Genetic Studies of Actinic Keratosis Development: Where Are We Now?
Ann Dermatol. 2023 Dec;35(6):389-399. doi: 10.5021/ad.23.072.ABSTRACTActinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin's outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA d...
Source: Annals of Dermatology - December 12, 2023 Category: Dermatology Authors: Young Bok Lee Jong-Il Kim Source Type: research
Genetic Studies of Actinic Keratosis Development: Where Are We Now?
Ann Dermatol. 2023 Dec;35(6):389-399. doi: 10.5021/ad.23.072.ABSTRACTActinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin's outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA d...
Source: Annals of Dermatology - December 12, 2023 Category: Dermatology Authors: Young Bok Lee Jong-Il Kim Source Type: research
Genetic Studies of Actinic Keratosis Development: Where Are We Now?
Ann Dermatol. 2023 Dec;35(6):389-399. doi: 10.5021/ad.23.072.ABSTRACTActinic keratosis (AK) is a common precancerous skin lesion that can develop into cutaneous squamous cell carcinoma (CSCC). AK is characterized by atypical keratinocytes in the skin's outer layer and is commonly found in sun-exposed areas. Like many precancerous lesions, the development of AK is closely associated with genetic mutations. The molecular biology and transcriptional mechanisms underlying AK development are not well understood. Ultraviolet (UV) light exposure, especially UVA and UVB radiation, is a significant risk factor for AK, causing DNA d...
Source: Annals of Dermatology - December 12, 2023 Category: Dermatology Authors: Young Bok Lee Jong-Il Kim Source Type: research
Cryosurgery and 5-Fluorouracil Combination Therapy for Treatment of Bowen's Disease and Superficial Basal Cell Carcinoma
CONCLUSION: Cryosurgery followed by immediate 5-FU use may be an effective mode of treatment for BD and sBCC, negating the need for invasive procedures and allowing for increased accessibility. Further studies with longer follow-up intervals, comparisons with other non-invasive treatments, and evidence of histologic cure are required. J Drugs Dermatol. 2023;22(12):1166-1171. doi:10.36849/JDD.7378.PMID:38051856 | DOI:10.36849/JDD.7378 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - December 5, 2023 Category: Dermatology Authors: Samina Nazarali Dusan Sajic Source Type: research
