits section. Then I had the brainwave to add them to the blog. They’re short and usually not too sweet! –Matthew Holt
Lots of news about bad behavior in health care this week, with real shots about patient & staff safety at home care company Papa, and Grail misinforming 400 people that they had cancer. But the prize for tone deafness this week comes from another very well funded health care provider system being heartless to its poorest patients.
This week it’s Allina, a Minn...
Source: The Health Care Blog - June 5, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt Allina Ascension UPMC Source Type: blogs
La Sombrita, or, How to Fail at Infrastructure
Paul MatzkoLos Angeles spent $200,000 on La Sombrita ( ‘“in the shade”), a bus stop shade/light structure that provides littleshade or light. It has been almost too easy to criticize its design, the token DEI framing given to the project, how most of the funds went to a global junket for the designers, or the fact that city officials held a tone deaf celebratory press conference for its unveiling. Would this “make waiting for the bus at night [feel]safer” to you?But La Sombrita isn ’t really the problem. Rather, its failures are symptoms of its designers trying to work around deeper, structural problems ...
Source: Cato-at-liberty - May 22, 2023 Category: American Health Authors: Paul Matzko Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Sensory Hair Cell Regeneration in the Inner Ear
Numerous forms of deafness, including age-related hearing loss, involve either loss of hair cells in the inner ear or loss of their axonal connections to the brain. These cells do not normally regenerate in mammals, and there is some interest in finding a way to bypass the suppression mechanisms that allow growth of hair cells during development but prevent regrowth during adult life. Approaches that show promise in animal studies include stem cell transplants, gene therapies, and small molecules targeting regulatory pathways. Here, researchers report on the ability of a mix of small molecules and siRNAs to produce regener...
Source: Fight Aging! - May 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Deep Elaboration & Other Stories of Teaching Anatomy & Physiology | TAPP 136
In Episode 136, host Kevin Patton looks at theeffects of tattoos on sweat glands, we discussaural diversity and how we can accommodate it, and we explore how to use the process ofdeep elaboration in our course to help challenged learners develop stronger and more useful memories.00:00 | Introduction00:47 | Tattoos May Impair Sweating05:37 | Sponsored by AAA06:41 | Aural Diversity. It ' s a Thing.22:36 | Sponsored by HAPI24:03 | Deep Elaboration34:22 | Sponsored by HAPS35:29 | Deeper Elaboration47:53 | Staying Connected ★ If you cannot see or activate the audio player, go to:theAPprofessor.org/podcast-...
Source: The A and P Professor - May 9, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Career Conversations: Q & A With Polymer Chemist Frank Leibfarth
Credit: Courtesy of Dr. Frank Leibfarth.
“I love that you can change the molecular-level structure of a material, then pull it, bend it, or twist it and see firsthand how the molecular changes you introduced influence its stretchiness or bendiness,” says Frank Leibfarth Ph.D., an associate professor of chemistry at the University of North Carolina (UNC) at Chapel Hill. In an interview, Dr. Leibfarth shares with us his scientific journey, his use of chemistry to tackle challenges in human health and sustainability, and his beliefs on what makes a career in science exciting.
Q: What led you to study chemistry?
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
111 Tired Quotes You Can Relate to (But Also Get a Boost of Energy From)
If you’re tired today then maybe this post can help you.
In it I want to share relatable and timeless thoughts on tiredness. To give you some comfort. To remind you that you’re not alone in feeling this way.
But I also want to offer thoughts that can bring you a new spark of energy and motivation. And wisdom that may give you new ideas about how to tackle being tired. To hopefully be less tired in the coming weeks and months.
This is 111 of the best and most powerful tired quotes. I truly hope you’ll find something helpful here.
And if you want more useful motivation then check out this post with quotes on dealing w...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 11, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
Utilizing Technology to Expand Language Access
The following is a guest article by Nic McMahon, CEO at United Language Group
Communication and connection are crucial in healthcare settings. To better connect with their community and ensure equitable access, healthcare organizations are shifting to a more human-focused, patient-centered care approach. Without a strong focus on language access, some groups of vulnerable patients may fall through the cracks.
As of 2019, almost 68 million people in the United States spoke a language other than English at home. A significant percentage of these people have limited English proficiency (LEP).
Research shows that patients ...
Source: EMR and HIPAA - April 5, 2023 Category: Information Technology Authors: Guest Author Tags: Administration AI/Machine Learning Ambulatory Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System LTPAC Accessible Communication Blind Patients Deaf Patients Hard of Hearing Patien Source Type: blogs
